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 Forschungsbericht für das Jahr 2017

Department für Radiologische Diagnostik und Therapie

Klinik für Nuklearmedizin

Hugstetter Strasse 55
79106 Freiburg
Tel: +49 761 / 270 39160 Fax: +49 761 / 270 39300
Email sek.nuklearmedizin@uniklinik-freiburg.de
http://www.uniklinik-freiburg.de/nuklearmedizin/live/index.html


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. med. Dr. nat. med. Philipp T. Meyer, Ärztlicher Direktor
  • Prof. Dr. rer. nat. Helmut R. Maecke, Gastprofessor (m/w), Radiopharmazie
  • Dr. rer. nat. Michael Mix, Leitender Medizinphysiker
  • Prof. Dr. med. Juri Ruf, Leitender Oberarzt
  • Dr. rer. nat. Mark Daniel Bartholomä, Radiopharmazie
  • Dr. med. Christian Goetz, Klinische Forschung
  • Dipl.-Biol. Friederike Braun, Radiopharmazie
  • Dipl.-Phys. Ursula Christ, Medizinphysik
  • Dr. med. Hans Christian Rischke, Klinische Forschung
Einträge in der Rubrik "Who is Who"

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Endres D, Vry MS, Dykierek P, Riering AN, Lungen E, Stich O, Dersch R, Venhoff N, Erny D, Mader I, Meyer PT, Tebartz van Elst L: Plasmapheresis Responsive Rapid Onset Dementia with Predominantly Frontal Dysfunction in the Context of Hashimoto's Encephalopathy. Front Psychiatry, 2017; 8: 212-212. : http://dx.doi.org/10.3389/fpsyt.2017.00212
  • Genseke P, Rogasch JM, Steffen IG, Neumann G, Apostolova I, Ruf J, Rissmann A, Wiemann D, Liehr UB, Schostak M, Amthauer H, Furth C: Detection of obstructive uropathy and assessment of differential renal function using two functional magnetic resonance urography tools. A comparison with diuretic renal scintigraphy in infants and children. Nuklearmed-nucl Med, 2017; 56 (1): 39-46. : http://dx.doi.org/10.3413/Nukmed-0833-16-06
  • Goetz C, Podein M, Braun F, Weber WA, Choquet P, Constantinesco A, Mix M: Influence of animal heating on PET imaging quantification and kinetics: results on the biodistribution of 18F-tetrafluoroborate and 18F-FDG in mice. J Nucl Med, 2017; 58 (7): 1162-1166. : http://dx.doi.org/10.2967/jnumed.116.177949
  • Gourni E, Del Pozzo L, Bartholoma M, Kiefer Y, T Meyer P, Maecke HR, Holland JP: Radiochemistry and Preclinical PET Imaging of 68Ga-Desferrioxamine Radiotracers Targeting Prostate-Specific Membrane Antigen. Mol Imaging, 2017; 16: 1536012117737010-1536012117737010. : http://dx.doi.org/10.1177/1536012117737010
  • Grosser OS, Wissel H, Wallbaum T, Genseke P, Kupitz D, Ricke J, Ruf J, Amthauer H: Extraction of 223Radium by haemodialysis after treatment of metastatic castration-resistant prostate cancer. Nuklearmed, 2017; 56 (3): 69-72. : http://dx.doi.org/10.3413/Nukmed-0874-16-12
  • Hutterer M, Ebner Y, Riemenschneider MJ, Willuweit A, McCoy M, Egger B, Schroder M, Wendl C, Hellwig D, Grosse J, Menhart K, Proescholdt M, Fritsch B, Urbach H, Stockhammer G, Roelcke U, Galldiks N, Meyer PT, Langen KJ, Hau P, Trinka E: Epileptic Activity Increases Cerebral Amino Acid Transport Assessed by 18F-Fluoroethyl-l-Tyrosine Amino Acid PET: A Potential Brain Tumor Mimic. J Nucl Med, 2017; 58 (1): 129-137. : http://dx.doi.org/10.2967/jnumed.116.176610
  • Jilg CA, Drendel V, Rischke HC, Beck T, Vach W, Schaal K, Wetterauer U, Schultze-Seemann W, Meyer PT: Diagnostic Accuracy of Ga-68-HBED-CC-PSMA-Ligand-PET/CT before Salvage Lymph Node Dissection for Recurrent Prostate Cancer. Theranostics, 2017; 7 (6): 1770-1780. : http://dx.doi.org/10.7150/thno.18421
  • Lappchen T, Tonnesmann R, Eersels J, Meyer PT, Maecke HR, Rylova SN: Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake. Plos One, 2017; 12 (1): e0170435-e0170435. : http://dx.doi.org/10.1371/journal.pone.0170435
  • Meyer PT, Frings L, Rucker G, Hellwig S: 18F-FDG PET in Parkinsonism: Differential Diagnosis and Cognitive Impairment in Parkinson's disease. J Nucl Med, 2017. : http://dx.doi.org/10.2967/jnumed.116.186403
  • Popp I, Del Pozzo L, Waser B, Reubi JC, Meyer PT, Maecke HR, Gourni E: Approaches to improve metabolic stability of a statine-based GRP receptor antagonist. Nucl Med Biol, 2017; 45: 22-29. : http://dx.doi.org/10.1016/j.nucmedbio.2016.11.004
  • Rahbar K, Ahmadzadehfar H, Kratochwil C, Haberkorn U, Schafers M, Essler M, Baum RP, Kulkarni HR, Schmidt M, Drzezga A, Bartenstein P, Pfestroff A, Luster M, Lutzen U, Marx M, Prasad V, Brenner W, Heinzel A, Mottaghy FM, Ruf J, Meyer PT, Heuschkel M, Eveslage M, Bogemann M, Fendler WP, Krause BJ: German Multicenter Study Investigating 177Lu-PSMA-617 Radioligand Therapy in Advanced Prostate Cancer Patients. J Nucl Med, 2017; 58 (1): 85-90. : http://dx.doi.org/10.2967/jnumed.116.183194
  • Rauschendorf MA, Jost M, Stock F, Zimmer A, Rosler B, Rijntjes M, Piroth T, Coenen VA, Reinacher PC, Meyer PT, Frings L, Weiller C, Fischer J, Klebe S: Novel compound heterozygous synaptojanin-1 mutation causes l-dopa-responsive dystonia-parkinsonism syndrome. Movement Disord, 2017; 32 (3): 478-480. : http://dx.doi.org/10.1002/mds.26876
  • Reubi JC, Waser B, Macke H, Rivier J: Highly Increased 125I-JR11 Antagonist Binding In Vitro Reveals Novel Indications for sst2 Targeting in Human Cancers. J Nucl Med, 2017; 58 (2): 300-306. : http://dx.doi.org/10.2967/jnumed.116.177733
  • Schiller F, Fechter T, Zamboglou C, Chirindel A, Salman N, Jilg CA, Drendel V, Werner M, Meyer PT, Grosu AL, Mix M: Comparison of PET/CT and whole-mount histopathology sections of the human prostate: a new strategy for voxel-wise evaluation. EJNMMI Phys, 2017; 4 (1): 21-21. : http://dx.doi.org/10.1186/s40658-017-0188-1
  • Schmidtke A, Lappchen T, Weinmann C, Bier-Schorr L, Keller M, Kiefer Y, Holland JP, Bartholoma MD: Gallium Complexation, Stability, and Bioconjugation of 1,4,7-Triazacyclononane Derived Chelators with Azaheterocyclic Arms. Inorg Chem, 2017; 56 (15): 9097-9110. : http://dx.doi.org/10.1021/acs.inorgchem.7b01129
  • Steinberg J, Amirabadi NE, Frings A, Mehlan J, Katz T, Linke SJ: Keratoconus Screening With Dynamic Biomechanical In Vivo Scheimpflug Analyses: A Proof-of-Concept Study. J Refract Surg, 2017; 33 (11): 773-778. : http://dx.doi.org/10.3928/1081597X-20170807-02
  • Stoykow C, Huber-Schumacher S, Almanasreh N, Jilg C, Ruf J: Strong PSMA Radioligand Uptake by Rectal Carcinoma: Who Put the "S" in PSMA? Clin Nucl Med, 2017; 42 (3): 225-226. : http://dx.doi.org/10.1097/RLU.0000000000001484
  • Tscherpel C, Dunkl V, Ceccon G, Stoffels G, Judov N, Rapp M, Meyer PT, Kops ER, Ermert J, Fink GR, Shah NJ, Langen KJ, Galldiks N: The use of O-(2-18F-fluoroethyl)-L-tyrosine PET in the diagnosis of gliomas located in the brainstem and spinal cord. Neuro-oncology, 2017; 19 (5): 710-718. : http://dx.doi.org/10.1093/neuonc/now243
  • Umlauft M, Radojewski P, Spanjol PM, Dumont R, Marincek N, Kollar A, Brunner P, Beyersmann J, Muller-Brand J, Maecke HR, Laimer M, Walter MA: Diabetes Mellitus and Its Effects on All-Cause Mortality After Radiopeptide Therapy for Neuroendocrine Tumors. J Nucl Med, 2017; 58 (1): 97-102. : http://dx.doi.org/10.2967/jnumed.116.180687
  • Wagner K, Schulze-Bonhage A, Urbach H, Trippel M, Spehl TS, Buschmann F, Metternich B, Ofer I, Meyer PT, Frings L: Reduced glucose metabolism in neocortical network nodes remote from hypothalamic hamartomas reflects cognitive impairment. Epilepsia, 2017; 58 Suppl 2: 41-49. : http://dx.doi.org/10.1111/epi.13757
  • Wetz C, Apostolova I, Steffen IG, Hofheinz F, Furth C, Kupitz D, Ruf J, Venerito M, Klose S, Amthauer H: Predictive Value of Asphericity in Pretherapeutic [111In]DTPA-Octreotide SPECT/CT for Response to Peptide Receptor Radionuclide Therapy with [177Lu]DOTATATE. Mol Imaging Biol, 2017; 19 (3): 437-445. : http://dx.doi.org/10.1007/s11307-016-1018-x
  • Wieser G, Popp I, Christian Rischke H, Drendel V, Grosu AL, Bartholoma M, Weber WA, Mansi R, Wetterauer U, Schultze-Seemann W, Meyer PT, Jilg CA: Diagnosis of recurrent prostate cancer with PET/CT imaging using the gastrin-releasing peptide receptor antagonist 68Ga-RM2: Preliminary results in patients with negative or inconclusive [18F]Fluoroethylcholine-PET/CT. Eur J Nucl Med Mol I, 2017; 44 (9): 1463-1472. : http://dx.doi.org/10.1007/s00259-017-3702-8
  • Zamboglou C, Drendel V, Jilg CA, Rischke HC, Beck TI, Schultze-Seemann W, Krauss T, Mix M, Schiller F, Wetterauer U, Werner M, Langer M, Bock M, Meyer PT, Grosu AL: Comparison of 68Ga-HBED-CC PSMA-PET/CT and multiparametric MRI for gross tumour volume detection in patients with primary prostate cancer based on slice by slice comparison with histopathology. Theranostics, 2017; 7 (1): 228-237. : http://dx.doi.org/10.7150/thno.16638
  • Zamboglou C, Sachpazidis I, Koubar K, Drendel V, Wiehle R, Kirste S, Mix M, Schiller F, Mavroidis P, Meyer PT, Werner M, Grosu AL, Baltas D: Evaluation of intensity modulated radiation therapy dose painting for localized prostate cancer using 68Ga-HBED-CC PSMA-PET/CT: A planning study based on histopathology reference. Radiother Oncol, 2017; 123 (3): 472-477. : http://dx.doi.org/10.1016/j.radonc.2017.04.021

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten