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 Forschungsbericht für das Jahr 2016

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Ahrens TD, Timme S, Ostendorp J, Bogatyreva L, Hoeppner J, Hopt UT, Hauschke D, Werner M, Lassmann S: Response of esophageal cancer cells to epigenetic inhibitors is mediated via altered thioredoxin activity. Lab Invest, 2016; 96: 307-316. : http://dx.doi.org/10.1038/labinvest.2015.148
  • Al-Ahmad A, Karygianni L, Schulze Wartenhorst M, Bächle M, Hellwig E, Follo M, Vach K, Han J-S: Bacterial adhesion and biofilm formation on yttria-stabilized, tetragonal zirconia and titanium oral implant materials with low surface roughness - an in situ study. J Med Microbiol, 2016; 65: 596-604. : http://dx.doi.org/10.1099/jmm.0.000267
  • Allignol A, Beyersmann J, Schmoor C: Statistical issues in the analysis of adverse events in time-to-event data: Pharm Stat, 2016; 15: 297-305. : http://dx.doi.org/10.1002/pst.1739
  • Anderson AC, Jonas D, Huber I, Karygianni L, Wölber J, Hellwig E, Arweiler N, Vach K, Wittmer A, Al-Ahmad A: Enterococcus faecalis from Food, Clinical Specimens, and Oral Sites: Prevalence of Virulence Factors in Association with Biofilm Formation. Front Microbiol, 2016; 6 (online): 1534. : http://dx.doi.org/10.3389/fmicb.2015.01534
  • Aumann K, Niermann K, Asberger J, Wellner U, Bronsert P, Erbes T, Hauschke D, Stickeler E, Gitsch G, Kayser G, Werner M: Structured reporting ensures complete content and quick detection of essential data in pathology reports of oncological breast resection specimens. Breast Cancer Res Tr, 2016; 156: 495-500. : http://dx.doi.org/10.1007/s10549-016-3769-0
  • Baier P, Ihorst G, Wolff-Vorbeck G, M. Hülld M, Hopta U, Deschler B: Independence and health related quality of life in 200 onco-geriatric surgical patients within 6 months of follow-up: Who is at risk to lose? Ejso-eur J Surg Onc, 2016; 42: 1890-1897. : http://dx.doi.org/10.1016/j.ejso.2016.07.013
  • Bickenbach J, Marx G, Schmoor C, Lemmen S, Marx N, Dreher M: Differences between prolonged weaning patients from medical and surgical intensive care units. Acta Anaesth Scand, 2016; 60: 1270-1280. : http://dx.doi.org/10.1111/aas.12775
  • Binder H, Kurz T, Teschner S, Kreutz C, Geyer M, Donauer J, Kraemer-Guth A, Timmer J, Schumacher M, Walz G: Dealing with prognostic signature instability: a strategy illustrated for cardiovascular events in patients with end-stage renal disease. Bmc Med Genomics, 2016; 9 (online): 43. : http://dx.doi.org/10.1186/s12920-016-0210-9
  • Bittner M-I, Wiedenmann N, Bucher S, Hentschel M, Mix M, Rücker G, Weber WA, Meyer PT, Werner M, Grosu A-L, Kayser G: Analysis of relation between hypoxia PET imaging and tissue-based biomarkers during head and neck radiochemotherapy. Acta Oncol, 2016; 55: 1299-1304. : http://dx.doi.org/10.1080/0284186X.2016.1219046
  • Boch T, Tennert C, Vach K, Al-Ahmad A, Hellwig E, Polydorou O: Effect of gaseous ozone on Enterococcus faecalis biofilm–an in vitro study. Clin Oral Invest, 2016; 20: 1733-1739. : http://dx.doi.org/10.1007/s00784-015-1667-1
  • Bonofiglio F, Beyersmann J, Schumacher M, Koller M, Schwarzer G: Meta-analysis for aggregated survival data with competing risks: a parametric approach using cumulative incidence functions. Research Synthesis Methods, 2016; 7: 282-293. : http://dx.doi.org/10.1002/jrsm.1165
  • Cattaneo G, Schumacher M, Maurer C, Wolfertz J, Jost T, Büchert M, Keuler A, Boos L, Shah MJ, Foerster K, Niesen W-D, Ihorst G, Urbach H, Meckel S: Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance. Am J Neuroradiol, 2016; 37: 885-891. : http://dx.doi.org/10.3174/ajnr.A4625
  • Chevalier N, Mueller M, Mougiakakos D, Ihorst G, Marks R, Schmitt-Graeff A, Veelken H: Analysis of dendritic cell subpopulations in follicular lymphoma with respect to the tumor immune microenvironment. Leukemia Lymphoma, 2016; 57: 2150-2160. : http://dx.doi.org/10.3109/10428194.2016.1143150
  • Coenen VA, Jenkner C, Honey CR, Mädler B: Electrophysiologic Validation of Diffusion Tensor Imaging Tractography during Deep Brain Stimulation Surgery. Am J Neuroradiol, 2016; 37: 1470-1478. : http://dx.doi.org/10.3174/ajnr.A4753
  • De Bin R, Janitza S, Sauerbrei W, Boulesteix A-L: Subsampling versus bootstrapping in resampling-based model selection for multivariable regression. Biometrics, 2016; 72: 272-280. : http://dx.doi.org/10.1111/biom.12381
  • Dersch E, Sommer H, Rauer S, Meerpohl JJ: Prevalence and spectrum of residual symptoms in Lyme neuroborreliosis after pharmacological treatment: a systematic review. J Neurol, 2016; 263: 17-24. : http://dx.doi.org/10.1007/s00415-015-7923-0
  • Dersch R, Hottenrott T, Schmidt S, Sommer H, Huppertz HI, Rauer S, Meerpohl JJ: Efficacy and safety of pharmacological treatments for Lyme neuroborreliosis in children: a systematic review. Bmc Neurol, 2016; 16 (1) (online): 189. : http://dx.doi.org/10.1186/s12883-016-0708-y
  • Dettenkofer M, Humphreys H, Saenz H, Carlet J, Hanberger H, Ruef C, Widmer A, Wolkewitz M, Cookson B: Key priorities in the prevention and control of healthcare-associated infection: a survey of European and other international infection prevention experts. Infection, 2016; 44: 719-724. : https://dx.doi.org/10.1007/s15010-016-0904-0
  • Diem R, Molnar F, Beisse F, Gross N, Drüschler K, Heinrich SP, Joachimsen L, Rauer S, Pielen A, Sühs K-W, Linker RA, Huchzermeyer C, Albrecht P, Hassenstein A, Aktas O, Guthoff T, Tonagel F, Kernstock C, Hartmann K, Kümpfel T, Hein K, van Oterendorp C, Grotejohann B, Ihorst G, Maurer J, Müller M, Volkmann M, Wildemann B, Platten M, Wick W, Heesen C, Schiefer U, Wolf S, Lagrèze WA: Treatment of optic neuritis with erythropoietin (TONE): a randomised, double-blind, placebo-controlled trial—study protocol. Bmj Open, 2016; 6 (online): e010956. : http://dx.doi.org/10.1136/bmjopen-2015-010956
  • Doerken S, Mockenhaupt M, Naldi L, Schumacher M, Sekula P: The case-crossover design via penalized regression. Bmc Med Res Methodol, 2016; 16 (online): 103. : http://dx.doi.org/10.1186/s12874-016-0197-0
  • Engelhardt M, Dold SM, Ihorst G, Zober A, Möller M, Reinhardt H, Hieke S, Schumacher M, Wäsch: Geriatric assessment in multiple myeloma patients: validation of the International Myeloma Working Group (IMWG) score and comparison with other common comorbidity scores. Haematologica, 2016; 101: 1110-1119. : http://dx.doi.org/10.3324/haematol.2016.148189
  • Engelhardt M, Ihorst G, Caers J, Günther A, Wäsch R: Autotransplants in older multiple myeloma patients: hype or hope in the era of novel agents? Haematologica, 2016; 101: 1276-1278. : http://dx.doi.org/10.3324/haematol.2016.154807
  • Erbes T, Hirschfeld M, Waldeck S, Rücker G, Jäger M, Willmann L, Kammerer B, Mayer S, Gitsch G, Stickeler E: Hyperthermia-driven aberrations of secreted microRNAs in breast cancer in vitro. Int J Hyperther, 2016; 32 (6): 630-642. : http://dx.doi.org/10.3109/02656736.2016.1161832
  • Erbes T, Stickeler E, Rücker G, Buroh S, Asberger J, Dany N, Thornton S, Iborra S, Hirschfeld M, Gitsch G, Mayer S: BMI and Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer: A Study and Meta-Analysis. Clin Breast Cancer, 2016; 16 (4): e119-e132. : http://dx.doi.org/10.1016/j.clbc.2016.02.018
  • Finke J, Schmoor C, Bertz H, Marks R, Wäsch R, Zeiser R, Hackanson B: Long-term follow-up of therapy-related myelodysplasia and AML patients treated with allogeneic hematopoietic cell transplantation. Bone Marrow Transpl, 2016; 51: 771-777. : http://dx.doi.org/10.1038/bmt.2015.338
  • Frick M, Fischer J, Helbling A, Ruëff F, Wieczorek D, Ollert M, Pfützner W, Müller S, Huss-Marp J, Dorna B, Biedermann T, Lidholm J, Ruecker G, Bantleon F, Miehe M, Spillner E, Jakob T: Predominant Api m 10 sensitization as risk factor for treatment failure in honey bee venom immunotherapy. J Allergy Clin Immun, 2016; 138: 1663-1671. : http://dx.doi.org/10.1016/j.jaci.2016.04.024
  • Goebel U, Gebele N, Ebner W, Dettenkofer M, Bürkle H, Hauschke D, Schulz-Stübner S: Bacterial Contamination of the Anesthesia Workplace and Efficiency of Routine Cleaning Procedures: A Prospective Cohort Study. Anesth Analg, 2016; 122: 1444-1447. : http://dx.doi.org/10.1213/ANE.0000000000001220
  • Heiland DH *, Mader I *, Schlosser P, Pfeifer D, Carro MS, Lange T, Schwarzwald R, Vasilikos I, Urbach H, Weyerbrock A: Integrative Network-based Analysis of Magnetic Resonance Spectroscopy and Genome Wide Expression in Glioblastoma multiforme. Sci Rep-uk, 2016; 6 (online): 29052. : http://dx.doi.org/10.1038/srep29052
  • Hein S, Miernik A, Wilhelm K, Schlager D, Schoeb DS, Adams F, Vach W, Schoenthaler M: Endoscopically Determined Stone Clearance Predicts Disease Recurrence Within 5 Years After Retrograde Intrarenal Surgery. J Endourol, 2016; 30: 644-649. : http://dx.doi.org/10.1089/end.2016.0101
  • Hieke S, Benner A, Schlenk RF, Schumacher M, Bullinger L, Binder H: Identifying Prognostic SNPs in Clinical Cohorts: Complementing Univariate Analyses by Resampling and Multivariable Modeling. Plos One, 2016; 11 (online): e0155226. : http://dx.doi.org/10.1371/journal.pone.0155226
  • Hieke S, Benner A, Schlenl RF, Schumacher M, Bullinger L, Binder H: Integrating multiple molecular sources into a clinical risk prediction signature by extracting complementary information: Bmc Bioinformatics, 2016; 17 (online): 327. : http://dx.doi.org/10.1186/s12859-016-1183-6
  • Hochholzer w, Amann M, Tito A, Younas I, Löffelhardt N, Riede F, Potocnik C, Stratz C, Hauschke D, Trenk D, Neumann F-J, Valina CM: Randomized Comparison of Different Thienopyridine Loading Strategies in Patients Undergoing Elective Coronary Intervention: The ExcelsiorLOAD Trial. Jacc-cardiovasc Inte, 2016; 9: 219-227. : http://dx.doi.org/10.1016/j.jcin.2015.10.036
  • Hoeppner J, Lordick F, Brunner T, Glatz T, Bronsert P, Röthling N, Schmoor C, Lorenz D, Ell C, Hopt UT, Siewert JR: ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286). Bmc Cancer, 2016; 16 (online): 503. : http://dx.doi.org/10.1186/s12885-016-2564-y
  • Hüttner FJ, Fitzmaurice C, Schwarzer G, Seiler CM, Antes G, Büchler MW, Diener MK: Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma. Cochrane Db Syst Rev, 2016; 2 (online): CD006053. : http://dx.doi.org/10.1002/14651858.CD006053.pub6
  • Illerhaus G, Kasenda B, Ihorst G, Egerer G, Lamprecht M, Keller U, Wolf H-H, Hirt C, Stilgenbauer S, Binder M, Hau P, Edinger M, Frickhofen N, Bentz M, Möhle R, Röth A, Pfreundschuh M, von Baumgarten L, Deckert M, Hader C, Fricker H, Valk E, Schorb E, Fritsch K, Finke J: High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial. Lancet Haematol, 2016; 3 (online): e388-e397. : http://dx.doi.org/10.1016/S2352-3026(16)30050-3
  • Jenkner C, Lorenz E, Becher H, Sauerbrei W: Modeling continuous covariates with a “spike” at zero: Bivariate approaches. Biometrical J, 2016; 58: 783-796. : http://dx.doi.org/10.1002/bimj.201400112
  • Karygianni L, Proksch S, Schneider S, Vach K, Hellwig E, Steinberg T, Schulz SD, Tchorz JP, Altenburger MJ: The effects of various mixing solutions on the biocompatibility of mineral trioxide aggregate. Int Endod J, 2016; 49: 561-573. : http://dx.doi.org/10.1111/iej.12483
  • Kasenda B, Sauerbrei W, Royston P, Mercat A, Slutsky AS, Cook D, Guyatt GH, Brochard L, Richard J-CM, Stewart TE, Meade M, Briel M: Multivariable fractional polynomial interaction to investigate continuous effect modifiers in a meta-analysis on higher versus lower PEEP for patients with ARDS. Bmj Open, 2016; 6 (online): e011148. : http://dx.doi.org/10.1136/bmjopen-2016-011148
  • Lampert FM, Grabin S, Antes G, Motschall E, Buroh S, Stark GB: Zellassistierte Eigenfetttransplantation - aktuelle Evidenzlage. Plastische Chirurgie, 2016; 16: 92-97.
  • Linde K, Rücker G, Schneider A, Kriston L: Questionable assumptions hampered interpretation of a network meta-analysis of primary care depression treatments. J Clin Epidemiol, 2016; 71: 86-96. : http://dx.doi.org/10.1016/j.jclinepi.2015.10.010
  • Lübbert M, Suciu S, Hagemeijer A, Rüter B, Platzbecker U, Giagounidis A, Selleslag D, Labar B, Germing U, Salih HR, Muus P, Pflüger K-H, Schaefer H-E, Bogatyreva L, AulC, de Witte T, Ganser A, Becker H, Huls G, van der Helm L, Vellenga E, Baron F, Marie J-P, Wijermans PW, on behalf of the EORTC Leukemia Group, the German MDS Study Grou: Decitabine improves progression-free survival in older high-risk MDS patients with multiple autosomal monosomies: results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group. Ann Hematol, 2016; 95: 191-199. : http://dx.doi.org/10.1007/s00277-015-2547-0
  • Lutz L, Fitzner IC, Ahrens T, Geißler AL, Makowiec F, Hopt UT, Bogatyreva L, Hauschke D, Werner M, Lassmann S: Histone modifiers and marks define heterogeneous groups of colorectal carcinomas and affect responses to HDAC inhibitors in vitro. Am J Cancer Res, 2016; 6: 664-676.
  • Machado V, Gilsbach R, Das R, Schober A, Bogatyreva L, Hauschke D, Krieglstein K, Unsicker K, Spittau B: Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice. Cell Tissue Res, 2016; 365: 209-223. : http://dx.doi.org/10.1007/s00441-016-2406-x
  • Maier S, Perlov E, Graf E, Dieter E, Sobanski E, Rump M, Warnke A, Ebert D, Berger M, Matthies S, Philipsen A, Tebartz van Elst L: Discrete Global but No Focal Gray Matter Volume Reductions in Unmedicated Adult Patients with Attention-Deficit/Hyperactivity Disorder. Biol Psychiat, 2016; 80: 905-915. : http://dx.doi.org/10.1016/j.biopsych.2015.05.012
  • Maurer J, Grotejohann B, Jenkner C, Schneider C, Flury T, Tassoni A, Angele P, Fritz J, Albrecht D, Niemeyer P: A Registry for Evaluation of Efficiency and Safety of Surgical Treatment of Cartilage Defects: The German Cartilage Registry (KnorpelRegister DGOU). JMIR Research Protocols, 2016; 5 (online): e122. : http://dx.doi.org/10.2196/resprot.5895
  • Meffert C, Rücker G, Hatami I, Becker G: Identification of hospital patients in need of palliative care – a predictive score. Bmc Palliat Care, 2016; 15 (online): 21. : http://dx.doi.org/10.1186/s12904-016-0094-7
  • Michalska M, Schultze-Seemann S, Bogatyreva L, Hauschke D, Wetterauer U, Wolf: In vitro and in vivo effects of a recombinant anti-PSMA immunotoxin in combination with docetaxel against prostate cancer. Oncotarget, 2016; 7 (16): 22531-22542. : http://dx.doi.org/10.18632/oncotarget.8001
  • Mueller KF, Meerpohl JJ, Briel M, Antes G, von Elm E, Lang B, Motschall E, Schwarzer G, Bassler D: Methods for detecting, quantifying, and adjusting for dissemination bias in meta-analysis are described. J Clin Epidemiol, 2016; 80: 25-33. : http://dx.doi.org/10.1016/j.jclinepi.2016.04.015
  • Oehlke O, Mix M, Graf E, Schimek-Jasch T, Nestle U, Götz I, Schneider-Fuchs S, Weyerbrock A, Mader I, Baumert BG, Short SC, Meyer PT, Webe WA, Grosu A-L: Amino-acid PET versus MRI guided re-irradiation in patients with recurrent glioblastoma multiforme (GLIAA) – protocol of a randomized phase II trial (NOA 10/ARO 2013-1). Bmc Cancer, 2016; 16 (online): 769. : http://dx.doi.org/10.1186/s12885-016-2806-z
  • Olivier CB, Schnabel K, Weber S, Zhou Q, Bode C, Moser M, Diehl P: Platelet reactivity after administration of third generation P2Y12-antagonists does not depend on body weight in contrast to clopidogrel. J Thromb Thrombolys, 2016; 42: 84-89. : http://dx.doi.org/10.1007/s11239-016-1340-9
  • Olivier CB, Weik P, Meyer M, Weber S, Anto-Michel N, Diehla P, Zhou Q, Geisen U, Bode C, Moser M: TRAP-induced platelet aggregation is enhanced in cardiovascular patients receiving dabigatran. Thromb Res, 2016; 138: 63-68. : http://dx.doi.org/10.1016/j.thromres.2015.10.038
  • Olivier CB, Weik P, Meyer M, Weber S, Diehl P, Bode C, Moser M, Zhou Q: Dabigatran and rivaroxaban do not affect AA- and ADP-induced platelet aggregation in patients receiving concomitant platelet inhibitors. J Thromb Thrombolys, 2016; 42: 161-166. : http://dx.doi.org/10.1007/s11239-016-1350-7
  • Proctor T, Schumacher M: Analysing adverse events by time-to-event models: the CLEOPATRA study. Pharm Stat, 2016; 15: 306-314. : http://dx.doi.org/10.1002/pst.1758
  • Rücker G, Schwarzer G: Automated drawing of network plots in network meta-analysis. Research Synthesis Methods, 2016; 7: 94-107. : http://dx.doi.org/10.1002/jrsm.1143
  • Sajonz BEA, Amtage F, Reinacher PC, Jenkner C, Piroth T, Kätzler J, Urbach H, Coenen VA: Deep brain stimulation for tremor tractographic versus traditional (DISTINCT): Study protocol of a randomized controlled feasibility trial. JMIR Research Protocols, 2016; 5 (online): e244. : http://dx.doi.org/10.2196/resprot.6885
  • Schmid B, Fink K, Olschewski M, Richter S, Schwab T, Brunner M, Busch HJ: Accuracy and precision of transcardiopulmonary thermodilution in patients with cardiogenic shock. J Clin Monit Comput, 2016; 30: 849-856. : http://dx.doi.org/10.1007/s10877-015-9782-8
  • Schorb E, Finke J, Ferreri AJM, Ihorst G, Mikesch K, Kasenda B, Fritsch K, Fricker H, Burger E, Grishina O, Valk E, Zucca E, Illerhaus G: High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma—a randomized phase III trial (MATRix). Bmc Cancer, 2016; 16 (online): 282. : http://dx.doi.org/10.1186/s12885-016-2311-4
  • Schröder W, Sommer H, Gladstone BP, Foschi F, Hellman J, Evengard B, Tacconelli E: Gender differences in antibiotic prescribing in the community: a systematic review and meta-analysis. J Antimicrob Chemoth, 2016; 71: 1800-1806. : http://dx.doi.org/10.1093/jac/dkw054
  • Schumacher M: Entwicklung klinischer Studien von Paul Martini bis heute Drug Research, 2016; 66: S5-S7. : https://dx.doi.org/10.1055/s-0042-112398
  • Sekula P, Del Greco M F, Pattaro C, Köttgen A: Mendelian Randomization as an Approach to Assess Causality Using Observational Data. J Am Soc Nephrol, 2016; 27: 3253-3265. : http://dx.doi.org/10.1681/ASN.2016010098
  • Sekula P, Goek ON, Quaye L, Barrios C, Levey AS, Römisch-Margl W, MenniC, Yet I, Gieger C, Inker LA, Adamski J, Gronwald W, Illig T, Dettmer K, Krumsiek J, Oefner PJ, Valdes AM, Meisinger C, Coresh J, Spector TD, Mohney RP, SuhreK, Kastenmüller G, Köttgen A: A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population. J Am Soc Nephrol, 2016; 27: 1175-1188. : http://dx.doi.org/10.1681/ASN.2014111099
  • Sekula P, Pressler JB, Sauerbrei W, Goebell PJ, Schmitz-Dräger BJ: Assessment of the extent of unpublished studies in prognostic factor research: a systematic review of p53 immunohistochemistry in bladder cancer as an example. Bmj Open, 2016; 6 (online): e009972. : http://dx.doi.org/10.1136/bmjopen-2015-009972
  • Siemens W, Xander C, Meerpohl JJ, Buroh S, Antes G, Schwarzer G, Becker G: Pharmacological interventions for pruritus in adult palliative care patients. Cochrane Db Syst Rev, 2016; 11 (online): CD008320. : https://dx.doi.org/10.1002/14651858.CD008320.pub3
  • Solari L, Krönig M, Ihorst G, Drognitz K, Heinz J, Jilg CA, Schultze-Seemann W, Engelhardt M, Waller CF: High Rates of Thromboembolic Events in Patients with Germ Cell Cancer Undergoing Cisplatin-Based Polychemotherapy. Urol Int, 2016; 96: 399-405. : https://dx.doi.org/10.1159/000445126
  • Spielmanns M, Gloeckl R, Schmoor C, Windisch W, Storre JH, Boensch M, Kenn K: Effects on pulmonary rehabilitation in patients with COPD or ILD: A retrospective analysis of clinical and functional predictors with particular emphasis on gender. Resp Med, 2016; 113: 8-14. : http://dx.doi.org/10.1016/j.rmed.2016.02.006
  • Spies BC, Nold J, Vach K, Kohal R-J: Two-piece zirconia oral implants withstand masticatory loads: An investigation in the artificial mouth. J Mech Behav Biomed, 2016; 53: 1-10. : http://dx.doi.org/10.1016/j.jmbbm.2015.07.005
  • Spies BC, Patzelt SBM, Vach K, Kohal R-J: Monolithic lithium-disilicate single crowns supported by zirconia oral implants: three-year results of a prospective cohort study. Clin Oral Implan Res, 2016; 27: 1160-1168. : http://dx.doi.org/10.1111/clr.12716
  • Spies BC, SperlichM, Fleiner J, Stampf S, Kohal R-J: Alumina reinforced zirconia implants: 1-year results from a prospective cohort investigation. Clin Oral Implan Res, 2016; 27: 481-490. : http://dx.doi.org/10.1111/clr.12560
  • Spies BC, Witkowski S, Butz F, Vach K, Kohal R-J: Bi-layered zirconia/fluor-apatite bridges supported by ceramic dental implants: a prospective case series after thirty months of observation Clin Oral Implan Res, 2016; 27: 1265-1273. : http://dx.doi.org/10.1111/clr.12731
  • Steinhauser S, Schumacher M, Rücker G: Modelling multiple thresholds in meta-analysis of diagnostic test accuracy studies. Bmc Medical Research Methodology, 2016; 16 (online): 97. : http://dx.doi.org/10.1186/s12874-016-0196-1
  • Stewardson AJ, Allignol A, Beyersmann J, Graves N, Schumacher M, Meyer R, Tacconelli E, De Angelis G, Farina C, Pezzoli F, Bertrand X, Gbaguidi-Haore H, Edgeworth J, Tosas O, Martinez JA, Ayala-Blanco MP, Pan A, Zoncada A, Marwick CA, Nathwani D, Seifert H, Hos N, Hagel S, Pletz M, Harbarth S, the TIMBER Study Group 18: The health and economic burden of bloodstream infections caused by antimicrobial-susceptible and non-susceptible Enterobacteriaceae and Staphylococcus aureus in European hospitals, 2010 and 2011: a multicentre retrospective cohort study. Eurosurveillance, 2016; 21 (online): 30319. : http://dx.doi.org/10.2807/1560-7917.ES.2016.21.33.30319
  • Taschner CA, Chapot R, Costalat V, Machi P, Courthéoux, Barreau X, Berge J, Pierot L, Kadziolka K, Jean B, Blanc, Biondi A, Brunel H, Gallas S, Berlis A, Herbreteau D, Berkefeld J, Urbach H, El Shikh S, Fiehler J, Desal H, Graf E, Bonafé A: GREAT—a randomized controlled trial comparing HydroSoft/HydroFrame and bare platinum coils for endovascular aneurysm treatment: procedural safety and core-lab-assessedangiographic results. Neuroradiology, 2016; 58: 777-786. : http://dx.doi.org/10.1007/s00234-016-1693-y
  • Tebartz van Elst L, Maier S, Klöppel S, Graf E, Killius C, Rump M, Sobanski E, Ebert D, Berger M, Warnke A, Matthies S, Perlov E, Philipsen A: The effect of methylphenidate intake on brain structure in adults with ADHD in a placebo-controlled randomized trial. J Psychiatr Neurosci, 2016; 41: 422-430. : https://dx.doi.org/10.1503%2Fjpn.150320
  • Tennert C, Fischer GF, Vach K, Woelber JP, Hellwig E, Polydorou O: A temporary filling material during endodontic treatment may cause tooth fractures in two-surface class II cavities in vitro. Clin Oral Invest, 2016; 20: 615-620. : http://dx.doi.org/10.1007/s00784-015-1543-z
  • Torbahn G, Hofmann H, Allert R, Freitag MH, Dersch R, Fingerle V, Sommer H, Motschall E, Meerpohl JJ, Schmucker C: Efficacy and safety of pharmacological agents in the treatment of erythema migrans in early Lyme borreliosis—systematic review protocol. Systematic Reviews, 2016; 5 (online): 73. : http://dx.doi.org/10.1186/s13643-016-0251-3
  • Urbain P, Ihorst G, Finke J, Bertz H: The impact of pre-transplant body weight on short- and long-term outcomes after allogeneic hematopoietic cell transplantation in adults using different weight classification tools. Bone Marrow Transpl, 2016; 51: 144-147. : http://dx.doi.org/10.1038/bmt.2015.219
  • Vry J, Gramsch K, Rodger S, Thompson R, Steffensen BF, Rahbek J, Doerken S, Tassoni A, Beytía, MdlA, Guergueltcheva V, Chamova T, Tournev I, Kostera-Pruszczyk A, Kaminska A, Lusakowska A, Mrazova L, Pavlovska L, Strenkova J, Vondráček P, Garami M, Karcagi V, Herczegfalvi Á, Bushby K, Lochmüller H, Kirschner J: European cross-sectional survey of current care practices for duchenne muscular dystrophy reveals regional and age-dependent differences. Journal of Neuromuscular Diseases, 2016; 3: 517-527. : http://dx.doi.org/10.3233/JND-160185
  • Weber S, von Cube M, Sommer H, Wolkewitz M: Necessity of a competing risk approach in risk factor analysis of central line–associated bloodstream infection. Infect Cont Hosp Ep, 2016; 37: 1255-1257. : http://dx.doi.org/10.1017/ice.2016.166
  • Wehrum T, Hagenlocher P, Lodemann T, Vach W, Dragonu I, Hennemuth A, von zur Mühlen C, Stuplich J, Ngo BTT, Harloff A: Age dependence of pulmonary artery blood flow measured by 4D flow cardiovascular magnetic resonance: results of a population-based study: J Cardiovasc Magn R, 2016; 18 (online): 31. : http://dx.doi.org/10.1186/s12968-016-0252-3
  • Wiksten A, Rücker G, Schwarzer G: Hartung–Knapp method is not always conservative compared with fixed-effect meta-analysis. Stat Med, 2016; 35: 2503-2515. : http://dx.doi.org/10.1002/sim.6879
  • Winzer K-J, Buchholz A, Schumacher M, Sauerbrei W: Improving the Prognostic Ability through Better Use of Standard Clinical Data - The Nottingham Prognostic Index as an Example. Plos One, 2016; 11 (online): e0149977. : http://dx.doi.org/10.1371/journal.pone.0149977
  • Wirsum C, Glaser C, Gutenberger S, Keller B, Unger S, Voll RE, Vach W, Ness T, Warnatz K: Secondary Antibody Deficiency in Glucocorticoid Therapy Clearly Differs from Primary Antibody Deficiency. J Clin Immunol, 2016; 36: 406-412. : http://dx.doi.org/10.​1007/​s10875-016-0264-7
  • Woelber JP, Bremer K, Vach K, König D, Hellwig E, Ratka-Krüger P, Al-Ahmad A, Tennert C: An oral health optimized diet can reduce gingival and periodontal inflammation in humans - a randomized controlled pilot study. Bmc Oral Health, 2016; 17 (online): 28. : http://dx.doi.org/10.1186/s12903-016-0257-1
  • Woelber JP, Ratka-Krueger P, Vach K, Frisch E: Decementation Rates and the Peri-Implant Tissue Status of Implant-Supported Fixed Restorations Retained via Zinc Oxide Cement: A Retrospective 10–23-Year Study. Clin Implant Dent R, 2016; 18: 917-925. : http://dx.doi.org/10.1111/cid.12372
  • Wolkewitz M, Cooper B, Palomar-Martinez M, Alvarez-Lerma F, Olaechea-Astigarraga P Barnett AG, Schumacher M: Multiple time scales in modeling the incidence of infections acquired in intensive care units. Bmc Med Res Methodol, 2016; 16 (online): 116. : http://dx.doi.org/10.1186/s12874-016-0199-y
  • Wolkewitz M, Palomar-Martinez M, Olaechea-Astigarraga P, Alvarez-Lerma F, Schumacher M: A full competing risk analysis of hospital-acquired infections can easily be performed by a case-cohort approach: J Clin Epidemiol, 2016; 74: 187-193. : http://dx.doi.org/10.1016/j.jclinepi.2015.11.011
  • Wolkewitz M, Schumacher M: Neuraminidase Inhibitors and Hospital Mortality in British Patients with H1N1 Influenza A: A Re-Analysis of Observational Data. Plos One, 2016; 11 (online): e0160430. : http://dx.doi.org/10.1371/journal.pone.0160430
Buchbeiträge:
Kurzbeiträge / short communications:
  • Bertz H, Lübbert M, Ohneberg K, Zeiser R, Wäsch R, Marks R, Finke J: Allogeneic hematopoietic cell transplantation with double alkylating agents containing reduced-intensity conditioning for patients greater than or equal to60 years with advanced AML/MDS. Leukemia, 2016; 30: 2426-2429. : https://dx.doi.org/10.1038/leu.2016.248
  • Binder N, Schumacher M: Incidence of Dementia over Three Decades in the Framingham Heart Study. New Engl J Med, 2016; 375: 92-93. : http://dx.doi.org/10.1056/NEJMc1604823#SA1
  • Hauschke D, Schmoor C: Methodological aspects of the benefit assessment of medical interventions. Biometrical J, 2016; 58: 5-7. : http://dx.doi.org/10.1002/bimj.201500160
  • Lorenz J, Waldschmidt J, Wider D, Follo M, Ihorst G, Chatterjee M, May AM, Duyster J, Rosenwald A, Wäsch R, Zirlik K, Engelhardt M: From CLL to Multiple Myeloma - Spleen Tyrosine Kinase (SYK) influences multiple myeloma cell survival and migration. Brit J Haematol, 2016; 174: 985-989. : http://dx.doi.org/10.1111/bjh.13825
  • Philipsen A, Tebartz van Elst L, Graf E: Quality of Life of Adult Patients With Attention-Deficit/Hyperactivity Disorder Taking Methylphenidate—Reply. Jama Psychiat, 2016; 73: 534-535. : http://dx.doi.org/10.1001/jamapsychiatry.2016.0051
  • Schmoor C, Bender R, Beyersmann J, Kieser M, Schumacher M: Adverse event development in clinical oncology trials. Lancet Oncol, 2016; 17 (online): e263-e264.
  • Schumacher M, Beyersmann J, Binder N: Contribution to the discussion on the paper by Keiding and Louis. Perils and potentials of self-selected entry to epidemiological studies and surveys (pp 319-376). J R Stat Soc A Stat, 2016; 179: 364-365. : http://dx.doi.org/10.1111/rssa.12136
  • Schumacher M, Ohneberg K, Beyersmann J: Competing risk bias in prominent medical journals. J Clin Epidemiol, 2016; 80: 134-136. : http://dx.doi.org/10.1016/j.jclinepi.2016.07.013
  • Schumacher M, Wanner C, Beyersmann J: Soluble Urokinase Receptor and Chronic Kidney Disease. New Engl J Med, 2016; 374: 890. : http://dx.doi.org/10.1056/NEJMc1515787
  • Wolkewitz M: Accounting for Competing Events in Multivariate Analyses of Hospital-Acquired Infection Risk Factors. Infect Cont Hosp Ep, 2016; 37: 1122-1124. : http://dx.doi.org/10.1017/ice.2016.162
  • Wolkewitz M, Beyersmann J, OhneberG K, Schumacher M: Re: "Comparison of statistical approaches for dealing with immortal time bias in drug effectnivenss studies. Am J Epidemiol, 2016; 184: 856-858. : http://dx.doi.org/10.1093/aje/kww156
Konferenzbeiträge:
  • Tinsel I, Siegel A, Ferusi M, Schmoor C, Niebling W: DECADE - Entscheidungs- und Handlungshilfe für Patienten zur Senkung des Herz-Kreislauf-Risikos. Aktuelle Pilotstudie und geplante multizentrische Studie, Hrsg: German Medical Science GMS Publishing House; Düsseldorf 50. Kongress für Allgemeinmedizin und Familienmedizin, 2016 (50. Kongress für Allgemeinmedizin und Familienmedizin), Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin (DEGAM) (Hrsg). : http://www.egms.de/en/meetings/degam2016/16degam285.shtml
Sonstige Publikationen:
  • Huebner M, Vach W, le Cessie S: A systematic approach to initial data analysis is good research practice. J Thorac Cardiov Sur, 2016; 151: 25-27. : http://dx.doi.org/10.1016/j.jtcvs.2015.09.085
  • Rücker G: Mis(Use) of Statistics in Science - Interview with Dr. Gerta Rücker. Journal of Unsolved Questions, 2016; 6: XXXII-XXXIV. (download: http://junq.info/wp-content/uploads/2016/07/JUnQ.pdf)
  • Woelber JP, Bremer K, Vach K, König D, Hellwig E, Ratka-Krüger P, Al-Ahmad A, Tennert C: Erratum to: An oral health optimized diet can reduce gingival and periodontal inflammation in humans - a randomized controlled pilot study. Bmc Oral Health, 2016; 16: 109. : https://doi.org/10.1186/s12903-016-0304-y