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TGF-ß signalling and epigenetic modifications in neuronal activity

TGF-ß are multifunctional extracellular signaling molecules acting in the nervous system from early development into adulthood. TGF-ß2 is first detectable in neurites and areas of neuronal differentiation. Current evidence suggests a role of TGF-ß in invertebrate PNS synaptogenesis. Previous work by this research group indicates that TGF-ß2 acts an important regulator of CNS synapse development and neuronal network function. Additionally, it is well known that neuronal activity and memory formation are modulated through so-called epigenetic modifications, such as DNA methylation. The goal of the project is to characterize the role of TGF-ßin the development and modulation of CNS neuronal networks and to explore in parallel changes in the epigenome.

Ansprechpartner: Prof. Dr. Tanja Vogel
Tel: 0761/203-5087
Email: tanja.vogel@anat.uni-freiburg.de
Projektbeginn: 2008
Projektende: (unbegrenzt)
Vogel T, Krieglstein K

Albert-Ludwigs-Universität Freiburg

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