TGF-ß signalling and epigenetic modifications in neuronal activity
TGF-ß are multifunctional extracellular signaling molecules acting in the nervous system from early development into adulthood. TGF-ß2 is first detectable in neurites and areas of neuronal differentiation. Current evidence suggests a role of TGF-ß in invertebrate PNS synaptogenesis. Previous work by this research group indicates that TGF-ß2 acts an important regulator of CNS synapse development and neuronal network function. Additionally, it is well known that neuronal activity and memory formation are modulated through so-called epigenetic modifications, such as DNA methylation.
The goal of the project is to characterize the role of TGF-ßin the development and modulation of CNS neuronal networks and to explore in parallel changes in the epigenome.
Ansprechpartner: Prof. Dr. Tanja Vogel
Vogel T, Krieglstein K