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 Forschungsbericht für das Jahr 2017

Department Neurozentrum

Institut für Neuropathologie

Breisacher Str. 64
79106 Freiburg
Tel: 0761-270-51060 Fax: 0761-270-50500


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Marco Prinz, Ärztlicher Direktor
  • Dr. med. Soroush Doostkam, Oberarzt, Stellv. des Ärztlichen Direktors
  • Dr. rer. nat. Klaus-Peter Knobeloch, Laborleiter
  • Margarethe Ditter, MTA
  • Christine el Gaz, MTA
  • Dr. Alexandra Müller, MTA, Biotechnologin
  • Viviana Sverdlick, MTA
  • Sylvia Blust, Schreibkraft
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Klinische und experimentelle Neuropathologie
  • Neuroimmunologie
  • Zelluläre Neurobiologie
  • Neurotoxikologie
  • Neurochemie

Finanzierung

  • Müller-Fahnenberg-Stiftung
  • BMBF

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Adoro S, Park KH, Bettigole SE, Lis R, Shin HR, Seo H, Kim JH, Knobeloch KP, Shim JH, Glimcher LH: Post-translational control of T cell development by the ESCRT protein CHMP5. Nat Immunol, 2017; 18 (7): 780-790. : http://dx.doi.org/10.1038/ni.3764
  • Arima Y *, Ohki T *, Nishikawa N *, Higuchi K *, Ota M, Tanaka Y, Nio-Kobayashi J, Elfeky M, Sakai R, Mori Y, Kawamoto T, Stofkova A, Sakashita Y, Morimoto Y, Kuwatani M, Iwanaga T, Yoshioka Y, Sakamoto N, Yoshimura A, Takiguchi M, Sakoda S, Prinz M, Kamimura D, Murakami M: Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit. Elife, 2017; 6 (online). : http://dx.doi.org/10.7554/eLife.25517
  • Basters A, Geurink PP *, Rocker A *, Witting KF, Tadayon R, Hess S, Semrau MS, Storici P, Ovaa H, Knobeloch KP, Fritz G: Structural basis of the specificity of USP18 toward ISG15. Nat Struct Mol Biol, 2017; 24 (3): 270-278. : http://dx.doi.org/10.1038/nsmb.3371
  • Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfafflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Rossler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, McEvoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Ozkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Muhlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Toledano Delgado R, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, von Oertzen TJ, Diepgen TL, Avanzini G: Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. New Engl J Med, 2017; 377 (17): 1648-1656. : http://dx.doi.org/10.1056/NEJMoa1703784
  • Deczkowska A *, Matcovitch-Natan O *, Tsitsou-Kampeli A, Ben-Hamo S, Dvir-Szternfeld R, Spinrad A, Singer O, David E, Winter DR, Smith LK, Kertser A, Baruch K, Rosenzweig N, Terem A, Prinz M, Villeda S, Citri A, Amit I *, Schwartz M *: Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner. Nat Commun, 2017; 8 (1): 717-717. : http://dx.doi.org/10.1038/s41467-017-00769-0
  • Degani G, Altomare AA, Colzani M, Martino C, Mazzolari A, Fritz G, Vistoli G, Popolo L, Aldini G: A capture method based on the VC1 domain reveals new binding properties of the human receptor for advanced glycation end products (RAGE). Redox Biol, 2017; 11: 275-285. : http://dx.doi.org/10.1016/j.redox.2016.12.017
  • Demerath T, Simon-Gabriel CP, Kellner E, Schwarzwald R, Lange T, Heiland DH, Reinacher P, Staszewski O, Mast H, Kiselev VG, Egger K, Urbach H, Weyerbrock A, Mader I: Mesoscopic imaging of glioblastomas: Are diffusion, perfusion and spectroscopic measures influenced by the radiogenetic phenotype? Neuroradiol J, 2017; 30 (1): 36-47. : http://dx.doi.org/10.1177/1971400916678225
  • Donkels C, Pfeifer D, Janz P, Huber S, Nakagawa J, Prinz M, Schulze-Bonhage A, Weyerbrock A, Zentner J, Haas CA: Whole Transcriptome Screening Reveals Myelination Deficits in Dysplastic Human Temporal Neocortex. Cereb Cortex, 2017; 27 (2): 1558-1572. : http://dx.doi.org/10.1093/cercor/bhv346
  • Endres D, Huzly D, Dersch R, Stich O, Berger B, Schuchardt F, Perlov E, Venhoff N, Hellwig S, Fiebich BL, Erny D, Hottenrott T *, Tebartz van Elst L *: Do patients with schizophreniform and bipolar disorders show an intrathecal, polyspecific, antiviral immune response? A pilot study. Fluids Barriers CNS, 2017; 14 (1): 34-34. : http://dx.doi.org/10.1186/s12987-017-0082-1
  • Fedele V *, Dai F *, Masilamani AP *, Heiland DH, Kling E, Gatjens-Sanchez AM, Ferrarese R, Platania L, Soroush D, Kim H, Nelander S, Weyerbrock A, Prinz M, Califano A, Iavarone A, Bredel M, Carro MS: Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression. Mol Cancer Res, 2017; 15 (8): 998-1011. : http://dx.doi.org/10.1158/1541-7786.MCR-16-0494
  • Hagemeyer N, Hanft KM, Akriditou MA, Unger N, Park ES, Stanley ER, Staszewski O, Dimou L, Prinz M: Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood. Acta Neuropathol, 2017; 134: 441-458. : http://dx.doi.org/10.1007/s00401-017-1747-1
  • Heiland DH, Demerath T, Kellner E, Kiselev VG, Pfeifer D, Schnell O, Staszewski O, Urbach H, Weyerbrock A, Mader I: Molecular differences between cerebral blood volume and vessel size in glioblastoma multiforme. Oncotarget, 2017; 8 (7): 11083-11093. : http://dx.doi.org/10.18632/oncotarget.11522
  • Heiland DH, Haaker G, Delev D, Mercas B, Masalha W, Heynckes S, Gabelein A, Pfeifer D, Carro MS, Weyerbrock A, Prinz M, Schnell O: Comprehensive analysis of PD-L1 expression in glioblastoma multiforme. Oncotarget, 2017; 8 (26): 42214-42225. : http://dx.doi.org/10.18632/oncotarget.15031
  • Heiland DH, Simon-Gabriel CP, Demerath T, Haaker G, Pfeifer D, Kellner E, Kiselev VG, Staszewski O, Urbach H, Weyerbrock A, Mader I: Integrative Diffusion-Weighted Imaging and Radiogenomic Network Analysis of Glioblastoma multiforme. Sci Rep-uk, 2017; 7 (online): 43523. : http://dx.doi.org/10.1038/srep43523
  • Heynckes S, Gaebelein A, Haaker G, Grauvogel J, Franco P, Mader I, Carro MS, Prinz M, Delev D, Schnell O *, Heiland DH *: Expression differences of programmed death ligand 1 in de-novo and recurrent glioblastoma multiforme. Oncotarget, 2017; 8 (43): 74170-74177. : http://dx.doi.org/10.18632/oncotarget.18819
  • Kogias E, Klingler JH, Urbach H, Scheiwe C, Schmeiser B, Doostkam S, Zentner J, Altenmuller DM: 3 Tesla MRI-negative focal epilepsies: Presurgical evaluation, postoperative outcome and predictive factors. Clin Neurol Neurosur, 2017; 163: 116-120. : http://dx.doi.org/10.1016/j.clineuro.2017.10.038
  • Lagumersindez-Denis N *, Wrzos C *, Mack M *, Winkler A, van der Meer F, Reinert MC, Hollasch H, Flach A, Bruhl H, Cullen E, Schlumbohm C, Fuchs E, Linington C, Barrantes-Freer A, Metz I, Wegner C, Liebetanz D, Prinz M, Bruck W, Stadelmann C, Nessler S: Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathol, 2017; 134 (1): 15-34. : http://dx.doi.org/10.1007/s00401-017-1706-x
  • Liu Y, Marin A, Ejlerskov P, Rasmussen LM, Prinz M, Issazadeh-Navikas S: Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1(+)Treg cells. Nat Commun, 2017; 8: 14709-14709. : http://dx.doi.org/10.1038/ncomms14709
  • Lukas D, Yogev N, Kel JM, Regen T, Mufazalov IA, Tang Y, Wanke F, Reizis B, Muller W, Kurschus FC, Prinz M, Kleiter I, Clausen BE *, Waisman A *: TGF-beta inhibitor Smad7 regulates dendritic cell-induced autoimmunity. P Natl Acad Sci Usa, 2017; 114 (8) (online): E1480-E1489. : http://dx.doi.org/10.1073/pnas.1615065114
  • Marzaioli V, Gross CJ, Weichenmeier I, Schmidt-Weber CB, Gutermuth J, Gross O, Alessandrini F: Specific Surface Modifications of Silica Nanoparticles Diminish Inflammasome Activation and In Vivo Expression of Selected Inflammatory Genes. Nanomaterials-basel, 2017; 7 (11): 355-355. : http://dx.doi.org/10.3390/nano7110355
  • Masilamani AP, Ferrarese R, Kling E, Thudi NK, Kim H, Scholtens DM, Dai F, Hadler M, Unterkircher T, Platania L, Weyerbrock A, Prinz M, Gillespie GY, Harsh GR IV, Bredel M *, Carro MS *: KLF6 depletion promotes NF-kappaB signaling in glioblastoma. Oncogene, 2017; 36 (25): 3562-3575. : http://dx.doi.org/10.1038/onc.2016.507
  • Muras V, Claussen B, Nasiri H, Fritz G, Steuber J: A miniaturized assay for kinetic characterization of the Na(+)-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae. Anal Biochem, 2017; 537: 56-59. : http://dx.doi.org/10.1016/j.ab.2017.08.025
  • Nakagawa JM, Donkels C, Fauser S, Schulze-Bonhage A, Prinz M, Zentner J, Haas CA: Characterization of focal cortical dysplasia with balloon cells by layer-specific markers: Evidence for differential vulnerability of interneurons. Epilepsia, 2017; 58 (4): 635-645. : http://dx.doi.org/10.1111/epi.13690
  • Schaadt NS, Alfonso JCL, Schonmeyer R, Grote A, Forestier G, Wemmert C, Kronke N, Stoeckelhuber M, Kreipe HH, Hatzikirou H, Feuerhake F: Image analysis of immune cell patterns in the human mammary gland during the menstrual cycle refines lymphocytic lobulitis. Breast Cancer Res Tr, 2017; 164 (2): 305-315. : http://dx.doi.org/10.1007/s10549-017-4239-z
  • Schmeiser B, Li J, Brandt A, Zentner J, Doostkam S, Freiman TM: Different mossy fiber sprouting patterns in ILAE hippocampal sclerosis types. Epilepsy Res, 2017; 136: 115-122. : http://dx.doi.org/10.1016/j.eplepsyres.2017.08.002
  • Schmeiser B, Wagner K, Schulze-Bonhage A, Elger CE, Steinhoff BJ, Wendling AS, Mader I, Prinz M, Scheiwe C, Zentner J: Transsylvian Selective Amygdalohippocampectomy for Mesiotemporal Epilepsy: Experience with 162 Procedures. Neurosurgery, 2017; 80 (3): 454-464. : http://dx.doi.org/10.1093/neuros/nyw089
  • Schmeiser B, Wagner K, Schulze-Bonhage A, Mader I, Wendling AS, Steinhoff BJ, Prinz M, Scheiwe C, Weyerbrock A, Zentner J: Surgical Treatment of Mesiotemporal Lobe Epilepsy: Which Approach is Favorable? Neurosurgery, 2017; 81 (6): 992-1004. : http://dx.doi.org/10.1093/neuros/nyx138
  • Schmeiser B, Zentner J, Prinz M, Brandt A, Freiman TM: Extent of mossy fiber sprouting in patients with mesiotemporal lobe epilepsy correlates with neuronal cell loss and granule cell dispersion. Epilepsy Res, 2017; 129: 51-58. : http://dx.doi.org/10.1016/j.eplepsyres.2016.11.011
  • Schneider KS, Gross CJ, Dreier RF, Saller BS, Mishra R, Gorka O, Heilig R, Meunier E, Dick MS, Cikovic T, Sodenkamp J, Medard G, Naumann R, Ruland J, Kuster B, Broz P, Gross O: The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. Cell Rep, 2017; 21 (13): 3846-3859. : http://dx.doi.org/10.1016/j.celrep.2017.12.018
  • Tay TL, Mai D, Dautzenberg J, Fernandez-Klett F, Lin G, Sagar, Datta M, Drougard A, Stempfl T, Ardura-Fabregat A, Staszewski O, Margineanu A, Sporbert A, Steinmetz LM, Pospisilik JA, Jung S, Priller J, Grun D, Ronneberger O, Prinz M: A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nat Neurosci, 2017; 20 (6): 793-803. : http://dx.doi.org/10.1038/nn.4547
  • Temam S, Spicer J, Farzaneh F, Soria JC, Oppenheim D, McGurk M, Hollebecque A, Sarini J, Hussain K, Soehrman Brossard S, Manenti L, Evers S, Delmar P, Di Scala L, Mancao C, Feuerhake F, Andries L, Ott MG *, Passioukov A *, Delord JP *: An exploratory, open-label, randomized, multicenter study to investigate the pharmacodynamics of a glycoengineered antibody (imgatuzumab) and cetuximab in patients with operable head and neck squamous cell carcinoma. Ann Oncol, 2017; 28 (11): 2827-2835. : http://dx.doi.org/10.1093/annonc/mdx489
  • Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nat Immunol, 2017; 18 (1): 54-63. : http://dx.doi.org/10.1038/ni.3581
  • Toulouse C *, Claussen B *, Muras V, Fritz G, Steuber J: Strong pH dependence of coupling efficiency of the Na+ - translocating NADH:quinone oxidoreductase (Na+-NQR) of Vibrio cholerae. Biol Chem, 2017; 398 (2): 251-260. : http://dx.doi.org/10.1515/hsz-2016-0238
  • Varol D, Mildner A, Blank T, Shemer A, Barashi N, Yona S, David E, Boura-Halfon S, Segal-Hayoun Y, Chappell-Maor L, Keren-Shaul H, Leshkowitz D, Hornstein E, Fuhrmann M, Amit I, Maggio N, Prinz M, Jung S: Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain. Immunity, 2017; 46 (6): 1030-1044. : http://dx.doi.org/10.1016/j.immuni.2017.05.003
  • Wolf Y, Shemer A, Polonsky M, Gross M, Mildner A, Yona S, David E, Kim KW, Goldmann T, Amit I, Heikenwalder M, Nedospasov S, Prinz M, Friedman N, Jung S: Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation. J Exp Med, 2017; 214 (4): 905-917. : http://dx.doi.org/10.1084/jem.20160499
  • Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Ollinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Hochst B, Wohlleber D, Jors S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Huser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D *, Heikenwalder M *: Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell, 2017; 31 (6): 771-789. : http://dx.doi.org/10.1016/j.ccell.2017.05.006
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:
  • Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzeriat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Loschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y: Targeting Neuroinflammation to Treat Alzheimer's Disease. Cns Drugs, 2017; 31 (12): 1057-1082. : http://dx.doi.org/10.1007/s40263-017-0483-3
  • Blank T, Prinz M: Type I interferon pathway in CNS homeostasis and neurological disorders. Glia, 2017; 65 (9): 1397-1406. : http://dx.doi.org/10.1002/glia.23154
  • Erny D*, Hrabe de Angelis AL*, Prinz M: Communicating systems in the body: how microbiota and microglia cooperate. Immunology, 2017; 150 (1): 7-15. : http://dx.doi.org/10.1111/imm.12645
  • Kierdorf K, Prinz M: Microglia in steady state. J Clin Invest, 2017; 127 (9): 3201-3209. : http://dx.doi.org/10.1172/JCI90602
  • Prinz M, Erny D *, Hagemeyer N *: Ontogeny and homeostasis of CNS myeloid cells. Nat Immunol, 2017; 18 (4): 385-392. : http://dx.doi.org/10.1038/ni.3703
  • Prinz M, Priller J: The role of peripheral immune cells in the CNS in steady state and disease. Nat Neurosci, 2017; 20 (2): 136-144. : http://dx.doi.org/10.1038/nn.4475
  • Suss P: Remote Control: Impacts of Peripheral Tumor Necrosis Factor-Alpha on Alzheimer Disease-Related Pathology. J Neurosci, 2017; 37 (34): 8045-8047. : http://dx.doi.org/10.1523/JNEUROSCI.1480-17.2017
  • Tay TL, Savage J, Hui CW, Bisht K, Tremblay ME: Microglia across the lifespan: from origin to function in brain development, plasticity and cognition. J Physiol-london, 2017; 595 (6): 1929-1945. : http://dx.doi.org/10.1113/JP272134
Fallbeispiele:
  • Endres D, Perlov E, Riering AN, Maier V, Stich O, Dersch R, Venhoff N, Erny D, Mader I, Tebartz van Elst L: Steroid-Responsive Chronic Schizophreniform Syndrome in the Context of Mildly Increased Antithyroid Peroxidase Antibodies. Front Psychiatry, 2017; 8 (online): 64-64. : http://dx.doi.org/10.3389/fpsyt.2017.00064
  • Endres D, Vry MS, Dykierek P, Riering AN, Lungen E, Stich O, Dersch R, Venhoff N, Erny D, Mader I, Meyer PT, Tebartz van Elst L: Plasmapheresis Responsive Rapid Onset Dementia with Predominantly Frontal Dysfunction in the Context of Hashimoto's Encephalopathy. Front Psychiatry, 2017; 8 (online): 212-212. : http://dx.doi.org/10.3389/fpsyt.2017.00212
  • Taschner CA, Doostkam S, Shah JM, Urbach H, Jager M, Prinz M: Freiburg Neuropathology Case Conference : Cystic Posterior Fossa Tumor. Clin Neuroradiol, 2017; 27 (3): 393-398. : http://dx.doi.org/10.1007/s00062-017-0614-8
  • Taschner CA, Erny D, Sajonz B, Urbach H, Guggenberger K, Prinz M: Freiburg Neuropathology Case Conference: A Cystic Lesion of the Cerebellum in an Adolescent. Clin Neuroradiol, 2017; 27 (1): 121-126. : http://dx.doi.org/10.1007/s00062-017-0562-3
  • Taschner CA, Sankowski R, Hubbe U, Urbach H, Schacht H, Prinz M: Freiburg Neuropathology Case Conference : Intradural, Intramedullary Mass Lesion in a 66-year-old Patient. Clin Neuroradiol, 2017; 27 (4): 525-529. : http://dx.doi.org/10.1007/s00062-017-0642-4
  • Taschner CA, Suss P, Sajonz B, Urbach H, Simon-Gabriel CP, Prinz M: Freiburg Neuropathology Case Conference : Widespread White Matter Lesions in a Patient with Progressive Paraparesis and Cortical Blindness. Clin Neuroradiol, 2017; 27 (2): 245-250. : http://dx.doi.org/10.1007/s00062-017-0589-5
Kurzbeiträge / short communications:
  • Basters A, Knobeloch KP, Fritz G: How USP18 deals with ISG15-modified proteins: structural basis for the specificity of the protease. Febs J, 2017. : http://dx.doi.org/10.1111/febs.14260 (in Druck)
  • Mass E, Jacome-Galarza CE *, Blank T *, Lazarov T, Durham BH, Ozkaya N, Pastore A, Schwabenland M, Chung YR, Rosenblum MK, Prinz M *, Abdel-Wahab O *, Geissmann F *: A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease. Nature, 2017; 549 (7672): 389-393. : http://dx.doi.org/10.1038/nature23672
  • Meincke J, Lutzen N, Doostkam S, Urbach H: Teaching Neuroimages: "Filling out" in Cavernous Hemangioma of the Cavernous Sinus. Clin Neuroradiol, 2017. : http://dx.doi.org/10.1007/s00062-017-0607-7 (in Druck)
  • Quintana FJ, Prinz M: A gut feeling about multiple sclerosis. P Natl Acad Sci Usa, 2017; 114 (40): 10528-10529. : http://dx.doi.org/10.1073/pnas.1714260114
  • Ralser DJ, Lestringant GG, Du-Thanh A, Kokordelis P, Fischer J, Basmanav FBU, Wolf S, Thiele H, Altmuller J, Nurnberg P, Oji V, Fritz G, Frank J, Betz RC: Functional implications of novel ADAM10 mutations in reticulate acropigmentation of Kitamura. Brit J Dermatol, 2017; 177 (6): e340-e343. : http://dx.doi.org/10.1111/bjd.16024
  • Sahm F *, Toprak UH *, Hubschmann D *, Kleinheinz K, Buchhalter I, Sill M, Stichel D, Schick M, Bewerunge-Hudler M, Schrimpf D, Zadeh G, Aldape K, Herold-Mende C, Beck K, Staszewski O, Prinz M, Harosh CB, Eils R, Sturm D, Jones DTW, Pfister SM, Paulus W, Ram Z, Schlesner M *, Grossman R *, von Deimling A *: Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature. Acta Neuropathol, 2017; 134 (1): 155-158. : http://dx.doi.org/10.1007/s00401-017-1715-9
Sonstige Publikationen:
  • Erny D, Prinz M: Microbiology: Gut microbes augment neurodegeneration. Nature, 2017; 544 (7650) : 304-305. : http://dx.doi.org/10.1038/nature21910
  • Liu Y, Marin A, Ejlerskov P, Rasmussen LM, Prinz M, Issazadeh-Navikas S: Corrigendum: Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1(+)Treg cells. Nat Commun, 2017; 8: 15792-15792. : http://dx.doi.org/10.1038/ncomms15792
  • Prinz M, Erny D, Hagemeyer N: Erratum: Ontogeny and homeostasis of CNS myeloid cells. Nat Immunol, 2017; 18 (8) : 951-951. : http://dx.doi.org/10.1038/ni0817-951d

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Abschlussarbeiten