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 Forschungsbericht für das Jahr 2018

Department für Medizinische Mikrobiologie und Hygiene

Institut für Virologie

Hermann-Herder-Strasse 11
79104 Freiburg
Tel: +49 761 203 6534 Fax: +49 761 203 6626
http://www.virologie.uniklinik-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Hartmut Hengel, Ärztlicher Direktor
  • Prof. Dr. Dieter Neumann-Haefelin
  • Prof. Dr. Georg Bauer
  • Prof. Dr. Otto Haller
  • Prof. Dr. Georg Kochs
  • Prof. Dr. Marcus Panning
  • Prof. Dr. Martin Schwemmle
  • Prof. Dr. Peter Stäheli
  • Dr. Valeria Falcone-Kapper
  • Dr. Daniela Huzly
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Orthomyxoviren (Influenza- und Thogotoviren)
  • Pneumoviren
  • Bornaviren.
  • Bunyaviren
  • IFN-induzierte Mx-Proteine und Virusabwehr.
  • Virale Strategien zur Ausschaltung der Wirtsabwehr.
  • Zytokine und antivirale Immunantwort.
  • HCMV-Pathogenese.
  • Kontrolle der Onkogenese durch reaktive Sauerstoffspezies.

Wissenschaftliche Projekte und Forschungsvorhaben


  • Analyse der Zytokinprofile bei Patienten mit akuten und chronischen viralen Infekten.
  • Charakterisierung von Pathogenitätsfaktoren von Pneumoviren
  • Identification and functional characterization of cellular interaction partners of the ribonucleoprotein complex of Borna Disease Virus
  • Interaction of SARS-Coronavirus and bunyaviruses with the interferon system
  • Interferon-Antagonisten als Pathogenitätsfaktoren bei hämorrhagischen Fieberviren.
  • Model of BDV-induced neurodevelopmental damage of hippocampal cells by altered neuronal connectivity of granule cells.
  • Respiratory-Syncytial-Virus(RSV)-Antigen-exprimierende Streptokokken: Immunisierung durch temporäre Besiedlung von Schleimhäuten?
  • Reverse Genetics of Bunyaviruses

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Bauer G: Autoamplificatory singlet oxygen generation sensitizes tumor cells for intercellular apoptosis-inducing signaling Mech Ageing Dev, 2018; 172: 59-77. : https://doi.org/10.1016/j.mad.2017.11.005
  • Bernasconi V, Bernocchi B, Ye L, Le MQ, Omokanye A, Carpentier R, Schon K, Saelens X, Staeheli P, Betbeder D, Lycke N: Porous Nanoparticles With Self-Adjuvanting M2e-Fusion Protein and Recombinant Hemagglutinin Provide Strong and Broadly Protective Immunity Against Influenza Virus Infections. Front Immunol, 2018; 9: 2060-2060. : http://dx.doi.org/10.3389/fimmu.2018.02060
  • Dalhoff K, Abele-Horn M, Andreas S, Deja M, Ewig S, Gastmeier P, Gatermann S, Gerlach H, Grabein B, Heussel CP, Hoffken G, Kolditz M, Kramme E, Kuhl H, Lange C, Mayer K, Nachtigall I, Panning M, Pletz M, Rath PM, Rohde G, Rosseau S, Schaaf B, Schreiter D, Schutte H, Seifert H, Spies C, Welte T: [Epidemiology, Diagnosis and Treatment of Adult Patients with Nosocomial Pneumonia - Update 2017 - S3 Guideline of the German Society for Anaesthesiology and Intensive Care Medicine, the German Society for Infectious Diseases, the German Society for Hygiene and Microbiology, the German Respiratory Society and the Paul-Ehrlich-Society for Chemotherapy, the German Radiological Society and the Society for Virology]. Pneumologie, 2018; 72 (1): 15-63. : http://dx.doi.org/10.1055/s-0043-121734
  • Ehrmann S, Ruyts SC, Scherer-Lorenzen M, Bauhus J, Brunet J, Cousins SAO, Deconchat M, Decocq G, De Frenne P, De Smedt P, Diekmann M, Gallet-Moron E, Gartner S, Hansen K, Kolb A, Lenoir J, Lindgren J, Naaf T, Paal T, Panning M, Prinz M, Valdes A, Verheyen K, Wulf M, Liira J: Habitat properties are key drivers of Borrelia burgdorferi (s.l.) prevalence in Ixodes ricinus populations of deciduous forest fragments. Parasite Vector, 2018; 11 (1): 23-23. : http://dx.doi.org/10.1186/s13071-017-2590-x
  • Fritz M, Berger B, Schemmerer M, Endres D, Wenzel JJ, Stich O, Panning M: Pathological Cerebrospinal Fluid Findings in Patients With Neuralgic Amyotrophy and Acute Hepatitis E Virus Infection. J Infect Dis, 2018; 217 (12): 1897-1901. : http://dx.doi.org/10.1093/infdis/jiy128
  • Graf L, Dick A, Sendker F, Barth E, Marz M, Daumke O, Kochs G: Effects of allelic variations in the human myxovirus resistance protein A on its antiviral activity. J Biol Chem, 2018; 293 (9): 3056-3072. : http://dx.doi.org/10.1074/jbc.M117.812784
  • Haas DA, Meiler A, Geiger K, Vogt C, Preuss E, Kochs G, Pichlmair A: Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity. Plos Pathog, 2018; 14 (4): e1006980-e1006980. : http://dx.doi.org/10.1371/journal.ppat.1006980
  • Haller O, Arnheiter H, Pavlovic J, Staeheli P: The Discovery of the Antiviral Resistance Gene Mx: A Story of Great Ideas, Great Failures, and Some Success. Annu Rev Virol, 2018; 5 (1): 33-51. : http://dx.doi.org/10.1146/annurev-virology-092917-043525
  • Held J, Schweizer H, Zange S, Panning M, Kern WV, Wagner D: Photo Quiz: Pneumonia and Pyogenic Skin Abscesses in a 79-Year-Old Man. J Clin Microbiol, 2018; 56 (2). : http://dx.doi.org/10.1128/JCM.03352-15
  • Held J, Schweizer H, Zange S, Panning M, Kern WV, Wagner D: Answer to February 2018 Photo Quiz. J Clin Microbiol, 2018; 56 (2): 1-2. : http://dx.doi.org/10.1128/JCM.03353-15
  • Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, Pichlmair A: Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nat Immunol, 2018; 19 (2): 130-140. : http://dx.doi.org/10.1038/s41590-017-0013-y
  • Horn J, Damm O, Greiner W, Hengel H, Kretzschmar ME, Siedler A, Ultsch B, Weidemann F, Wichmann O, Karch A, Mikolajczyk RT: Influence of demographic changes on the impact of vaccination against varicella and herpes zoster in Germany - a mathematical modelling study. Bmc Med, 2018; 16 (1): 3-3. : http://dx.doi.org/10.1186/s12916-017-0983-5
  • Jorgensen SE, Christiansen M, Ryo LB, Gad HH, Gjedsted J, Staeheli P, Mikkelsen JG, Storgaard M, Hartmann R, Mogensen TH: Defective RNA sensing by RIG-I in severe influenza virus infection. Clin Exp Immunol, 2018; 192 (3): 366-376. : http://dx.doi.org/10.1111/cei.13120
  • Khosa S, Scholz R, Schwarz C, Trilling M, Hengel H, Jaeger KE, Smits SHJ, Schmitt L: An A/U-Rich Enhancer Region Is Required for High-Level Protein Secretion through the HlyA Type I Secretion System. Appl Environ Microb, 2018; 84 (1): 15-20. : http://dx.doi.org/10.1128/AEM.01163-17
  • Kiener R, Fleischmann M, Schwegler C, Ruzsics Z, Thirion C, Schrodel S, Asbach B, Wagner R: Vaccine vectors based on Adenovirus 19a/64 exhibit broad cellular tropism and potently restimulate HCMV-specific T cell responses ex vivo. Sci Rep-uk, 2018; 8 (1): 1474-1474. : http://dx.doi.org/10.1038/s41598-018-19874-1
  • Klambt V, Panning M, Seidl M, Haffner K, Pohl M: Ribavirin therapy of hepatitis E infection may cause hyporegenerative anemia in pediatric renal transplant patients. Pediatr Transplant, 2018; 22 (4): e13195-e13195. : http://dx.doi.org/10.1111/petr.13195
  • Klinkhammer J, Schnepf D, Ye L, Schwaderlapp M, Gad HH, Hartmann R, Garcin D, Mahlakoiv T, Staeheli P: IFN-lambda prevents influenza virus spread from the upper airways to the lungs and limits virus transmission. Elife, 2018; 7: 1-18. : http://dx.doi.org/10.7554/eLife.33354
  • Koestner W, Spanier J, Klause T, Tegtmeyer PK, Becker J, Herder V, Borst K, Todt D, Lienenklaus S, Gerhauser I, Detje CN, Geffers R, Langereis MA, Vondran FWR, Yuan Q, van Kuppeveld FJM, Ott M, Staeheli P, Steinmann E, Baumgartner W, Wacker F, Kalinke U: Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice. Plos Pathog, 2018; 14 (8): e1007235-e1007235. : http://dx.doi.org/10.1371/journal.ppat.1007235
  • Kolpe A, Schepens B, Ye L, Staeheli P, Saelens X: Passively transferred M2e-specific monoclonal antibody reduces influenza A virus transmission in mice. Antivir Res, 2018; 158: 244-254. : http://dx.doi.org/10.1016/j.antiviral.2018.08.017
  • Luxenburger H, Grass F, Baermann J, Boettler T, Marget M, Emmerich F, Panning M, Thimme R, Nitschke K, Neumann-Haefelin C: Differential virus-specific CD8(+) T-cell epitope repertoire in hepatitis C virus genotype 1 versus 4. J Viral Hepatitis, 2018; 25: 779-790. : http://dx.doi.org/10.1111/jvh.12874
  • Mathe P, Egah DZ, Muller JA, Shehu NY, Obishakin ET, Shwe DD, Pam VC, Okolo MO, Yilgwan C, Gomerep SS, Fuchs J, Abok I, Onyedibe KI, Olugbo EJ, Isa SE, Machunga-Mambula SS, Attah CJ, Munch J, Oguche S, Panning M: Low Zika virus seroprevalence among pregnant women in North Central Nigeria, 2016. J Clin Virol, 2018; 105: 35-40. : http://dx.doi.org/10.1016/j.jcv.2018.05.011
  • Meier K, Jaguva Vasudevan AA, Zhang Z, Bahr A, Kochs G, Haussinger D, Munk C: Equine MX2 is a restriction factor of equine infectious anemia virus (EIAV). Virology, 2018; 523: 52-63. : http://dx.doi.org/10.1016/j.virol.2018.07.024
  • Metelmann H-R, Seebauer C, Miller V, Fridman A, Bauer G, Graves DB, Pouvesle J-M, Rutkowski R, Schuster M, Bekeschus S, Wende K, Masur K, Hasse S, Gerling T, Hori M, Tanaka H, Choi EH, Weltmann K-D, Metelmann PH, von Hoff DD, von Woedtke T: Clinical Experience with Cold Plasma in the Treatment of Locally Advanced Head and Neck Cancer Clinical Plasma Medicine, 2018; 9: 6-13.
  • Rattay S, Graf D, Kislat A, Homey B, Herebian D, Haussinger D, Hengel H, Zimmermann A, Schupp AK: Anti-inflammatory consequences of bile acid accumulation in virus-infected bile duct ligated mice. Plos One, 2018; 13 (6): e0199863-e0199863. : http://dx.doi.org/10.1371/journal.pone.0199863
  • Schilling M, Bulli L, Weigang S, Graf L, Naumann S, Patzina C, Wagner V, Bauersfeld L, Goujon C, Hengel H, Halenius A, Ruzsics Z, Schaller T, Kochs G: Human MxB Protein Is a Pan-herpesvirus Restriction Factor. J Virol, 2018; 92 (17): 1056-1058. : http://dx.doi.org/10.1128/JVI.01056-18
  • Schuster M, Rutkowski R, Hauschild A, Shojaei RK, von Woedtke T, Rana A, Bauer G, Metelmann P, Seebauer C: Side effects in cold plasma treatment of advanced oral cancer-Clinical data and biological interpretation Clinical Plasma Medicine, 2018; 10: 9-15.
  • Torelli F, Zander S, Ellerbrok H, Kochs G, Ulrich RG, Klotz C, Seeber F: Recombinant IFN-gamma from the bank vole Myodes glareolus: a novel tool for research on rodent reservoirs of zoonotic pathogens. Sci Rep-uk, 2018; 8 (1): 2797-2797. : http://dx.doi.org/10.1038/s41598-018-21143-0
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:
Buchbeiträge:

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten

Promotionen
  • Hassan, Ebrahim: MxA represents a decisive species barrier against influenza viruses in vivo, 2018.