Prof. Dr. rer. nat. Roland Schüle

geb. am 11.10.1957 in Neuenstadt

1980-1985 Graduate student, department of biochemistry University Tübingen, diploma in biochemistry Grade: 1 (i.e.A) 1985-1988 Ph.D. work in the lab of R. Renkawitz Max-Planck-Institute for Biochemistry, Martinsried, Germany 1988-1991 Postdoc in the lab of Ronald M. Evans, The Salk Institute, La Jolla CA, USA. 1991-1993 Principle Investigator, Preclinical Research Sandoz Ltd, Basle, Switzerland 1993-1999 Principle Investigator, Klinik für Tumorbiologie 1996 "Habilitation" for Molecular Biology and Genetics at the University of Freiburg 1999-now Associate Professor University of Freiburg,

Hauptforschungsgebiete

Generation of mouse models for human diseases Androgen receptor function in prostate cancer Characterization of LIM-only coactivators and their regulation by second messenger signaling pathways Study of co-factor function in transgenic mice and knock out mice models Transcriptional co-factors in chromatin remodelling Transcription factors in bone development and osteoporosis

Wichtige Publikationen

Wissmann M, Yin N, Mueller JM, Greschik H, Fodor BD, Jenuwein T, Vogler C, Schneider R, Guenther T, Buettner R, Metzger E, Schuele R (2007). Co-operative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol. 9, 347-353. Hublitz P, Kunowska N, Mayer UP, Muller JM, Heyne K, Yin N, Fritzsche C,Poli C, Miguet L, Schupp IW, van Grunsven LA, Potiers N, van Dorsselaer A,Metzger E, Roemer K, Schuele, R. (2005). NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev. 19, 2912-24. Metzger E, Wissmann M, Yin N, Muller JM, Schneider R, Peters AH, Gunther T, Buettner R, Schuele, R. (2005). LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription Nature. 437, 436-439. Gunther T, Poli C, Muller JM, Catala-Lehnen P, Schinke T, Yin N, Vomstein S, Amling M, Schuele, R. (2005). Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts. EMBO J. 24, 3049-56. Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schule R. (2003). All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Nat. Struct. Biol. 10, 820-825. Metzger E, Muller JM, Ferrari S, Buettner R, Schuele, R. (2003). A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer. EMBO J. 15, 270-280. Mueller, J.M., Metzger, E., Greschik, H., Bosserhoff, A-K., Mercep, L., Buettner, R. and Schuele, R. (2002). The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus. EMBO J. 21, 736-748. Stehlin C, Wurtz JM, Steinmetz A, Greiner E, Schuele R., Moras D, Renaud JP. (2001). X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. EMBO J. 20, 5822-5831. Mueller, J.M., Isele, U., Metzger, E., Rempel, A., Moser, M., Pscherer, A., Breyer, T., Holubarsch, C., Buettner, R. and Schuele, R. (2000) FHL2, a novel tissue-specific coactivator of the androgen receptor. EMBO J. 19, 359-369. Schuele, R., Pundi, R., Kliewer, S., Ransone, L.J., Bolado, J., Yang, N., Verma, I.M. and Evans, R.M. (1990) Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62, 1217-1226. Schuele, R., Umesono, K., Mangelsdorf, D., Bolado, J., Pike, W.J. and Evans, R.M. (1990). Jun/Fos and receptors for vitamin A and D recognize a common response element in the human osteocalcin gene. Cell 61, 497-504. Schuele, R., Muller, M., Kaltschmidt, Ch. and Renkawitz, R. (1988) Many transcription factors interact synergistically with steroid receptors. Science 242, 1418-1420. Schuele, R., Muller, M., Otzuka-Murakami, H. and Renkawitz, R. (1988) Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature 322, 87-90.

Kontaktaufnahme

Tel: +49-761-270-6310
Fax: +49-761-270-6311
Email: roland.schuele@uniklinik-freiburg.de

Adresse / Postanschrift:
Department Chirurgie
Klinik für Urologie
Breisacherstr. 66
79106 Freiburg

Telefon: +49 761 270 63100
Fax: +49 761 270 63110
Email: roland.schuele@uniklinik-freiburg.de
http://www.uniklinik-freiburg.de/schuelelab.html