Dr Tuan Leng Tay

2003-2005: Master of Science, Lab of Zhiyuan Gong, Department of Biological Sciences, National University of Singapore |2005-2010: Doctor rerum naturalium, Lab of Wolfgang Driever, Institute of Biology I (Zoology), University of Freiburg |2011: Postdoctoral Scientist, Lab of Hui Zhang, Department of Psychiatry, Columbia University Medical Centre, New York |2012-2018: Postdoctoral Scientist, Lab of Marco Prinz, Institute of Neuropathology, University Medical Centre of Freiburg |2017-present: Lecturer for Developmental Neurobiology, Faculty of Biology, University of Freiburg |2018-present: Member/PI, Cluster of Excellence BrainLinks-BrainTools, University of Freiburg

Zentrale Einrichtungen

Hauptforschungsgebiete

Entwicklungs-Neurobiologie

Wichtige Publikationen

Falk T, Mai D, Bensch R, Çiçek Ö, Abdulkadir A, Marrakchi Y, Böhm A, Deubner J, Jäckel Z, Seiwald K, Dovzhenko A, Tietz O, Dal Bosco C, Walsh S, Saltukoglu D, Tay TL, Prinz M, Palme K, Simons M, Diester I, Brox T, Ronneberger O. U-Net: deep learning for cell counting, detection, and morphometry. Nat Methods. 2019 Jan;16(1):67-70. doi:10.1038/s41592-018-0261-2. |Shemer A, Grozovski J, Tay TL, Tao J, Volaski A, Süß P, Ardura-Fabregat A, Gross-Vered M, Kim JS, David E, Chappell-Maor L, Thielecke L, Glass CK, Cornils K, Prinz M, Jung S. Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge. Nat Commun. 2018 Dec 6;9(1):5206. doi: 10.1038/s41467-018-07548-5. |Tay TL, Sagar, Dautzenberg J, Grün D, Prinz M. Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration. Acta Neuropathol Commun. 2018 Sep 5;6(1):87. doi: 10.1186/s40478-018-0584-3. |Datta M, Staszewski O, Raschi E, Frosch M, Hagemeyer N, Tay TL, Blank T, Kreutzfeldt M, Merkler D, Ziegler-Waldkirch S, Matthias P, Meyer-Luehmann M, Prinz M. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner. Immunity. 2018 Mar 20;48(3):514-529.e6. doi: 10.1016/j.immuni.2018.02.016. |Weinhard L, d'Errico P, Tay TL. Headmasters: Microglial regulation of learning and memory in health and disease. AIMS Mol Sci. 2018 Mar 5;5(1):63-89. doi: 10.3934/molsci.2018.1.63. |Tay TL, Béchade C, D'Andrea I, St-Pierre MK, Henry MS, Roumier A, Tremblay ME. Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan. Front Mol Neurosci. 2018 Jan 4;10:421. doi: 10.3389/fnmol.2017.00421. |Tay TL, Mai D, Dautzenberg J, Fernández-Klett F, Lin G, Sagar, Datta M, Drougard A, Stempfl T, Ardura-Fabregat A, Staszewski O, Margineanu A, Sporbert A, Steinmetz LM, Pospisilik JA, Jung S, Priller J, Grün D, Ronneberger O, Prinz M. A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nat Neurosci. 2017 Jun;20(6):793-803. doi: 10.1038/nn.4547 |Tay TL, Savage JC, Hui CW, Bisht K, Tremblay MÈ. Microglia across the lifespan: from origin to function in brain development, plasticity and cognition. J Physiol. 2017 Mar 15;595(6):1929-1945. doi: 10.1113/JP272134. |Tay TL, Hagemeyer N, Prinz M. The force awakens: insights into the origin and formation of microglia. Curr Opin Neurobiol. 2016 Aug;39:30-7. doi: 10.1016/j.conb.2016.04.003. |Tay TL, Ronneberger O, Ryu S, Nitschke R, Driever W. Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems. Nat Commun. 2011 Jan 25;2:171. |Tay TL, Lin Q, Seow TK, Tan KH, Hew CL, Gong Z. Proteomic analysis of protein profiles during early development of the zebrafish, Danio rerio. Proteomics. 2006 May;6(10):3176-88.

Kontaktaufnahme

Tel: +49-761-203-8347
Email: tuan.leng.tay@biologie.uni-freiburg.de
Persönliche Homepage: https://loop.frontiersin.org/people/502442/

Adresse / Postanschrift:
Exzellenzcluster BrainLinks-BrainTools

Georges-Köhler-Allee 079
79110 Freiburg

Telefon: +49 (0) 761 203-8026
Email: burgard@informatik.uni-freiburg.de
http://www.brainlinks.uni-freiburg.de/