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 Forschungsbericht für das Jahr 2017

Institut für Medizinische Biometrie und Statistik

Stefan-Meier-Strasse 26
79104 Freiburg
Tel: 0761 203 6662 Fax: 0761 203 6680
Email sec@imbi.uni-freiburg.de
http://www.imbi.uni-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. M. Schumacher
  • Prof. Dr. J. Schulte Mönting
  • Arthur Allignol
  • Dr. G. Antes
  • Dr. J. Beyersmann
  • Dr. H. Binder
  • Dr. Anette Blümle
  • D. Booker
  • Dipl.-Stat. Anika Buchholz
  • Dr. A. Caputo
  • Dr. J. Carpenter
  • Dr. Erik von Elm
  • Dipl.-Math. C. Gall
  • Dr. T. Gerds
  • Dipl.-Stat. A. Gerlach
  • Dr. E. Graf
  • Prof. Dr. Dieter Hauschke
  • Dr. G. Ihorst
  • Dr. B. Lang
  • Dr. Jörg Meerpohl
  • Dipl.-Stat. M. Olschewski
  • Dipl.-Stat. Christine Porzelius
  • Dipl.-Math. G. Rücker
  • PD Dr. W. Sauerbrei
  • Dr. C. Schmoor
  • Dr. Christine Schmucker
  • Dipl.-Math.Oec. R. Schoop
  • Dr. G. Schwarzer
  • Dipl.-Math. P. Sekula
  • Dipl.-Stat. S. Stampf
  • PD Dr. A. Timmer
  • Robert Wolff
  • Dr. M. Wolkewitz
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Biometrische Methodologie
  • Epidemiologische Studien
  • Klinische Studien
  • Multizentrische Therapiestudien

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Abou-Ayash S, Strasding M, Rücker G, Att W: Impact of prosthetic material on mid- and long-term outcome of dental implants supporting single crowns and fixed partial dentures: A systematic review and meta-analysis. Eur J Oral Implantol, 2017; 10: 47-65.
  • Alsahhaf A, Spies BC, Vach K, Kohal RJ: Fracture resistance of zirconia-based implant abutments after artificial long-term aging. J Mech Behav Biomed, 2017; 66: 224-232. : https://dx.doi.org/10.1016/j.jmbbm.2016.11.018
  • Anderson AC, Andisha H, Hellwig E, Jonas D, Vach K, Al-Ahmad A: Antibiotic Resistance Genes and Antibiotic Susceptibility of Oral Enterococcus faecalis Isolates Compared to Isolates from Hospitalized Patients and Food. Adv Exp Med Biol, 2017. : https://doi.org/10.1007/5584_2017_53 (in Druck)
  • Andrlová H, Mastroianni J, Madl J, Kern JS, Melchinger W, Dierbach H, Wernet F, Follo M, Technau-Hafsi K, Has C, Mittapalli VR, Idzko M, Herr R, Brummer T, Ungefroren H, Busch H, Boerries M, Narr A, Ihorst G, Vennin C, Schmitt-Graeff A, Minguet S, Timpson P, Duyster J, Meiss F, Römer W, Zeiser R: Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression. Oncotarget, 2017; 8: 42901-42916. : https://doi.org/10.18632/oncotarget.17160
  • Augustin NH, Kim SW, Uhlig A, Hanser C, Henke M, Schumacher M: A flexible multivariate random effects proportional odds model with application to adverse effects during radiation therapy. Biometrical J, 2017; 59: 1339-1351. : https://doi.org/10.1002/bimj.201600142
  • Ballesio A, Aquino MRJV, Feige B, Johann AF, Kyle SD, Spiegelhalder K, Lombardo C, Rücker G, Riemann D, Baglioni C: The effectiveness of behavioural and cognitive behavioural therapies for insomnia on depressive and fatigue symptoms: a systematic review and network meta-analysis. Sleep Med Rev, 2017. : http://dx.doi.org/10.1016/j.smrv.2017.01.006 (in Druck)
  • Barnett AG, Stephen D, Huang C, Wolkewitz M: Time series models of environmental exposures: Good predictions or good understanding. Environ Res, 2017; 154: 222-225. : http://dx.doi.org/10.1016/j.envres.2017.01.007
  • Binder N, Herrnböck A-S, Schumacher M: Estimating hazard ratios in cohort data with missing disease information due to death. Biometrical J, 2017; 59: 251-269. : http://dx.doi.org/10.1002/bimj.201500167
  • Binder N, Manderscheid L, Schumacher M: The combined association of alcohol consumption with dementia risk is likely biased due to lacking account of death cases. Eur J Epidemiol, 2017; 32: 627-629. : http://dx.doi.org/10.1007/s10654-017-0252-0
  • Böger CA, Gorski M, McMahon GM, Xu H, Chang YC, van der Most PJ, Navis G, Nolte IM, de Borst MH, Zhang W, Lehne B, Loh M, Tan ST, Boerwinkle E, Grams ME, Sekula P, Li M, Wilmot B, Moon JG, Scheet P, Cucca F, Xiao X, Lyytikäinen LP, Delgado G, Grammer TB, Kleber ME, Sedaghat S, Rivadeneira F, Corre T, Kutalik Z, Bergmann S, Nielson CM, Srikanth P, Teumer A, Müller-Nurasyid M, Brockhaus AC, Pfeufer A, Rathmann W, Peters A, Matsumoto M, de Andrade M, Atkinson EJ, Robinson-Cohen C, de Boer IH, Hwang SJ, Heid IM, Gögele M, Concas MP, Tanaka T, Bandinelli S, Nalls MA, Singleton A, Tajuddin SM, Adeyemo A, Zhou J, Doumatey A, McWeeney S, Murabito J, Franceschini N, Flessner M, Shlipak M, Wilson JG, Chen G, Rotimi CN, Zonderman AB, Evans MK, Ferrucci L, Devuyst O, Pirastu M, Shuldiner A, Hicks AA, Pramstaller PP, Kestenbaum B, Kardia SL, Turner ST, LifeLines Cohort Study, Briske TE, Gieger C, Strauch K, Meisinger C, Meitinger T, Völker U, Nauck M, Völzke H, Vollenweider P, Bochud M, Waeber G, Kähönen M, Lehtimäki T, März W, Dehghan A, Franco OH, Uitterlinden AG, Hofman A, Taylor HA, Chambers JC, Kooner JS, Fox CS, Hitzemann R, Orwoll ES, Pattaro C, Schlessinger D, Köttgen A, Snieder H, Parsa A, Cohen DM: NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality. J Am Soc Nephrol, 2017; 28: 2311-2321. : https://doi.org/10.1681/ASN.2016080892
  • Bollig C, Nothacker, Lehane C, Motschall E, Lang B, Meerpohl JJ, Schmucker C: Prophylactic antibiotics before cord clamping in cesarean delivery: a systematic review. Acta Obstet Gyn Scan, 2017. : http://dx.doi.org/10.1111/aogs.13276 (in Druck)
  • Bollig C, Schell LK, Rücker G, Allert R, Motschall E, Niemeyer CM, Bassler D, Meerpohl JJ: Deferasirox for managing iron overload in people with thalassaemia. Cochrane Db Syst Rev, 2017; 8 (online): CD007476. : http://dx.doi.org/10.1002/14651858.CD007476.pub3
  • Brinkhaus B, Roll S, Jena S, Icke K, Adam D, Binting S, Lotz F, Willich SN, Witt CM: Acupuncture in Patients with Allergic Asthma: A Randomized Pragmatic Trial. J Altern Complem Med, 2017; 23 (4): 268-277. : http://dx.doi.org/10.1089/acm.2016.0357
  • Diener MK, Hüttner FJ, Kieser M, Knebel P, Dörr-Harim C, Distler M, Grützmann R, Wittel UA, Schirren R, Hau HM, Kleespies A, Heidecke CD, Tomazic A, Halloran CM, Wilhelm TJ, Bahra M, Beckurts T, Börner T, Glanemann M, Steger U, Treitschke F, Staib L, Thelen K, Bruckner T, Mihaljevic AL, Werner J, Ulrich A, Hackert T, Büchler MW, ChroPac Trial Group.: Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind ChroPac trial. Lancet, 2017; 390: 1027-1037. : https://doi.org/10.1016/S0140-6736(17)31960-8
  • Döpfner M, Hautmann C, Dose C, Banaschewski T, Becker K, Brandeis D, Holtmann M, Jans T, Jenkner C, Millenet S, Renner T, Romanos M, von Wirth E: ESCAschool study: trial protocol of an adaptive treatment approach for school-age children with ADHD including two randomised trials. Bmc Psychiatry, 2017; 17 (1) (online): 269. : http://dx.doi.org/10.1186/s12888-017-1433-9
  • Duiverman ML, Maagh P, Magnet FS, Schmoor C, Arellano-Maric MP, Meissner A, Storre JH, Wijkstra PJ, Windisch W, Callegari J: Impact of High-Intensity-NIV on the heart in stable COPD: a randomised cross-over pilot study. Resp Res, 2017; 18 (online): 76. : http://dx.doi.org/10.1186/s12931-017-0542-9
  • Duttenhoefer F, Probst FA, Vach K, Cornelius CP, Zens M, Schmelzeisen R, Metzger MC: Clinical analysis of MatrixMANDIBLE Preformed Reconstruction Plate design. J Cranio Maxill Surg, 2017; 45: 1521-1525. : https://doi.org/10.1016/j.jcms.2017.05.022
  • Eismann J, Hirschfeld M, Erbes T, Rücker G, Jäger M, Ritter A, Weiss D, Gitsch G, Mayer S: Hypoxia- and acidosis-driven aberrations of secreted microRNAs in endometrial cancer in vitro. Oncol Rep, 2017; 38: 993-1004. : https://doi.org/10.3892/or.2017.5717
  • Engelhardt M, Domm A-S, Dold SM, Ihorst G, Reinhardt H, Zober A, Hieke S, Baayen C, Müller SJ, Einsele H, Sonneveld P, Landgren O, Schumacher M, Wäsch R: A concise revised myeloma comorbidity Index as a valid prognostic instrument in a large cohort of 801 multiple myeloma patients. Haematologica, 2017; 102: 910-921. : http://dx.doi.org/10.3324/haematol.2016.162693
  • Engelhardt M, Selder R, Pandurevic M, Möller M, Ihorst G, Waldschmidt J, Herget G, Wäsch R: Multidisciplinary Tumor Boards: Facts and Satisfaction Analysis of an Indispensable Comprehensive Cancer Center Instrument. Deut Med Wochenschr, 2017; 142 (online): e51-e60. : https://dx.doi.org/10.1055/s-0043-100054
  • Finke J, Schmoor C, Bethge WA, Ottinger H, Stelljes M, Volin L, Heim D, Bertz H, Grishina O, Socie G: Long-term outcomes after standard graft-versus-host disease prophylaxis with or without anti-human-T-lymphocyte immunoglobulin in haemopoietic cell transplantation from matched unrelated donors: final results of a randomised controlled trial. Lancet Haematol, 2017; 293: e293-e301. : https://doi.org/10.1016/S2352-3026(17)30081-9
  • Friedrich F, Beyersmann J, Winterfeld U, Schumacher M, Allignol A: Nonparametric estimation of pregnancy outcome probabilities. Ann Appl Stat, 2017; 11: 840-867. : http://dx.doi.org/10.1214/17-AOAS1020
  • Fritsch K, Kasenda B, Schorb E, Hau P, Bloehdorn J, Möhle R, Löw S, Binder M, Atta J, Keller U, Wolf H-H, Krause SW, Heß G, Naumann R, Sasse S, Hirt C, Lamprecht M, Martens U, Morgner A, Panse J, Frickhofen N, Röth A, Hader C, Deckert M, Fricker H, Ihorst G, Finke J, Illerhaus G: High-dose methotrexate-based immuno-chemotherapy for elderly primary CNS lymphoma patients (PRIMAIN study). Leukemia, 2017; 31: 846-852. : https://dx.doi.org/10.1038/leu.2016.334
  • Gaertner J, Siemens W, Meerpohl JJ, Antes G, Meffert C, Xander C, Stock S, Mueller D, Schwarzer G, Becker G: Effect of specialist palliative care services on quality of life in adults with advanced incurable illness in hospital, hospice, or community settings: systematic review and meta-analysis. Bmj-brit Med J, 2017; 357 (online): j2925. : http://dx.doi.org/10.1136/bmj.j2925
  • Greil C, Ihorst G, Gaiser F, Salzer U, Bisse E, Kastritis E, Ludwig H, Wäsch R, Engelhardt M: The serum heavy/light chain immunoassay: A valuable tool for sensitive paraprotein assessment, risk, and disease monitoring in monoclonal gammopathies. Eur J Haematol, 2017; 99: 449-458. : https://doi.org/10.1111/ejh.12958
  • Greil C, Kiote-Schmidt C, Fink G, Ihorst G, Hildenbeutel S, Bosse R, Duyster J, Engelhardt M, Wäsch R: Successful peripheral blood stem cell mobilization with a cost-efficient single fixed-dose plerixafor schedule in poor mobilizers. Leukemia Lymphoma, 2017; 58: 1849-1858. : http://dx.doi.org/10.1080/10428194.2016.1271946
  • Grigioni F, Clavel MA, Vanoverschelde JL, Tribouilloy C, Pizarro R, Huebner M, Avierinos JF, Barbieri A, Suri R, Pasquet A, Rusinaru D, Gargiulo GD, Oberti P, Théron A, Bursi F, Michelena H, Lazam S, Szymanski C, Nkomo VT, Schumacher M, Bacchi-Reggiani L, Enriquez-Sarano M, MIDA Investigators: The MIDA Mortality Risk Score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation. Eur Heart J, 2017. : https://doi.org/10.1093/eurheartj/ehx465 (in Druck)
  • Grohmann J, Wildberg C, Zartner P, Abu-Tair T, Tarusninov G, Kitzmüller E, Schmoor C, Stiller B, Kampmann C: Multicenter midterm follow-up results using the gore septal occluder for atrial septal defect closure in pediatric patients. Catheter Cardio Inte, 2017; 89 (online): E226-E232. : http://dx.doi.org/10.1002/ccd.26881
  • Groß V, Lücke C, Graf E, Lam AP, Matthies S, Borel P, Sobanski E, Rösler M, Retz W, Jacob C, Colla M, Huss M, Jans T, Kis B, Abdel-Hamid M, van Elst LT, Philipsen A, Comparison of Methylphenidate, Psychotherapy in Adult ADHD Study (COMPAS) Consortium: Effectiveness of Psychotherapy in Adult ADHD: What Do Patients Think? Results of the COMPAS Study. J Atten Disord, 2017. : https://doi.org/10.1177/1087054717720718 (in Druck)
  • Haddad C, Chosidow O, Valeyrie-Allanore L, Ghaleh B, Legrand T, Mockenhaupt M, Barau C, Khoudour N, Sekula P, Wolkenstein P, Hulin A: Are Idiopathic Stevens-Johnson syndrome/Toxic Epidermal Necrolysis Related to Drugs in Food? Example of Phenylbutazone. J Invest Dermatol, 2017; 137: 1179-1181. : https://dx.doi.org/10.1016/j.jid.2016.11.041
  • Haun MW, Estel S, Rücker G, Friederich HC, Villalobos M, Thomas M, Hartmann M: Early palliative care for adults with advanced cancer. Cochrane Db Syst Rev, 2017; 6 (online): CD011129. : http://dx.doi.org/10.1002/14651858.CD011129.pub2
  • Hess M, Lenz S, Blätte TJ, Bullinger L, Binder H: Partitioned learning of deep Boltzmann machines for SNP data. Bioinformatics, 2017; 33: 3173-3180. : https://doi.org/10.1093/bioinformatics/btx408
  • Hiller JK, Schmoor C, Gaidzik VI, Schmidt-Salzmann C, Yalcin A, Abdelkarim M, Blagitko-Dorfs N, Döhner K, Bullinger L, Duyster J, Lübbert M, Hackanson B: Evaluating the impact of genetic and epigenetic aberrations on survival and response in acute myeloid leukemia patients receiving epigenetic therapy. Ann Hematol, 2017; 96: 559-565. : https://dx.doi.org/10.1007/s00277-016-2912-7
  • Hochholzer W, Kleiner P, Younas I, Valina CM, Löffelhardt N, Amann M, Bömicke T, Ferenc M, Hauschke D, Trenk D, Neumann FJ, Stratz C: Randomized Comparison of Oral P2Y12-Receptor Inhibitor Loading Strategies for Transitioning From Cangrelor: The ExcelsiorLOAD2 Trial. Jacc-cardiovasc Inte, 2017; 10: 121-129. : https://dx.doi.org/10.1016/j.jcin.2016.10.004
  • Huebner M, Wolkewitz M, Enriquez-Sarano M, Schumacher M: Competing risks need to be considered in survival analysis models for cardiovascular outcomes. J Thorac Cardiov Sur, 2017; 153: 1427-1431. : https://doi.org/10.1016/j.jtcvs.2016.12.039
  • Hummel J, Rücker G, Stiller B: Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease. Cochrane Db Syst Rev, 2017; 3: CD011312. : http://dx.doi.org/10.1002/14651858.CD011312.pub2
  • Jackson D, Law M, Rücker G, Schwarzer G: The Hartung-Knapp modification for random-effects meta-analysis: A useful refinement but are there any residual concerns? Stat Med, 2017; 36: 3923-3934. : http://dx.doi.org/10.1002/sim.7411
  • Jahn-Eimermacher A, Ingel K, Preussler S, Bayes-Genis A, Binder H: A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials. Bmc Med Res Methodol, 2017; 17 (1) (online): 92. : http://dx.doi.org/10.1186/s12874-017-0366-9
  • Jansen L, Weberpals J, Kuiper JG, Vissers PAJ, Wolkewitz M, Hoffmeister M, Brenner H: Pre- and post-diagnostic beta-blocker use and prognosis after colorectal cancer: Results from a population-based study. Int J Cancer, 2017; 141: 62-71. : http://dx.doi.org/10.1002/ijc.30717
  • Jeserich M, Merkely B, Schlosser P, Kimmel S, Pavlik G, Achenbach S: Assessment of edema using STIR+ via 3D cardiovascular magnetic resonance imaging in patients with suspected myocarditis. Magn Reson Mater Phy, 2017; 30: 309-316. : http://dx.doi.org/10.1007/s10334-016-0603-y
  • Jung M, Wissing M, Motschall E, Türp JC: Time-related quantitative analysis of articles about randomized controlled trials in medicine and dentistry cited in PubMed. [Zeitbezogene Quantitätsanalyse von in PubMed zitierten Artikeln über randomisierte kontrollierte Studien in der Zahnmedizin]. Zeitschrift für Kraniomandibuläre Funktion - Journal of Craniomandibular Function, 2017; 9 (4): 291-302.
  • Kaier K, Hils S, Fetzer S, Hehn P, Schmid A, Hauschke D, Bogatyreva L, Jänigen B, Pisarski P: Results of a randomized controlled trial analyzing telemedically supported case management in the first year after living donor kidney transplantation - a budget impact analysis from the healthcare perspective. Health Economics Review, 2017; 7 (online): 1. : http://dx.doi.org/10.1186/s13561-016-0141-3
  • Kaier K, Reinecke H, Schmoor C, Frankenstein L, Vach W, Hehn P, Zirlik A, Bode C, Zehender M, Reinöhl J: Learning Curves Among All Patients Undergoing Transcatheter Aortic Valve Implantation in Germany: A Retrospective Observational Study. Int J Cardiol, 2017; 235: 17-21. : https://doi.org/10.1016/j.ijcard.2017.02.138
  • Kaiser MR, Motschall E, Türp JC: Entwicklung einer Suchstrategie zur Identifizierung von Fachartikeln über den Behandlungsbedarf in der Kieferorthopädie. [Development of a search strategy to identify specialist articles on the need for treatment in orthodontics]. Deutsche Zahnärztliche Zeitschrift, 2017; 72 (4): 306-313. : https://www.online-dzz.de/article/entwicklung-einer-suchstrategie-zur-identifizierung-von-fachartikeln-ueber-den-behandlungsbedarf-in-der-kieferorthopaedie/ebm-splitter/y/m/4963
  • Karrasch S, Linde K, Rücker G, Sommer H, Karsch-Völk M, Kleijnen J, Jörres RA, Schneider A: Accuracy of FENO for diagnosing asthma: a systematic review. Thorax, 2017; 72: 109-116. : http://dx.doi.org/10.1136/thoraxjnl-2016-208704
  • Kasenda B, Ihorst G, Schroers R, Korfel A, Schmidt-Wolf I, Egerer G, von Baumgarten L, Röth A, Bloehdorn J, Möhle R, Binder M, Keller U, Lamprecht M, Pfreundschuh M, Valk E, Fricker H, Schorb E, Fritsch K, Finke J, Illerhaus G: High-dose chemotherapy with autologous haematopoietic stem cell support for relapsed or refractory primary CNS lymphoma: a prospective multicentre trial by the German Cooperative PCNSL study group. Leukemia, 2017; 31: 2623-2629. : https://doi.org/10.1038/leu.2017.170
  • Kaufmann KB, Stein L, Bogatyreva L, Ulbrich F, Kaifi JT, Hauschke D, Loop T, Goebel U: Oesophageal Doppler guided goal-directed haemodynamic therapy in thoracic surgery - a single centre randomized parallel-arm trial. Brit J Anaesth, 2017; 118: 852-861. : https://doi.org/10.1093/bja/aew447
  • Klok FA, Ageno W, Barco S, Binder H, Brenner B, Duerschmied D, Empen K, Faggiano P, Ficker JH, Galie N, Ghuysen A, Held M, Heydenreich N, Huisman MV, Jimenez D, Kozak M, Lang IM, Lankeit M, Munzel T, Petris A, Pruszczyk P, Quitzau K, Schellong S, Schmidt KH, Stefanovic BS, Verschuren F, Wolf-Puetz A, Meyer G, Konstantinides SV: Dabigatran after Short Heparin Anticoagulation for Acute Intermediate-Risk Pulmonary Embolism: Rationale and Design of the Single-Arm PEITHO-2 Study. Thromb Haemostasis, 2017; 117 (12): 2425-2434.
  • Kruse AB, Kuerschner AC, Kunze M, Woelber JP, Al-Ahmad A, Wittmer A, Vach K, Ratka-Krueger P: Association between high risk for preterm birth and changes in gingiva parameters during pregnancy-a prospective cohort study. Clin Oral Invest, 2017. : https://doi.org/10.1007/s00784-017-2209-9 (in Druck)
  • Landgrebe M, Hajak G, Wolf S, Padberg F, Klupp P, Fallgatter AJ, Polak T, Höppner J, Haker R, Cordes J, Klenzner T, Schönfeldt-Lecuona C, Kammer T, Graf E, Koller M, Kleinjung T, Lehner A, Schecklmann M, Pöppl TB, Kreuzer P, Frank E, Langguth B: 1-Hz rTMS in the Treatment of Tinnitus: A Sham-controlled, Randomized Multicenter Trial. Brain Stimul, 2017; 10: 1112-1120. : https://doi.org/10.1016/j.brs.2017.08.001
  • Limberger KA, Bogatyreva L, Todorova R, Herde B, Hauschke D, Pahl HL, Werner M, Aumann K: Tissue microarray technique is applicable to bone marrow biopsies of myeloproliferative neoplasms. Histochemistry and Cell Biology, 2017; 147: 75-82. : http://dx.doi.org/10.1007/s00418-016-1476-x
  • Lorenz E, Jenkner C, Sauerbrei W, Becher H: Modeling Variables With a Spike at Z ero: Examples and Practical Recommendations: Am J Epidemiol, 2017; 185: 650-660. : https://doi.org/10.1093/aje/kww122
  • Lübbert M, Ihorst G, Sander PN, Bogatyreva L, Becker H, Wijermans PW, Suciu S, Bissé E, Claus R: Elevated fetal haemoglobin is a predictor of better outcome in MDS/AML patients receiving 5-aza-2′-deoxycytidine (Decitabine). Brit J Haematol, 2017; 176: 609-617. : https://dx.doi.org/10.1111/bjh.14463
  • Magnet FS, Callegari J, Dieninghoff D, Spielmanns M, Storre JH, Schmoor C, Windisch W: Impact of Pseudomonas aeruginosa Infection on Respiratory Muscle Function in Adult Cystic Fibrosis Patients. Respiration, 2017; 93: 42-50. : https://dx.doi.org/10.1159/000452893
  • Magnet FS, Majorski DS, Callegari J, Schwarz SB, Schmoor C, Windisch W, Storre JH: Capillary PO2 does not adequately reflect arterial PO2 in hypoxemic COPD patients. Int J Chronic Obstr, 2017; 12: 2647-2653. : https://doi.org/10.2147/COPD.S140843
  • Mayer S, Erbes T, Timme-Bronsert S, Jaeger M, Rücker G, Kuf F, Stickeler E, Gitsch G, Hirschfeld M: Clinical relevance of Cyr61 expression in patients with hormone-dependent breast cancer. Oncol Lett, 2017; 14: 2334-2340. : https://doi.org/10.3892/ol.2017.6406
  • Mayer S, Gabriel B, Erbes T, Timme-Bronsert S, Jäger M, Rücker G, Kuf F, Bouda J, Bartakova A, Hausen AZ, Stickeler E, Gitsch G, Hirschfeld M: Cyr61 Expression Pattern and Association with Clinicopathological Factors in Patients with Cervical Cancer. Anticancer Res, 2017; 37: 2451-2456. : https://doi.org/10.21873/anticanres.11585
  • Mayer S, Kayser G, Rücker G, Bögner D, Hirschfeld M, Hug C, Stickeler E, Gitsch G, Erbes T: Absence of epithelial atypia in B3-lesions of the breast is associated with decreased risk for malignancy. Breast, 2017; 31: 144-149. : http://dx.doi.org/10.1016/j.breast.2016.11.007
  • Meyer PT, Frings L, Rücker G, Hellwig S: 18F-FDG PET in Parkinsonism: Differential Diagnosis and Cognitive Impairment in Parkinson's disease. J Nucl Med, 2017; 58: 1888-1898. : https://doi.org/10.2967/jnumed.116.186403
  • Naegele M, Kirsch M, Ihorst G, Fierz K, Engelhardt M, De Geest S: Symptom experience of multiple myeloma (syMMex) patients treated with autologous stem cell transplantation following high-dose melphalan: a descriptive longitudinal study. Support Care Cancer, 2017. : https://doi.org/10.1007/s00520-017-3897-z (in Druck)
  • Niglio de Figueiredo M, Krippeit L, Freund J, Ihorst G, Joos A, Bengel J, Wuensch A: Assessing Communication Skills in Real Medical Encounters in Oncology: Development and Validation of the ComOn-Coaching Rating Scales. J Cancer Educ, 2017. : https://doi.org/10.1007/s13187-017-1269-5 (in Druck)
  • Ohneberg K, Schumacher M, Beyersmann J: Modelling two cause-specific hazards of competing risks in one cumulative proportional odds model? Stat Med, 2017; 36: 4353-4363. : https://dx.doi.org/10.1002/sim.7437
  • Paling FP, Troeman DPR, Wolkewitz M, Kalyani R, Prins DR, Weber S, Lammens C, Timbermont L, Goossens H, Malhotra-Kumar S, Sifakis F, Bonten MJM, Kluytmans JAJW: Rationale and design of ASPIRE-ICU: a prospective cohort study on the incidence and predictors of Staphylococcus aureus and Pseudomonas aeruginosa pneumonia in the ICU. Bmc Infect Dis, 2017; 17: 643. : https://doi.org/10.1186/s12879-017-2739-4
  • Paling FP, Wolkewitz M, Bode LGM, Klein Klouwenberg PMC, Ong DSY, Depuydt P, de Bus L, Sifakis F, Bonten MJM, Kluytmans JAJW: Staphylococcus aureus colonization at ICU admission as a risk factor for developing S. aureus ICU pneumonia. Clin Microbiol Infec, 2017; 23: 49.e9-49.e14. : http://dx.doi.org/10.1016/j.cmi.2016.09.022
  • Paling FP, Wolkewitz M, Depuydt P, de Bus L, Sifakis F, Bonten MJM, Kluytmans JAJW: P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia. Antimicrob Resist in, 2017; 6 (online): 38. : http://dx.doi.org/10.1186/s13756-017-0197-9
  • Pieralli S, Kohal RJ, Jung RE, Vach K, Spies BC: Clinical Outcomes of Zirconia Dental Implants. A Systematic Review. J Dent Res, 2017; 91: 38-46. : https://doi.org/10.1177/0022034516664043
  • Pieralli S, Kohal RJ, Lopez Hernandez E, Doerken S, Spies BC: Osseointegration of zirconia dental implants in animal investigations: A systematic review and meta-analysis. Dent Mater, 2017. : https://doi.org/10.1016/j.dental.2017.10.008 (in Druck)
  • Polydorou O, Scheitza S, Spraul M, Vach K, Hellwig E: The effect of long-term use of tooth bleaching products on the human enamel surface. Odontology, 2017. : https://doi.org/10.1007/s10266-017-0308-3 (in Druck)
  • Reinacher PC, Kruger MT, Coenen VA, Shah M, Roelz R, Jenkner C, Egger K: Determining the Orientation of Directional Deep Brain Stimulation Electrodes Using 3D Rotational Fluoroscopy. Am J Neuroradiol, 2017; 38 (6): 1111-1116. : http://dx.doi.org/10.3174/ajnr.A5153
  • Rücker G, Cates CJ, Schwarzer G: Methods for including information from multi-arm trials in pairwise meta-analysis. Res Synth Methods, 2017; 8 (4): 392-403. : https://doi.org/10.1002/jrsm.1259
  • Rücker G, Schwarzer G: Resolve conflicting rankings of outcomes in network meta-analysis: Partial ordering of treatments. Res Synth Methods, 2017; 8 (4): 526-536. : https://doi.org/10.1002/jrsm.1270
  • Rylski B, Hahn N, Beyersdorf F, Kondov S, Wolkewitz M, Plonek T, Czerny M, Siepe M: Fate of the dissected aortic arch after ascending replacement in type A aortic dissection†. Eur J Cardio-thorac, 2017; 51: 1127-1134. : https://doi.org/10.1093/ejcts/ezx062
  • Schmid A, Hils S, Kramer-Zucker A, Bogatyreva L, Hauschke D, De Geest S, Pisarski P: Telemedically-supported case management of living-donor renal transplant recipients to optimize routine evidence-based aftercare: A single-center randomized controlled trial. Am J Transplant, 2017; 17: 1594-1605. : http://dx.doi.org/10.1111/ajt.14138
  • Schmucker CM, Blümle A, Schell LK, Schwarzer G, Oeller P, Cabrera L, von Elm E, Briel M, Meerpohl JJ;, OPEN consortium.: Systematic review finds that study data not published in full text articles have unclear impact on meta-analyses results in medical research. Plos One, 2017; 12 (online): e0176210. : https://doi.org/10.1371/journal.pone.0176210
  • Schneider A, Linde K, Reitsma JB, Steinhauser S, Rücker G: A novel statistical model for analyzing data of a systematic review generates optimal cut-off values for fractional exhaled nitric oxide for asthma diagnosis. J Clin Epidemiol, 2017; 92: 69-78. : https://doi.org/10.1016/j.jclinepi.2017.09.001
  • Schulz A, Zoeller D, Nickels S, Beutel ME, Blettner M, Wild PS, Binder H: Simulation of complex data structures for planning of studies with focus on biomarker comparison. Bmc Med Res Methodol, 2017; 17 (1) (online): 90. : http://dx.doi.org/10.1186/s12874-017-0364-y
  • Schumacher M: Norman Edward Breslow–Key figure in the foundation of modern biostatistics. Biometrical J, 2017; 59: 399-404. : http://dx.doi.org/10.1002/bimj.201600196
  • Schwarz SB, Windisch W, Magnet FS, Schmoor C, Karagiannidis C, Callegari J, Huttmann SE, Storre JH: Continuous non-invasive PCO2 monitoring in weaning patients: Transcutaneous is advantageous over end-tidal PCO2. Respirology, 2017; 22: 1579-1584. : https://doi.org/10.1111/resp.13095
  • Sekula P, Li Y, Stanescu HC, Wuttke M, Ekici AB, Bockenhauer D, Walz G, Powis SH, Kielstein JT, Brenchley P, GCKD Investigators, Eckardt K-U, Kronenberg F, Kleta R, Köttgen A: Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies. Nephrol Dial Transpl, 2017; 32: 325-332. : http://dx.doi.org/10.1093/ndt/gfw001
  • Sekula P, Mallett S, Altman DG, Sauerbrei W: Did the reporting of prognostic studies of tumour markers improve since the introduction of REMARK guideline? A comparison of reporting in published articles. Plos One, 2017; 12 (online): e0178531. : https://doi.org/10.1371/journal.pone.0178531
  • Sillem M, Timme S, Bronsert P, Bogatyreva L, Hauschke D, Zur Hausen A, Werner M, Stickeler E: Anti-Phosphohistone H3-Positive Mitoses Are Linked to Pathological Response in Neoadjuvantly Treated Breast Cancer. Breast Care, 2017; 12: 244-250. : https://doi.org/10.1159/000463377
  • Sommer H, Bluhmki T, Beyersmann J, Schumacher M, COMBACTE-NET, COMBACTE-MAGNET consortium.: Assessing non-inferiority in treatment trials regarding severe infectious diseases: An extension to the entire follow-up period using a cure-death multistate model. Antimicrob Agents Ch, 2017. : https://doi.org/10.1128/AAC.01691-17 (in Druck)
  • Sommer H, Wolkewitz M, Schumacher M, COMBACTE-NET consortium: The time-dependent "cure-death" model investigating two equally important endpoints simultaneously in trials treating high-risk patients with resistant pathogens. Pharm Stat, 2017; 16: 267-279. : https://doi.org/10.1002/pst.1809
  • Speckmann C, Doerken S, Aiuti A, Albert MH, Al-Herz W, Allende LM, Scarselli A, Avcin T, Perez-Becker R, Cancrini C, Cant A, Di Cesare S, Finocchi A, Fischer A, Gaspar HB, Ghosh S, Gennery A, Gilmour K, González-Granado LI, Martinez-Gallo M, Hambleton S, Hauck F, Hoenig M, Moshous D, Neven B, Niehues T, Notarangelo L, Picard C, Rieber N, Schulz A, Schwarz K, Seidel MG, Soler-Palacin P, Stepensky P, Strahm B, Vraetz T, Warnatz K, Winterhalter C, Worth A, Fuchs S, Uhlmann A, Ehl S, on behalf of the P-CID study of the Inborn Errors Working Party of the EBMT: A prospective study on the natural history of patients with profound combined immunodeficiency: An interim analysis. J Allergy Clin Immun, 2017; 139: 1302-1310. : https://doi.org/10.1016/j.jaci.2016.07.040
  • Spies BC, Balmer M, Jung RE, Sailer I, Vach K, Kohal RJ: All-ceramic, bi-layered crowns supported by zirconia implants: Three-year results of a prospective multicenter study. J Dent, 2017; 67: 58-65. : https://doi.org/10.1016/j.jdent.2017.09.008
  • Spies BC, Kohal RJ, Balmer M, Vach K, Jung RE: Evaluation of zirconia-based posterior single crowns supported by zirconia implants: preliminary results of a prospective multicenter study. Clin Oral Implan Res, 2017; 28: 613-619. : https://dx.doi.org/10.1111/clr.12842
  • Spies BC, Maass ME, Adolfsson E, Sergo V, Kiemle T, Berthold C, Gurian E, Fornasaro S, Vach K, Kohal RJ: Long-term stability of an injection-molded zirconia bone-level implant: A testing protocol considering aging kinetics and dynamic fatigue. Dent Mater, 2017; 33: 954-964. : https://doi.org/10.1016/j.dental.2017.06.002
  • Spies BC, Pieralli S, Vach K, Kohal RJ: CAD/CAM-fabricated ceramic implant-supported single crowns made from lithium disilicate: Final results of a 5-year prospective cohort study. Clin Implant Dent R, 2017; 19: 876-883. : https://doi.org/10.1111/cid.12508
  • Spies BC, Witkowski S, Vach K, Kohal RJ: Clinical and patient-reported outcomes of zirconia-based implant fixed dental prostheses: Results of a prospective case series 5 years after implant placement. Clin Oral Implan Res, 2017. : https://doi.org/10.1111/clr.13072 (in Druck)
  • Strüßmann T, Fritsch K, Baumgarten A, Fietz T, Engelhardt M, Mertelsmann R, Ihorst G, Duyster J, Finke J, Marks R: Favourable outcomes of poor prognosis diffuse large B-cell lymphoma patients treated with dose-dense Rituximab, high-dose Methotrexate and six cycles of CHOP-14 compared to first-line autologous transplantation. Brit J Haematol, 2017; 178: 927-935. : https://doi.org/10.1111/bjh.14802
  • Su SC, Mockenhaupt M, Wolkenstein P, Dunant A, Le Gouvello S, Chen CB, Chosidow O, Valeyrie-Allanore L, Bellon T, Sekula P, Wang CW, Schumacher M, Kardaun SH, Hung SI, Roujeau JC, Chung WH: Interleukin-15 is associated with severity and mortality in Stevens-Johnson syndrome/toxic epidermal necrolysis. J Invest Dermatol, 2017; 137: 1065-1076. : http://dx.doi.org/10.1016/j.jid.2016.11.034
  • Tacconelli E, Sifakis F, Harbarth S, Schrijver R, van Mourik M, Voss A, Sharland M, Rajendran NB, Rodríguez-Baño J, EPI-Net COMBACTE-MAGNET Group.: Surveillance for control of antimicrobial resistance. Lancet Infect Dis, 2017. : https://doi.org/10.1016/S1473-3099(17)30485-1 (in Druck)
  • Thomsen AR, Aldrian C, Bronsert P, Thomann Y, Nanko N, Melin N, Rucker G, Follo M, Grosu AL, Niedermann G, Layer PG, Heselich A, Lund PG: A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement. Lab Chip, 2017. : http://dx.doi.org/10.1039/c7lc00832e (in Druck)
  • Timsit J-F, de Kraker MEA, Sommer H, Weiss E, Bettiol E, Wolkewitz M, Nikolakopoulos S, Wilson D, Harbarth S, on behalf of the COMBACTE-NET consortium: Appropriate endpoints for evaluation of new antibiotic therapies for severe infections: a perspective from COMBACTE’s STAT-Net. Intens Care Med, 2017; 43: 1002-1012. : http://dx.doi.org/10.1007/s00134-017-4802-4
  • Tinsel I, Siegel A, Schmoor C, Buchholz A, Niebling W: DECADE-pilot: decision aid, action planning, and follow-up support for patients to reduce the 10-year risk of cardiovascular diseases-a protocol of a randomized controlled pilot trial. Pilot and Feasibility Studies, 2017 (online). : https://doi.org/10.1186/s40814-017-0172-5
  • Toews I, Binder N, Wolff RF, Toprak G, von Elm E, Meerpohl JJ: Guidance in author instructions of hematology and oncology journals: A cross sectional and longitudinal study. Plos One, 2017; 12: e0176489. : https://doi.org/10.1371/journal.pone.0176489
  • von Cube M, Schumacher M, Palomar-Martinez M, Olaechea-Astigarraga P, Alvarez-Lerma F, Wolkewitz M: A case-cohort approach for multi-state models in hospital epidemiology: Stat Med, 2017; 36: 481-495. : http://dx.doi.org/10.1002/sim.7146
  • von Cube M, Schumacher M, Wolkewitz M: Basic parametric analysis for a multi-state model in hospital epidemiology. Bmc Med Res Methodol, 2017; 17: 111. : https://doi.org/10.1186/s12874-017-0379-4
  • Waldschmidt JM, Simon A, Wider D, Müller SJ, Follo M, Ihorst G, Decker S, Lorenz J, Chatterjee M, Azab AK, Duyster J, Wäsch R, Engelhardt M: CXCL12 and CXCR7 are relevant targets to reverse cell adhesion-mediated drug resistance in multiple myeloma. Brit J Haematol, 2017; 179: 36-49. : https://doi.org/10.1111/bjh.14807
  • Weberpals J, Jansen L, Haefeli WE, Hoffmeister M, Wolkewitz M, Herk-Sukel MPPV, Vissers PAJ, Brenner H: Pre- and post-diagnostic β-blocker use and lung cancer survival: A population-based cohort study. Sci Rep-uk, 2017; 7 (online): 2911. : https://doi.org/10.1038/s41598-017-02913-8
  • Weibel S, Jelting Y, Pace NL, Rücker G, Raj D, Schaefer MS, Backhaus I, Kienbaum P, Eberhart LHJ, Kranke P: Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis. Cochrane Db Syst Rev, 2017; 11: CD012859. : http://dx.doi.org/10.1002/14651858.CD012859
  • Woelber JP, Bremer K, Vach K, König D, Hellwig E, Ratka-Krüger P, Al-Ahmad A, Tennert C: An oral health optimized diet can reduce gingival and periodontal inflammation in humans - a randomized controlled pilot study. Bmc Oral Health, 2017; 17 (online): 28. : https://doi.org/10.1186/s12903-016-0257-1
  • Wolkewitz M, Schumacher M: Survival biases lead to flawed conclusions in observational treatment studies of influenza patients. J Clin Epidemiol, 2017; 84: 121-129. : http://dx.doi.org/10.1016/j.jclinepi.2017.01.008
  • Wolkewitz M, von Cube M, Schumacher M: Multistate Modeling to Analyze Nosocomial Infection Data: An Introduction and Demonstration. Infect Cont Hosp Ep, 2017; 38: 953-959. : https://doi.org/10.1017/ice.2017.107
  • Wolkewitz M, Zortel M, Palomar-Martinez M, Alvarez-Lerma F, Olaechea-Astigarraga P, Schumacher M: Landmark prediction of nosocomial infection risk to disentangle short- and long-stay patients. J Hosp Infect, 2017; 96: 81-84. : https://doi.org/10.1016/j.jhin.2017.01.017
  • Wuensch A, Goelz T, Ihorst G, Terris DD, Bertz H, Bengel J, Wirsching M, Fritzsche K: Effect of individualized communication skills training on physicians’ discussion of clinical trials in oncology: results from a randomized controlled trial. Bmc Cancer, 2017; 17 (online): 264. : https://doi.org/10.1186/s12885-017-3238-0
  • Zimmermann S, Sekula P, Venhoff M, Motschall E, Knaus J, Schumacher M, Mockenhaupt M: Systemic Immunomodulating Therapies for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. A Systematic Review and Meta-analysis Jama Dermatol, 2017; 153 (online): 514-522. : http://dx.doi.org/10.1001/jamadermatol.2016.5668
Rezensionen:
  • Wolkewitz M, Schumacher M: Correction: Neuraminidase Inhibitors and Hospital Mortality in British Patients with H1N1 Influenza A: A Re-Analysis of Observational Data. Plos One, 2017; 12 (online): e0175660. : http://dx.doi.org/10.1371/journal.pone.0175660
Buchbeiträge:
  • Boulesteix A-L, Hornung R, Sauerbrei w: On Fishing for Significance and Statistician's Degree of Freedom in the Era of Big Molecular Data. In: Max Ott, Wolfgang Pietsch, Jörg Wernecke (Hrsg.): Berechenbarkeit der Welt? Philosohpie und Wissenschaft im Zeitalter von Big Data. Wiesbaden: Springer Fachmedien Wiesbaden, 2017; 155-170.
Kurzbeiträge / short communications:
  • Altman DG, Sauerbrei W, McShane LM: Importance of the distinction between quality of methodology and quality of reporting. Hpb, 2017; 19: 649-650. : https://doi.org/10.1016/j.hpb.2017.02.444
  • Gerds TA, Schumacher M: Discussion of "A risk-based measure of time-varying prognostic discrimination for survival models," by C. Jason Liang and Patrick J. Heagerty. Biometrics, 2017; 73: 739-741. : https://doi.org/10.1111/biom.12629
  • Heister T, Kaier K, Wolkewitz M: Estimating the burden of nosocomial infections: Time dependency and cost clustering should be taken into account. Am J Infect Control, 2017; 45: 94-95. : http://dx.doi.org/10.1016/j.ajic.2016.07.030
  • Rücker G, Steinhauser S, Schumacher M: Re: "Selective cutoff reporting in studies of diagnostic test accuracy: A comparison of conventional and individual-patient-data meta-analyses of the patient health questionnaire-9 depression screening toll". Am J Epidemiol, 2017; 186: 894-895. : https://doi.org/10.1093/aje/kwx275
  • Schwarzer G, Schumacher M, Rücker G: Sole reliance on I2 may mislead. Heart, 2017; 103: 1471-1472. : https://doi.org/10.1136/heartjnl-2017-311767
  • Sommer H, Timsit JF, Wolkewitz M, for the COMBACTE-NET Consortium: Bezlotoxumab and Recurrent Clostridium difficile Infection. New Engl J Med, 2017; 376: 1594. : http://dx.doi.org/10.1056/NEJMc1702531
  • Weber S, Wolkewitz M, Schumacher M: Analyzing the impact of depth of response on survival in patients with metastatic non-small-cell lung cancer. Ann Oncol, 2017. : https://doi.org/10.1093/annonc/mdx558 (in Druck)
  • Wolkewitz M, Rücker G, Schumacher M: Changes in Rates of Ventilator-Associated Pneumonia. Jama-j Am Med Assoc, 2017; 317: 1580-1581. : http://dx.doi.org/10.1001/jama.2017.2411
Konferenzbeiträge:
  • Kempf E, Porcher R, de Beyer J, Moons K, Altman D, Reitsma H, Hopewell S, Sauerbrei W, Collins G: Overinterpretation and misreporting of prognostic factor studies in oncology. Diagnostic and Prognostic Research, 2017; 1 Suppl. 1 (online): P39 (Methods for Evaluating Medical Tests and Biomarkers Birmingham, UK. 19–20 July 2016). : http://dx.doi.org/10.1186/s41512-016-0001-y
  • Mallett S, Sekula P, Altman DG, Sauerbrei W: Reporting of prognostic tumour marker studies after the introduction of the REMARK guideline needs improvement: Diagnostic and Prognostic Research, 2017; 1 Suppl. 1 (online): P36 (Methods for Evaluating Medical Tests and Biomarkers Birmingham, UK. 19–20 July 2016). : http://dx.doi.org/10.1186/s41512-016-0001-y
  • Rücker G, Steinhauser S, Schumacher M: Modelling multiple biomarker thresholds in meta-analysis of diagnostic test accuracy studies: Diagnostic and Prognostic Research, 2017; 1 Suppl. 1 (online): P7 (Methods for Evaluating Medical Tests and Biomarkers Birmingham, UK. 19–20 July 2016). : http://dx.doi.org/10.1186/s41512-016-0001-y
Sonstige Publikationen:
  • Sommer H, Rücker G, Labonté V: Netzwerkmetaanalysen: Wie man vergleichen kann, was nie verglichen wurde. Wissen was wirkt. Cochrane bloggt auf deutsch, 2017. : https://t.co/tTeW9Vk9YB

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