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 Forschungsbericht für das Jahr 2019

Institut für Medizinische Biometrie und Statistik

Stefan-Meier-Strasse 26
79104 Freiburg
Tel: 0761 203 6662 Fax: 0761 203 6680
Email sec@imbi.uni-freiburg.de

Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. M. Schumacher
  • Prof. Dr. J. Schulte Mönting
  • Arthur Allignol
  • Dr. G. Antes
  • Dr. J. Beyersmann
  • Dr. H. Binder
  • Dr. Anette Blümle
  • D. Booker
  • Dipl.-Stat. Anika Buchholz
  • Dr. A. Caputo
  • Dr. J. Carpenter
  • Dr. Erik von Elm
  • Dipl.-Math. C. Gall
  • Dr. T. Gerds
  • Dipl.-Stat. A. Gerlach
  • Dr. E. Graf
  • Prof. Dr. Dieter Hauschke
  • Dr. G. Ihorst
  • Dr. B. Lang
  • Dr. Jörg Meerpohl
  • Dipl.-Stat. M. Olschewski
  • Dipl.-Stat. Christine Porzelius
  • Dipl.-Math. G. Rücker
  • PD Dr. W. Sauerbrei
  • Dr. C. Schmoor
  • Dr. Christine Schmucker
  • Dipl.-Math.Oec. R. Schoop
  • Dr. G. Schwarzer
  • Dipl.-Math. P. Sekula
  • Dipl.-Stat. S. Stampf
  • PD Dr. A. Timmer
  • Robert Wolff
  • Dr. M. Wolkewitz
Einträge in der Rubrik "Who is Who"


  • Biometrische Methodologie
  • Epidemiologische Studien
  • Klinische Studien
  • Multizentrische Therapiestudien

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Adebahr S, Hechtner M, Schräder N, Schimek-Jasch T, Kaier K, Rohr VD, Gkika E, Momm F, Gärtner J, Becker G, Grosu AL, Nestle U: Early impact of pulmonary stereotactic fractionated body radiotherapy (SBRT) on Quality of Life (QoL): Benefit for patients with low initial scores (STRIPE trial). J Thorac Oncol, 2019; 14: 708-419. : https://doi.org/10.1016/j.jtho.2018.10.170
  • Akhtar J, Kreim N, Marini F, Mohana G, Brüne D, Binder H, Roignant JY: Promoter-proximal pausing mediated by the exon junction complex regulates splicing. Nat Commun, 2019; 10 (online): 521. : https://doi.org/10.1038/s41467-019-08381-0
  • Al Said S, Alabed S, Kaier K, Bode C, Meerpohl JJ, Duerschmied D: Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis. Cochrane Db Syst Rev, 2019 ( 1) (online): CD013252. : https://doi.org/10.1002/14651858.CD013252.pub2
  • Asundi A, Beliavsky A, Liu XJ, Akaberi A, Schwarzer G, Bisoffi Z, Requena-Méndez A, Shrier I, Greenaway C: Prevalence of strongyloidiasis and schistosomiasis among migrants: a systematic review and meta-analysis. Lancet Glob Health, 2019; 7 (online): e236-e248. : https://doi.org/10.1016/S2214-109X(18)30490-X
  • Bagegni A, Abou-Ayash S, Rücker G, Algarny A, Att W: The influence of prosthetic material on implant and prosthetic survival of implant-supported fixed complete dentures: a systematic review and meta-analysis. J Prosthodont Res, 2019; 63: 251-265. : https://doi.org/10.1016/j.jpor.2019.02.001
  • Balduzzi S, Rücker G, Schwarzer G: How to perform a meta-analysis with R: a practical tutorial Evid Based Mental Health, 2019; 22: 153-160. : https://doi.org/10.1136/ebmental-2019-300117
  • Binder N, Balmford J, Schumacher M: A multi-state model based reanalysis of the Framingham Heart Study: Is dementia incidence really declining? Eur J Epidemiol, 2019; 34: 1075-1083. : https://doi.org/10.1007/s10654-019-00567-6
  • Binder N, Blümle A, Balmford J, Motschall E, Oeller P, Schumacher M: Cohort studies were found to be frequently biased by missing disease information due to death. J Clin Epidemiol, 2019; 105: 68-79. : https://doi.org/10.1016/j.jclinepi.2018.09.010
  • Blazhenets G, Ma Y, Sörensen A, Rücker G, Schiller F, Eidelberg D, Frings L, Meyer PT: Principal component analysis of brain metabolism predicts development of Alzheimer's dementia. J Nucl Med, 2019; 60: 837-843. : https://doi.org/10.2967/jnumed.118.219097
  • Borde JP, Kaier K, Hehn P, Böhmer MM, Kreusch TM, Dobler G: Tick-borne encephalitis virus infections in Germany. Seasonality and in-year patterns. A retrospective analysis from 2001-2018. Plos One, 2019; 14 (online): e0224044. : https://doi.org/10.1371/journal.pone.0224044
  • Brühmann BA, Reese C, Kaier K, Ott M, Maurer C, Kunert S, Saurer BR, Farin E: A complex health services intervention to improve medical care in long-term care homes: study protocol of the controlled coordinated medical care (CoCare) study. Bmc Health Serv Res, 2019; 19 (online): 332. : https://doi.org/10.1186/s12913-019-4156-4
  • Burchard T, Karygianni L, Hellwig E, Follo M, Wrbas T, Wittmer A, Vach K, Al-Ahmad A: Inactivation of oral biofilms using visible light and water-filtered infrared A radiation and indocyanine green. Future Med Chem, 2019; 11: 1721-1739. : https://doi.org/10.4155/fmc-2018-0522
  • Chaabane S, Harfouche M, Chemaitelly H, Schwarzer G, Abu-Raddad LJ: Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions. Sci Rep-uk, 2019; 9 (online): 1136. : https://doi.org/10.1038/s41598-018-37833-8
  • Clemens E, Meijer AJ, Broer L, Langer T, van der Kooi AL, Uitterlinden AG, de Vries A, Kuehni CE, Garrè ML, Kepak T, Kruseova J, Winther JF, Kremer LC, van Dulmen-den Broeder E, Tissing WJ, Rechnitzer C, Kenborg L, Hasle H, Grabow D, Parfitt R, Binder H, Carleton BC, Byrne J, Kaatsch P, Am Zehnhoff-Dinnesen A, Zolk O, van den Heuvel-Eibrink MM: Genetic Determinants of Ototoxicity During and After Childhood Cancer Treatment: Protocol for the PanCareLIFE Study. JMIR research protocols, 2019; 8 (online): e11868. : https://doi.org/10.2196/11868
  • Dammann P, Wittek P, Darkwah Oppong M, Hütter BO, Jabbarli R, Wrede K, Wanke I, Mönninghoff C, Kaier K, Frank B, Müller O, Kleinschnitz C, Forsting M, Sure U: Relative health-related quality of life after treatment of unruptured intracranial aneurysms: long-term outcomes and influencing factors. Ther Adv Neurol Diso, 2019; 12 (online). : https://doi.org/10.1177/1756286419833492
  • Darkwah Oppong M, Gembruch O, Pierscianek D, Köhrmann M, Kleinschnitz C, Deuschl C, Mönninghoff C, Kaier K, Forsting M, Sure U, Jabbarli R: Post-treatment Antiplatelet Therapy Reduces Risk for Delayed Cerebral Ischemia due to Aneurysmal Subarachnoid Hemorrhage. Neurosurgery, 2019; 85: 827-833. : https://doi.org/10.1093/neuros/nyy550
  • Das A, Roy B, Schwarzer G, Silverman MG, Ziegler O, Bandyopadhyay D, Philpotts LL, Sinha S, Blumenthal JA, Das S: Comparison of treatment options for depression in heart failure: A network meta-analysis. J Psychiatr Res, 2019; 108: 7-23. : https://doi.org/10.1016/j.jpsychires.2018.10.007
  • Dittrich S, Graf E, Trollmann R, Neudorf U, Schara U, Heilmann A, von der Hagen M, Stiller B, Kirschner J, Pozza RD, Müller-Felber W, Weiss K, von Au K, Khalil M, Motz R, Korenke C, Lange M, Wilichowski E, Pattathu J, Ebinger F, Wiechmann N, Schröder R, German Competence Network for Congenital Heart Defects, the Treat-NMD Neuromuscular Network Investigators list of additional local Investigators, co-workers of the German Competence Network for Congenital Heart Defects and the Treat-NMD Neuromuscular Network.: Effect and safety of treatment with ACEinhibitor Enalapril and β-blocker metoprolol on the onset of left ventricular dysfunction in Duchenne muscular dystrophy - a randomized, double-blind, placebocontrolled trial. Orphanet J Rare Dis, 2019; 14 (online): 105. : https://doi.org/10.1186/s13023-019-1066-9
  • Doerken S, Avalos M, Lagarde E, Schumacher M: Penalized logistic regression with low prevalence exposures beyond high dimensional settings. Plos One, 2019; 14 (online): e0217057. : https://doi.org/10.1371/journal.pone.0217057
  • Dudareva M, Kümin M, Vach W, Kaier K, Ferguson J, McNally M, Scarborough M: Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO): a randomised controlled open-label non-inferiority trial of duration of systemic antibiotics in adults with orthopaedic infection treated operatively with local antibiotic therapy. Trials, 2019; 20: 693. : https://doi.org/10.1186/s13063-019-3832-3
  • Eckert M, Vach W: Constructing treatment selection rules based on an estimated treatment effect function: different approaches to take stochastic uncertainty into account have a substantial effect on performance. Bmc Med Res Methodol, 2019; 19 (online): 168. : https://doi.org/10.1186/s12874-019-0805-x
  • Efthimiou O, Mavridis D, Nikolakopoulou A, Rücker G, Trelle S, Egger M, Salanti G: A model for meta-analysis ofcorrelated binary outcomes:The case of split-body interventions. Stat Methods Med Res, 2019; 28: 1998-2014. : https://doi.org/10.1177/0962280217746436
  • Efthimiou O, Rücker G, Schwarzer G, Higgins JPT, Egger M, Salanti G: Network meta-analysis of rare events using the Mantel-Haenszel method. Stat Med, 2019; 38: 2992-3012. : https://doi.org/10.1002/sim.8158
  • Essi R, Spraul M, Vach K, Hahn P: Influence of delayed light curing on the cuspal deflection and microleakage of a dual-cured composite resin in Class 2 restorations. Quintessence Int, 2019; 50: 94-102. : https://doi.org/10.3290/j.qi.a41706
  • Fecker J, Schumacher M, Ohneberg K, Wolkewitz M: Correction of Survival Bias in a Study About Increased Mortality of Heads of Government. Am Stat, 2019 (online): 1537-2731. : https://doi.org/10.1080/00031305.2019.1638831
  • Frank F, Bjerregaard F, Bengel J, Bitzer EM, Heimbach B, Kaier K, Kiekert J, Krämer L, Kricheldorff C, Laubner K, Maun A, Metzner G, Niebling W, Salm C, Schütter S, Seufert J, Farin E, Voigt-Radloff S: Local, collaborative, stepped and personalised care management for older people with chronic diseases (LoChro): study protocol of a randomised comparative effectiveness trial. Bmc Geriatr, 2019; 19 (online): 64. : https://doi.org/10.1186/s12877-019-1088-0
  • Geschke K, Weyer-Elberich V2, Mueller AK, Binder H, Fellgiebel A: Feasibility and utility of a cognitive screening for risk stratification in hospitalized older patients. Int J Geriatr Psych, 2019; 34: 588-593. : https://doi.org/10.1002/gps.5056
  • Goedeke J, Ertl A, Zöller D, Rohleder S, Muensterer OJ: Telemedicine for pediatric surgical outpatient follow-up: A prospective, randomized single-center trial. J Pediatr Surg, 2019; 1: 200-207. : https://doi.org/10.1016/j.jpedsurg.2018.10.014
  • Gomila A, Carratalà J, Eliakim-Raz N, Shaw E, Tebé C, Wolkewitz M, Wiegand I, Grier S, Vank C, Cuperus N, Van den Heuvel L, Vuong C, MacGowan A, Leibovici L, Addy I, Pujol M, & on behalf of RESCUING Study Group, Study Sites: Clinical outcomes of hospitalised patients with catheter-associated urinary tract infection in countries with a high rate of multidrug-resistance: the COMBACTE-MAGNET RESCUING study. Antimicrob Resist in, 2019; 8 (online): 198. : https://doi.org/10.1186/s13756-019-0656-6
  • Gonzalez AI, Schmucker C, Nothacker J, Motschall E, Nguyen TS, Brueckle MS, Blom J, van den Akker M, Rottger K, Wegwarth O, Hoffmann T, Straus SE, Gerlach FM, Meerpohl JJ, Muth C: Health-related preferences of older patients with multimorbidity: an evidence map. Bmj Open, 2019; 9 (12) (online): e034485-e034485. : http://dx.doi.org/10.1136/bmjopen-2019-034485
  • Graetz C, Gröger A, Luessi F, Salmen A, Zöller D, Schultz J, Siller N, Fleischer V, Bellenberg B, Berthele A, Biberacher V, Havla J, Hecker M, Hohlfeld R, Infante-Duarte C, Kirschke JS, Kümpfel T, Linker R, Paul F, Pfeuffer S, Sämann P, Toenges G, Weber F, Zettl UK, Jahn-Eimermacher A, Antony G, Groppa S, Wiendl H, Hemmer B, Mühlau M, Lukas C, Gold R, Lill CM, Zipp F: Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis. Mult Scler J, 2019; 25: 661-668. : https://doi.org/10.1177/1352458518763541
  • Groß V, Lücke C, Graf E, Lam AP, Matthies S, Borel P, Sobanski E, Rösler M, Retz W, Jacob C, Colla M, Huss M, Jans T, Kis B, Abdel-Hamid M, van Elst LT, Philipsen A, Comparison of Methylphenidate, Psychotherapy in Adult ADHD Study (COMPAS) Consortium: Effectiveness of Psychotherapy in Adult ADHD: What Do Patients Think? Results of the COMPAS Study. J Atten Disord, 2019; 23: 1047-1058. : https://doi.org/10.1177/1087054717720718
  • Hagel S, Ludewig K, Pletz MW, Frosinski J, Moeser A, Wolkewitz M, Gastmeier P, Harbarth S, Brunkhorst FM, Kesselmeier M, Scherag A: Effectiveness of a hospital-wide infection control programme on the incidence of healthcare-associated infections and associated severe sepsis and septic shock: a prospective interventional study. Clin Microbiol Infec, 2019; 25: 462-468. : https://doi.org/10.1016/j.cmi.2018.07.010
  • Harloff A, Hagenlocher P, Lodemann T, Hennemuth A, Weiller C, Hennig J, Vach W: Retrograde aortic blood flow as a mechanism of stroke: MR evaluation of the prevalence in a population-based study. Eur Radiol, 2019; 29: 5172-5179. : https://doi.org/10.1007/s00330-019-06104-z
  • Heister T, Wolkewitz M, Hehn P, Wolff J, Dettenkofer M, Grundmann H, Kaier K: Costs of hospital-acquired Clostridium difficile infections: an analysis on the effect of time-dependent exposures using routine and surveillance data. Cost Effectiveness and Resource Allocation, 2019; 17: 16. : https://doi.org/10.1186/s12962-019-0184-5
  • Hellwig S, Frings L, Bormann T, Vach W, Buchert R, Meyer PT: Amyloid imaging for differential diagnosis of dementia: incremental value compared to clinical diagnosis and [(18)F]FDG PET. Eur J Nucl Med Mol I, 2019; 46 (2): 312-323. : http://dx.doi.org/10.1007/s00259-018-4111-3
  • Hentschel R, Guenther K, Vach W, Bruder I: Risk-adjusted mortality of VLBW infants in high-volume versus low-volume NICUs. Arch Dis Child-fetal, 2019; 104: F390-F395. : https://doi.org/10.1136/archdischild-2018-314956
  • Herrmann AM, Meckel S, Gounis MJ, Kringe L, Motschall E, Mulling C, Boltze J: Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations. J Cerebr Blood F Met, 2019; 39: 375-394. : http://dx.doi.org/10.1177/0271678X19827446
  • Hertenstein E, Feige B, Gmeiner T, Kienzler C, Spiegelhalder K, Johann A, Jansson-Fröjmark M, Palagini L, Rücker G, Riemann D, Baglioni C: Insomnia as a predictor of mental disorders: A systematic review and meta-analysis. Sleep Med Rev, 2019; 43: 96-105. : https://doi.org/10.1016/j.smrv.2018.10.006
  • Hillemanns P, Friese K, Dannecker C, Klug S, Seifert U, Iftner T, Hädicke J, Löning T, Horn L, Schmidt D, Ikenberg H, Steiner M, Freitag U, Siebert U, Sroczynski G, Sauerbrei W, Beckmann MW, Gebhardt M, Friedrich M, Münstedt K, Schneider A, Kaufmann A, Petry KU, Schäfer APA, Pawlita M, Weis J, Mehnert A, Fehr M, Grimm C, Reich O, Arbyn M, Kleijnen J, Wesselmann S, Nothacker M, Follmann M, Langer T, Jentschke M: Prevention of Cervical Cancer: Guideline of the DGGG and the DKG (S3 Level, AWMF Register Number 015/027OL, December 2017) - Part 1 with Introduction, Screening and the Pathology of Cervical Dysplasia. Geburtsh Frauenheilk, 2019; 79: 148-159. : https://doi.org/10.1055/a-0818-5440
  • Hillemanns P, Friese K, Dannecker C, Klug S, Seifert U, Iftner T, Hädicke J, Löning T, Horn L, Schmidt D, Ikenberg H, Steiner M, Freitag U, Siebert U, Sroczynski G, Sauerbrei W, Beckmann MW, Gebhardt M, Friedrich M, Münstedt K, Schneider A, Kaufmann A, Petry KU, Schäfer APA, Pawlita M, Weis J, Mehnert A, Fehr M, Grimm C, Reich O, Arbyn M, Kleijnen J, Wesselmann S, Nothacker M, Follmann M, Langer T, Jentschke M: Prevention of Cervical Cancer: Guideline of the DGGG and the DKG (S3 Level, AWMF Register Number 015/027OL, December 2017) - Part 2 on Triage, Treatment and Follow-up. Geburtsh Frauenheilk, 2019; 79: 160-176. : https://doi.org/10.1055/a-0828-7722
  • Jabbarli R, Dinger TF, Pierscianek D, Oppong MD, Chen B, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Sure U: Intracranial aneurysms in sickle cell disease: A systematic review and case-control study. Curr Neurovasc Res, 2019; 16: 63-76. : https://doi.org/10.2174/1567202616666190131160847
  • Jabbarli R, Pierscianek D, Darkwah Oppong M, Sato T, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Roos A, Sure U: Laboratory biomarkers of delayed cerebral ischemia after subarachnoid hemorrhage: a systematic review. Neurosurg Rev, 2019 (online). : https://doi.org/10.1007/s10143-018-1037-y
  • Jabbarli R, Pierscianek D, Rölz R, Darkwah Oppong M, Kaier K, Shah M, Taschner C, Mönninghoff C, Urbach H, Beck J, Sure U, Forsting M: Endovascular treatment of cerebral vasospasm after subarachnoid hemorrhage: More is more. Neurology, 2019; 93 (online): e1-e9. : https://doi.org/10.1212/WNL.0000000000007862
  • Jaite C, van Noort BM, Vloet TD, Graf E, Kappel V, Geissler J, Warnke A, Jacob C, Groß-Lesch S, Hennighausen K, Haack-Dees B, Schneider-Momm K, Philipsen A, Matthies S, Rösler M, Retz W, Hänig S, von Gontard A, Sobanski E, Alm B, Hohmann S, Häge A, Poustka L, Colla M, Gentschow L, Freitag CM, Becker K, Jans T: A multicentre randomized controlled trial on trans-generational attention deficit/hyperactivity disorder (ADHD) in mothers and children (AIMAC): an exploratory analysis of predictors and moderators of treatment outcome. Z Kinder Jug-psych, 2019; 47: 49-65. : https://doi.org/10.1024/1422-4917/a000602
  • Jilg CA, Drendel V, Rischke HC, Beck TI, Reichel K, Kronig M, Wetterauer U, Schultze-Seemann W, Meyer PT, Vach W: Detection Rate of (18)F-Choline PET/CT and (68)Ga-PSMA-HBED-CC PET/CT for Prostate Cancer Lymph Node Metastases with Direct Link from PET to Histopathology: Dependence on the Size of Tumor Deposits in Lymph Nodes. J Nucl Med, 2019; 60 (7): 971-977. : http://dx.doi.org/10.2967/jnumed.118.220541
  • Kaier K, Heister T, Götting T, Wolkewitz M, Mutters NT: Measuring the in-hospital costs of Pseudomonas aeruginosa pneumonia: methodology and results from a German teaching hospital. Bmc Infect Dis, 2019; 19 (online): 1028. : https://doi.org/10.1186/s12879-019-4660-5
  • Kaier K, Heister T, Motschall E, Hehn P, Bluhmki T, Wolkewitz M: Impact of mechanical ventilation on the daily costs of ICU care: a systematic review and meta regression. Epidemiol Infect, 2019; 147 (online): e314. : https://doi.org/10.1017/S0950268819001900
  • Kaier K, von Zur Mühlen C, Zirlik A, Bothe W, Hehn P, Zehender M, Bode C, Stachon P: Estimating the additional costs per life saved due to transcatheter aortic valve replacement: a secondary data analysis of electronic health records in Germany. Eur J Health Econ, 2019; 20: 625-632. : https://doi.org/10.1007/s10198-018-1023-x
  • Kalisch R, Cramer AOJ, Binder H, Fritz J, Leertouwer I, Lunansky G, Meyer B, Timmer J, Veer IM, van Harmelen AL: Deconstructing and Reconstructing Resilience: A Dynamic Network Approach. Perspect Psychol Sci, 2019; 14: 765-777. : https://doi.org/10.1177/1745691619855637
  • Khadr L, Harfouche M, Omori R, Schwarzer G, Chemaitelly H, Abu-Raddad LJ: The Epidemiology of Herpes Simplex Virus Type 1 in Asia: Systematic Review, Meta-analyses, and Meta-regressions. Clin Infect Dis, 2019; 68: 757-772. : https://doi.org/10.1093/cid/ciy562
  • Kitzmann J, Ratka-Krueger P, Vach K, Woelber JP: The impact of motivational interviewing on communication of patients undergoing periodontal therapy. J Clin Periodontol, 2019; 46: 40-750. : https://doi.org/10.1111/jcpe.13132
  • Koeber G, Oberwittler D: How older people became less afraid of crime—An age-period-cohort analysis using repeated cross-sectional survey data. Soc Sci Res, 2019; 79: 221-225. : https://doi.org/10.1016/j.ssresearch.2018.10.010
  • Kreutz C: Guidelines for benchmarking of optimization-based approaches for fitting mathematical models. Genome Biol, 2019; 20 (online): 281. : https://doi.org/10.1186/s13059-019-1887-9
  • Kruse AB, Akakpo DL, Maamar R, Woelber JP, Al-Ahmad A, Vach K, Ratka-Krueger P: Trehalose powder for subgingival air-polishing during periodontal maintenance therapy: A randomized controlled trial. J Periodontol, 2019; 90: 263-270. : https://doi.org/10.1002/JPER.17-0403
  • Küllenberg de Gaudry D, Lohner S, Schmucker C, Kapp P, Motschall E, Hörrlein S, Roger C, Meerpohl JJ: Milk A1 beta-casein and health-related outcomes in humans: a systematic review. Nutr Rev, 2019; 77: 278-306. : http://dx.doi.org/10.1093/nutrit/nuy063
  • Lam AP, Matthies S, Graf E, Colla M, Jacob C, Sobanski E, Alm B, Rösler M, Retz W, Retz-Junginger P, Kis B, Abdel-Hamid M, Müller HHO, Lücke C, Huss M, Jans T, Berger M, van Elst LT, Philipsen A, for the Comparison of Methylphenidate, Psychotherapy in Adult ADHD Study (COMPAS) Consortium: Long-term Effects of Multimodal Treatment on Adult Attention-Deficit/Hyperactivity Disorder Symptoms. Follow-up Analysis of the COMPAS Trial JAMA Netw Open, 2019; 2: e194980. : http://dx.doi.org/10.1001/jamanetworkopen.2019.4980
  • Marini F, Binder H: pcaExplorer: an R/Bioconductor package for interacting with RNA-seq principal components. Bmc Bioinformatics, 2019; 20 (online): 331. : https://doi.org/10.1186/s12859-019-2879-1
  • Merz J, Schwarzer G, Gerger H: Comparative Efficacy and Acceptability of Pharmacological, Psychotherapeutic, and Combination Treatments in Adults With Posttraumatic Stress Disorder: A Network Meta-analysis. Jama Psychiat, 2019; 76: 904-913. : https://doi.org/10.1001/jamapsychiatry.2019.0951
  • Mockenhaupt M, Wang CW, Hung SI, Sekula P, Schmidt AH, Pan RY, Chen CB, Dunant A, Gouvello SL, Schumacher M, Valeyrie-Allanore L, Bellon T, Kardaun SH, Jan YS, Chung WH, Roujeau JC, RegiSCAR group: HLA-B*57:01 confers genetic susceptibility to carbamazepine-induced SJS/TEN in Europeans. Allergy, 2019; 74: 2227-2230. : https://doi.org/10.1111/all.13821
  • Nieters A, Blagitko-Dorfs N, Peter HH, Weber S: Psychophysiological insomnia and respiratory tract infections: results of an infection-diary-based cohort study. Sleep, 2019; 42 (online): zsz098. : https://doi.org/10.1093/sleep/zsz098
  • Ohneberg K, Beyersmann J, Schumacher M: Exposure density sampling: Dynamic matching with respect to a time-dependent exposure. Stat Med, 2019; 38: 4390-4403. : https://doi.org/10.1002/sim.8305
  • Olivier M, Boeker M, Hanser S, Hehn P, Kaier K: Der Pflegekomplexmaßnahmen-Score: Paradigmenwechsel im G-DRG System oder Tropfen auf den heißen Stein? Eine Sekundäranalyse auf Basis von Abrechnungsdaten. Gesundheitsökonomie & Qualitätsmanagement, 2019; 24: 191-196. : http://dx.doi.org/10.1055/a-0659-1706
  • Peikert A, Kaier K, Merz J, Manhart L, Schäfer I, Hilgendorf I, Hehn P, Wolf D, Willecke F, Sheng X, Clemens A, Zehender M, von Zur Mühlen C, Bode C, Zirlik A, Stachon P: Residual inflammatory risk in coronary heart disease: incidence of elevated high-sensitive CRP in a real-world cohort. Clin Res Cardiol, 2019 (online). : https://doi.org/10.1007/s00392-019-01511-0
  • Peikert S, Spurzem W, Vach K, Frisch E, Ratka-Krüger P, Woelber JP: Association of non-surgical periodontal therapy on patients' oral health related quality-of-life - a multi-center cohort study. J Clin Periodontol, 2019; 46: 529-538. : https://doi.org/10.1111/jcpe.13093
  • Perperoglou A, Sauerbrei W, Abrahamowicz M, Schmid M: A review of spline function procedures in R. Bmc Med Res Methodol, 2019; 19 (online): 46. : https://doi.org/10.1186/s12874-019-0666-3
  • Ponto KA, Scharrer I, Binder H, Korb C, Rosner AK, Ehlers TO, Rieser N, Grübel NC, Rossmann H, Wild PS, Feltgen N, Pfeiffer N, Mirshahi A: Hypertension and multiple cardiovascular risk factors increase the risk for retinal vein occlusions: results from the Gutenberg Retinal Vein Occlusion Study. J Hypertens, 2019; 37: 1372-1383. : https://doi.org/10.1097/HJH.0000000000002057
  • Prasse A, Binder H, Schupp JC, Kayser G, Bargagli E, Jaeger B, Hess M, Rittinghausen S, Vuga L, Lynn H, Violette S, Jung B, Quast K, Vanaudenaerde B, Xu Y, Hohlfeld JM, Krug N, Herazo-Maya JD, Rottoli P, Wuyts WA, Kaminski N: BAL Cell Gene Expression is Indicative of Outcome and Airway Basal Cell Involvement in IPF. Am J Resp Crit Care, 2019; 199: 622-630. : https://doi.org/10.1164/rccm.201712-2551OC
  • Proksch S, Kirsch K, Vach K, Hellwig E, Tomakidi P: Comparative differentiation analysis of distinct oral tissue-derived cells in response to osteogenic stimulation. Clin Oral Invest, 2019; 23: 1077-1089. : https://doi.org/10.1007/s00784-018-2529-4
  • Rieg S, von Cube M, Kaasch A, Bonaventura B, Bothe W, Wolkewitz M, Peyerl-Hoffmann G, Deppe AC, Wahlers T, Beyersdorf F, Seifert H, Kern WV: Investigating the impact of early valve surgery on survival in Staphylococcus aureus infective endocarditis using a marginal structural model approach - results of a large prospectively evaluated cohort. Clin Infect Dis, 2019; 69: 487-494. : https://doi.org/10.1093/cid/ciy908
  • Ritter A, Hirschfeld M, Berner K, Rücker G, Jäger M, Weiss D, Medl M, Nöthling C, Gassner S, Asberger J, Erbes T: Circulating non‑coding RNA‑biomarker potential in neoadjuvant chemotherapy of triple negative breast cancer? Int J Oncol, 2019 (online): 47-68. : https://doi.org/10.3892/ijo.2019.4920
  • Schmidtmann I, Konstantinides S, Binder H: Power of the Wilcoxon–Mann–Whitney test for non‐inferiority in the presence of death‐censored observations. Biometrical J, 2019; 61: 1187-1200. : https://doi.org/10.1002/bimj.201700296
  • Schmucker C, Kapp P, Motschall E, Loehler J, Meerpohl JJ: Prevalence of hearing loss and use of hearing aids among children and adolescents in Germany: a systematic review. Bmc Public Health, 2019; 19 (1) (online): 1277. : http://dx.doi.org/10.1186/s12889-019-7602-7
  • Schöpf AC, Vach W, Jakob M, Saxer F: Routine patient surveys: Patients' preferences and information gained by healthcare providers. Plos One, 2019; 14 (online): e0220495. : https://doi.org/10.1371/journal.pone.0220495
  • Schubert I, Siegel A, Graf E, Farin-Glattacker E, Ihle P, Köster I, Stelzer D, Mehl C, Schmitz J, Dröge P, Günster C, Klöss A, Vach W, Geraedts M: Study protocol for a quasi-experimental claims-based study evaluating 10-year results of the population-based integrated healthcare model ‘Gesundes Kinzigtal’ (Healthy Kinzigtal): the INTEGRAL study. Bmj Open, 2019; 9: e025945. : http://dx.doi.org/10.1136/bmjopen-2018-025945
  • Schulz J, Takousis P, Wohlers I, Itua IOG, Dobricic V, Rücker G, Binder H, Middleton L, Ioannidis JPA, Perneczky R, Bertram L, Lill CM: Meta-analyses identify differentially expressed microRNAs in Parkinson's disease. Ann Neurol, 2019; 85: 835-851. : https://doi.org/10.1002/ana.25490
  • Schwarzer G, Chemaitelly H, Abu-Raddad LJ, Rücker G: Seriously misleading results using inverse of Freeman‐Tukey double arcsine transformation in meta‐analysis of single proportions. Res Synth Methods, 2019; 10: 476-483. : https://doi.org/10.1002/jrsm.1348
  • Schweitzer VA, van Heijl I, van Werkhoven CH, Islam J, Hendriks-Spoor KD, Bielicki J, Bonten MJM, Walker AS, Llewelyn MJ, Consensus on Antimicrobial Stewardship Evaluations (CASE) study group., Collaborators:, Harbarth S, Huttner B, Little P, Rodriguez-Baño J, Savoldi A, van Smeden M, Tacconelli E, Timsit JF, Wolkewitz M.: The quality of studies evaluating antimicrobial stewardship interventions: a systematic review. Clin Microbiol Infec, 2019; 25: 555-561. : https://doi.org/10.1016/j.cmi.2018.11.002
  • Schwingshackl L, Krause M, Schmucker C, Hoffmann G, Rücker G, Meerpohl JJ: Impact of different types of olive oil on cardiovascular risk factors: A systematic review and network meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases, 2019; 29: 1030-1039. : https://doi.org/10.1016/j.numecd.2019.07.001
  • Schwingshackl L, Schwarzer G, Rücker G, Meerpohl JJ: Perspective: Network Meta-analysis Reaches Nutrition Research: Current Status, Scientific Concepts, and Future Directions. Adv Nutr, 2019; 10: 739-754. : https://doi.org/10.1093/advances/nmz036
  • Shim SR, Kim SJ, Lee J, Rücker G: Network Meta-analysis: Application and Practice using R software. Epidemiology and Health, 2019; 41 (online): e2019013-. : https://doi.org/10.4178/epih.e2019013
  • Sörensen A, Blazhenets G, Rücker G, Schiller F, Meyer PT, Frings L, Alzheimer's Disease Neuroimaging Initiative.: Prognosis of conversion of mild cognitive impairment to Alzheimer's dementia by voxel-wise Cox regression based on FDG PET data. Neuroimage-clin, 2019; 21 (online): 101637. : https://doi.org/10.1016/j.nicl.2018.101637
  • Spies BC, Balmer M, Jung RE, Sailer I, Vach K, Kohal RJ: All-ceramic single crowns supported by zirconia implants: 5-year results of a prospective multicenter study. Clin Oral Implan Res, 2019; 30: 466-475. : https://doi.org/10.1111/clr.13433
  • Sprinzl MF, Kirstein MM, Koch S, Seib M-L, Weinmann-Menke J, Lang H, Düber C, Toenges G, Zöller D, Marquardt JU, Wörns M-A, Galle PR, Vogel A, Pinter M, Weinmann A: Improved Prediction of Survival by a Risk Factor-Integrating Inflammatory Score in Sorafenib-Treated Hepatocellular Carcinoma. Liver Cancer, 2019 (online). : http://dx.doi.org/10.1159/000492628
  • Stachon P, Kaier K, Zirlik A, Bothe W, Heidt T, Zehender M, Bode C, von Zur Mühlen C: Risk-Adjusted Comparison of In-Hospital Outcomes of Transcatheter and Surgical Aortic Valve Replacement. J Am Heart Assoc, 2019; 8 (online): e011504. : https://doi.org/10.1161/JAHA.118.011504
  • Steiert B, Kreutz C, Raue A, Timmer J: Recipes for Analysis of Molecular Networks Using the Data2Dynamics Modeling Environment. Methods in Molecular Biology, 2019; 1945: 341-362. : https://doi.org/10.1007/978-1-4939-9102-0_16
  • Stelzer A-S, Maccioni L, Gerhold-Ay A, Smedby KE, Schumacher M, Nieters A, Binder H: A multivariable approach for riskmarkers from pooled molecular data withonly partial overlap. Bmc Med Genet, 2019; 20 (online): 128. : https://doi.org/10.1186/s12881-019-0849-0
  • Tacconelli E, Sifakis F, Harbarth S, Schrijver R, van Mourik M, Voss A, Sharland M, Rajendran NB, Rodriguez-Bano, Wolkewitz M, J Group Author(s): EPI-Net COMBACTE-MAGNET. Surveillance for control of antimicrobial resistance. Lancet Infect Dis, 2019; 18 (online): E99-E106. : http://dx.doi.org/10.1016/S1473-3099(17)30485-1
  • Tchorz JP, Wrbas KT, Von See C, Vach K, Patzelt SBM: Accuracy of Software-Based Three-Dimensional Root Canal Length Measurements Using Cone-Beam Computed Tomography European endodontic journal, 2019; 4: 28-32. : http://dx.doi.org/10.14744/eej.2018.46320
  • Tibubos AN, Ernst M, Brähler E, Fischbeck S, Hinz A, Blettner M, Zeissig SR, Weyer V, Imruck BH, Binder H, Beutel ME: Fatigue in survivors of malignant melanoma and its determinants: a register-based cohort study. Support Care Cancer, 2019; 27: 2809-2818. : https://doi.org/10.1007/s00520-018-4587-1
  • Toews I, Lohner S, Küllenberg de Gaudry D, Sommer H, Meerpohl JJ: Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies. Bmj-brit Med J, 2019; 364 (online): k4718 . : https://doi.org/10.1136/bmj.k4718
  • Tönsing C, Timmer J, Kreutz C: Optimal Paths Between Parameter Estimates in Non-linear ODE Systems Using the Nudged Elastic Band Method. Frontiers in Physics, 2019; 7 (online): 149. : https://doi.org/10.3389/fphy.2019.00149
  • Uhlig J, Strauss A, Rücker G, Seif Amir Hosseini A, Lotz J, Trojan L, Kim HS, Uhlig A: Partial nephrectomy versus ablative techniques for small renal masses: a systematic review and network meta-analysis. Eur Radiol, 2019; 29: 1293-1307. : https://doi.org/10.1007/s00330-018-5660-3
  • Voigt-Radloff S, Schöpf AC, Boeker M, Frank L, Farin E, Kaier K, Körner M, Wollmann K, Lang B, Meerpohl JJ, Möhler R, Niebling W, Serong J, Lange R, van der Keylen P, Maun A: Well informed physician-patient communication in consultations on back pain - study protocol of the cluster randomized GAP trial. Bmc Fam Pract, 2019; 20 (online): 33. : https://doi.org/10.1186/s12875-019-0925-8
  • Volkmann A, De Bin R, Sauerbrei W, Boulesteix AL: A plea for taking all available clinical information into account when assessing the predictive value of omics data. Bmc Med Res Methodol, 2019; 19 (online): 162. : https://doi.org/10.1186/s12874-019-0802-0
  • Vollmer A, Al-Ahmad A, Argyropoulou A, Thurnheer T, Hellwig E, Attin T, Vach K, Wittmer A, Ferguson K, Skaltsounis AL, Karygianni L: Antimicrobial Photoinactivation Using Visible Light Plus Water-Filtered Infrared-A (VIS + wIRA) and Hypericum Perforatum Modifies In Situ Oral Biofilms. Sci Rep-uk, 2019; 9: 20325. : https://doi.org/10.1038/s41598-019-56925-7
  • von Cube M, Schumacher M, Bailly S, Timsit JF, Lepape A, Savey A, Machut A, Wolkewitz M: The population-attributable fraction for time-dependent exposures and competing risks-A discussion on estimands. Stat Med, 2019; 38: 3880-3895. : https://doi.org/10.1002/sim.8208
  • Walther LE, Lohler J, Agrawal Y, Motschall E, Schubach F, Meerpohl JJ, Schmucker C: Evaluating the Diagnostic Accuracy of the Head-Impulse Test: A Scoping Review. Jama Otolaryngol, 2019; 145: 550-560. : http://dx.doi.org/10.1001/jamaoto.2019.0243
  • Wengenmayer T, Duerschmied D, Graf E, Chiabudini M, Benk C, Mühlschlegel S, Philipp A, Lubnow M, Bode C, Staudacher DL: Development and validation of a prognostic model for survival in patients treated with venoarterial extracorporeal membrane oxygenation: the PREDICT VA-ECMO score. European Heart Journal: Acute Cardiovascular Care, 2019; 8: 350-359. : https://doi.org/10.1177/2048872618789052
  • White IR, Kaptoge S, Royston P, Sauerbrei W, Emerging Risk Factors Collaboration: Meta-analysis of non-linear exposure-outcome relationships using individual participant data: A comparison of two methods. Stat Med, 2019; 38: 326-338. : https://doi.org/10.1002/sim.7974
  • Woelber JP, Gärtner M, Breuninger L, Anderson A, König D, Hellwig E, Al-Ahmad A, Vach K, Dötsch A, Ratka-Krüger P, Tennert C: The influence of an anti-inflammatory diet on gingivitis. A randomized controlled trial. J Clin Periodontol, 2019; 46: 481-490. : https://doi.org/10.1111/jcpe.13094
  • Wolkewitz M, Palomar-Martinez M, Alvarez-Lerma F, Olaechea-Astigarraga P, Schumacher M: Analyzing the impact of duration of ventilation, hospitalization, and ventilation episodes on the risk of pneumonia. Infect Cont Hosp Ep, 2019; 40: 301-306. : https://doi.org/10.1017/ice.2018.360
  • Wolkewitz M, Schumacher M, Rücker G, Harbarth S, Beyersmann J: Estimands to quantify prolonged hospital stay associated with nosocomial infections. Bmc Med Res Methodol, 2019; 19 (online): 111. : https://doi.org/10.1186/s12874-019-0752-6
  • Zamboglou C, Carles M, Fechter T, Kiefer S, Reichel K, Fassbender TF, Bronsert P, Koeber G, Schilling O, Ruf J, Werner M, Jilg CA, Baltas D, Mix M, Grosu AL: Radiomic features from PSMA PET for non-invasive intraprostatic tumor discrimination and characterization in patients with intermediate- and high-risk prostate cancer - a comparison study with histology reference. Theranostics, 2019; 13: 2595-2605. : https://doi.org/10.7150/thno.32376
  • Zotzmann V, Rilinger J, Lang CN, Kaier K, Benk C, Duerschmied D, Biever PM, Bode C, Wengenmayer T, Staudacher DL: Epinephrine, inodilator, or no inotrope in venoarterial extracorporeal membrane oxygenation implantation: a single-center experience. Crit Care, 2019; 23 (online): 320. : https://doi.org/10.1186/s13054-019-2605-4
Kurzbeiträge / short communications:
  • Becker E, Orellana Rios CL, Lahmann C, Rücker G, Bauer J, Boeker M: Anxiety as a risk factor of Alzheimer's disease and vascular dementia - ERRATUM. Brit J Psychiat, 2019; 214: 174. : https://doi.org/10.1192/bjp.2018.228
  • Kaier K, Bode C, Zehender M, von Zur Mühlen C, Stachon P: Modeling the Volume-Outcome Relationship for TAVR. J Am Coll Cardiol, 2019; 74: 2115-2116. : https://doi.org/10.1016/j.jacc.2019.08.999
  • Kaier K, Mutters NT, Wolkewitz M: Measuring the financial burden of resistance: What should be compared? Clin Infect Dis, 2019; 69: 1082. : https://doi.org/10.1093/cid/ciz096
  • Khadr L, Harfouche M, Omori R, Schwarzer G, Chemaitelly H, Abu-Raddad LJ: Reply to Brijwal et al. Clin Infect Dis, 2019; 68: 1784. : http://10.1093/cid/ciy944
  • Ohneberg K, Wolkewitz M, Schumacher M: RE: "Risk Set Matching to Assess the Impact of Hospital-Acquired Bloodstream Infections." Am J Epidemiol, 2019; 188: 1192-1193. : https://doi.org/10.1093/aje/kwz035
  • Rücker G: This design is even more complex than it is accounted for in the protocol. Bmj Open, 2019; 9 (online).
  • Wong Y, Hysi P, Cheung G, Tedja M, Hoang QV, Tompson SWJ, Whisenhunt KN, Verhoeven VJM, Zhao W, Hess M, Wong CW, Kifley A, Hosoda Y, Haarman AEG, Hopf S, Laspas P, Sensaki S, Sim X, Miyake M, Tsujikawa A, Lamoureux E, Ohno-Matsui K, Nickels S, Mitchell P, Wong TY, Wang JJ, Hammond CJ, Barathi VA, Cheng CY, Yamashiro K, Young TL, Klaver CCW, Saw SM, Consortium of Refractive Error, Myopia (CREAM).: Correction: Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium. Plos One, 2019; 14 (online): e0223942. : https://doi.org/10.1371/journal.pone.0223942
  • Wong YL, Hysi P, Cheung G, Tedja M, Hoang QV, Tompson SWJ, Whisenhunt KN, Verhoeven V, Zhao W, Hess M, Wong CW, Kifley A, Hosoda Y, Haarman AEG, Hopf S, Laspas P, Sensaki S, Sim X, Miyake M, Tsujikawa A, Lamoureux E, Ohno-Matsui K, Nickels S, Mitchell P, Wong TY, Wang JJ, Hammond CJ, Barathi VA, Cheng CY, Yamashiro K, Young TL, Klaver CCW, Saw SM, Consortium of Refractive Error, Myopia (CREAM): Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium. Plos One, 2019; 14 (online): e0220143. : https://doi.org/10.1371/journal.pone.0220143
Sonstige Publikationen:
  • Blümle A, Lagreze WA, Motschall E: Systematische Literaturrecherche in PubMed. Eine Kurzanleitung. [Systematic literature search in PubMed : A short introduction]. Schmerz, 2019; 33: 75-92. : http://dx.doi.org/10.1007/s00482-018-0334-2
  • Blümle A, Lagreze WA, Motschall E: Systematische Literaturrecherche in PubMed. Eine Kurzanleitung. [Systematic literature search in PubMed : A short introduction]. Z Rheumatol, 2019; 78 (2) : 155-172. : http://dx.doi.org/10.1007/s00393-019-0603-1
  • Blümle A, Sow D, Nothacker M, Schaefer C, Motschall E, Boeker M, Lang B, Kopp I, Meerpohl JJ: Manual systematische Recherche für Evidenzsynthesen und Leitlinien. Version 2.0 vom 01.04.2019 2019. : http://dx.doi.org/10.6094/UNIFR/149324

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