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 Forschungsbericht für das Jahr 2018

Institut für Medizinische Biometrie und Statistik

Stefan-Meier-Strasse 26
79104 Freiburg
Tel: 0761 203 6662 Fax: 0761 203 6680
Email sec@imbi.uni-freiburg.de
http://www.imbi.uni-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. M. Schumacher
  • Prof. Dr. J. Schulte Mönting
  • Arthur Allignol
  • Dr. G. Antes
  • Dr. J. Beyersmann
  • Dr. H. Binder
  • Dr. Anette Blümle
  • D. Booker
  • Dipl.-Stat. Anika Buchholz
  • Dr. A. Caputo
  • Dr. J. Carpenter
  • Dr. Erik von Elm
  • Dipl.-Math. C. Gall
  • Dr. T. Gerds
  • Dipl.-Stat. A. Gerlach
  • Dr. E. Graf
  • Prof. Dr. Dieter Hauschke
  • Dr. G. Ihorst
  • Dr. B. Lang
  • Dr. Jörg Meerpohl
  • Dipl.-Stat. M. Olschewski
  • Dipl.-Stat. Christine Porzelius
  • Dipl.-Math. G. Rücker
  • PD Dr. W. Sauerbrei
  • Dr. C. Schmoor
  • Dr. Christine Schmucker
  • Dipl.-Math.Oec. R. Schoop
  • Dr. G. Schwarzer
  • Dipl.-Math. P. Sekula
  • Dipl.-Stat. S. Stampf
  • PD Dr. A. Timmer
  • Robert Wolff
  • Dr. M. Wolkewitz
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Biometrische Methodologie
  • Epidemiologische Studien
  • Klinische Studien
  • Multizentrische Therapiestudien

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Adánez MH, Brezavšček M, Vach K, Fonseca M, Att W: Clinical and Radiographic Evaluation of Short Implants Placed in the Posterior Mandible: A 1-Year Pilot Split-Mouth Study. J Oral Implantol, 2018; 44 (4): 250-259. : https://doi.org/10.1563/aaid-joi-D-18-00037
  • Al-Ahmad A, Muzafferiy F, Anderson AC, Wölber JP, Ratka-Krüger P, Fretwurst T, Nelson K, Vach K, Hellwig E: Shift of microbial composition of peri-implantitis-associated oral biofilm as revealed by 16S rRNA gene cloning. J Med Microbiol, 2018; 67: 332-340. : https://doi.org/10.1099/jmm.0.000682
  • Anderson AC, Andisha H, Hellwig E, Jonas D, Vach K, Al-Ahmad A: Antibiotic Resistance Genes and Antibiotic Susceptibility of Oral Enterococcus faecalis Isolates Compared to Isolates from Hospitalized Patients and Food. Adv Exp Med Biol, 2018; 1057: 47-62. : https://doi.org/10.1007/5584_2017_53
  • Ballesio A, Aquino MRJV, Feige B, Johann AF, Kyle SD, Spiegelhalder K, Lombardo C, Rücker G, Riemann D, Baglioni C: The effectiveness of behavioural and cognitive behavioural therapies for insomnia on depressive and fatigue symptoms: a systematic review and network meta-analysis. Sleep Med Rev, 2018; 37: 114-129. : http://dx.doi.org/10.1016/j.smrv.2017.01.006
  • Balmer M, Spies BC, Vach K, Kohal RJ, Hammerle CHF, Jung RE: Three-year analysis of zirconia implants used for single-tooth replacement and three-unit fixed dental prostheses: A prospective multicenter study. Clin Oral Implan Res, 2018; 29 (3): 290-299. : http://dx.doi.org/10.1111/clr.13115
  • Becker E, Orellana Rios CL, Lahmann C, Rücker G, Bauer J, Boeker M: Anxiety as a risk factor of Alzheimer's disease and vascular dementia. Brit J Psychiat, 2018; 213 (5): 654-660. : https://doi.org/10.1192/bjp.2018.173
  • Bender R, Friede T, Koch A, Kuss O, Schlattmann P, Schwarzer G, Skipka G: Methods for evidence synthesis in the case of very few studies. Res Synth Methods, 2018; 9 (3): 382-392. : http://dx.doi.org/10.1002/jrsm.1297
  • Binder H: Big Data und Deep Learning in der Onkologie. Onkologe, 2018; 24: 361-367. : http://dx.doi.org/10.1007/s00761-018-0359-2
  • Bluhmki T, Schmoor C, Dobler D, Pauly M, Finke J, Schumacher M, Beyersmann J: A wild bootstrap approach for the Aalen-Johansen estimator. Biometrics, 2018; 74: 977-985. : https://doi.org/10.1111/biom.12861
  • Bollig C, Nothacker M, Lehane C, Motschall E, Lang B, Meerpohl JJ, Schmucker C: Prophylactic antibiotics before cord clamping in cesarean delivery: a systematic review. Acta Obstet Gyn Scan, 2018; 97: 521-535. : http://dx.doi.org/10.1111/aogs.13276
  • Brinster R, Köttgen A, Tayo BO, Schumacher M, Sekula P, CKDGen Consortium: Control procedures and estimators of the false discovery rate and their application in low-dimensional settings: an empirical investigation. Bmc Bioinformatics, 2018; 19 (online): 78. : https://doi.org/10.1186/s12859-018-2081-x
  • Byrne J, Grabow D, Campbell H, O'Brien K, Bielack S, Am Zehnhoff-Dinnesen, Calaminus G, Kremer L, Langer T, van den Heuvel-Eibrink MM, van Dulmen-den Broeder E, Baust K, Bautz A, Beck JD, Berger C, Binder H, Borgmann-Staudt A, Broer L, Cario H, Casagranda L, Clemens E, Deuster D, de Vries A, Dirksen U, Falck Winther J, Fosså S, Font-Gonzalez A, Grandage V, Haupt R, Hecker-Nolting S, Hjorth L, Kaiser M, Kenborg L, Kepak T, Kepáková K, Knudsen LE, Krawczuk-Rybak M, Kruseova J, Kuehni CE, Kunstreich M, Kuonen R, Lackner H, Leiper A, Loeffen EAH, Luks A, Modan-Moses D, Mulder R, Parfitt R, Paul NW, Ranft A, Ruud E, Schilling R, Spix C, Stefanowicz J, Strauβ G, Uitterlinden AG, van den Berg M, van der Kooi AL, van Dijk M, van Leeuwen F, Zolk O, Zöller D, Kaatsch P, PanCareLIFE consortium: PanCareLIFE: The scientific basis for a European project to improve long-term care regarding fertility, ototoxicity and health-related quality of life after cancer occurring among children and adolescents. Eur J Cancer, 2018; 103: 227-237. : https://doi.org/10.1016/j.ejca.2018.08.007
  • Das A, Roy B, Schwarzer G, Silverman MG, Ziegler O, Bandyopadhyay D, Philpotts LL, Sinha S, Blumenthal JA, Das S: Comparison of treatment options for depression in heart failure: A network meta-analysis. J Psychiatr Res, 2018; 108: 7-23. : https://doi.org/10.1016/j.jpsychires.2018.10.007
  • De Bin R, Sauerbrei W: Handling co-dependence issues in resampling-based variable selection procedures: a simulation study. J Stat Comput Sim, 2018; 88 (1): 28-55. : http://dx.doi.org/10.1080/00949655.2017.1378654
  • Eggebrecht L, Prochaska JH, Schulz A, Arnold N, Jünger C, Göbel S, Laubert‐Reh D, Binder H, Beutel ME, Pfeiffer N, Blankenberg S, Lackner KJ, Spronk HM, ten Cate H, Münzel T, Wild PS: Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population‐Based Gutenberg Health Study. J Am Heart Assoc, 2018; 7 (online): e008650. : https://doi.org/10.1161/JAHA.118.008650
  • Engler-Hüsch S, Heister T, Mutters NT, Wolff J, Kaier K: In-hospital costs of community-acquired colonization with multidrug-resistant organisms at a German teaching hospital. Bmc Health Serv Res, 2018; 18 (online): 737. : https://doi.org/10.1186/s12913-018-3549-0
  • Fischbeck S, Weyer-Elberich V, Zeissig SR, Imruck BH, Blettner M, Binder H, Beutel ME: Determinants of illness-specific social support and its relation to distress in long-term melanoma survivors. Bmc Public Health, 2018; 18 (online): 511. : https://doi.org/10.1186/s12889-018-5401-1
  • Goedeke J, Ertl A, Zöller D, Rohleder S, Muensterer OJ: Telemedicine for pediatric surgical outpatient follow-up: A prospective, randomized single-center trial. J Pediatr Surg, 2018. : https://doi.org/10.1016/j.jpedsurg.2018.10.014 (in Druck)
  • Graetz C, Gröger A, Luessi F, Salmen A, Zöller D, Schultz J, Siller N, Fleischer V, Bellenberg B, Berthele A, Biberacher V, Havla J, Hecker M, Hohlfeld R, Infante-Duarte C, Kirschke JS, Kümpfel T, Linker R, Paul F, Pfeuffer S, Sämann P, Toenges G, Weber F, Zettl UK, Jahn-Eimermacher A, Antony G, Groppa S, Wiendl H, Hemmer B, Mühlau M, Lukas C, Gold R, Lill CM, Zipp F: Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis. Mult Scler J, 2018. : https://doi.org/10.1177/1352458518763541 (in Druck)
  • Grigioni F, Clavel MA, Vanoverschelde JL, Tribouilloy C, Pizarro R, Huebner M, Avierinos JF, Barbieri A, Suri R, Pasquet A, Rusinaru D, Gargiulo GD, Oberti P, Théron A, Bursi F, Michelena H, Lazam S, Szymanski C, Nkomo VT, Schumacher M, Bacchi-Reggiani L, Enriquez-Sarano M, MIDA Investigators: The MIDA Mortality Risk Score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation. Eur Heart J, 2018; 39: 1281-1291. : https://doi.org/10.1093/eurheartj/ehx465
  • Groß V, Lücke C, Graf E, Lam AP, Matthies S, Borel P, Sobanski E, Rösler M, Retz W, Jacob C, Colla M, Huss M, Jans T, Kis B, Abdel-Hamid M, van Elst LT, Philipsen A, Comparison of Methylphenidate, Psychotherapy in Adult ADHD Study (COMPAS) Consortium: Effectiveness of Psychotherapy in Adult ADHD: What Do Patients Think? Results of the COMPAS Study. J Atten Disord, 2018. : https://doi.org/10.1177/1087054717720718 (in Druck)
  • Häge A, Alm B, Banaschewski T, Becker K, Colla M, Freitag C, Geissler J, von Gontard A, Graf E, Haack-Dees B, Hänig S, Hennighausen K, Hohmann S, Jacob C, Jaite C, Jennen-Steinmetz C, Kappel V, Matthies S, Philipsen A, Poustka L, Retz W, Rösler M, Schneider-Momm K, Sobanski E, Vloet TD, Warnke A, Jans T: Does the efficacy of parent-child training depend on maternal symptom improvement? Results from a randomized controlled trial on children and mothers both affected by attention-deficit/hyperactivity disorder (ADHD). Eur Child Adoles Psy, 2018; 27: 1011-1021. : https://doi.org/10.1007/s00787-018-1109-0
  • Hazard D, Schumacher M, Palomar-Martinez M, Alvarez-Lerma F, Olaechea-Astigarraga P, Wolkewitz M: Improving nested case-control studies to conduct a full competing-risks analysis for nosocomial infections. Infect Cont Hosp Ep, 2018; 39 (10): 1196-1201. : https://doi.org/10.1017/ice.2018.186
  • Hertenstein E, Feige B, Gmeiner T, Kienzler C, Spiegelhalder K, Johann A, Jansson-Fröjmark M, Palagini L, Rücker G, Riemann D, Baglioni C: Insomnia as a predictor of mental disorders: A systematic review and meta-analysis. Sleep Med Rev, 2018. : https://doi.org/10.1016/j.smrv.2018.10.006 (in Druck)
  • Inzucchi SE, Zinman B, Fitchett D, Wanner C, Ferrannini E, Schumacher M, Schmoor C, Ohneberg K, Johansen OE, George JT, Hantel S, Bluhmki E, Lachin JM: How Does Empagliflozin Reduce Cardiovascular Mortality? Insights From a Mediation Analysis of the EMPA-REG OUTCOME Trial. Diabetes Care, 2018; 41: 356-363. : https://doi.org/10.2337/dc17-1096
  • Jabbarli R, Pierscianek D, Darkwah Oppong M, Sato T, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Roos A, Sure U: Laboratory biomarkers of delayed cerebral ischemia after subarachnoid hemorrhage: a systematic review. Neurosurg Rev, 2018. : https://doi.org/10.1007/s10143-018-1037-y (in Druck)
  • Jabbarli R, Pierscianek D, Rölz R, Reinhard M, Darkwah Oppong M, Scheiwe C, Dammann P, Kaier K, Wrede KH, Shah M, Zentner J, Sure U: Gradual External Ventricular Drainage Weaning Reduces The Risk of Shunt Dependency After Aneurysmal Subarachnoid Hemorrhage: A Pooled Analysis. Oper Neurosurg, 2018; 15 (5): 498-504. : https://doi.org/10.1093/ons/opy009
  • Jaite C, van Noort BM, Vloet TD, Graf E, Kappel V, Geissler J, Warnke A, Jacob C, Groß-Lesch S, Hennighausen K, Haack-Dees B, Schneider-Momm K, Philipsen A, Matthies S, Rösler M, Retz W, Hänig S, von Gontard A, Sobanski E, Alm B, Hohmann S, Häge A, Poustka L, Colla M, Gentschow L, Freitag CM, Becker K, Jans T: A multicentre randomized controlled trial on trans-generational attention deficit/hyperactivity disorder (ADHD) in mothers and children (AIMAC): an exploratory analysis of predictors and moderators of treatment outcome. Z Kinder Jug-psych, 2018. : https://doi.org/10.1024/1422-4917/a000602 (in Druck)
  • Jayasekera J, Li Y, Schechter CB, Jagsi R, Song J, White J, Luta G, Chapman JW, Feuer EJ, Zellars RC, Stout N, Julian TB, Whelan T, Huang X, Shelley Hwang E, Hopkins JO, Sparano JA, Anderson SJ, Fyles AW, Gray R, Sauerbrei W, Mandelblatt J, Berry DA, CISNET-BOLD Collaborative Group: Simulation Modeling of Cancer Clinical Trials: Application to Omitting Radiotherapy in Low-risk Breast Cancer. Jnci-j Natl Cancer I, 2018; 110 (online): djy059. : https://doi.org/10.1093/jnci/djy059
  • Jayasekera J, Schechter CB, Sparano JA, Jagsi R, White J, Chapman JW, Whelan T, Anderson SJ, Fyles AW, Sauerbrei W, Zellars RC, Li Y, Song J, Huang X, Julian TB, Luta G, Berry DA, Feuer EJ, Mandelblatt J, CISNET-BOLD Collaborative Group: Effects of Radiotherapy in Early-Stage, Low-Recurrence Risk, Hormone-Sensitive Breast Cancer. Jnci-j Natl Cancer I, 2018. : https://doi.org/10.1093/jnci/djy128 (in Druck)
  • Jenny B, Beyersmann J, Schumacher M: A simulation approach for power calculation in large cohort studies based on multistate models. Biometrical J, 2018; 60: 671-686. : https://doi.org/10.1002/bimj.201700074
  • Jeserich M, Merkely B, Schlosser P, Kimmel S, Pavlik G, Biermann J: Early diastolic septal movement in patients with myocarditis. Clin Radiol, 2018; 73 (online): 219e.9-219e.15. : http://dx.doi.org/10.1016/j.crad.2017.09.008
  • Kaier K, Oettinger V, Reinecke H, Schmoor C, Frankenstein L, Vach W, Hehn P, von Zur Mühlen C, Bode C, Zehender M, Reinöhl J: Volume-outcome relationship in transcatheter aortic valve implantations in Germany 2008-2014: a secondary data analysis of electronic health records. Bmj Open, 2018; 8 (online): e020204. : https://doi.org/10.1136/bmjopen-2017-020204
  • Kaier K, von zur Mühlen C, Zirlik A, Schmoor C, Roth K, Bothe W, Hehna P, Reinöhl J, Zehender M, Bode C, Stachon P: Sex-specific differences in outcome of transcatheter or surgical aortic valve replacement. Can J Cardiol, 2018; 34: 992-998. : https://doi.org/10.1016/j.cjca.2018.04.009
  • Kaufmann KB, Heinrich S, Staehle HF, Bogatyreva L, Buerkle H, Goebel U: Perioperative cytokine profile during lung surgery predicts patients at risk for postoperative complications-A prospective, clinical study. Plos One, 2018; 13 (7) (online): e0199807-e0199807. : http://dx.doi.org/10.1371/journal.pone.0199807
  • Keilmann A, Neumann K, Zöller D, Freude C: Clinical trial of the D.E.L.P.H.I.N. speech treatment for children and adolescents who stutter. Logop Phoniatr Voco, 2018. : https://doi.org/10.1080/14015439.2018.1498917 (in Druck)
  • Kern WV, Weber S, Dettenkofer M, Kaier K, Bertz H, Behnke M, Weisser M, Götting T, Widmer AF, Theilacker C, Hospital Infection Surveillance System for Patients with Haematologic/Oncologic Malignancies Study Group (ONKO-KISS).: Impact of fluoroquinolone prophylaxis during neutropenia on bloodstream infection: Data from a surveillance program in 8,755 patients receiving high-dose chemotherapy for haematologic malignancies between 2009 and 2014. J Infection, 2018; 77: 68-74. : https://doi.org/10.1016/j.jinf.2018.05.004
  • Khadr L, Harfouche M, Omori R, Schwarzer G, Chemaitelly H, Abu-Raddad LJ: The Epidemiology of Herpes Simplex Virus Type 1 in Asia: Systematic Review, Meta-analyses, and Meta-regressions. Clin Infect Dis, 2018. : https://doi.org/10.1093/cid/ciy562 (in Druck)
  • Koeber G, Oberwittler D: How older people became less afraid of crime—An age-period-cohort analysis using repeated cross-sectional survey data. Soc Sci Res, 2018. : https://doi.org/10.1016/j.ssresearch.2018.10.010 (in Druck)
  • Kohal R, Fross A, Adolfsson E, Bagegni A, Doerken S, Spies BC: Fatigue resistance of a two‐piece zirconia oral implant. An investigation in the chewing simulator. Clin Oral Implan Res, 2018; 29 Suppl. 17: 54. : https://doi.org/10.1111/clr.11_13356
  • Kowalzik F, Binder H, Zöller D, Riera-Montes M, Clemens R, Verstraeten T, Zepp F: Norovirus Gastroenteritis among Hospitalized Patients, Germany, 2007-2012. Emerg Infect Dis, 2018; 24: 2021-2028. : https://doi.org/10.3201/eid2411.170820
  • Kruse AB, Kuerschner AC, Kunze M, Woelber JP, Al-Ahmad A, Wittmer A, Vach K, Ratka-Krueger P: Association between high risk for preterm birth and changes in gingiva parameters during pregnancy-a prospective cohort study. Clin Oral Invest, 2018; 22: 1263-1271. : https://doi.org/10.1007/s00784-017-2209-9
  • Lamparter J, Schmidtmann I, Schuster AK, Siouli A, Wasielica-Poslednik J, Mirshahi A, Höhn R, Unterrainer J, Wild PS, Binder H, Lackner K, Beutel ME, Münzel T, Pfeiffer N, Hoffmann EM: Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness. Plos One, 2018; 13 (online): e0197682. : https://doi.org/10.1371/journal.pone.0197682
  • Maccioni L *, Weber S *, Elgizouli M, Stoehlker AS, Geist I, Peter HH, Vach W, Nieters A: Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study. Bmc Public Health, 2018; 18 (1) (online): 271. : http://dx.doi.org/10.1186/s12889-018-5172-8
  • Naegele M, Kirsch M, Ihorst G, Fierz K, Engelhardt M, De Geest S: Symptom experience of multiple myeloma (syMMex) patients treated with autologous stem cell transplantation following high-dose melphalan: a descriptive longitudinal study. Support Care Cancer, 2018; 26: 833-841. : https://doi.org/10.1007/s00520-017-3897-z
  • Niglio de Figueiredo M, Krippeit L, Freund J, Ihorst G, Joos A, Bengel J, Wuensch A: Assessing Communication Skills in Real Medical Encounters in Oncology: Development and Validation of the ComOn-Coaching Rating Scales. J Cancer Educ, 2018. : https://doi.org/10.1007/s13187-017-1269-5 (in Druck)
  • Nührenberg TG, Cederqvist M, Marini F, Stratz C, Grüning BA, Trenk D, Binder H, Gilsbach R, Neumann F-J, Hein L: Uncontrolled Diabetes Mellitus Has No Major Influence on the Platelet Transcriptome. Biomed Res Int, 2018; 2018 (online): ID 8989252. : https://doi.org/10.1155/2018/8989252
  • Olivier M, Boeker M, Hanser S, Hehn P, Kaier K: Der Pflegekomplexmaßnahmen-Score: Paradigmenwechsel im G-DRG System oder Tropfen auf den heißen Stein? Eine Sekundäranalyse auf Basis von Abrechnungsdaten. Gesundheitsökonomie & Qualitätsmanagement, 2018. : http://dx.doi.org/10.1055/a-0659-1706 (in Druck)
  • Paling FP, Olsen K, Ohneberg K, Wolkewitz M, Fowler VG Jr, DiNubile MJ, Jafri HS, Sifakis F, Bonten MJM, Harbarth SJ, Kluytmans JAJW: Risk prediction for Staphylococcus aureus surgical site infection following cardiothoracic surgery; A secondary analysis of the V710-P003 trial. Plos One, 2018; 13 (3) (online): e0193445-e0193445. : http://dx.doi.org/10.1371/journal.pone.0193445
  • Papakonstantinou T, Nikolakopoulou A, Rücker G, Chaimani A, Schwarzer G, Egger M, Salanti G: Estimating the contribution of studies in network meta-analysis: paths, flows and streams [version 2; referees: 2 approved, 1 approved with reservations]. F1000 Research, 2018 (online). : http://dx.doi.org/10.12688/f1000research.14770.2
  • Pieralli S, Kohal RJ, Lopez Hernandez E, Doerken S, Spies BC: Osseointegration of zirconia dental implants in animal investigations: A systematic review and meta-analysis. Dent Mater, 2018; 34: 171-182. : https://doi.org/10.1016/j.dental.2017.10.008
  • Pieralli S, Kohal RJ, Rabel K, von Stein-Lausnitz M, Vach K, Spies BC: Clinical outcomes of partial and full-arch all-ceramic implant-supported fixed dental prostheses. A systematic review and meta-analysis. Clin Oral Implan Res, 2018; 29 Suppl. 18: 224-236. : http://dx.doi.org/10.1111/clr.13345
  • Poguntke I, Schumacher M, Beyersmann J, On Behalf Of Combacte-Magnet Consortium MW: Simulation shows undesirable results for competing risks analysis with time-dependent covariates for clinical outcomes. Bmc Med Res Methodol, 2018; 18 (online): 79. : https://doi.org/10.1186/s12874-018-0535-5
  • Polydorou O, Scheitza S, Spraul M, Vach K, Hellwig E: The effect of long-term use of tooth bleaching products on the human enamel surface. Odontology, 2018; 106: 64-72. : https://doi.org/10.1007/s10266-017-0308-3
  • Prasse A, Binder H, Schupp JC, Kayser G, Bargagli E, Jaeger B, Hess M, Rittinghausen S, Vuga L, Lynn H, Violette S, Jung B, Quast K, Vanaudenaerde B, Xu Y, Hohlfeld JM, Krug N, Herazo-Maya JD, Rottoli P, Wuyts WA, Kaminski N: BAL Cell Gene Expression is Indicative of Outcome and Airway Basal Cell Involvement in IPF. Am J Resp Crit Care, 2018. : https://doi.org/10.1164/rccm.201712-2551OC (in Druck)
  • Prokosch HU, Acker T, Bernarding J, Binder H, Boeker M, Boerries M, Daumke P, Ganslandt T, Hesser J, Höning G, Neumaier M, Marquardt K, Renz H, Rothkötter HJ, Schade-Brittinger C, Schmücker P, Schüttler J, Sedlmayr M, Serve H, Sohrabi K, Storf H: MIRACUM: Medical Informatics in Research and Care in University Medicine. Method Inform Med, 2018; 57 Suppl. 1: e82-e91. : https://doi.org/10.3414/ME17-02-0025
  • Proksch S, Brossart J, Vach K, Hellwig E, Altenburger MJ, Karygianni L: Evaluation of the bioactivity of fluoride-enriched mineral trioxide aggregate on osteoblasts. Int Endod J, 2018; 51: 912-923. : https://doi.org/10.1111/iej.12905
  • Proksch S, Kirsch K, Vach K, Hellwig E, Tomakidi P: Comparative differentiation analysis of distinct oral tissue-derived cells in response to osteogenic stimulation. Clin Oral Invest, 2018. : https://doi.org/10.1007/s00784-018-2529-4 (in Druck)
  • Rabel K, Spies BC, Pieralli S, Vach K, Kohal RJ: The clinical performance of all-ceramic implant-supported single crowns: A systematic review and meta-analysis. Clin Oral Implan Res, 2018; 29 Suppl. 18: 196-223. : http://dx.doi.org/10.1111/clr.13337
  • Rahman S, von Cube M, Schumacher M, Wolkewitz M: Bias due to censoring of deaths when calculating extra length of stay for patients acquiring a hospital infection. Bmc Med Res Methodol, 2018; 18 (online): 49. : https://doi.org/10.1186/s12874-018-0500-3
  • Rauch G, Kieser M, Binder H, Bayes-Genis A, Jahn-Eimermacher A: Time-to-first-event versus recurrent-event analysis: points to consider for selecting a meaningful analysis strategy in clinical trials with composite endpoints. Clin Res Cardiol, 2018; 107: 437-443. : https://doi.org/10.1007/s00392-018-1205-7
  • Sauerbrei W, Taube SE, McShane LM, Cavenagh MM, Altman DG: Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): An Abridged Explanation and Elaboration Jnci-j Natl Cancer I, 2018; 110 (8): 803-811. : https://doi.org/10.1093/jnci/djy088
  • Scherer RW, Meerpohl JJ, Pfeifer N, Schmucker C, Schwarzer G, von Elm E: Full publication of results initially presented in abstracts. Cochrane Db Syst Rev, 2018. : https://doi.org/10.1002/14651858.MR000005.pub4 (in Druck)
  • Schmidtmann I, Konstantinides S, Binder H: Power of the Wilcoxon–Mann–Whitney test for non‐inferiority in the presence of death‐censored observations. Biometrical J, 2018. : https://doi.org/10.1002/bimj.201700296 (in Druck)
  • Sommer H, Bluhmki T, Beyersmann J, Schumacher M, COMBACTE-NET, COMBACTE-MAGNET consortium.: Assessing non-inferiority in treatment trials regarding severe infectious diseases: An extension to the entire follow-up period using a cure-death multistate model. Antimicrob Agents Ch, 2018; 62 (online): e01691-17. : https://doi.org/10.1128/AAC.01691-17
  • Sommer H, Timsit JF, von Cube M, Schumacher M, Darmon M, Schwebel C, Ruckly S, Wolkewitz M, COMBACTE-MAGNET Consortium.: The Impact of Early Adequate Treatment on Extubation and Discharge Alive of Patients With Pseudomonas aeruginosa-Related Ventilator-Associated Pneumonia. Crit Care Med, 2018; 46: 1643-1648. : https://doi.org/10.1097/CCM.0000000000003305
  • Sommer S, Cruijsen M, Claus R, Bertz H, Wasch R, Marks R, Zeiser R, Bogatyreva L, Blijlevens NMA, May A, Duyster J, Huls G, van der Velden WJFM, Finke J, Lubbert M: Decitabine in combination with donor lymphocyte infusions can induce remissions in relapsed myeloid malignancies with higher leukemic burden after allogeneic hematopoietic cell transplantation. Leukemia Res, 2018; 72: 20-26. : http://dx.doi.org/10.1016/j.leukres.2018.07.005
  • Spies BC, Bateli M, Ben Rahal G, Christmann M, Vach K, Kohal RJ: Does Oral Implant Design Affect Marginal Bone Loss? Results of a Parallel-Group Randomized Controlled Equivalence Trial. Biomed Res Int, 2018 (online): 8436437. : https://doi.org/10.1155/2018/8436437
  • Spies BC, Fross A, Adolfsson E, Bagegni A, Doerken S, Kohal RJ: Stability and aging resistance of a zirconia oral implant using a carbon fiber-reinforced screw for implant-abutment connection. Dent Mater, 2018; 34 (10): 1585-1595. : http://dx.doi.org/10.1016/j.dental.2018.08.290
  • Spies BC, Witkowski S, Vach K, Kohal RJ: Clinical and patient-reported outcomes of zirconia-based implant fixed dental prostheses: Results of a prospective case series 5 years after implant placement. Clin Oral Implan Res, 2018; 29: 91-99. : https://doi.org/10.1111/clr.13072
  • Spitznagel FA, Scholz KJ, Strub JR, Vach K, Gierthmuehlen PC: Polymer-infiltrated ceramic CAD/CAM inlays and partial coverage restorations: 3-year results of a prospective clinical study over 5 years. Clin Oral Invest, 2018; 22: 1973-1983. : https://doi.org/10.1007/s00784-017-2293-x
  • Sprinzl MF, Kirstein MM, Koch S, Seib M-L, Weinmann-Menke J, Lang H, Düber C, Toenges G, Zöller D, Marquardt JU, Wörns M-A, Galle PR, Vogel A, Pinter M, Weinmann A: Improved Prediction of Survival by a Risk Factor-Integrating Inflammatory Score in Sorafenib-Treated Hepatocellular Carcinoma. Liver Cancer, 2018. : http://dx.doi.org/10.1159/000492628 (in Druck)
  • Stachon P, Kaier K, Zirlik A, Bothe W, Zehender M, Bode C, von zur Mühlen C: Die Entwicklung und Ergebnisse von TAVI und chirurgischem Aortenklappenersatz in Deutschland 2014 bis 2015. Development and Results of Transcatheter and Surgical Aortic Valve Replacement in Germany 2014 and 2015. Deut Med Wochenschr, 2018; 143 (online): e206-e212. : http://dx.doi.org/10.1055/a-0655-6218
  • Stachon P, Kaier K, Zirlik A, Reinöhl J, Heidt T, Bothe W, Hehn P, Zehender M, Bode C, von Zur Mühlen C: Risk factors and outcome of postoperative delirium after transcatheter aortic valve replacement. Clin Res Cardiol, 2018; 107: 756-762. : https://doi.org/10.1007/s00392-018-1241-3
  • Stomper J, Ihorst G, Suciu S, Sander PN, Becker H, Wijermans PW, Plass C, Weichenhan D, Bissé E, Claus R, Lübbert M: Fetal hemoglobin induction during decitabine treatment of elderly high-risk myelodysplastic syndrome and acute myeloid leukemia patients: a potential dynamic biomarker for outcome. Haematologica, 2018. : https://doi.org/10.3324/haematol.2017.187278 (in Druck)
  • Taschner CA, Chapot R, Costalat V, Machi P, Courthéoux P, Barreau X, Berge J, Pierot L, Kadziolka K, Jean B, Blanc R, Biondi A, Brunel H, Gallas S, Berlis A, Herbreteau D, Berkefeld J, Urbach H, Elsheikh S, Fiehler J, Desal H, Graf E, Bonafé A: Second-Generation Hydrogel Coils for the Endovascular Treatment of Intracranial Aneurysms. A Randomized Controlled Trial. Stroke, 2018; 49: 667-674. : https://doi.org/10.1161/STROKEAHA.117.018707
  • Thomsen AR, Aldrian C, Bronsert P, Thomann Y, Nanko N, Melin N, Rücker G, Follo M, Grosu AL, Niedermann G, Layer PG, Heselich A, Lund PG: A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement. Lab Chip, 2018; 18: 179-189. : http://dx.doi.org/10.1039/c7lc00832e
  • Torbahn G, Hofmann H, Rücker G, Bischoff K, Freitag MH, Dersch R, Fingerle V, Motschall E, Meerpohl JJ, Schmucker C: Efficacy and Safety of Antibiotic Therapy in Early Cutaneous Lyme Borreliosis: A Network Meta-analysis. Jama Dermatol, 2018; 154 (11): 1293-1303. : https://doi.org/10.1001/jamadermatol.2018.3186
  • Treppner M, Lenz S, Binder H, Zöller D: Modeling Activity Tracker Data Using Deep Boltzmann Machines. Studies in Health Technology and Informatics, 2018; 53: 155-159.
  • Uhlig J, Strauss A, Rücker G, Seif Amir Hosseini A, Lotz J, Trojan L, Kim HS, Uhlig A: Partial nephrectomy versus ablative techniques for small renal masses: a systematic review and network meta-analysis. Eur Radiol, 2018. : https://doi.org/10.1007/s00330-018-5660-3 (in Druck)
  • van der Kooi T, Sax H, Pittet D, van Dissel J, van Benthem B, Walder B, Cartier V, Clack L, de Greeff S, Wolkewitz M, Hieke S, Boshuizen H, van de Kassteele J, Van den Abeele A, Boo TW, Diab-Elschahawi M, Dumpis U, Ghita C, FitzGerald S, Lejko T, Leleu K, Martinez MP, Paniara O, Patyi M, Schab P, Raglio A, Szilágyi E, Ziętkiewicz M, Wu AW, Grundmann H, Zingg W, PROHIBIT consortium: Prevention of hospital infections by intervention and training (PROHIBIT): results of a pan-European cluster-randomized multicentre study to reduce central venous catheter-related bloodstream infections. Intens Care Med, 2018; 44: 48-60. : https://doi.org/10.1007/s00134-017-5007-6
  • Vlachojannis C, Chrubasik-Hausmann S, Hellwig E, Vach K, Al-Ahmad A: Activity of preparations from Spilanthes oleracea, propolis, Nigella sativa, and black garlic on different microorganisms involved in oral diseases and on total human salivary bacteria: A pilot study. Phytother Res, 2018; 32: 1992-2001. : https://doi.org/10.1002/ptr.6129
  • Vukovic E, Czerny M, Beyersdorf F, Wolkewitz M, Berezowski M, Siepe M, Blanke P, Rylski B: Abdominal aortic aneurysm neck remodeling after Anaconda stent graft implantation. J Vasc Surg, 2018; 68 (5): 1354-1359.e2. : http://dx.doi.org/10.1016/j.jvs.2018.02.041
  • Weibel S, Jelting Y, Pace NL, Rücker G, Raj D, Schaefer MS, Backhaus I, Kienbaum P, Eberhart LHJ, Kranke P: Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis. (Protocol). Cochrane Db Syst Rev, 2018; 11 (online): CD012859. : http://dx.doi.org/10.1002/14651858.CD012859 (in Druck)
  • Wengenmayer T, Duerschmied D, Graf E, Chiabudini M, Benk C, Mühlschlegel S, Philipp A, Lubnow M, Bode C, Staudacher DL: Development and validation of a prognostic model for survival in patients treated with venoarterial extracorporeal membrane oxygenation: the PREDICT VA-ECMO score. European Heart Journal: Acute Cardiovascular Care, 2018. : https://doi.org/10.1177/2048872618789052 (in Druck)
  • Wengenmayer T, Schroth F, Biever PM, Duerschmied D, Benk C, Trummer G, Kaier K, Bode C, Staudacher DL: Albumin fluid resuscitation in patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy is associated with improved survival. Intens Care Med, 2018; 44: 2312-2314. : https://doi.org/10.1007/s00134-018-5443-y
  • White IR, Kaptoge S, Royston P, Sauerbrei W, Emerging Risk Factors Collaboration: Meta-analysis of non-linear exposure-outcome relationships using individual participant data: A comparison of two methods. Stat Med, 2018. : https://doi.org/10.1002/sim.7974 (in Druck)
  • Wolf D, Tüscher O, Teipel S, Mierau A, Strüder H, Drzezga A, Baier B, Binder H, Fellgiebel A, German AgeGain study group: Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study. Trials, 2018; 19: 337. : https://doi.org/10.1186/s13063-018-2688-2
  • Wolff J, Heister T, Normann C, Kaier K: Hospital costs associated with psychiatric comorbidities: a retrospective study. Bmc Health Serv Res, 2018; 18 (online): 67. : https://doi.org/10.1186/s12913-018-2892-5
  • Wolkewitz M, Mandel M, Palomar-Martinez M, Alvarez-Lerma F, Olaechea-Astigarraga P, Schumacher M.: Methodological challenges in using point-prevalence versus cohort data in risk factor analyses of nosocomial infections. Ann Epidemiol, 2018; 28: 475-480. : https://doi.org/10.1016/j.annepidem.2018.03.017
Buchbeiträge:
Kurzbeiträge / short communications:
  • Boulesteix AL, Binder H, Abrahamowicz M, Sauerbrei W, Simulation Panel of the STRATOS Initiative: On the necessity and design of studies comparing statistical methods. Biometrical J, 2018; 60: 216-218. : https://doi.org/10.1002/bimj.201700129
  • Doerken S, Mandel M, Zingg W, Wolkewitz M: Use of prevalence data to study sepsis incidence and mortality in intensive care units. Lancet Infect Dis, 2018; 18 (3): 252-252. : http://dx.doi.org/10.1016/S1473-3099(18)30081-1
  • Heister T, Wolkewitz M, Kaier K: Determining the Attributable Costs of Clostridium difficile Infections When Exposure Time Is Lacking: Be Wary of "Conditioning on the Future". Infect Cont Hosp Ep, 2018; 39: 759-760. : https://doi.org/10.1017/ice.2018.42
  • Heister T, Wolkewitz M, Kaier K: Estimating the additional costs of surgical site infections: length bias, time-dependent bias, and conditioning on the future. J Hosp Infect, 2018; 99: 103-104. : https://doi.org/10.1016/j.jhin.2018.02.012
  • Kaier K, Wolkewitz M, Heister T: Estimating the attributable costs of hospital-acquired infections requires a distinct categorization of cases based on time of infection. Am J Infect Control, 2018; 46: 729. : https://doi.org/10.1016/j.ajic.2018.02.014
  • Rücker G, Schwarzer G: Contribution to the discussion of "When should meta-analysis avoid making hidden normality assumptions?" Biometrical J, 2018. : https://doi.org/10.1002/bimj.201800182 (in Druck)
  • Rücker G, Schwarzer G: Differences in the placebo response between trials do not necessarily preclude network meta‐analysis Acta Psychiat Scand, 2018. : https://doi.org/10.1111/acps.12974 (in Druck)
  • Sauerbrei w, Haeussler T: Comment on 'BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses'. Brit J Cancer, 2018; 118: 1152-1153. : https://doi.org/10.1038/s41416-018-0023-z
  • Stachon P, Zehender M, Bode C, von Zur Mühlen C, Kaier K: Development and In-Hospital Mortality of Transcatheter and Surgical Aortic Valve Replacement in 2015 in Germany. J Am Coll Cardiol, 2018; 72: 475-476. : https://doi.org/10.1016/j.jacc.2018.04.077
  • Veroniki AA, Straus SE, Rücker G, Tricco AC: Is providing uncertainty intervals in treatment ranking helpful in a network meta-analysis? J Clin Epidemiol, 2018; 100: 122-129. : https://doi.org/10.1016/j.jclinepi.2018.02.009
  • von Cube MK, Timsit JF, Sommer H, Darmon M, Schwebel C, Bailly S, Souweine B, Wolkewitz M: Relative risk and population-attributable fraction of ICU death caused by susceptible and resistant Pseudomonas aeruginosa ventilator-associated pneumonia: a competing risks approach to investigate the OUTCOMEREA database. Intens Care Med, 2018; 44 (7): 1177-1179. : http://dx.doi.org/10.1007/s00134-018-5109-9
  • Weber S, Wolkewitz M, Schumacher M: Analyzing the impact of depth of response on survival in patients with metastatic non-small-cell lung cancer. Ann Oncol, 2018; 29: 282-283. : https://doi.org/10.1093/annonc/mdx558
Konferenzbeiträge:
Sonstige Publikationen:
  • Blümle A, Lagreze WA, Motschall E: Systematische Literaturrecherche in PubMed. Eine Kurzanleitung. [Systematic literature search in PubMed. A short introduction]. Radiologe, 2018; 58 (9) : 855-872. : http://dx.doi.org/10.1007/s00117-018-0425-1
  • Blümle A, Lagreze WA, Motschall E: Systematische Literaturrecherche in PubMed. Eine Kurzanleitung. [Systematic literature search in PubMed : A short introduction]. Hno, 2018; 66 (8) : 631-648. : http://dx.doi.org/10.1007/s00106-018-0538-x
  • Blümle A, Lagreze WA, Motschall E: Systematische Literaturrecherche in PubMed. Eine Kurzanleitung. [Systematic literature search in PubMed : A short introduction]. Manuelle Medizin, 2018; 56 (4) : 281-292. : http://dx.doi.org/10.1007/s00337-018-0439-9
  • Blümle A, Lagreze WA, Motschall E: Systematische Literaturrecherche in PubMed. Eine Kurzanleitung. [Systematic literature search in PubMed : A short introduction]. Gefäßchirurgie, 2018; 23 (4) : 264-275. : http://dx.doi.org/10.1007/s00772-018-0373-0
  • Blümle A, Lagreze WA, Motschall E: Systematische Literaturrecherche in PubMed. Eine Kurzanleitung. [Systematic literature search in PubMed : A short introduction]. Schmerz, 2018. : http://dx.doi.org/10.1007/s00482-018-0334-2 (in Druck)
  • Blümle A, Lagreze WA, Motschall E: Systematische Literaturrecherche in PubMed. Eine Kurzanleitung. [Systematic literature search in PubMed : A short introduction]. Anaesthesist, 2018. : http://dx.doi.org/10.1007/s00101-018-0504-8 (in Druck)
  • Blümle A, Lagrèze WA, Motschall E: Systematische Literaturrecherche in PubMed. Eine Kurzanleitung. [Systematic literature search in PubMed. A short introduction]. Ophthalmologe, 2018; 115 (3) : 243-260. : http://dx.doi.org/10.1007/s00347-018-0659-3
  • Blümle A, Lagrèze WA, Motschall E: Systematische Literaturrecherche in PubMed. Eine Kurzanleitung. [Systematic literature search in PubMed. A short introduction]. Diabetologe, 2018; 14 (3) : 185-202. : http://dx.doi.org/10.1007/s11428-018-0334-y

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