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 Forschungsbericht für das Jahr 2017

Department für Medizinische Mikrobiologie und Hygiene

Institut für Virologie

Hermann-Herder-Strasse 11
79104 Freiburg
Tel: +49 761 203 6534 Fax: +49 761 203 6626
http://www.virologie.uniklinik-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Hartmut Hengel, Ärztlicher Direktor
  • Prof. Dr. Dieter Neumann-Haefelin
  • Prof. Dr. Georg Bauer
  • Prof. Dr. Otto Haller
  • Prof. Dr. Georg Kochs
  • Prof. Dr. Marcus Panning
  • Prof. Dr. Martin Schwemmle
  • Prof. Dr. Peter Stäheli
  • Dr. Valeria Falcone-Kapper
  • Dr. Daniela Huzly
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Orthomyxoviren (Influenza- und Thogotoviren)
  • Pneumoviren
  • Bornaviren.
  • Bunyaviren
  • IFN-induzierte Mx-Proteine und Virusabwehr.
  • Virale Strategien zur Ausschaltung der Wirtsabwehr.
  • Zytokine und antivirale Immunantwort.
  • HCMV-Pathogenese.
  • Kontrolle der Onkogenese durch reaktive Sauerstoffspezies.

Wissenschaftliche Projekte und Forschungsvorhaben


  • Analyse der Zytokinprofile bei Patienten mit akuten und chronischen viralen Infekten.
  • Charakterisierung von Pathogenitätsfaktoren von Pneumoviren
  • Identification and functional characterization of cellular interaction partners of the ribonucleoprotein complex of Borna Disease Virus
  • Interaction of SARS-Coronavirus and bunyaviruses with the interferon system
  • Interferon-Antagonisten als Pathogenitätsfaktoren bei hämorrhagischen Fieberviren.
  • Model of BDV-induced neurodevelopmental damage of hippocampal cells by altered neuronal connectivity of granule cells.
  • Respiratory-Syncytial-Virus(RSV)-Antigen-exprimierende Streptokokken: Immunisierung durch temporäre Besiedlung von Schleimhäuten?
  • Reverse Genetics of Bunyaviruses

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Amarasinghe GK, Bao Y, Basler CF, Bavari S, Beer M, Bejerman N, Blasdell KR, Bochnowski A, Briese T, Bukreyev A, Calisher CH, Chandran K, Collins PL, Dietzgen RG, Dolnik O, Durrwald R, Dye JM, Easton AJ, Ebihara H, Fang Q, Formenty P, Fouchier RAM, Ghedin E, Harding RM, Hewson R, Higgins CM, Hong J, Horie M, James AP, Jiang D, Kobinger GP, Kondo H, Kurath G, Lamb RA, Lee B, Leroy EM, Li M, Maisner A, Muhlberger E, Netesov SV, Nowotny N, Patterson JL, Payne SL, Paweska JT, Pearson MN, Randall RE, Revill PA, Rima BK, Rota P, Rubbenstroth D, Schwemmle M, Smither SJ, Song Q, Stone DM, Takada A, Terregino C, Tesh RB, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Volchkov VE, Wahl-Jensen V, Walker PJ, Wang B, Wang D, Wang F, Wang LF, Werren JH, Whitfield AE, Yan Z, Ye G, Kuhn JH: Taxonomy of the order Mononegavirales: update 2017. Arch Virol, 2017; 162 (8): 2493-2504. : http://dx.doi.org/10.1007/s00705-017-3311-7
  • Bailer SM, Funk C, Riedl A, Ruzsics Z: Herpesviral vectors and their application in oncolytic therapy, vaccination, and gene transfer. Virus Genes, 2017; 53: 741-748. : http://dx.doi.org/10.1007/s11262-017-1482-7
  • Bauer G: siRNA-based Analysis of the Abrogation of the Protective Function of Membrane-associated Catalase of Tumor Cells. Anticancer Res, 2017; 37 (2): 567-581. : http://dx.doi.org/10.21873/anticanres.11350
  • Bauer G: Central Signaling Elements of Intercellular Reactive Oxygen/Nitrogen Species-dependent Induction of Apoptosis in Malignant Cells. Anticancer Res, 2017; 37 (2): 499-513. : http://dx.doi.org/10.21873/anticanres.11342
  • Bauer G: Targeting protective catalase of tumor cells with cold atmospheric plasma-treated medium (PAM). Anti-cancer Agent Me, 2017 (online). : http://dx.doi.org/10.2174/1871520617666170801103708
  • Bauer G: Signal amplification by tumor cells: clue to the understanding of the antitumor effects of cold atmospheric plasma and plasma-activated medium IEEE Transactions on Radiation and Plasma Medical Sciences, 2017; 1 (6): 1-12.
  • Bauer G: HOCl and the control of oncogenesis J Inorg Biochem, 2017 (online). : http://doi:10.1016/j.jinorgbio.2017.11.005
  • Bauer G: Autoamplificatory singlet oxygen generation sensitizes tumor cells for intercellular apoptosis-inducing signaling Mech Ageing Dev, 2017 (online). : https://doi.org/10.1016/j.mad.2017.11.005
  • Beug ST, Beauregard CE, Healy C, Sanda T, St-Jean M, Chabot J, Walker DE, Mohan A, Earl N, Lun X, Senger DL, Robbins SM, Staeheli P, Forsyth PA, Alain T, LaCasse EC, Korneluk RG: Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma. Nat Commun, 2017; 8 (online). : http://dx.doi.org/10.1038/ncomms14278
  • Chen Y, Zhang L, Graf L, Yu B, Liu Y, Kochs G, Zhao Y, Gao S: Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET. Nat Commun, 2017; 8: 15744-15744. : http://dx.doi.org/10.1038/ncomms15744
  • Ciminski K, Thamamongood T, Zimmer G, Schwemmle M: Novel insights into bat influenza A viruses. J Gen Virol, 2017; 98 (10): 2393-2400. : http://dx.doi.org/10.1099/jgv.0.000927
  • Coch C, Stumpel JP, Lilien-Waldau V, Wohlleber D, Kummerer BM, Bekeredjian-Ding I, Kochs G, Garbi N, Herberhold S, Schuberth-Wagner C, Ludwig J, Barchet W, Schlee M, Hoerauf A, Bootz F, Staeheli P, Hartmann G, Hartmann E: RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection. Mol Ther, 2017; 25 (9): 2093-2103. : http://dx.doi.org/10.1016/j.ymthe.2017.07.003
  • Deeg CM, Hassan E, Mutz P, Rheinemann L, Gotz V, Magar L, Schilling M, Kallfass C, Nurnberger C, Soubies S, Kochs G, Haller O, Schwemmle M, Staeheli P: In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein. J Exp Med, 2017; 214 (5): 1239-1248. : http://dx.doi.org/10.1084/jem.20161033
  • Fiebig U, Holzer A, Ivanusic D, Plotzki E, Hengel H, Neipel F, Denner J: Antibody Cross-Reactivity between Porcine Cytomegalovirus (PCMV) and Human Herpesvirus-6 (HHV-6). Viruses-basel, 2017; 9 (11): 1-13. : http://dx.doi.org/10.3390/v9110317
  • Giese S, Ciminski K, Bolte H, Moreira EA, Lakdawala S, Hu Z, David Q, Kolesnikova L, Gotz V, Zhao Y, Dengjel J, Chin YE, Xu K, Schwemmle M: Role of influenza A virus NP acetylation on viral growth and replication. Nat Commun, 2017; 8 (1): 1259-1259. : http://dx.doi.org/10.1038/s41467-017-01112-3
  • Graul S, Bottcher S, Eibach D, Krumkamp R, Kasmaier J, Adu-Sarkodie Y, May J, Tannich E, Panning M: High diversity of human parechovirus including novel types in stool samples from Ghanaian children. J Clin Virol, 2017; 96: 116-119. : http://dx.doi.org/10.1016/j.jcv.2017.10.008
  • Herberhold S, Hellmich M, Panning M, Bartok E, Silling S, Akgul B, Wieland U: Human polyomavirus and human papillomavirus prevalence and viral load in non-malignant tonsillar tissue and tonsillar carcinoma. Med Microbiol Immun, 2017; 206 (2): 93-103. : http://dx.doi.org/10.1007/s00430-016-0486-6
  • Heyd R, Eis-Hubinger AM, Berger A, Bierbaum S, Pietzonka S, Wenzel JJ, Huzly D, Keppler OT, Panning M: Retrospective analysis of clinical and virological parameters of influenza cases at four university hospitals in Germany, 2015. Infection, 2017; 45 (3): 349-354. : http://dx.doi.org/10.1007/s15010-017-1008-1
  • Khosa S, Scholz R, Schwarz C, Trilling M, Hengel H, Jaeger KE, Smits SHJ, Schmitt L: An A/U-rich enhancer region is required for high-level protein secretion through the HlyA Type I secretion system. Appl Environ Microb, 2017; 84 (1): 1-14. : http://dx.doi.org/10.1128/AEM.01163-17
  • Kruger H, Bauer G: Lactobacilli enhance reactive oxygen species-dependent apoptosis-inducing signaling. Redox Biol, 2017; 11: 715-724. : http://dx.doi.org/10.1016/j.redox.2017.01.015
  • Matschulla T, Berry R, Gerke C, Doring M, Busch J, Paijo J, Kalinke U, Momburg F, Hengel H, Halenius A: A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle. Sci Rep-uk, 2017; 7 (1): 2933-2933. : http://dx.doi.org/10.1038/s41598-017-02994-5
  • Metelmann H-R, Seebauer C, Miller V, Fridman A, Bauer G, Graves DB, Pouvesle J-M, Rutkowski R, Schuster M, Bekeschus S, Wende K, Masur K, Hasse S, Gerling T, Hori M, Tanaka H, Choi EH, Weltmann K-D, Metelmann PH, von Hoff DD, von Woedtke T: Clinical Experience with Cold Plasma in the Treatment of Locally Advanced Head and Neck Cancer Clinical Plasma Medicine, 2017 (online). : http://doi. org/10.1016/j.cpme.2017.09.001
  • Niller HH, Bauer G: Epstein-Barr Virus: Clinical Diagnostics. Methods Mol Biol, 2017; 1532: 33-55. : http://dx.doi.org/10.1007/978-1-4939-6655-4_2
  • Panning, M: Zika Virus Serology: More Diagnostic Targets, more Reliable Answers? EBioMedicine, 2017; 16: 12-13.
  • Postler TS, Clawson AN, Amarasinghe GK, Basler CF, Bavari S, Benko M, Blasdell KR, Briese T, Buchmeier MJ, Bukreyev A, Calisher CH, Chandran K, Charrel R, Clegg CS, Collins PL, Juan Carlos T, Derisi JL, Dietzgen RG, Dolnik O, Durrwald R, Dye JM, Easton AJ, Emonet S, Formenty P, Fouchier RAM, Ghedin E, Gonzalez JP, Harrach B, Hewson R, Horie M, Jiang D, Kobinger G, Kondo H, Kropinski AM, Krupovic M, Kurath G, Lamb RA, Leroy EM, Lukashevich IS, Maisner A, Mushegian AR, Netesov SV, Nowotny N, Patterson JL, Payne SL, PaWeska JT, Peters CJ, Radoshitzky SR, Rima BK, Romanowski V, Rubbenstroth D, Sabanadzovic S, Sanfacon H, Salvato MS, Schwemmle M, Smither SJ, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Volchkov VE, Wahl-Jensen V, Walker PJ, Wang LF, Varsani A, Whitfield AE, Zerbini FM, Kuhn JH: Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials. Syst Biol, 2017; 66 (3): 463-473. : http://dx.doi.org/10.1093/sysbio/syw096
  • Prinz M, Fuchs J, Ehrmann S, Scherer-Lorenzen M, Kochs G, Panning M: Molecular identification of novel phlebovirus sequences in European ticks. Ticks Tick-borne Dis, 2017; 8 (5): 795-798. : http://dx.doi.org/10.1016/j.ttbdis.2017.06.005
  • Pupuleku A, Costa-Garcia M, Farre D, Hengel H, Angulo A, Muntasell A, Lopez-Botet M: Elusive Role of the CD94/NKG2C NK Cell Receptor in the Response to Cytomegalovirus: Novel Experimental Observations in a Reporter Cell System. Front Immunol, 2017; 8: 1317-1317. : http://dx.doi.org/10.3389/fimmu.2017.01317
  • Rahn E, Thier K, Petermann P, Rubsam M, Staeheli P, Iden S, Niessen CM, Knebel-Morsdorf D: Epithelial Barriers in Murine Skin during Herpes Simplex Virus 1 Infection: The Role of Tight Junction Formation. J Invest Dermatol, 2017; 137 (4): 884-893. : http://dx.doi.org/10.1016/j.jid.2016.11.027
  • Romania P, Cifaldi L, Pignoloni B, Starc N, D'Alicandro V, Melaiu O, Li Pira G, Giorda E, Carrozzo R, Bergvall M, Bergstrom T, Alfredsson L, Olsson T, Kockum I, Seppala I, Lehtimaki T, Hurme MA, Hengel H, Santoni A, Cerboni C, Locatelli F, D'Amato M, Fruci D: Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion. Cell Rep, 2017; 20 (4): 846-853. : http://dx.doi.org/10.1016/j.celrep.2017.06.084
  • Runge S, Olbert M, Herden C, Malberg S, Romer-Oberdorfer A, Staeheli P, Rubbenstroth D: Viral vector vaccines protect cockatiels from inflammatory lesions after heterologous parrot bornavirus 2 challenge infection. Vaccine, 2017; 35 (online): 557-563. : http://dx.doi.org/10.1016/j.vaccine.2016.12.022
  • Santhakumar D, Rubbenstroth D, Martinez-Sobrido L, Munir M: Avian Interferons and Their Antiviral Effectors. Front Immunol, 2017; 8: 49-49. : http://dx.doi.org/10.3389/fimmu.2017.00049
  • Schnepf D, Staeheli P: License to kill: IFN-lambda regulates antifungal activity of neutrophils. Sci Immunol, 2017; 2 (17): 1-2. : http://dx.doi.org/10.1126/sciimmunol.aap9614
  • Teske L, Rubbenstroth D, Meixner M, Liere K, Bartels H, Rautenschlein S: Identification of a novel aviadenovirus, designated pigeon adenovirus 2 in domestic pigeons (Columba livia). Virus Res, 2017; 227: 15-22. : http://dx.doi.org/10.1016/j.virusres.2016.09.024
  • Van den Hoecke S, Ehrhardt K, Kolpe A, El Bakkouri K, Deng L, Grootaert H, Schoonooghe S, Smet A, Bentahir M, Roose K, Schotsaert M, Schepens B, Callewaert N, Nimmerjahn F, Staeheli P, Hengel H, Saelens X: Hierarchical and Redundant Roles of Activating FcgammaRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies. J Virol, 2017; 91 (7): 1-13. : http://dx.doi.org/10.1128/JVI.02500-16
  • van Eijk JJJ, Dalton HR, Ripellino P, Madden RG, Jones C, Fritz M, Gobbi C, Melli G, Pasi E, Herrod J, Lissmann RF, Ashraf HH, Abdelrahim M, Masri OABAL, Fraga M, Benninger D, Kuntzer T, Aubert V, Sahli R, Moradpour D, Blasco-Perrin H, Attarian S, Gerolami R, Colson P, Giordani MT, Hartl J, Pischke S, Lin NX, Mclean BN, Bendall RP, Panning M, Peron JM, Kamar N, Izopet J, Jacobs BC, van Alfen N, van Engelen BGM: Clinical phenotype and outcome of hepatitis E virus-associated neuralgic amyotrophy. Neurology, 2017; 89 (9): 909-917. : http://dx.doi.org/10.1212/WNL.0000000000004297
  • Wiese-Posselt M, Siedler A, Mankertz A, Sauerbrei A, Hengel H, Wichmann O, Poethko-Muller C: Varicella-zoster virus seroprevalence in children and adolescents in the pre-varicella vaccine era, Germany. Bmc Infect Dis, 2017; 17 (1): 356-356. : http://dx.doi.org/10.1186/s12879-017-2461-2
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:
Buchbeiträge:
  • Bauer G: Helicobacter and Reactive Oxygen Species In: Gastrointestinal tissue. Oxidative stress and dietary antioxidants, 1. Auflage. London: Academic Press, 2017; 81-96.
Fallbeispiele:
  • Miernik B, Casetti F, Panning M, Huzly D, Meyer H, Technau-Hafsi K: Multilocular Facial Necrosis in a Young Boy: A Quiz. Acta Derm-venereol, 2017; 97 (2): 299-301. : http://dx.doi.org/10.2340/00015555-2499
Sonstige Publikationen:
  • Siedler A, Koch J, Ultsch B, Garbe E, von Kries R, Ledig T, Mertens T, Überla K, Zepp F, Hengel H: Background paper to the decision not to recommend a standard vaccination with the live attenuated herpes zoster vaccine for the elderly in Germany Bundesgesundheitsbla, 2017; 60: 1162-1179.

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten

Promotionen
  • Ehrhardt, Katrin: Analysis of activating Fc gamma receptors and IgG subclasses in the mouse model of cytomegalovirus infection, 2017.
  • Stader, Barbara: Charakterisierung der antiviralen Aktivität der myxovirus resistance (Mx) Proteine von Nagetieren, 2017.
Master
  • Adam, Julia: Generation of authentic and chimeric replication competent bat Influenza A-like reporter viruses, 2017.
  • Schwaderlapp, Marilena: Identifying Epithelial Cells in the Upper Respiratory Tract of Mice that Rely on IFN-λ for Antiviral Defense, 2017.
Bachelor
  • Becker, Jan: TSLP – link between IFN-λ and the adaptive immune system?, 2017.
  • Kessler, Susanne: Establishing Reverse Genetics for Avian Bornaviruses, 2017.
  • Polcik, Laura: The impact of Tyrosine Kinase 2 deficiency on Interferon Type I and Type III signaling, 2017.
  • Sinning, Katrin: Establishment of methods for chIFN-λ detection, 2017.