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 Forschungsbericht für das Jahr 2017

Department Innere Medizin

Klinik für Rheumatologie und Klinische Immunologie

Hugstetterstrasse 55
79106 Freiburg
Tel: 0761 - 270 34212 Fax: 0761 - 270 34211
Email ingeborg.wuensche(at)uniklinik-freiburg.de
https://www.uniklinik-freiburg.de/rheuim.html


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. med. Reinhard Voll, Ärztlicher Direktor
  • Dr. med. Jens Thiel, Stellvertretender Ärztlicher Direktor, Oberarzt, Stellvertr. Ärztlicher Direktor
  • PD Dr. med. Nils Venhoff, Oberarzt, Oberarzt
  • Prof. Dr. med. Klaus Warnatz, Oberarzt
  • Dr. med. Marta Rizzi, Gruppenleiter (m/w), Forschung, Wrangell-Stipendiatin
  • Dr. med. Ulrich Salzer, Laborleitung, Laborleitung
  • Dr. Stephanie Finzel, Funktionsoberärztin
  • Dr. med. Florian Kollert, Gruppenleiter (m/w), Facharzt
  • Dr. med. Antigoni Triantafyllopoulou, Gruppenleiter (m/w), Fachärztin
  • Dr. med. Nina Chevalier, Assistent / Gruppenleiter (m/w)
  • Dr. Natalie Frede, Assistent
  • Dr. Anna-Maria Kanne, Assistent / Gruppenleiter (m/w)
  • Dr. Raquel Lorenzetti, Wissenschaftlicher Mitarbeiter (m/w)
  • Marei-Theresa Schleyer, Wissenschaftlicher Mitarbeiter (m/w)
  • Dr. Bettina Sehnert, Wissenschaftlicher Mitarbeiter (m/w)
  • Arianna Troilo, Wissenschaftlicher Mitarbeiter (m/w)
Einträge in der Rubrik "Who is Who"

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Endres D, Dersch R, Hochstuhl B, Fiebich B, Hottenrott T, Perlov E, Maier S, Berger B, Baumgartner A, Venhoff N, Stich O, Tebartz van Elst L: Intrathecal Thyroid Autoantibody Synthesis in a Subgroup of Patients With Schizophreniform Syndromes. J Neuropsych Clin N, 2017; 29 (4): 365-374. : http://dx.doi.org/10.1176/appi.neuropsych.16110296
  • Endres D, Perlov E, Feige B, Altenmuller DM, Venhoff N, Tebartz van Elst L: Schizophrenia Associated with Epileptiform Discharges without Seizures Successfully Treated with Levetiracetam. Front Psychiatry, 2017; 8 (online): 12. : http://dx.doi.org/10.3389/fpsyt.2017.00012
  • Endres D, Perlov E, Riering AN, Maier V, Stich O, Dersch R, Venhoff N, Erny D, Mader I, Tebartz van Elst L: Steroid-Responsive Chronic Schizophreniform Syndrome in the Context of Mildly Increased Antithyroid Peroxidase Antibodies. Front Psychiatry, 2017; 8 (online): 64. : http://dx.doi.org/10.3389/fpsyt.2017.00064
  • Endres D, Vry MS, Dykierek P, Riering AN, Lungen E, Stich O, Dersch R, Venhoff N, Erny D, Mader I, Meyer PT, Tebartz van Elst L: Plasmapheresis Responsive Rapid Onset Dementia with Predominantly Frontal Dysfunction in the Context of Hashimoto's Encephalopathy. Front Psychiatry, 2017; 8: 212-212. : http://dx.doi.org/10.3389/fpsyt.2017.00212
  • Gerer KF, Erdmann M, Hadrup SR, Lyngaa R, Martin LM, Voll RE, Schuler-Thurner B, Schuler G, Schaft N, Hoyer S, Dorrie J: Preclinical evaluation of NF-kappaB-triggered dendritic cells expressing the viral oncogenic driver of Merkel cell carcinoma for therapeutic vaccination. Ther Adv Med Oncol, 2017; 9 (7): 451-464. : http://dx.doi.org/10.1177/1758834017712630
  • Glaser C, Rieg S, Wiech T, Scholz C, Endres D, Stich O, Hasselblatt P, Geissdorfer W, Bogdan C, Serr A, Hacker G, Voll RE, Thiel J, Venhoff N: Whipple's disease mimicking rheumatoid arthritis can cause misdiagnosis and treatment failure. Orphanet J Rare Dis, 2017; 12 (1): 99. : http://dx.doi.org/10.1186/s13023-017-0630-4
  • Joost I, Kaasch A, Pausch C, Peyerl-Hoffmann G, Schneider C, Voll RE, Seifert H, Kern WV, Rieg S: Staphylococcus aureus bacteremia in patients with rheumatoid arthritis - Data from the prospective INSTINCT cohort. J Infection, 2017; 74 (6): 575-584. : http://dx.doi.org/10.1016/j.jinf.2017.03.003
  • Kanne AM, Julich M, Mahmutovic A, Troster I, Sehnert B, Urbonaviciute V, Voll RE, Kollert F: Serum levels of HMGB1 and sRAGE are associated to extraglandular involvement and disease activity as defined by ESSDAI in Sjogren's syndrome. Arthrit Care Res, 2017. : http://dx.doi.org/10.1002/acr.23420 (in Druck)
  • Klemann C, Esquivel M, Magerus-Chatinet A, Lorenz MR, Fuchs I, Neveux N, Castelle M, Rohr J, da Cunha CB, Ebinger M, Kobbe R, Kremens B, Kollert F, Gambineri E, Lehmberg K, Seidel MG, Siepermann K, Voelker T, Schuster V, Goldacker S, Schwarz K, Speckmann C, Picard C, Fischer A, Rieux-Laucat F, Ehl S, Rensing-Ehl A, Neven B: Evolution of disease activity and biomarkers on and off rapamycin in 28 patients with autoimmune lymphoproliferative syndrome. Haematologica, 2017; 102 (2): 52-56. : http://dx.doi.org/10.3324/haematol.2016.153411
  • Proft F, Schulze-Koops H, Grunke M, Schrezenmeier E, Halleck F, Henes J, Unger L, Schmidt E, Fiehn C, Jacobi A, Iking-Konert C, Kneitz C, Schmidt RE, Bannert B, Voll RE, Fischer-Betz R, Kotter I, Tony HP, Holle J, Aringer M, Erler A, Behrens F, Burmester GR, Dorner T: [Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy : Data from a nationwide German registry (GRAID2)]. Z Rheumatol, 2017 (online). : http://dx.doi.org/10.1007/s00393-017-0330-4
  • Rizzi M, Lorenzetti R, Fischer K, Staniek J, Janowska I, Troilo A, Strohmeier V, Erlacher M, Kunze M, Bannert B, Kyburz D, Voll RE, Venhoff N, Thiel J: Impact of tofacitinib treatment on human B-cells in vitro and in vivo. J Autoimmun, 2017; 77: 55-66. : http://dx.doi.org/10.1016/j.jaut.2016.10.005
  • Salzer U, Warnatz K: [Primary Immunodeficiency in Adults]. Deut Med Wochenschr, 2017; 142 (11): 829-832. : http://dx.doi.org/10.1055/s-0043-105094
  • Schubert D, Klein MC, Hassdenteufel S, Caballero-Oteyza A, Yang L, Proietti M, Bulashevska A, Kemming J, Kuhn J, Winzer S, Rusch S, Fliegauf M, Schaffer AA, Pfeffer S, Geiger R, Cavalie A, Cao H, Yang F, Li Y, Rizzi M, Eibel H, Kobbe R, Marks AL, Peppers BP, Hostoffer RW, Puck JM, Zimmermann R, Grimbacher B: Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1). J Allergy Clin Immun, 2017. : http://dx.doi.org/10.1016/j.jaci.2017.06.042 (in Druck)
  • Sehnert B, Burkhardt H, Finzel S, Dubel S, Voll RE: The sneaking ligand approach for cell type-specific modulation of intracellular signalling pathways. Clin Immunol, 2017; 17 (6616): 30636-30638. : http://dx.doi.org/10.1016/j.clim.2017.08.018
  • Smulski CR, Decossas M, Chekkat N, Beyrath J, Willen L, Guichard G, Lorenzetti R, Rizzi M, Eibel H, Schneider P, Fournel S: Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling. Cell Death Dis, 2017; 8 (2) (online): e2601. : http://dx.doi.org/10.1038/cddis.2017.22
  • Smulski CR, Kury P, Seidel LM, Staiger HS, Edinger AK, Willen L, Seidl M, Hess H, Salzer U, Rolink AG, Rizzi M, Schneider P, Eibel H: BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells. Cell Rep, 2017; 18 (9): 2189-2202. : http://dx.doi.org/10.1016/j.celrep.2017.02.005
  • Speckmann C, Sahoo SS, Rizzi M, Hirabayashi S, Karow A, Serwas NK, Hoemberg M, Damatova N, Schindler D, Vannier JB, Boulton SJ, Pannicke U, Gohring G, Thomay K, Verdu-Amoros JJ, Hauch H, Woessmann W, Escherich G, Laack E, Rindle L, Seidl M, Rensing-Ehl A, Lausch E, Jandrasits C, Strahm B, Schwarz K, Ehl SR, Niemeyer C, Boztug K, Wlodarski MW: Clinical and Molecular Heterogeneity of RTEL1 Deficiency. Front Immunol, 2017; 8: 449-449. : http://dx.doi.org/10.3389/fimmu.2017.00449
  • Speckmann C, Sahoo SS, Rizzi M, Hirabayashi S, Karow A, Serwas NK, Hoemberg M, Damatova N, Schindler D, Vannier JB, Boulton SJ, Pannicke U, Gohring G, Thomay K, Verdu-Amoros JJ, Hauch H, Woessmann W, Escherich G, Laack E, Rindle L, Seidl M, Rensing-Ehl A, Lausch E, Jandrasits C, Strahm B, Schwarz K, Ehl SR, Niemeyer C, Boztug K, Wlodarski MW: Corrigendum: Clinical and Molecular Heterogeneity of RTEL1 Deficiency. Front Immunol, 2017; 8: 1250-1250. : http://dx.doi.org/10.3389/fimmu.2017.01250
  • Stickel N, Hanke K, Marschner D, Prinz G, Kohler M, Melchinger W, Pfeifer D, Schmitt-Graeff A, Brummer T, Heine A, Brossart P, Wolf D, von Bubnoff N, Finke J, Duyster J, Ferrara J, Salzer U, Zeiser R: MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation. Leukemia, 2017 (online). : http://dx.doi.org/10.1038/leu.2017.137 (in Druck)
  • Stok KS, Finzel S, Burghardt AJ, Conaghan PG, Barnabe C: The SPECTRA Collaboration OMERACT Special Interest Group: Current Research and Future Directions. J Rheumatol, 2017. : http://dx.doi.org/10.3899/jrheum.161197 (in Druck)
  • Terslev L, Iagnocco A, Bruyn GAW, Naredo E, Vojinovic J, Collado P, Damjanov N, Filer A, Filippou G, Finzel S, Gandjbakhch F, Ikeda K, Keen HI, Kortekaas MC, Magni-Manzoni S, Ohrndorf S, Pineda C, Ravagnani V, Richards B, Sahbudin I, Schmidt WA, Siddle HJ, Stoenoiu MS, Szkudlarek M, Tzaribachev N, D'Agostino MA: The OMERACT Ultrasound Group: A Report from the OMERACT 2016 Meeting and Perspectives. J Rheumatol, 2017; 44 (11): 1740-1743. : http://dx.doi.org/10.3899/jrheum.161240
  • Thiel J, Rizzi M, Engesser M, Dufner AK, Troilo A, Lorenzetti R, Voll RE, Venhoff N: B cell repopulation kinetics after rituximab treatment in ANCA-associated vasculitides compared to rheumatoid arthritis, and connective tissue diseases: a longitudinal observational study on 120 patients. Arthritis Res Ther, 2017; 19 (1): 101. : http://dx.doi.org/10.1186/s13075-017-1306-0
  • Thiel J, Troilo A, Salzer U, Schleyer T, Halmschlag K, Rizzi M, Frede N, Venhoff A, Voll RE, Venhoff N: Rituximab as Induction Therapy in Eosinophilic Granulomatosis with Polyangiitis Refractory to Conventional Immunosuppressive Treatment: A 36-Month Follow-Up Analysis. J Aller Cl Imm-pract, 2017; 17: 30552-30554. : http://dx.doi.org/10.1016/j.jaip.2017.07.027
  • Unger S, Seidl M, van Schouwenburg P, Rakhmanov M, Bulashevska A, Frede N, Grimbacher B, Pfeiffer J, Schrenk K, Munoz L, Hanitsch L, Stumpf I, Kaiser F, Hausmann O, Kollert F, Goldacker S, van der Burg M, Keller B, Warnatz K: TH1 phenotype of T follicular helper cells indicates an IFNgamma-associated immune dysregulation in CD21low CVID patients. J Allergy Clin Immun, 2017. : http://dx.doi.org/10.1016/j.jaci.2017.04.041 (in Druck)
  • van de Ven AAJM, Seidl M, Drendel V, Schmitt-Graeff A, Voll RE, Rensing-Ehl A, Speckmann C, Ehl S, Warnatz K, Kollert F: IgG4-related disease in autoimmune lymphoproliferative syndrome. Clin Immunol, 2017; 180: 97-99. : http://dx.doi.org/10.1016/j.clim.2017.05.003
  • Venhoff N, Proft F, Schulze-Koops H, Holle J, Voll RE, Iking-Konert C, Jacobi AM, Henes J, Unger L, Kneitz O, Dorner T, Thiel J: [Off-label biologic therapy of ANCA-associated and non-ANCA-associated small-vessel vasculitis : Efficacy and safety analysis of a national registry (GRAID2)]. Z Rheumatol, 2017. : http://dx.doi.org/10.1007/s00393-017-0315-3 (in Druck)
  • Venhoff N, Voll RE, Glaser C, Thiel J: [IL-1-blockade with Anakinra during pregnancy : Retrospective analysis of efficacy and safety in female patients with familial Mediterranean fever]. Z Rheumatol, 2017 (online). : http://dx.doi.org/10.1007/s00393-017-0354-9 (in Druck)
  • Wechsler ME, Akuthota P, Jayne D, Khoury P, Klion A, Langford CA, Merkel PA, Moosig F, Specks U, Cid MC, Luqmani R, Brown J, Mallett S, Philipson R, Yancey SW, Steinfeld J, Weller PF, Gleich GJ: Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis. New Engl J Med, 2017; 376 (20): 1921-1932. : http://dx.doi.org/10.1056/NEJMoa1702079
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten