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Wissenschaftliche Publikationen
Originalarbeiten in wissenschaftlichen
Fachzeitschriften:
- Al-Ahmad A, Bucher M, Anderson AC, Tennert C, Hellwig E, Wittmer A, Vach K, Karygianni L: Antimicrobial Photoinactivation Using Visible Light Plus Water-Filtered Infrared-A (VIS + wIRA) Alters In Situ Oral Biofilms. Plos One, 2015; 10 (online): e0132107. : http://dx.doi.org/10.1371/journal.pone.0132107
- Aldegheishem A, Alfaer A, Brezavšček M, Vach K, Eliades G, Att W: Wear behavior of zirconia substrates against different antagonist materials. International Journal of Esthetic Dentistry, 2015; 10: 468-485.
- Arezzo A, Passera R, Salvai A, Arolfo S, Allaix ME, Schwarzer G, Morino M: Laparoscopy for rectal cancer is oncologically adequate: a systematic review and meta-analysis of the literature. Surg Endosc, 2015; 29: 334-348. : http://dx.doi.org/10.1007/s00464-014-3686-4
- Baghai M, Heilmann C, Beyersdorf F, Nakamura L, Geisen U, Olschewski M, Zieger B: Platelet dysfunction and acquired von Willebrand syndrome in patients with left ventricular assist devices. Eur J Cardio-thorac, 2015; 48: 421-427. : http://dx.doi.org/10.1093/ejcts/ezu510
- Bittermann G, Thönissen P, Poxleitner P, Zimmerer R, Vach K, Metzger MC: Microvascular transplants in head and neck reconstruction: 3D evaluation of volume loss. J Cranio Maxill Surg, 2015; 43: 1319-1324. : http://dx.doi.org/ doi:10.1016/j.jcms.2015.06.013
- Bittermann G, Voss P, Duttenhoefer F, Zimmerer R, Vach K, Metzger MC: The validity of surgical clips as radiographic markers for the tumour resection cavity in head and neck cancer treatment. J Cranio Maxill Surg, 2015; 43: 758-762. : http://dx.doi.org/10.1016/j.jcms.2015.04.005
- Burkhardt BEU, Rücker G, Stiller B: Prophylactic milrinone for the prevention of low cardiac output syndrome and mortality in children undergoing surgery for congenital heart disease. Cochrane Db Syst Rev, 2015; 3 (online): CD009515-CD009515. : http://dx.doi.org/10.1002/14651858.CD009515.pub2
- Callizo J, Feltgen N, Pantenburg S, Wolf A, Neubauer AS, Jurklies B, Wachter R, Schmoor C, Schumacher M, Junker B, Pielen A, for the European Assessment Group for Lysis in the Eye: Cardiovascular risk factors in central retinal artery occlusion: results of a prospective and standardized medical examination. Ophthalmology, 2015; 122: 1881-1888. : http://dx.doi.org/10.1016/j.ophtha.2015.05.044
- Chrubasik-Hausmann SA, Cosima Chrubasik CA, Piper J, Schulte Mönting J, Erne P: Impact of risk factors on cardiovascular risk: a perspective on risk estimation in a Swiss population. Swiss Med Wkly, 2015; 145 (online): w14180. (download: http://dx.doi.org/10.4414/smw.2015.14180)
- Conrad A, Grotejohann B, Schmoor C, Cosic D, Dettenkofer M: Safety and tolerability of virucidal hand rubs: a randomized, double-blind, cross-over trial with healthy volunteers. Antimicrobial Resistance and Infection Control, 2015; 4 (online): 37. : http://dx.doi.org/10.1186/s13756-015-0079-y
- Dersch R, Freitag MH, Schmidt S, Sommer H, Rauer S, Meerpohl JJ: Efficacy and safety of pharmacological treatments for acute Lyme neuroborreliosis – a systematic review. Eur J Neurol, 2015; 22: 1249-1259. : http://dx.doi.org/10.1111/ene.12744
- Dersch R, Toews I, Sommer H, Rauer S, Meerpohl JJ: Methodological quality of guidelines for management of Lyme neuroborreliosis. Bmc Neurol, 2015; 15 (online): 242. : http://dx.doi.org/10.1186/s12883-015-0501-3
- Dittrich S, Tuerk M, Haaker G, Greim V, Buchholz A, Burkhardt B, Fujak A, Trollmann R, Schmid A, Schroeder R: Cardiomyopathy in Duchenne Muscular Dystrophy: Current Value of Clinical, Electrophysiological and Imaging Findings in Children and Teenagers. Klin Padiatr, 2015; 227: 225-231. : http://dx.doi.org/10.1055/s-0034-1398689
- Dreher M, Ekkernkamp E, Schmoor C, Schoenheit-Kenn U, Winterkamp S, Kenn K: Pulmonary rehabilitation and noninvasive ventilation in patients with hypercapnic interstitial lung disease. Respiration, 2015; 89 (3): 208-213. : http://dx.doi.org/10.1159/000369862
- Ekkernkamp E, Welte L, Schmoor C, Huttmann SE, Dreher M, Windisch W, Storre JH: Spot check analysis of gas exchange: invasive versus noninvasive methods. Respiration, 2015; 89 (4): 294-303. : http://dx.doi.org/10.1159/000371769
- Endres D, Perlov E, Maier S, Feige B, Nickel K, Goll P, Bubl E, Lange T, Glauche V, Graf E, Ebert D, Sobanski E, Philipsen A, Tebartz van Elst L: Normal Neurochemistry in the Prefrontal and Cerebellar Brain of Adults with Attention-Deficit Hyperactivity Disorder. Front Behav Neurosci, 2015; 9 (online): 242. : http://dx.doi.org/10.3389/fnbeh.2015.00242
- Engelhardt M, Ihorst G, Landgren O, Pantic M, Reinhardt H, Waldschmidt J, May AM, Schumacher M, Kleber M, Wäsch R: Large registry analysis to accurately define second malignancy rates and risks in a well-characterized cohort of 744 consecutive multiple myeloma patients followed-up for 25 years. Haematologica, 2015; 100: 1340-1349. : http://dx.doi.org/10.3324/haematol.2015.127548
- Erbes T, Hirschfeld M, Rücker G, Jaeger M, Boas J, Iborra S, Mayer S, Gitsch G, Stickeler E: Feasibility of urinary microRNA detection in breast cancer patients and its potential as an innovative non-invasive biomarker. Bmc Cancer, 2015; 15 (online): 193. : http://dx.doi.org/10.1186/s12885-015-1190-4
- Ermer MA, Kirsch K, Bittermann G, Fretwurst T, Vach K, Metzger MC: Recurrence rate and shift in histopathological differentiation of oral squamous cell carcinoma - A long-term retrospective study over a period of 13.5 years. J Cranio Maxill Surg, 2015; 43: 1309-1313. : http://dx.doi.org/10.1016/j.jcms.2015.05.011
- Fleck K, Jacob C, Philipsen A, Matthies S, Graf E, Hennighausen K, Haack-Dees B, Weyers P, Warnke A, Rösler M, Retz W, von Gontard A, Hänig S, Freitag C, Sobanski E, Schumacher-Stien M, Poustka L, Bliznak L, Becker K, Holtmann M, Colla M, Gentschow L, Kappel V, Jaite C, Jans T: Child impact on family functioning: a multivariate analysis in multiplex families with children and mothers both affected by attention-deficit/hyperactivity disorder (ADHD). ADHD Attention Deficit and Hyperactivity Disorders, 2015; 7 (online): 211-223. : http://dx.doi.org/10.1007/s12402-014-0164-8
- Frisch E, Ziebolz D, Vach K, Ratka-Krüger P: The effect of keratinized mucosa width on peri-implant outcome under supportive postimplant therapy. Clin Implant Dent R, 2015; 17 Suppl. S1: e236-e244. : http://dx.doi.org/10.1111/cid.12187
- Gaertner J, Siemens W, Antes G, Meerpohl JJ, Xander C, Schwarzer G, Stock S, Becker G: Specialist palliative care services for adults with advanced, incurable illness in hospital, hospice, or community settings—protocol for a systematic review Systematic Reviews, 2015; 4 (online): 123. : http://dx.doi.org/10.1186/s13643-015-0121-4
- Grabin S, Antes G, Stark GB, Motschall E, Buroh S, Lampert FM: Cell-assisted lipotransfer - a critical appraisal of the evidence. [Zellassistierte Eigenfetttransplantation: Eine systematische Literaturübersicht und kritische Bewertung der Evidenzlage]. Dtsch Arztebl Int, 2015; 112 (15): 255-261. : http://dx.doi.org/10.3238/arztebl.2015.0255
- Green N, Johnson AP, Henderson KL, Muller-Pebody B, Thelwall S, Robotham JV, Sharland M, Wolkewitz M, Deeny SR: Quantifying the burden of hHospital-acquired bloodstream infection in children in England by estimating excess length of hospital stay and mortality using a multistate analysis of linked, routinely collected data. Pediatr Infect Dis J, 2015; 4: 305-312. : http://dx.doi.org/10.1093/jpids/piu073
- Grishina O, Schmoor C, Döhner K, Hackanson B, Lubrich B, May AM, Cieslik C, Müller MJ, Lübbert M: DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients >60 years with acute myeloid leukemia who are ineligible for induction chemotherapy. Bmc Cancer, 2015; 15 (online): 430. : http://dx.doi.org/10.1186/s12885-015-1432-5
- Hieke S, Kleber M, König C, Engelhardt M, Schumacher M: Conditional Survival: A Useful Concept to Provide Information on How Prognosis Evolves over Time. Clin Cancer Res, 2015; 21: 1530-1536. : http://dx.doi.org/10.1158/1078-0432.CCR-14-2154
- Jander N, Sommer H, Pingpoh C, Kienzle R-P, Martin G, Zeh W, Pache G, Siepe M, Beyersdorf F, Schumacher M, Neumann F-J, Minners J: The porcine valve type predicts obstructive thrombosis beyond the first three postoperative months in bioprostheses in the aortic position. Int J Cardiol, 2015; 199: 90-95. : http://dx.doi.org/10.1016/j.ijcard.2015.07.022
- Jans T, Jacob C, Warnke A, Zwanzger U, Groß-Lesch S, Matthies S, Borel P, Hennighausen K, Haack-Dees B, Rösler M, Retz W, von Gontard A, Hänig S, Sobanski E, Alm B, Poustka L, Hohmann S, Colla M, Gentschow L, Jaite C, Kappel V, Becker K, Holtmann M, Freitag C, Graf E, Ihorst G, Philipsen A: Does intensive multimodal treatment for maternal ADHD improve the efficacy of parent training for children with ADHD? A randomized controlled multicenter trial. J Child Psychol Psyc, 2015; 56: 1298-1313. : http://dx.doi.org/10.1111/jcpp.12443
- Jeserich M, Merkely B, Olschewski M, Kimmel S, Pavlik G, Bode C: Patients with exercise-associated ventricular ectopy present evidence of myocarditis. J Cardiovasc Magn R, 2015; 17 (online): 100. : http://dx.doi.org/10.1186/s12968-015-0204-3
- Jost WH, Benecke R, Hauschke D, Jankovic J, Kaňovský P, Roggenkämper P, Simpson DM, Comella CL: Clinical and pharmacological properties of incobotulinumtoxinA and its use in neurological disorders. Drug Des Dev Ther, 2015; 9: 1913-1926. (download: http://dx.doi.org/10.2147/DDDT.S79193)
- Kohal RJ, Gubik S, StrohlC, Stampf S, Bächle M, Hurrle AA, Patzelt SBM: Effect of two different healing times on the mineralization of newly formed bone using a bovine bone substitute in sinus floor augmentation: A randomized, controlled, clinical and histological investigation. J Clin Periodontol, 2015; 42 (11): 1052-1059. : http://dx.doi.org/10.1111/jcpe.12466
- Kohal RJ, Straub LM, Wolkewitz M, Bächle M, Patzelt SBM: Evaluation of Guided Bone Regeneration around Oral Implants over Different Healing Times Using Two Different Bovine Bone Materials: A Randomized, Controlled Clinical and Histological Investigation: Clin Implant Dent R, 2015; 17: 957-971. : http://dx.doi.org/10.1111/cid.12206
- Kowalski C, Jena S, Kliemann D, Antes G: Up for Discussion: Using study registries for Oncology: StudyBox and the German Clinical Trials Register (DRKS). Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen (ZEFQ), 2015; 109: 431-436. : http://dx.doi.org/10.1016/j.zefq.2015.09.009
- Küllenberg de Gaudry D, Blümle A, Sommer H, Steinau S, Lindenberg J, Antes G, Niemeyer C, Meerpohl JJ: Studien und Publikationspraxis in der Pädiatrischen Hämatologie und Onkologie in Deutschland - Analyse der Jahre 1970-2006. [Studies and Publication Practice in Pediatric Hematology and Oncology in Germany - An Analysis of the Period 1970-2006]. Klin Padiatr, 2015; 227 (6-07): 339-349. : http://dx.doi.org/10.1055/s-0035-1565085
- Küllenberg de Gaudry D, Grede N, Motschall E, Lins S: Analysis of German nutrition brochures for pregnant women with evidence-based patient information criteria. Patient Educ Couns, 2015; 98 (2): 207-212. : http://dx.doi.org/10.1016/j.pec.2014.10.015
- Kunath F, Grobe HR, Rücker G, Motschall E, Antes G, Dahm P, Wullich B, Meerpohl JJ: Non-steroidal antiandrogen monotherapy compared with luteinising hormone-releasing hormone agonists or surgical castration monotherapy for advanced prostate cancer: a Cochrane systematic review. Bju Int, 2015; 116: 30-36. : http://dx.doi.org/10.1111/bju.13026
- Lang R, Baumann P, Schmoor C, Odermatt EK, Wente MN, Jauch KW: A-Part Gel, an adhesion prophylaxis for abdominal surgery: a randomized controlled phase I-II safety study [NCT00646412]. Ann Surg Innov Res, 2015; 9 (online): 5. : http://dx.doi.org/10.1186/s13022-015-0014-1
- Leisser C, Kaufmann TA, Feltgen N, Schumacher M, Schmoor C, Meckel S: Distribution of internal carotid artery plaque locations among patients with central retinal artery occlusion in the Eagle study population. Graef Arch Clin Exp, 2015; 253 (8): 1227-1230. : http://dx.doi.org/10.1007/s00417-014-2804-2
- Linde K, Kriston L, Rücker G, Jamil S, Schumann I, Meissner K, Sigterman K, Schneider A: Efficacy and Acceptability of Pharmacological Treatments for Depressive Disorders in Primary Care: Systematic Review and Network Meta-Analysis. Ann Fam Med, 2015; 13: 69-79. : http://dx.doi.org/10.1370/afm.1687
- Linde K, Rücker G, Sigterman K, Jamil S, Meissner K, Schneider A, Kriston L: Comparative effectiveness of psychological treatments for depressive disorders in primary care: network meta-analysis. Bmc Fam Pract, 2015; 16 (online): 103. : http://dx.doi.org/10.1186/s12875-015-0314-x
- Linde K, Sigterman K, Kriston L, Rücker G, Jamil S, Meissner K, Schneider A: Effectiveness of Psychological Treatments for Depressive Disorders in Primary Care: Systematic Review and Meta-Analysis. Ann Fam Med, 2015; 13: 56-68. : http://dx.doi.org/10.1370/afm.1719.
- Münch C, Dragoi D, Frey A-V, Thurig K, Lübbert M, Wäsch R, Bogatyreva L, Hauschke D, Lassmann S, Werner M, May AM: Therapeutic polo-like kinase 1 inhibition results in mitotic arrest and subsequent cell death of blasts in the bone marrow of AML patients and has similar effects in non-neoplastic cell lines. Leukemia Res, 2015; 39: 462-470. : http://dx.doi.org/10.1016/j.leukres.2015.01.007
- Naegele M, Leppla L, Kiote-Schmidt C, Ihorst G, Rebafka A, Koller A, M. May AM, Hasemann M, Duyster J, Wäsch R, Engelhardt M: Trained clinical nurse specialists proficiently obtain bone marrow aspirates and trephine biopsies in a nearly painless procedure—a prospective evaluation study. Ann Hematol, 2015; 94: 1577-1584. (download: http://dx.doi.org/10.1007/s00277-015-2405-0)
- Ohneberg K, Wolkewitz M, Beyersmann J, Palomar-Martinez M, Olaechea-Astigarraga P, Alvarez-Lerma F, Schumacher M: Analysis of Clinical Cohort Data Using Nested Case-control and Case-cohort Sampling Designs: A Powerful and Economical Tool. Method Inform Med, 2015; 54: 505-514. : http://dx.doi.org/10.3414/ME14-01-0113
- Patzelt SBM, Schaible LK, Stampf S, Kohal RJ: Software-Based Evaluation of Human Age: A Pilot Study. J Esthet Restor Dent, 2015; 27: 100-106. : http://dx.doi.org/10.1111/jerd.12125
- Petropoulou A, Vrochari AD, Hellwig E, Stampf S, Polydorou O: Water sorption and water solubility of self-etching and self-adhesive resin cements. J Prosthet Dent, 2015; 114: 674-679. : http://dx.doi.org/10.1016/j.prosdent.2015.06.002
- Philipsen A, Jans T, Graf E, Matthies S, Borel P, Colla M, Gentschow L, Langner D, Jacob C, Groß-Lesch S, Sobanski E, Alm B, Schumacher-Stien M, Roesler M, Retz W, Retz-Junginger P, Kis B, Abdel-Hamid M, Heinrich V, Huss M, Kornmann C, Bürger A, Perlov E, Ihorst G, Schlander M, Berger M, van Elst LT, for the Comparison of Methylphenidate, Psychotherapy in Adult ADHD Study (COMPAS) Consortium: Effects of Group Psychotherapy, Individual Counseling, Methylphenidate, and Placebo in the Treatment of Adult Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial.
Jama Psychiat, 2015; 72: 1199-1210. : http://dx.doi.org/10.1001/jamapsychiatry.2015.2146
- Pielen A, Pantenburg S, Schmoor C, Schumacher M, Feltgen N, Junker B, Callizo J, for the EAGLE Study Group: Predictors of prognosis and treatment outcome in central retinal artery occlusion: local intra-arterial fibrinolysis vs. conservative treatment. Neuroradiology, 2015; 57: 1055-1062. : http://dx.doi.org/10.1007/s00234-015-1588-3
- Proksch S, Bittermann G, Vach K, Nitschke R, Tomakidi P, Hellwig E: hMSC-Derived VEGF Release Triggers the Chemoattraction of Alveolar Osteoblasts. Stem Cells, 2015; 33: 3114-3124. : http://dx.doi.org/10.1002/stem.2119
- Rücker G, Schwarzer G: Ranking treatments in frequentist network meta-analysis works without resampling methods. Bmc Med Res Methodol, 2015; 15 (online): 58. : http://dx.doi.org/10.1186/s12874-015-0060-8
- Sauerbrei W, Buchholz A, Boulesteix AL, Binder H: On stability issues in deriving multivariable regression models. Biometrical J, 2015; 57: 531-555. : http://dx.doi.org/10.1002/bimj.201300222
- Schimek-Jasch T, Troost EGC, Rücker G, Prokic V, Avlar M, Duncker-Rohr V, Mix M, Doll C, Grosu A-L, Nestle U: A teaching intervention in a contouring dummy run improved target volume delineation in locally advanced non-small cell lung cancer. Strahlenther Onkol, 2015; 191: 525-533. : http://dx.doi.org/10.1007/s00066-015-0812-8
- Schmucker CM, Rücker G, Sommer H, Virgili G, Loke YK, OellerP, Agostini H, Ehlken C: Treatment as Required versus Regular Monthly Treatment in the Management of Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis. Plos One, 2015; 10 (9) (online): e0137866. : http://dx.doi.org/10.1371/journal.pone.0137866
- Selz CF, Bogler J, Vach K, Strub JR, Guess PC: Veneered anatomically designed zirconia FDPs resulting from digital intraoral scans: Preliminary results of a prospective clinical study. J Dent, 2015; 43: 1428-1435. : http://dx.doi.org/10.1016/j.jdent.2015.10.017
- Sijare F, Geißler A-L, Fichter CD, Hergeth SP, Bogatyreva L, Hauschke D, Schneider R, Werner M, Lassmann S: Aurora B expression and histone variant H1.4S27 phosphorylation are no longer coordinated during metaphase in aneuploid colorectal carcinomas. Virchows Arch, 2015; 466 (5): 503-515. : http://dx.doi.org/10.1007/s00428-015-1727-6
- Speckmann C, Uhlmann A, Doerken S, Wolkewitz M, Ehl S: A prospective outcome study on patients with profound combined immunodeficiency. LymphoSign Journal, 2015; 2: 91-106. : http://dx.doi.org/10.14785/lpsn-2015-0002
- Spies BC, Balmer M, Patzelt SBM, Vach K, Kohal RJ: Clinical and Patient-reported Outcomes of a Zirconia Oral Implant: Three-year Results of a Prospective Cohort Investigation. J Dent Res, 2015; 94: 1385-1391. : http://dx.doi.org/10.1177/0022034515598962
- Spies BC, Sauter C, Wolkewitz M, Kohal R-J: Alumina reinforced zirconia implants: Effects of cyclic loading and abutment modification on fracture resistance. Dent Mater, 2015; 31: 262-272. : http://dx.doi.org/10.1016/j.dental.2014.12.013
- Spies BC, Stampf S, Kohal RJ: Evaluation of Zirconia-Based All-Ceramic Single Crowns and Fixed Dental Prosthesis on Zirconia Implants: 5-Year Results of a Prospective Cohort Study. Clin Implant Dent R, 2015; 17: 1014-1028. : http://dx.doi.org/10.1111/cid.12203
- Taschner C, Chapot R, Costalat V, Courthéoux P, Barreau X, Berge J, Pierot L, Kadziolka K, Jean B, Blanc R, Biondi A, Brunel H, Gallas S, Berlis A, Herbreteau D, Berkefeld J, Groden C, Urbach H, El Shikh S, Graf E, Bonafé A: GREAT—a randomized aneurysm trial. Design of a randomized controlled multicenter study comparing HydroSoft/HydroFrame and bare platinum coils for endovascular aneurysm treatment. Neuroradiology, 2015; 57: 599-604. : http://dx.doi.org/10.1007/s00234-015-1501-0
- Tchorz JP, Brandl M, Ganter PA, Karygianni L, Polydorou O, Vach K, Hellwig E, Altenburger MJ: Pre-clinical endodontic training with artificial instead of extracted human teeth: does the type of exercise have an influence on clinical endodontic outcomes? Int Endod J, 2015; 48: 888-893. : http://dx.doi.org/10.1111/iej.12385
- Weber J, Veith P, Jung B, Ihorst G, Moske-Eick O, Meckel S, Urbach H, Taschner CA: MR angiography at 3 tesla to assess proximal internal carotid artery stenoses: contrast-enhanced or 3D time-of-flight MR angiography? Clin Neuroradiol, 2015; 25: 41-48. : http://dx.doi.org/10.1007/s00062-013-0279-x
- Woelber JP, Bienas H, Fabry G, Silbernagel W, Giesler M, Tennert C, Stampf S, Ratka-Kruger P, Hellwig E: Oral hygiene-related self-efficacy as a predictor of oral hygiene behavior. A prospective cohort study. J Clin Periodontol, 2015; 42: 142-149. : http://dx.doi.org/10.1111/jcpe.12348
- Zeiser R, Burchert A, Lengerke C, Verbeek M, Maas-Bauer K, Metzelder SK, Spoerl S, Ditschkowski M, Ecsedi M, Sockel K, Ayuk F, Ajib S, de Fontbrune FS, Na I-K, Penter L, Holtick U, Wolf D, Schuler E, Meyer E, Apostolova P, Bertz H, Marks R, Lübbert M, Wäsch R, Scheid C, Stölzel F, Ordemann R, Bug G, Kobbe G, Negrin R, Brune M, Spyridonidis A, Schmitt-Gräff A, van der Velden W, Huls G, Mielke S, Grigoleit GU, Kuball J, Flynn R, Ihorst G, Du J, Blazar BR, Arnold R, Kröger N, Passweg J, Halter J, Socié G, Beelen D, Peschel C, Neubauer A, Finke J, Duyster J, von Bubnoff N: Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multi-center survey. Leukemia, 2015; 29: 2062-2068. : http://dx.doi.org/10.1038/leu.2015.212
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