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 Forschungsbericht für das Jahr 2014

Institut für Anatomie und Zellbiologie

Abteilung Molekulare Embryologie

Albertstr. 17
79104 Freiburg i. Br.
Tel: ++49-761/203 5087 Fax: ++49-761/203-5091
https://www.anatomie.uni-freiburg.de/anatomie2


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Kerstin Krieglstein
  • Prof. Dr. Dr. h.c. emer. Bodo Christ
  • PD Dr. Katrin Huber-Wittmer
  • Prof. Dr. Eleni Roussa
  • Prof. Dr. Dr. h. c. Klaus Unsicker, Gastprofessor
  • Prof. Dr. Tanja Vogel
  • Dr. Jan Pruszak
  • Dr. Christian Schachtrup
  • Dr. habil. Andreas Schober
  • Dr. Björn Spittau
  • Dr. Petar Charalambous
  • Dr. Oliver Oehlke
  • Dr. Sandra Werner
  • Stefanie Krück
  • Ahmed Sharaf
  • Stella Shtukmaster
  • Dr. Jan Speer
  • Shalaka Wahane
  • Katalin Zajzon
  • Xiaolai Zhou
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Developmental Neurobiology
  • Signaling mechanisms in vertebrate development
  • Neurodegenerative Disease
  • Entwicklung des Nervensstems
  • Entwicklungsbiologie der Wirbeltiere
  • Medizinische Embryologie

Finanzierung

  • SFB 780: Teilprojekt B2: Role of TGF-ß in the development of neuronal networks (Krieglstein)
  • DFG KR1477/10-2: Development and regeneration of mesencephalic dopaminergic neurons (Krieglstein)
  • DFG KR1477/11-2 (Krieglstein)
  • DFG RO2495/1-3 (Roussa)

Wissenschaftliche Projekte und Forschungsvorhaben


  • Characterization of CDNF as a neurotrophic factor for developing, adult and aged nigrostriatal dopamine neurons
  • Development and regeneration of mesencephalic dopaminergic neurons
  • Functions of Growth/Differentiation Factor-15 (GDF-15) in neuron survival and peripheral myelination
  • Kontrolle der Somitenkompartimentierung
  • Molekulare Kontrolle des embryonalen Muskelwachstums
  • Plasticity in the temporal lobe: Involvement of acetylcholine and NGF signaling
  • Role of TGF-ß in the development of neuronal networks
  • Signaling mechanisms in somite cell specification
  • Specification and maintenance of chromaffin cells and their preganglionic innervation

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Balakrishnan-Renuka A, Morosan-Puopolo G, Yusuf F, Abduelmula A, Chen J, Zoidl G, Philippi S, Dai F, Brand-Saberi B: ATOH8, a regulator of skeletal myogenesis in the hypaxial myotome of the trunk. Histochem Cell Biol, 2014; 141 (3): 289-300. : http://dx.doi.org/10.1007/s00418-013-1155-0
  • Boonla C, Tosukhowong P, Spittau B, Schlosser A, Pimratana C, Krieglstein K: Inflammatory and fibrotic proteins proteomically identified as key protein constituents in urine and stone matrix of patients with kidney calculi. Clin Chim Acta, 2014; 429: 81-89. : http://dx.doi.org/10.1016/j.cca.2013.11.036
  • Carrillo-Garcia C, Prochnow S, Simeonova IK, Strelau J, Holzl-Wenig G, Mandl C, Unsicker K, von Bohlen Und Halbach O, Ciccolini F: Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice. Development, 2014; 141 (4): 773-783. : http://dx.doi.org/10.1242/dev.096131
  • Chankiewitz V, Morosan-Puopolo G, Yusuf F, Rudloff S, Prols F, Kleff V, Hofmann DK, Brand-Saberi B: A thymosin beta15-like peptide promotes intersegmental myotome extension in the chicken embryo. Histochem Cell Biol, 2014; 141 (3): 275-287. : http://dx.doi.org/10.1007/s00418-013-1156-z
  • Dokter M, Busch R, Poser R, Vogt MA, von Bohlen Und Halbach V, Gass P, Unsicker K, von Bohlen Und Halbach O: Implications of p75NTR for dentate gyrus morphology and hippocampus-related behavior revisited. Brain Struct Funct, 2014. : http://dx.doi.org/10.1007/s00429-014-0737-5 (in Druck)
  • Grassi D, Lagunas N, Calmarza-Font I, Diz-Chaves Y, Garcia-Segura LM, Panzica GC: Chronic unpredictable stress and long-term ovariectomy affect arginine-vasopressin expression in the paraventricular nucleus of adult female mice. Brain Res, 2014; 1588: 55-62. : http://dx.doi.org/10.1016/j.brainres.2014.09.006
  • Hainmuller T, Krieglstein K, Kulik A, Bartos M: Joint CP-AMPA and group I mGlu receptor activation is required for synaptic plasticity in dentate gyrus fast-spiking interneurons. P Natl Acad Sci Usa, 2014; 111 (36): 13211-13216. : http://dx.doi.org/10.1073/pnas.1409394111
  • Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T: Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet, 2014; 23 (23): 6177-6190. : http://dx.doi.org/10.1093/hmg/ddu338
  • Irmady K, Jackman KA, Padow VA, Shahani N, Martin LA, Cerchietti L, Unsicker K, Iadecola C, Hempstead BL: Mir-592 regulates the induction and cell death-promoting activity of p75NTR in neuronal ischemic injury. J Neurosci, 2014; 34 (9): 3419-3428. : http://dx.doi.org/10.1523/JNEUROSCI.1982-13.2014
  • Khanghahi AM, Zeynali B, Akhlaghpoor A, Tafreshi AP, Krieglstein K: Activation of TGFbeta1 signaling enhances early dopaminergic differentiation in unrestricted somatic stem cells. Neurosci Lett, 2014; 583: 60-64. : http://dx.doi.org/10.1016/j.neulet.2014.08.055
  • Morosan-Puopolo G, Balakrishnan-Renuka A, Yusuf F, Chen J, Dai F, Zoidl G, Ludtke TH, Kispert A, Theiss C, Abdelsabour-Khalaf M, Brand-Saberi B: Wnt11 is required for oriented migration of dermogenic progenitor cells from the dorsomedial lip of the avian dermomyotome. Plos One, 2014; 9 (3): 1-16. : http://dx.doi.org/10.1371/journal.pone.0092679
  • Narayanan KL, Subramaniam S, Bengston CP, Irmady K, Unsicker K, von Bohlen, Halbach O: Role of transient receptor potential channel 1 (TRPC1) in glutamate-induced cell death in the hippocampal cell line HT22. J Mol Neurosci, 2014; 52 (3): 425-433. : http://dx.doi.org/10.1007/s12031-013-0171-9
  • Schildge S, Bohrer C, Pfurr S, Mammadzada K, Schachtrup K, Schachtrup C: Instructions from the vascular system - directing neural stem cell fate in health and disease. Curr Med Chem, 2014; 21 (19): 2190-2207. : http://dx.doi.org/10.2174/0929867321666131227162215
  • Schondorf DC, Aureli M, McAllister FE, Hindley CJ, Mayer F, Schmid B, Sardi SP, Valsecchi M, Hoffmann S, Schwarz LK, Hedrich U, Berg D, Shihabuddin LS, Hu J, Pruszak J, Gygi SP, Sonnino S, Gasser T, Deleidi M: iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis. Nat Commun, 2014; 5: 1-17. : http://dx.doi.org/10.1038/ncomms5028
  • Sinn R, Peravali R, Heermann S, Wittbrodt J: Differential responsiveness of distinct retinal domains to Atoh7. Mech Develop, 2014; 133: 218-229. : http://dx.doi.org/10.1016/j.mod.2014.08.002
  • Spittau B, Rilka J, Steinfath E, Zoller T, Krieglstein K: TGFbeta1 increases microglia-mediated engulfment of apoptotic cells via upregulation of the milk fat globule-EGF factor 8. Glia, 2014: 1-12. : http://dx.doi.org/10.1002/glia.22740 (in Druck)
  • Wahane SD, Hellbach N, Prentzell MT, Weise SC, Vezzali R, Kreutz C, Timmer J, Krieglstein K, Thedieck K, Vogel T: PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2. J Neurochem, 2014; 130 (2): 255-267. : http://dx.doi.org/10.1111/jnc.12718
  • Zlotnik A, Spittau B: GDNF fails to inhibit LPS-mediated activation of mouse microglia. J Neuroimmunol, 2014; 270 (1-2): 22-28. : http://dx.doi.org/10.1016/j.jneuroim.2014.03.006
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:
Sonstige Publikationen:

Besondere wissenschaftliche Aktivitäten

Preise / Ehrungen:
  • Prof. Dr. Eleni Roussa: Walther-Engel-Preis 2010, der Akademie für Zahnärztliche Fortbildung Karlsruhe im Rahmen der 25. Karlsruher Konferenz 2010, 26.03.2010.
Ehrendoktorschaften:
  • Prof. Dr. Bodo Christ: Dr.h.c., Universität Iasi, Rumänien, seit 27.11.2003.
Ehrung:
  • Prof. Dr. Kerstin Krieglstein: Mitglied der Deutschen Akademie der Naturforscher Leopoldina, seit 28.11.2007.

Abschlussarbeiten