[Zurück]
 
Bitte auswählen
Jahr
Details
Sprache
Sortierung
Ausgabe
neu: RTF !
 Forschungsbericht für das Jahr 2008

Department Neurozentrum

Institut für Neuropathologie

Breisacher Str. 64
79106 Freiburg
Tel: 0761-270-51060 Fax: 0761-270-50500


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Marco Prinz, Ärztlicher Direktor
  • Dr. med. Soroush Doostkam, Oberarzt, Stellv. des Ärztlichen Direktors
  • PD Dr. Friedrich Feuerhake
  • Dr. rer. nat. Klaus-Peter Knobeloch, Laborleiter
  • Sandra Baumgartner, Assistenzärztin
  • Dr. Ildiko Dunay, Arbeitsgruppenleiterin Immunoparasitologie
  • Dr. med. Klaus Müller, Oberarzt
  • Andrea Ullrich, Assistenzärztin
  • Dr. rer. nat. Nicolas Zeller, Postdoc
  • Angela Dann
  • Dr. rer. nat. Rolf Knoth, wissenschaftlicher Assistent
  • PD Dr. rer. nat. Ralf Peter Meyer, Forschungsgruppenleiter
  • Dr. rer. nat. Alexander Mildner, Postdoc
  • Carolin Bürck, Diplomandin
  • Ricarda Schwab, Diplomandin
  • cand. med. Philipp Capetian, Dr.
  • cand. med. Andreas Fahrner, med. Doktorand
  • Margarethe Ditter, MTA
  • Christine el Gaz, MTA
  • Christine Kremer, MTA
  • Dr. Alexandra Müller, MTA, Biotechnologin
  • Viviana Sverdlick, MTA
  • Sylvia Blust, Schreibkraft
  • Prof. Dr. Benedikt Volk, Emeritus
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Klinische und experimentelle Neuropathologie
  • Neuroimmunologie
  • Zelluläre Neurobiologie
  • Neurotoxikologie
  • Neurochemie

Finanzierung

  • Müller-Fahnenberg-Stiftung
  • BMBF

Wissenschaftliche Projekte und Forschungsvorhaben


  • Funktion und Regulation von Zytochrom P450 im Gehirn

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Beck J, Rohrer JD, Campbell T, Isaacs A, Morrison KE, Goodall EF, Warrington EK, Stevens J, Revesz T, Holton J, Al-Sarraj S, King A, Scahill R, Warren JD, Fox NC, Rossor MN, Collinge J, Mead S: A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series. Brain, 2008; 131 (Pt 3): 706-720. : http://dx.doi.org/10.1093/brain/awm320
  • Borroni B, Archetti S, Alberici A, Agosti C, Gennarelli M, Bigni B, Bonvicini C, Ferrari M, Bellelli G, Galimberti D, Scarpini E, Di Lorenzo D, Caimi L, Caltagirone C, Di Luca M, Padovani A: Progranulin genetic variations in frontotemporal lobar degeneration: evidence for low mutation frequency in an Italian clinical series. Neurogenetics, 2008; 9 (3): 197-205. : http://dx.doi.org/10.1007/s10048-008-0127-3
  • Cortini F, Fenoglio C, Guidi I, Venturelli E, Pomati S, Marcone A, Scalabrini D, Villa C, Clerici F, Dalla Valle E, Mariani C, Cappa S, Bresolin N, Scarpini E, Galimberti D: Novel exon 1 progranulin gene variant in Alzheimer's disease. Eur J Neurol, 2008; 15 (10): 1111-1117. : http://dx.doi.org/10.1111/j.1468-1331.2008.02266.x
  • Doostkam S, Bohl JR, Sahraian A, Mahjoor AA: Amyloid deposits in senile vertebral arteries, immunohistological and ultrastructural findings. Pakistan Journal of Biological Sciences, 2008; 11 (14): 1852-1855.
  • Genoud N, Ott D, Braun N, Prinz M, Schwarz P, Suter U, Trono D, Aguzzi A: Antiprion prophylaxis by gene transfer of a soluble prion antagonist. Am J Pathol, 2008; 172 (5): 1287-1296. : http://dx.doi.org/10.2353/ajpath.2008.070836
  • Gijselinck I, Van Broeckhoven C, Cruts M: Granulin mutations associated with frontotemporal lobar degeneration and related disorders: an update. Hum Mutat, 2008; 29 (12): 1373-1386. : http://dx.doi.org/10.1002/humu.20785
  • Guerra S, Caceres A, Knobeloch KP, Horak I, Esteban M: Vaccinia virus E3 protein prevents the antiviral action of ISG15. Plos Pathog, 2008; 4 (7): 1-16. : http://dx.doi.org/10.1371/journal.ppat.1000096
  • Guerreiro RJ, Santana I, Bras JM, Revesz T, Rebelo O, Ribeiro MH, Santiago B, Oliveira CR, Singleton A, Hardy J: Novel progranulin mutation: screening for PGRN mutations in a Portuguese series of FTD/CBS cases. Movement Disord, 2008; 23 (9): 1269-1273. : http://dx.doi.org/10.1002/mds.22078
  • Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A: Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity, 2008; 29 (6): 998-1008. : http://dx.doi.org/10.1016/j.immuni.2008.10.014
  • Heikenwalder M, Prinz M, Zeller N, Lang KS, Junt T, Rossi S, Tumanov A, Schmidt H, Priller J, Flatz L, Rulicke T, Macpherson AJ, Hollander GA, Nedospasov SA, Aguzzi A: Overexpression of lymphotoxin in T cells induces fulminant thymic involution. Am J Pathol, 2008; 172 (6): 1555-1570. : http://dx.doi.org/10.2353/ajpath.2008.070572
  • Illerhaus G, Muller F, Feuerhake F, Schafer AO, Ostertag C, Finke J: High-dose chemotherapy and autologous stem-cell transplantation without consolidating radiotherapy as first-line treatment for primary lymphoma of the central nervous system. Haematol-hematol J, 2008; 93 (1): 147-148. : http://dx.doi.org/10.3324/haematol.11771
  • Janzarik WG, Muller K, Lubbert M, Spreer J, Trippel M, Uhlig I, Weiller C, Rauer S: Occurrence of a germinoma 22 years after resection of a mature cerebral teratoma. J Neuro-oncol, 2008; 88 (2): 217-219. : http://dx.doi.org/10.1007/s11060-008-9554-0
  • Jehle T, Dimitriu C, Auer S, Knoth R, Vidal-Sanz M, Gozes I, Lagreze WA: The neuropeptide NAP provides neuroprotection against retinal ganglion cell damage after retinal ischemia and optic nerve crush. Graef Arch Clin Exp, 2008; 246 (9): 1255-1263. : http://dx.doi.org/10.1007/s00417-007-0746-7
  • Julius C, Heikenwalder M, Schwarz P, Marcel A, Karin M, Prinz M, Pasparakis M, Aguzzi A: Prion propagation in mice lacking central nervous system NF-kappaB signalling. J Gen Virol, 2008; 89 (Pt 6): 1545-1550. : http://dx.doi.org/10.1099/vir.0.83622-0
  • Kaivorinne AL, Kruger J, Kuivaniemi K, Tuominen H, Moilanen V, Majamaa K, Remes AM: Role of MAPT mutations and haplotype in frontotemporal lobar degeneration in Northern Finland. Bmc Neurol, 2008; 8: 48-48. : http://dx.doi.org/10.1186/1471-2377-8-48
  • Le Ber I, Camuzat A, Hannequin D, Pasquier F, Guedj E, Rovelet-Lecrux A, Hahn-Barma V, van der Zee J, Clot F, Bakchine S, Puel M, Ghanim M, Lacomblez L, Mikol J, Deramecourt V, Lejeune P, de la Sayette V, Belliard S, Vercelletto M, Meyrignac C, Van Broeckhoven C, Lambert JC, Verpillat P, Campion D, Habert MO, Dubois B, Brice A: Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study. Brain, 2008; 131 (Pt 3): 732-746. : http://dx.doi.org/10.1093/brain/awn012
  • McNeal KM, Meyer RP, Lukacs K, Senseney A, Mintzer J: Using risperidone for Alzheimer's dementia-associated psychosis. Expert Opin Pharmaco, 2008; 9 (14): 2537-2543. : http://dx.doi.org/10.1517/14656566.9.14.2537
  • Mildner A, Djukic M, Garbe D, Wellmer A, Kuziel WA, Mack M, Nau R, Prinz M: Ly-6G+CCR2- myeloid cells rather than Ly-6ChighCCR2+ monocytes are required for the control of bacterial infection in the central nervous system. J Immunol, 2008; 181 (4): 2713-2722.
  • Nuytemans K, Pals P, Sleegers K, Engelborghs S, Corsmit E, Peeters K, Pickut B, Mattheijssens M, Cras P, De Deyn PP, Theuns J, Van Broeckhoven C: Progranulin variability has no major role in Parkinson disease genetic etiology. Neurology, 2008; 71 (15): 1147-1151. : http://dx.doi.org/10.1212/01.wnl.0000327563.10320.2b
  • Pickering-Brown SM, Rollinson S, Du Plessis D, Morrison KE, Varma A, Richardson AM, Neary D, Snowden JS, Mann DM: Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations. Brain, 2008; 131 (Pt 3): 721-731. : http://dx.doi.org/10.1093/brain/awm331
  • Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Hacker G, Neuenhahn M, Busch D, Ruland J, Rothenfusser S, Prinz M, Hornung V, Endres S, Tuting T, Hartmann G: 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med, 2008; 14 (11): 1256-1263. : http://dx.doi.org/10.1038/nm.1887
  • Prinz M, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Bruck W, Kalinke U: Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity, 2008; 28 (5): 675-686. : http://dx.doi.org/10.1016/j.immuni.2008.03.011
  • Rene R, Campdelacreu J, Escrig A, Gascon-Bayarri J, Hernandez-Pardo M, Jauma S, Rubio F: [Frontotemporal lobar degeneration: a descriptive study of 42 patients] Neurologia, 2008; 23 (8): 511-517.
  • Sleegers K, Brouwers N, Maurer-Stroh S, van Es MA, Van Damme P, van Vught PW, van der Zee J, Serneels S, De Pooter T, Van den Broeck M, Cruts M, Schymkowitz J, De Jonghe P, Rousseau F, van den Berg LH, Robberecht W, Van Broeckhoven C: Progranulin genetic variability contributes to amyotrophic lateral sclerosis. Neurology, 2008; 71 (4): 253-259. : http://dx.doi.org/10.1212/01.wnl.0000289191.54852.75
  • Uryu K, Nakashima-Yasuda H, Forman MS, Kwong LK, Clark CM, Grossman M, Miller BL, Kretzschmar HA, Lee VM, Trojanowski JQ, Neumann M: Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies. J Neuropath Exp Neur, 2008; 67 (6): 555-564. : http://dx.doi.org/10.1097/NEN.0b013e31817713b5
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:
  • Meyer RP: Brain's action on xenobiotic treatment. [Wie reagiert das Gehirn auf Fremdstoffe?] Medizinische Welt, 2008; 59 (9): 336-342.

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten