Elektrophysiologische Korrelate humaner kognitiver Leistungen

Mittels intracranieller EEG-Registrierungen werden elektrophysiologische Korrelate des episodischen Gedächtnisse bei verbalen und räumlichen Gedächtnisparadigmen, musikalischer Analysen, von Navigationsaufgaben und von visuellen Erkennungsprozesse, insbesondere oszillatorische Aktivität, Synchronisierungsphänomene und Aktivitätsmuster einzelner Neurone untersucht.

Ansprechpartner: Dipl. biol. Armin Brandt, Dr. Lukas Kunz
Tel: 9312
Email: armin.brandt@uniklinik-freiburg.de

Projektbeginn: 2001
Projektende: (unbegrenzt)

Schulze-Bonhage A
Stellvertretung: Dr. rer.nat. Matthias Dümpelmann
Albert-Ludwigs-Universität Freiburg
Klinik für Neurochirurgie
Abteilung Epileptologie
Breisacherstrasse 64
79106 Freiburg

Telefon: +49 761 270 53660
Fax: +49 761 270 50030
www.epi-freiburg.de

• Dr. Lukas Kunz

Prof. Michael Kahana, Department of Psychology, University of Pennsylvania, Philadelphia, USA Prof. Joshua Jacobs, Department of Bioengineerung, Columbia University, New York, USA Prof. Gabriel Kreiman, Harward Univeristy, Boston, USA Prof. Michael Kemper, Humboldt-Universität Berlin

• NIH Grant 2R01MH061975-07A2, Sonstiges
• SFB 780: Synaptic Mechanisms, TP C3, DFG
• NIH Grant 2-R01-MH-061975-12A1, Sonstiges
• Grant ,lntegratioonf b ottom-uapn dt op-downsi gnalsin visualr ecogniti, BMBF
• The roles of grid and place cells and phase precession in human episodic memory, BMBF

human cognition, episodic memory, electrophysiology, oscillations, single unit activity

• Hefft S, Brandt A, Zwick S, von Elverfeldt D, Mader I, Cordeiro J, Trippel M, Blumberg J, Schulze-Bonhage A: Safety of hybrid electrodes for single-neuron recordings in humans. Neurosurgery, 2013; 73 (1): 78-85; discussion 85. : http://dx.doi.org/10.1227/01.neu.0000429840.76460.8c
• Miller JF, Neufang M, Solway A, Brandt A, Trippel M, Mader I, Hefft S, Merkow M, Polyn SM, Jacobs J, Kahana MJ, Schulze-Bonhage A: Neural activity in human hippocampal formation reveals the spatial context of retrieved memories. Science, 2013; 342 (6162): 1111-1114. : http://dx.doi.org/10.1126/science.1244056
• Sammler D, Koelsch S, Ball T, Brandt A, Grigutsch M, Huppertz HJ, Knosche TR, Wellmer J, Widman G, Elger CE, Friederici AD, Schulze-Bonhage A: Co-localizing linguistic and musical syntax with intracranial EEG. Neuroimage, 2013; 64: 134-146. : http://dx.doi.org/10.1016/j.neuroimage.2012.09.035
• Jacobs J, Korolev IO, Caplan JB, Ekstrom AD, Litt B, Baltuch G, Fried I, Schulze-Bonhage A, Madsen JR, Kahana MJ: Right-lateralized Brain Oscillations in Human Spatial Navigation J Cognitive Neurosci, 2010; 22: 824-836. : http://dx.doi.org/10.1162/jocn.2009.21240
• van Vugt MK, Schulze-Bonhage A, Litt B, Brandt A, Kahana MJ: Hippocampal gamma oscillations increase with memory load. J Neurosci, 2010; 30: 2694-2699.
• Sammler D, Koelsch S, Ball T, Brandt A, Elger CE, Friederici AD, Grigutsch M, Huppertz HJ, Knösche TR, Wellmer J, Widman G, Schulze-Bonhage A: Overlap of Musical and Linguistic Syntax Processing: Intracranial ERP Evidence Ann Ny Acad Sci, 2009; 1169: 494-498.
• van Vugt MK, Schulze-Bonhage A, Sekuler R, Litt B, Brandt A, Baltuch G, Kahana MJ: Intracranial electroencephalography reveals two distinct similarity effects during item recognition. Brain Res, 2009; 1299: 33-44. : http://dx.doi.org/10.1016/j.brainres.2009.07.016
• Sederberg PB, Schulze-Bonhage A, Madsen JR, Bromfield EB, McCarthy DC, Brandt A, Tully MS, Kahana MJ: Hippocampal and Neocortical Gamma Oscillations Predict Memory Formation in Humans. Cereb Cortex, 2007; 17: 1190-1196.
• Rizzuto DS, Madsen JR, Bromfield EB, Schulze-Bonhage A, Kahana MJ: Human neocortical oscillations exhibit theta phase differences between encoding and retrieval. Neuroimage, 2006; 31: 1352-1358.
• Caplan JB, Madsen JR, Schulze-Bonhage A, Aschenbrenner-Scheibe R, Newman EL, Kahana MJ: Human theta oscillations related to sensorimotor integration and spatial learning. J Neurosci, 2003; 23 (11): 4726-4736.
• Rizzuto DS, Madsen JR, Bromfield EB, Schulze-Bonhage A, Seelig D, Aschenbrenner-Scheibe R, Kahana MJ: Reset of human neocortical oscillations during a working memory task. P Natl Acad Sci Usa, 2003; 100 (13): 7931-7936.