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 Forschungsbericht für das Jahr 2018

Department für Pathologie

Institut für Klinische Pathologie

Breisacher Str. 115a
79106 Freiburg
Tel: ( +49) 0761 / 270-8006 Fax: ( +49) 0761 / 270-8004
Email direktion-pathologie@uniklinik-freiburg.de
http://www.uniklinik-freiburg.de/pathologie/live/index.html


Einträge in der Rubrik "Who is Who"

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Bronsert P, Reichel K, Ruf J: Loss of PSMA Expression in Non-neuroendocrine Dedifferentiated Acinar Prostate Cancer. Clin Nucl Med, 2018; 43 (7): 526-528. : http://dx.doi.org/10.1097/RLU.0000000000002100
  • Christopoulos P, Schneider MA, Bozorgmehr F, Kuon J, Engel-Riedel W, Kollmeier J, Baum V, Muley T, Schnabel PA, Bischoff H, Grohe C, Serke M, Thomas M, Fisch P, Meister M: Large cell neuroendocrine lung carcinoma induces peripheral T-cell repertoire alterations with predictive and prognostic significance. Lung Cancer-j Iaslc, 2018; 119: 48-55. : http://dx.doi.org/10.1016/j.lungcan.2018.03.002
  • Csanadi A, Oser A, Aumann K, Gumpp V, Rawluk J, Nestle U, Kayser C, Wiesemann S, Werner M, Kayser G: Overexpression of SLC1a5 in lymph node metastases outperforms assessment in the primary as a negative prognosticator in non-small cell lung cancer. Pathology, 2018; 50 (3): 269-275. : http://dx.doi.org/10.1016/j.pathol.2017.10.016
  • Diamandis E, Gabriel CPS, Wurtemberger U, Guggenberger K, Urbach H, Staszewski O, Lassmann S, Schnell O, Grauvogel J, Mader I, Heiland DH: MR-spectroscopic imaging of glial tumors in the spotlight of the 2016 WHO classification. J Neuro-oncol, 2018. : http://dx.doi.org/10.1007/s11060-018-2881-x (in Druck)
  • Foll MC, Fahrner M, Oria VO, Kuhs M, Biniossek ML, Werner M, Bronsert P, Schilling O: Reproducible proteomics sample preparation for single FFPE tissue slices using Clin Proteom, 2018; 15: 11-11. : http://dx.doi.org/10.1186/s12014-018-9188-y
  • Freudenberg N: The Lessons of Spring 1968 for Public Health. Am J Public Health, 2018; 108 (6): 724-725. : http://dx.doi.org/10.2105/AJPH.2018.304387
  • Freudenberg N: ToxicDocs: a new resource for assessing the impact of corporate practices on health. J Public Health Pol, 2018; 39 (1): 30-33. : http://dx.doi.org/10.1057/s41271-017-0101-0
  • Galiger C, Loffek S, Stemmler MP, Kroeger JK, Mittapalli VR, Fauth L, Esser PR, Kern JS, Meiss F, Lassmann S, Bruckner-Tuderman L, Franzke CW: Targeting of Cell Surface Proteolysis of Collagen XVII Impedes Squamous Cell Carcinoma Progression. Mol Ther, 2018; 26 (1): 17-30. : http://dx.doi.org/10.1016/j.ymthe.2017.09.022
  • Hein S, Schoeb DS, Grunwald I, Richter K, Haberstroh J, Seidl M, Bronsert P, Wetterauer U, Schoenthaler M, Miernik A: Viability and biocompatibility of an adhesive system for intrarenal embedding and endoscopic removal of small residual fragments in minimally-invasive stone treatment in an in vivo pig model. World J Urol, 2018; 36 (4): 673-680. : http://dx.doi.org/10.1007/s00345-018-2188-8
  • Hirsch B, Endris V, Lassmann S, Weichert W, Pfarr N, Schirmacher P, Kovaleva V, Werner M, Bonzheim I, Fend F, Sperveslage J, Kaulich K, Zacher A, Reifenberger G, Kohrer K, Stepanow S, Lerke S, Mayr T, Aust DE, Baretton G, Weidner S, Jung A, Kirchner T, Hansmann ML, Burbat L, von der Wall E, Dietel M, Hummel M: Multicenter validation of cancer gene panel-based next-generation sequencing for translational research and molecular diagnostics. Virchows Arch, 2018; 472 (4): 557-565. : http://dx.doi.org/10.1007/s00428-017-2288-7
  • Kirste S, Kayser G, Zipfel A, Grosu AL, Brunner T: Unresectable hepatic PEComa: a rare malignancy treated with stereotactic body radiation therapy (SBRT) followed by complete resection. Radiat Oncol, 2018; 13 (1): 28-28. : http://dx.doi.org/10.1186/s13014-018-0974-5
  • Klambt V, Panning M, Seidl M, Haffner K, Pohl M: Ribavirin therapy of hepatitis E infection may cause hyporegenerative anemia in pediatric renal transplant patients. Pediatr Transplant, 2018 (online): e13195-e13195. : http://dx.doi.org/10.1111/petr.13195
  • Klett H, Fuellgraf H, Levit-Zerdoun E, Hussung S, Kowar S, Kusters S, Bronsert P, Werner M, Wittel U, Fritsch R, Busch H, Boerries M: Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma. Front Genet, 2018; 9 (online): 108-108. : http://dx.doi.org/10.3389/fgene.2018.00108
  • Makowiec F, Bronsert P, Klock A, Hopt UT, Neeff HP: Prognostic influence of hepatic margin after resection of colorectal liver metastasis: role of modern preoperative chemotherapy. Int J Colorectal Dis, 2018; 33 (1): 71-78. : http://dx.doi.org/10.1007/s00384-017-2916-3
  • Marks R, Engelhardt M, Hager S, Fullgraf H, Sudkamp NP, Herget GW: Diffuse large B cell lymphoma (DLBCL): bilateral vanishing tibiae. Ann Hematol, 2018. : http://dx.doi.org/10.1007/s00277-018-3308-7
  • Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Muller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lubbert M, Rummelt C, Bertz H, Wasch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rosler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stolzel F, Ordemann R, Muller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kroger N, Ayuk F, Vago L, Ciceri F, Muller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dorfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Borries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Shah O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socie G, Caligiuri MA, Ruggiero E, Bonini C, Hacker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R: Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nat Med, 2018; 24 (4): 282-291. : http://dx.doi.org/10.1038/nm0418-526c
  • Migalovich Sheikhet H, Villacorta Hidalgo J, Fisch P, Balbir-Gurman A, Braun-Moscovici Y, Bank I: Dysregulated CD25 and Cytokine Expression by gammadelta T Cells of Systemic Sclerosis Patients Stimulated With Cardiolipin and Zoledronate. Front Immunol, 2018; 9 (online): 753-753. : http://dx.doi.org/10.3389/fimmu.2018.00753
  • Muller AK, Foll M, Heckelmann B, Kiefer S, Werner M, Schilling O, Biniossek ML, Jilg CA, Drendel V: Proteomic Characterization of Prostate Cancer to Distinguish Nonmetastasizing and Metastasizing Primary Tumors and Lymph Node Metastases. Neoplasia, 2018; 20 (2): 140-151. : http://dx.doi.org/10.1016/j.neo.2017.10.009
  • Neeff HP, Holzner PA, Menzel M, Bronsert P, Klock A, Lang SA, Fichtner-Feigl S, Hopt UT, Makowiec F: [Intrahepatic cholangiocarcinoma : Results after 84 resections]. Chirurg, 2018; 89 (5): 374-380. : http://dx.doi.org/10.1007/s00104-018-0609-2
  • Prestipino A, Emhardt AJ, Aumann K, O'Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholoma M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kroger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R: Oncogenic JAK2(V617F) causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Sci Transl Med, 2018; 10 (429) (online). : http://dx.doi.org/10.1126/scitranslmed.aam7729
  • Schwab C, Gabrysch A, Olbrich P, Patino V, Warnatz K, Wolff D, Hoshino A, Kobayashi M, Imai K, Takagi M, Dybedal I, Haddock JA, Sansom DM, Lucena JM, Seidl M, Schmitt-Graeff A, Reiser V, Emmerich F, Frede N, Bulashevska A, Salzer U, Schubert D, Hayakawa S, Okada S, Kanariou M, Kucuk ZY, Chapdelaine H, Petruzelkova L, Sumnik Z, Sediva A, Slatter M, Arkwright PD, Cant A, Lorenz HM, Giese T, Lougaris V, Plebani A, Price C, Sullivan KE, Moutschen M, Litzman J, Freiberger T, van de Veerdonk FL, Recher M, Albert MH, Hauck F, Seneviratne S, Pachlopnik Schmid J, Kolios A, Unglik G, Klemann C, Speckmann C, Ehl S, Leichtner A, Blumberg R, Franke A, Snapper S, Zeissig S, Cunningham-Rundles C, Giulino-Roth L, Elemento O, Duckers G, Niehues T, Fronkova E, Kanderova V, Platt CD, Chou J, Chatila TA, Geha R, McDermott E, Bunn S, Kurzai M, Schulz A, Alsina L, Casals F, Deya-Martinez A, Hambleton S, Kanegane H, Tasken K, Neth O, Grimbacher B: Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects. J Allergy Clin Immun, 2018 (online). : http://dx.doi.org/10.1016/j.jaci.2018.02.055
  • Seidl M, Bader M, Vaihinger A, Wellner UF, Todorova R, Herde B, Schrenk K, Maurer J, Schilling O, Erbes T, Fisch P, Pfeiffer J, Hoffmann L, Franke K, Werner M, Bronsert P: Morphology of Immunomodulation in Breast Cancer Tumor Draining Lymph Nodes Depends on Stage and Intrinsic Subtype. Sci Rep-uk, 2018; 8 (1) (online): 5321-5321. : http://dx.doi.org/10.1038/s41598-018-23629-3
  • Thomsen AR, Aldrian C, Bronsert P, Thomann Y, Nanko N, Melin N, Rucker G, Follo M, Grosu AL, Niedermann G, Layer PG, Heselich A, Lund PG: A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement. Lab Chip, 2018; 18 (1): 179-189. : http://dx.doi.org/10.1039/c7lc00832e
  • Unger S, Seidl M, van Schouwenburg P, Rakhmanov M, Bulashevska A, Frede N, Grimbacher B, Pfeiffer J, Schrenk K, Munoz L, Hanitsch L, Stumpf I, Kaiser F, Hausmann O, Kollert F, Goldacker S, van der Burg M, Keller B, Warnatz K: The TH1 phenotype of follicular helper T cells indicates an IFN-gamma-associated immune dysregulation in patients with CD21low common variable immunodeficiency. J Allergy Clin Immun, 2018; 141 (2): 730-740. : http://dx.doi.org/10.1016/j.jaci.2017.04.041
  • van der Putten LJM, Visser NCM, van de Vijver K, Santacana M, Bronsert P, Bulten J, Hirschfeld M, Colas E, Gil-Moreno A, Garcia A, Mancebo G, Alameda F, Trovik J, Kopperud RK, Huvila J, Schrauwen S, Koskas M, Walker F, Weinberger V, Minar L, Jandakova E, Snijders MPLM, van den Berg-van Erp S, Matias-Guiu X, Salvesen HB, Werner HMJ, Amant F, Massuger LFAG, Pijnenborg JMA: Added Value of Estrogen Receptor, Progesterone Receptor, and L1 Cell Adhesion Molecule Expression to Histology-Based Endometrial Carcinoma Recurrence Prediction Models: An ENITEC Collaboration Study. Int J Gynecol Cancer, 2018; 28 (3): 514-523. : http://dx.doi.org/10.1097/IGC.0000000000001187
  • Vermeulen JF, Van Hecke W, Adriaansen EJM, Jansen MK, Bouma RG, Villacorta Hidalgo J, Fisch P, Broekhuizen R, Spliet WGM, Kool M, Bovenschen N: Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma. Oncoimmunology, 2018; 7 (3) (online): e1398877-e1398877. : http://dx.doi.org/10.1080/2162402X.2017.1398877
  • Welte T, Arnold F, Kappes J, Seidl M, Haffner K, Bergmann C, Walz G, Neumann-Haefelin E: Treating C3 glomerulopathy with eculizumab. Bmc Nephrol, 2018; 19 (1) (online): 7-7. : http://dx.doi.org/10.1186/s12882-017-0802-4
  • Yasuda-Yamahara M, Rogg M, Frimmel J, Trachte P, Helmstaedter M, Schroder P, Schiffer M, Schell C, Huber TB: FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology. Matrix Biol, 2018. : http://dx.doi.org/10.1016/j.matbio.2018.01.003 (in Druck)
  • Zamboglou C, Thomann B, Koubar K, Bronsert P, Krauss T, Rischke HC, Sachpazidis I, Drendel V, Salman N, Reichel K, Jilg CA, Werner M, Meyer PT, Bock M, Baltas D, Grosu AL: Focal dose escalation for prostate cancer using (68)Ga-HBED-CC PSMA PET/CT and MRI: a planning study based on histology reference. Radiat Oncol, 2018; 13 (1) (online): 81-81. : http://dx.doi.org/10.1186/s13014-018-1036-8
  • Zortel T, Schmitt-Graeff A, Kirschnek S, Hacker G: Apoptosis modulation in the immune system reveals a role of neutrophils in tissue damage in a murine model of chlamydial genital infection. J Infect Dis, 2018; 217 (11): 1832-1843. : http://dx.doi.org/10.1093/infdis/jiy126
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:
Buchbeiträge:
  • Werner Martin: Histologie und Tumorbiologie: Plattenepithelkarzinome In: Gastrointestinale Onkologie Stuttgart: Thieme Verlag, 2018; 98-100.: http://10.1055/b-005-143320
Fallbeispiele:
  • Rassner MP, Seidl M, Salzer U, Rajkumar SV, Epting T, Wasch R, Neumann-Haefelin E, Engelhardt M: Cast Nephropathy and Deceptively Low Absolute Serum Free Light Chain Levels: Resolution of a Challenging Case and Systematic Review of the Literature. Cl Lymph Myelom Leuk, 2018; 18 (1): e1-e7. : http://dx.doi.org/10.1016/j.clml.2017.09.019

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten

Promotionen
  • Dorsel Cornelia Elisabeth: In vitro-Untersuchungen zur funktionellen Bedeutung des Splicingfaktors hTra2ß1 und bestimmten Effektoren beim Mamma-Karzinom (Erstgutachter/in Prof. Dr. E. Stickeler, Frauenklinik, Zweitgutachter/in Prof. Dr. M. Werner, Pathologie), 2018.