The role of Id3 as a transcriptional regulator of neuronal differentiation in CNS injury or disease
Adult neural stem cells (NSCs) of the subventricular zone (SVZ) are an endogenous source for neuronal replacement in CNS disease, but adult neurogenesis is compromised after brain injury in favor of a glial cell fate. The failure of NSCs to differentiate into neurons after brain injury has been attributed to changes in the NSC environment, such as elevated levels of bone morphogenetic proteins (BMPs). However, it is unknown how this unfavorable extracellular environment translates into an intrinsic transcriptional program that regulates NSC differentiation. Our research focuses on the transcriptional regulator Id3 and its role in NSC fate decisions in brain injury.
Ansprechpartner: Christian Schachtrup