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 Forschungsbericht für das Jahr 2017

Physiologisches Institut

Hermann-Herder-Str. 7
79104 Freiburg i. Br.
Tel: +49 761 203-5176/5150 Fax: +49 761 203-5191/5204
http://www.physiologie.uni-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Bernd Fakler
  • Prof. Dr. emer. Hermann Antoni
  • Prof. Dr. Jan Behrends
  • Prof. Dr. Gisa Fleckenstein-Grün
  • PD Dr. Jörg Weirich
  • Dr. Detlef Bentrop
  • Dr. Henrike Berkefeld
  • Dr. Wolfgang Bildl
  • PD Dr. Akos Kulik
  • Dr. Uwe Schulte
  • Dr. Gerd Zolles
  • Dr. Jochen Schwenk
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Direct recordings from presynaptic elements and dendrites
  • Excitatory and inhibitory synaptic transmission in the mammalian central nervous system
  • Functional significance of K+ channels in various types of cell (neurons, sensory hair cells in the inner ear)
  • GABAergic interneurons
  • Glutamate receptors of the AMPA and NMDA subtype
  • Ion channels
  • Ion transport
  • Mechanisms of transmitter release
  • Molecular mechanisms underlying function and regulation of ion channels (K+, Ca2+) and other membrane proteins (prestin)
  • NMR-based structure analysis of functional domains of membrane proteins (in particular ion channel proteins)
  • Protein-protein interaction in ion channels
  • Proteom analysis of the microdomains associated with membrane proteins including ion channels, transporters and GPCRs
  • Somatodendritic integration of synaptic signals
  • Voltage-gated ion channels (Na+, K+, Ca2+)

Finanzierung

  • Fördermittel der Tinnitus GmbH

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Bettler B, Fakler B: Ionotropic AMPA-type glutamate and metabotropic GABAB receptors: determining cellular physiology by proteomes Curr Opin Neurobiol, 2017; 45: 16-23.
  • Birkou M, Chasapis CT, Marousis KD, Loutsidou AK, Bentrop D, Lelli M, Herrmann T, Carthy JM, Episkopou V, Spyroulias GA: A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational Plasticity J Mol Biol, 2017; 429 (15): 2373-2386. : http://dx.doi.org/10.1016/j.jmb.2017.06.012
  • Booker, SA, Althof D, Degro CE, Watanabe M, Kulik A, Vida I: Differential surface density and modulatory effects of presynaptic GABAB receptors in hippocampal cholecystokinin and parvalbumin basket cells. Brain Structure and Function Brain Struct Funct, 2017. (in Druck)
  • Booker SA, Althof D, Gross A, Loreth D, Müller J, Unger A, Fakler B, Varro A, Watanabe M, Gassmann M, Bettler B, Shigemoto R, Vida I, Kulik A: KCTD12 auxiliary proteins modulate kinetics of GABA(B) receptor-mediated inhibition in cholecystokinin-containing interneurons. Cereb Cortex, 2017; 27 (3): 2318-2334.
  • Boukhet M, König NF, Ouahabi AA, Baaken G, Lutz JF, Behrends JC: Translocation of Precision Polymers through Biological Nanopores Macromol Rapid Comm, 2017. : http://dx.doi.org/10.1002/marc.201700680 (in Druck)
  • Brechet A, Buchert R, Schwenk J, Boudkkazi S, Zolles G, Siquier-Pernet K, Schaber I, Bildl W, Saadi A, Bole-Feysot C, Nitschke P, Reis A, Sticht H, Al-Sanna’a N, Rolfs A, Kulik A, Schulte U, Colleaux L, Abou Jamra R, Fakler B: AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability Nat Commun, 2017; 8: 15910. : http://dx.doi.org/10.1038/ncomms15910
  • Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle1 J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M: Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory Embo J, 2017; 36 (18): 2770-2789.
  • Constantin CE, Müller CS, Leitner MG, Bildl W, Schulte U, Oliver D, Fakler B: Identification of Cav2-PKCβ and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling. P Natl Acad Sci Usa, 2017; 114 (22): 5707-5712. : http://dx.doi.org/10.1073/pnas.1616394114
  • Dembla S, Behrendt M, Mohr F, Goecke C, Sondermann J, Schneider FM, Schmidt M, Stab J, Enzeroth R, Leitner MG, Nuñez-Badinez P, Schwenk J, Nürnberg B, Cohen A, Philipp SE, Greffrath W, Bünemann M, Oliver D, Zakharian E, Schmidt M, Oberwinkler J: Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels Elife, 2017; 6: 1-32. : http://dx.doi.org/10.7554/eLife.26280
  • Dressler FF, Body I, Menza M, Moss R, Bugger H, Bode C, Behrends JC, Seeman G, Odening KE: Interregional electro-mechanical heterogeneity in the rabbit myocardium Prog Biophys Mol Bio, 2017. : http://dx.doi.org/10.1016/j.pbiomolbio.2017.06.016 (in Druck)
  • Li L, Banerjee A, Bischof LF, Maklad HR, Hoffmann L, Henche AL, Veliz F, Bild W, Schulte U, Orell A, Essen LO, Peeters E, Albers SV: Wing phosphorylation is a major functional determinant of the Lrs14-type biofilm and motility regulator AbfR1 in Sulfolobus acidocaldarius Mol Microbiol, 2017. (in Druck)
  • Schmidt N, Kollewe A, Constantin C, Henrich S, Ritzau-Jost A, Bildl W, Saalbach A, Hallermann S, Kulik A, Fakler B, Schulte U: Neuroplastin and Basigin are essential auyiliary subunits of plasma membrane ca2+-ATPases and key regulators of ca2+ clearance Neuron, 2017; 96: 827-838. : http://doi.org/10.016/j.neuron.2017.09.038
  • Sterky FH, Trotter JH, Lee SJ, Recktenwald CV, Du X, Zhou B, Zhou P, Schwenk J, Fakler B, Südhof TC: Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand P Natl Acad Sci Usa, 2017; 114 (7): E1253-E1262. : http://doi.org/10.1073/pnas.1621321114

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten