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 Forschungsbericht alle Jahre

Klinik für Neurochirurgie

Abteilung Stereotaktische und Funktionelle Neurochirurgie

Breisacherstr. 64
79106 Freiburg
Tel: +49 761 270-50630 Fax: +49 761 270-50100
Email stereo@uniklinik-freiburg.de
https://www.uniklinik-freiburg.de/stereotaxie.html


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Volker A. Coenen, Ärztlicher Leiter
  • Prof. Dr. Guido Nikkhah, Ärztlicher Direktor
  • PD Dr. Marcus O. Pinsker, Leitender Oberarzt
  • Dr. Peter Reinacher, Oberarzt
  • Dr. Thomas Reithmeier, Oberarzt
  • Dr. Michael Trippel, Oberarzt
  • Sasan Adib
  • Fabian Büchele, Wissenschaftlicher Mitarbeiter (m/w)
  • Dr. Philipp Capetian
  • Dr. Joacir Graziolli Cordeiro
  • Dr. Jessica Eismann-Schweimler
  • Dipl.-Biol. Ulf Kahlert
  • Dr. Robert D. Kirch
  • Dr. Marlene Löffler
  • Dr. Jarek Maciaczyk
  • Dr. Tobias Piroth
  • Dr. Thomas Prokop, Facharzt
  • Dr. Jan Pruszak
  • Dr. med. univ. Tanja Ramic
  • Dr. Helga Schrecker
  • Dr. Elisabeth Schültke, Fachärztin
  • Dr. Elisabeth Schültke, Gastwissenschaftlerin
  • Dr. Kaveh Shariat
  • Dr. Maria Thöni, Assistenzärztin
  • Dr. Florian Volz, Assistenzarzt
  • Inigo Aguirre Aranda, Master Student
  • Luis Manuel Azmitia Henrìquez, Hospitant
  • Dr. Walter Birg
  • Tomasz Bogiel
  • Dr. M. Boltenstern
  • Dr. D. Fritzsche
  • Luciano Furlanetti
  • Dr. Claudia Ganser
  • Dr. Christina Hackl
  • Dr. E. Kasper
  • Dr. Alexander Klein
  • Dr. Karina Kohn Cordeiro
  • K. Kopitzki
  • Martin Krause
  • Dr. Simone Krebs
  • Guilherme Lepski
  • Cinthia Elim Jannes Lepski
  • Luciano Lopes Furlanetti, Hospitant
  • William Omar Lopez, SIEHE CONTRERAS LOPEZ
  • Donata Maciaczyk
  • Verena Martini, Medizinische Doktorandin
  • Dr. Sven Möllers, Leiter Zelltherapie-Labor
  • Prof. Dr. Christoph Ostertag, Emeritus
  • Dr. Anna Papazoglou
  • Anika Rath
  • Dr. Bastian Sajonz, Arzt, MSc
  • C. Schäfer
  • Prof. Dr. Jan Vesper
  • Dr. PC Warnke
  • Dr. Christian Wille
  • Luis Manuel Azmitia Henriquez
  • William Omar Contreras Lopez
  • Dipl.-Biol. Joanna Garcia
  • Dipl.-Biol. Marie-Christine Pauly
  • Stefanie Schackel
  • Dr. med. Barbara Schmeiser, Rotationsassistentin
  • Dr. med. Marie Krüger, Rotationsassistentin
  • Talib Omer
  • Yashar Naseri, Rotationsassistent
  • Dr. Máté Döbrössy, Laborleiter
  • Dr. Marie-Christin Pauly, Biologin
  • Dr. Tsvetan Serchov, Wissenschaftlicher Mitarbeiter (m/w)
  • Dipl. Ing. Jasmin Weis, techn. biolog. Assistentin
  • Dipl. Ing. Meng Li, Wissenschaftlicher Mitarbeiter (m/w)
  • Dipl. Ing. Leyla Roohisefat, Wissenschaftlicher Mitarbeiter (m/w)
  • Johanna Wessolleck, Techn. Biolog. Assistentin
  • Lisa Pfeiffer, (geb. Selesnew), MSc
  • Wilf Gardner, Doktorand (m/w), MSc
  • Dr. Bibek Dhital, Wissenschaftlicher Mitarbeiter (m/w)
  • Stephanie Thiele, MSc
  • Alexander Cook, MSc
  • Paul Jakob Schlanstein, Doktorand (m/w)
  • Clemens Wiedenmann, Doktorand (m/w)
  • Yu Zangh, Gastwissenschaftler (m/w)
  • Dr. Luciano Furlanetti, Doktorand (m/w)
  • Marta Orlowska, Gastwissenschaftler (m/w)
  • Maria Jesus Alvarez Holzapfel, Doktorand (m/w)
  • Verena Martini, Doktorand (m/w)
  • Felipe Branco de Paiva, Doktorand (m/w)
  • Lidia Miguel Telega, Wissenschaftlicher Mitarbeiter (m/w)
  • Chockalingam Ramanathan, Master-Student (m/w)
  • Chockalingam Ramanathan, Wissenschaftlicher Mitarbeiter (m/w)
  • Christian Ramelow, Bachelor-Student (m/w)
  • Anna Tadros, Wissenschaftlicher Mitarbeiter (m/w)
  • Yixin Tong, Wissenschaftlicher Mitarbeiter (m/w)
  • Mariam Harmouche, HiWi (m/w)
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Tiefe Hirnstimulation in tierexperimentellen Fragestellungen zur therapeutischen Anwendung bei Depression und anderen neuropsychiatrischen Erkrankungen
  • Tumorbiologie und Radiobiologie primärer und sekundärer Hirntumore. Tiefe Hirnstimulation bei M. Parkinson und bei Dystonie. Stammzellbasierte Therapie von M. Parkinson, M. Huntington und von Hirntumoren. Funktionell restaurative Therapie von neurodegenerativen Krankheiten. Charakterisierung von Bewegungsstörungen bei Dystonien und M. Parkinson.
  • Elektrophysiologische Untersuchungen sowie verhaltensbiologische Evaluation des Tiermodells der Depression und Auswirkung der Tiefe Hirnstimulation
  • Neuromodulation durch optogenetische Zelltherapie
  • Tumorbiologie und Radiobiologie primärer und sekundärer Hirntumore
  • Tiefe Hirnstimulation bei M. Parkinson und bei Dystonie
  • Tiefe Hirnstimulation bei therapierefraktären psychiatrischen Erkrankungen (Depression, OCD, Anorexie)
  • Bildgebungsassistierte Implantationstechniken (v.A. DTI-Bildgebung) für die THS
  • Charakterisierung von Bewegungsstörungen bei Dystonien und M. Parkinson

Finanzierung

  • BrainLinks – BrainTools MFB DBS in Depression (MIND) #Projekt 148 – Volker Coenen, Máté Döbrössy
  • BrainLinks – BrainTools MFB DBS in Depression (MIND II) #Projekt 148 – Volker Coenen, Máté Döbrössy
  • BrainLab, Prof. Volker A. Coenen: "Imaging-basiertes Planungs-, Simulations- und Therapieverfolgungssystem für die Tiefe Hirnstimulation" Projekt I: "Entwicklungen im Bereich Fibertracking & Deep-Brain Stimulation".
  • BrainLab, Prof. Volker A. Coenen: "Imaging-basiertes Planungs-, Simulations- und Therapieverfolgungssystem für die Tiefe Hirnstimulation" Projekt II: "DBS-Outcome Registry".
  • Sachmittelzuschuss der Wissenschaftlichen Gesellschaft Freiburg im Breisgau für das Forschungsprojekt "Behandlung von Depressionen mittels Tiermodellen"
  • NeuroTime Erasmus Mundus Joint Doctorate "Neural Processing of Time", 5th Edition 2016-2020 Universität Freiburg - Universität Straßburg, F Project 11 – Wilf Gardner "The Impact of Deep-Brain Stimulation of the Medial Forebrain Bundle on Depressive-like Symptoms in Rodent Models of Depression".
  • Erasmus + HE Study Placement Stipendium 2016-2017 Hannah Golton, Universität Freiburg – Universität Manchester, UK.

Wissenschaftliche Projekte und Forschungsvorhaben


  • (Einfügen)
    • Projektleitung: Nikkhah G (Mitantragsteller)
    • Laufzeit: 01.10.2010 bis 31.12.2011
    • Details zum Projekt
  • A phase III multicenter study of intratumoral / interstitial therapy with TransMID™ compared to best standard of care in patients with progressive and / or recurrent, non-resectable glioblastoma multiforme
  • Characterizing BAC transgenic mice lines expressing GFP under the control of D2 and M4 promoters corresponding to the striatal indirect and direct pathways, respectively
  • Cilengitide (EMD121 974) and temozolomide 2006 with concomitant radiation therapy, followed by cilengitide and temozolomide maintenance therapy in subjects with newly diagnosed glioblastoma – a multicenter, open-label, uncontrolled Phase I/II a study
  • Deutsch-chinesische Forschungsanbahnung
  • Differenzierung und Integration humaner dopaminerger neuraler Stammzellen
  • Differenzierung und Integration humaner dopaminerger Stammzellen im Tiermodell
  • Dopamine signal transduction in the nigrostriatal projection pathway: modulation and reconstitution
  • Foetal neural transplant as a treatment for Huntington’s disease: from pilot studies to clinical application
  • Funktionalisierte Nanopartikel für die molekulare Bildgebung (FunkMoB)
  • Funktionelle in vivo Untersuchungen zur Rolle des FGF 2 Systems bei der Regeneration peripherer Nerven
  • Gliome: Interdisziplinäre Neuro-Onkologie, Molekulare Diagnostik und neue Therapieansätze am Standort Freiburg
  • Gliome: Interdisziplinäre Neuro-Onkologie, Molekulare Diagnostik und neue Therapieansätze am Standort Freiburg
  • Intracerebrale Transplantation fetaler neuronaler Stammzellen zur Behandlung der Huntington Erkrankung
  • Molekulare Steuerungsmechanismen dopaminanabhängiger Dyskinesien im Tiermodell der Parkinsonschen Erkrankung
  • Neural circuitry of impulse control: an integrative approach towards the understanding of normal and disturbed control in humans
    • Projektleitung: Nikkhah G (Mitantragsteller)
    • Laufzeit: 01.01.2007 bis 31.03.2011
    • Details zum Projekt
  • Neuralstem
    • Projektleitung: Nikkhah G, Döbrössy M
    • Laufzeit: 01.11.2010 bis 31.10.2011
    • Details zum Projekt
  • Neural transplantation in the treatment of patients with Parkinson’s disease (TRANSEURO)
  • Neurex
  • Neurotrophe und –tope Modulation der morphologischen und funktionellen Plastizität von embryonalen dopaminergen Transplantaten im Tiermodell der Parkinsonschen Erkrankung
  • Parkinson-Forschung
  • Protocol H6Q-MC-JCBF: A Randomized Phase 3 Study of Enzastaurin versus Lomustine in the Treatment of Recurrent, Intracranial Glioblastoma Multiforme
  • SAPPHIRE
  • StemStroke
  • Wiederherstellung neuronaler Funktion durch die Transplantation dopaminergen Neurone im Tiermodell der Parkinsonschen Erkrankung
  • Wiederherstellung neuronaler Funktionen durch die Transplantation dopaminerger Neurone im Tiermodell der Parkinsonschen Erkrankung - Fortsetzungsantrag

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Alesch F., Kitz K., Koos W.T., Ostertag Ch.B.: Diagnostic potential of stereotactic biopsy of midline lesions (Wien) Acta Neurochir Suppl, 1991; 53: 33-36.
  • Alesch F., Moringlane J.R., Ostertag C.B.: Die stereotaktische Hirnbiopsie als Grundlage der Therapieplanung Bull. Soc. Sci. Med., 1988; 1: 5.
  • Alesch F., Ostertag C.B., Koos W.T.: Combined Stereotactic and Microsurgical Approach to Cerebral Lesions. Acta Neurochir Suppl, 1991; 53: 19-22.
  • Alesch F., Ostertag Ch.B., Dietrich B., Piepgras U.: Korrelation computertomographischer Befund mit histologischen Diagnosen Akt. Neurologie, 1991; 18: 95-99.
  • Allert N, Barbe MT, Timmermann L, Coenen VA: Rapid battery depletion and loss of therapy due to a short circuit in bipolar DBS for essential tremor. Acta Neurochir, 2017; 159 (5): 795-798. : http://dx.doi.org/10.1007/s00701-017-3090-7
  • Allert N, Gippert SM, Sajonz BE, Nelles C, Bewernick B, Schlaepfer TE, Coenen VA: Arachnophobia alleviated by subthalamic nucleus stimulation for Parkinson's disease. J Neural Transm, 2016; 123 (6): 631-635. : http://dx.doi.org/10.1007/s00702-016-1546-1
  • Allgaier C, Warnke PC, Stangl A, Feuerstein TJ: Effects of 5-HT receptor agonists on depolarization-induced [3H]-noradrenaline release in human neocortex and rabbit hippocampus. Br J Pharmacol, 1995; 116: 1769-1774.
  • Amtage F, Feuerstein TJ, Meier S, Prokop T, Piroth T, Pinsker MO: Hypokinesia upon Pallidal Deep Brain Stimulation of Dystonia: Support of a GABAergic Mechanism. Front Neurol, 2013; 4 (198): 1-7. : http://dx.doi.org/10.3389/fneur.2013.00198
  • Amtage F, Henschel K, Schelter B, Vesper J, Timmer J, Lucking CH, Hellwig B: Tremor-correlated neuronal activity in the subthalamic nucleus of Parkinsonian patients. Neurosci Lett, 2008; 442 (3): 195-199. : http://dx.doi.org/10.1016/j.neulet.2008.06.087
  • Amtage F, Lambeck J, Rutsch S, Prokop T, Pinsker M, Rijntjes M: Behind the screen: pseudobulbar symptoms after deep brain stimulation. Acta Neurochir Suppl, 2013; 117: 43-46. : http://dx.doi.org/10.1007/978-3-7091-1482-7_7
  • Ashouri Vajari D, Ramanathan C, Tong Y, Stieglitz T, Coenen VA, Döbrössy MD: Medial forebrain bundle DBS differentially modulates dopamine release in the nucleus accumbens in a rodent model of depression. Exp Neurol, 2020; 327 (online): 113224. : http://dx.doi.org/10.1016/j.expneurol.2020.113224
  • Ashouri Vajari D, Vomero M, Erhardt JB, Sadr A, Ordonez JS, Coenen VA, Stieglitz T: Integrity Assessment of a Hybrid DBS Probe that Enables Neurotransmitter Detection Simultaneously to Electrical Stimulation and Recording. Micromachines-basel, 2018; 9 (10) (online): 510. : http://dx.doi.org/10.3390/mi9100510
  • Astolfo A, Arfelli F, Schultke E, James S, Mancini L, Menk RH: A detailed study of gold-nanoparticle loaded cells using X-ray based techniques for cell-tracking applications with single-cell sensitivity. Nanoscale, 2013; 5 (8): 3337-3345. : http://dx.doi.org/10.1039/c3nr34089a
  • Astolfo A, Schultke E, Menk RH, Kirch RD, Juurlink BH, Hall C, Harsan LA, Stebel M, Barbetta D, Tromba G, Arfelli F: In vivo visualization of gold-loaded cells in mice using x-ray computed tomography. Nanomed-nanotechnol, 2013; 9 (2): 284-292. : http://dx.doi.org/10.1016/j.nano.2012.06.004
  • Babel TB, Warnke PC, Ostertag CB.: Immediate and long term outcome after infrathalamic and thalamic lesioning for intractable Tourette's syndrome. J Neurol Neurosur Ps, 2001; 70 (5): 666-671.
  • Barker RA, Piroth T, Winkler C: Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease Nat Med, 2019; 25 (7): 1045-1053.
  • Bartsch T, Pinsker MO, Rasche D, Kinfe T, Hertel F, Diener HC, Tronnier V, Mehdorn HM, Volkmann J, Deuschl G, Krauss JK: Hypothalamic deep brain stimulation for cluster headache: experience from a new multicase series. Cephalalgia, 2008; 28 (3): 285-295. : http://dx.doi.org/10.1111/j.1468-2982.2007.01531.x
  • Baxan N, Kahlert U, Maciaczyk J, Nikkhah G, Hennig J, von Elverfeldt D: Microcoil-based MR phase imaging and manganese enhanced microscopy of glial tumor neurospheres with direct optical correlation. Magn Reson Med, 2011. : http://dx.doi.org/10.1002/mrm.23208 (in Druck)
  • Baxan N, Kahlert U, Maciaczyk J, Nikkhah G, Hennig J, von Elverfeldt D: Microcoil-based MR phase imaging and manganese enhanced microscopy of glial tumor neurospheres with direct optical correlation. Magn Reson Med, 2012; 68 (1): 86-97. : http://dx.doi.org/10.1002/mrm.23208
  • Beeker T, Schlaepfer TE, Coenen VA: Autonomy in Depressive Patients Undergoing DBS-Treatment: Informed Consent, Freedom of Will and DBS' Potential to Restore It. Front Integr Neurosci., 2017; 11 (online): 00011. : http://dx.doi.org/10.3389/fnint.2017.00011
  • Behrens P, Warnke PC, Ostertag CB: Cerebral blood flow in peritumoral brain edema in man. J Cereb Blood Flow Metab, 1995; 2: 736.
  • Behrens P., Ostertag CB., Warnke PC.: Regional cerebral blood flow in peritumoral brain edema during dexamethasone treatment. A xenon-CT study. Neurosurgery, 1998; 43: 235-241.
  • Behrens P., Ostertag Ch.: Cystische Fehlbildungen des Gehirns. Stereotaktische Diagnostik und Therapie Nervenarzt, 1992; 63: 725-730.
  • Behrens P., Ostertag Ch.B: Stereotactic management of congenital midline cysts Acta Neurochir, 1993: 141-146.
  • Behrens P., Ostertag Ch. B: Stereotaktisches Vorgehen bei Pinealiszysten Fortschr. Neurol. Psychiat., 1993; 61: 284-289.
  • Bender BU, Eng C, Olschewski M, Berger DP, Laubenberger J, Altehofer C, , Kirste G, Orszagh M, van Velthoven V, Miosczka H, Schmidt D, Neumann HP.: VHL c.505 T>C mutation confers a high age related penetrance but no increased overall mortality. J Med Genet. 2001 Aug;38(8):508-14. J Med Genet, 2001; 38 (8): 508-514.
  • Benedetti-Isaac JC, Torres-Zambrano M, Varqas-Toscano A, Perea-Castro E, Alcalä-Cerra G, Furlanetti LL, Reithmeier T, Tierney TS, Anastasopoulos C, Fonoff ET, Contreras Lopez WO: Seizure frequency reduction after posteromedial hypothalamus deep brain Stimulation in drug-resistant epilepsy associated with intractable aggressive behavior. Epilepsia, 2015; 56 (7): 1152-1161. : http://dx.doi.org/10.1111/epi.13025
  • Bentlage C, Nikkhah G, Cunningham MG, Bjorklund A: Reformation of the nigrostriatal pathway by fetal dopaminergic micrografts into the substantia nigra is critically dependent on the age of the host. Exp Neurol, 1999; 159 (1): 177-190. : http://dx.doi.org/10.1006/exnr.1999.7110
  • Bentlage C, Nikkhah G, Cunningham MG, Bjorklund A: Reformation of the nigrostriatal pathway by fetal dopaminergic micrografts into the substantia nigra is critically dependent on the age of the host. Exp Neurol, 1999; 159 (1): 177-190. : http://dx.doi.org/10.1006/exnr.1999.7110
  • Berding G, Odin P, Brooks DJ, Nikkhah G, Matthies C, Peschel T, Shing M, Kolbe H, van Den Hoff J, Fricke H, Dengler R, Samii M, Knapp WH: Resting regional cerebral glucose metabolism in advanced Parkinson's disease studied in the off and on conditions with [(18)F]FDG-PET. Movement Disord, 2001; 16 (6): 1014-1022.
  • Berding G, Odin P, Brooks DJ, Nikkhah G, Matthies C, Peschel T, Shing M, Kolbe H, van Den Hoff J, Fricke H, Dengler R, Samii M, Knapp WH: Resting regional cerebral glucose metabolism in advanced Parkinson's disease studied in the off and on conditions with [(18)F]FDG-PET. Movement Disord, 2001; 16 (6): 1014-1022.
  • Berlis A, Vesper J, Ostertag C: Innere Drainage von intrakraniellen Zysten durch Stenteinlage Klin Neuroradiol, 2005; 15: 212-212.
  • Berlis A, Vesper J, Ostertag C: Stent placement for intracranial cysts by combined stereotactic/endoscopic surgery. Neurosurgery, 2006; 59 (4 Su): ONS474-ONS480.
  • Berlis A, Warnke PC, Henne K, Boltenstern M, Ostertag C: Stellenwert der stereotaktisch-radiochirurgischen Behandlung in der multimodalen Therapie von cerebralen arteriovenösen Malformation. Eigene Erfahrungen und Literaturübersicht. Aktuel Neurol, 1999; 26 (1999): 123-129.
  • Bewernick BH, Kayser S, Gippert SM, Switala C, Coenen VA, Schlaepfer TE: Deep brain stimulation to the medial forebrain bundle for depression- long-term outcomes and a novel data analysis strategy. Brain Stimul, 2017; 10 (3): 664-671. : http://dx.doi.org/10.1016/j.brs.2017.01.581
  • Bewernick BH, Kilian HM, Schmidt K, Reinfeldt RE, Kayser S, Coenen VA, Markett S, Schlaepfer TE: Deep brain stimulation of the supero-lateral branch of the medial forebrain bundle does not lead to changes in personality in patients suffering from severe depression. Psychol Med, 2018; 48 (16): 2684-2692. : http://dx.doi.org/10.1017/S0033291718000296
  • Boon P, Vonck K, van Rijckevorsel K, Tahry RE, Elger CE, Mullatti N, Schulze-Bonhage A, Wagner L, Diehl B, Hamer H, Reuber M, Kostov H, Legros B, Noachtar S, Weber YG, Coenen VA, Rooijakkers H, Schijns OE, Selway R, Van Roost D, Eggleston KS, Van Grunderbeek W, Jayewardene AK, McGuire RM: A prospective, multicenter study of cardiac-based seizure detection to activate vagus nerve stimulation. Seizure-eur J Epilep, 2015; 32: 52-61. : http://dx.doi.org/10.1016/j.seizure.2015.08.011
  • Bosche B, Graf R, Ernestus RI, Dohmen C, Reithmeier T, Brinker G, Strong AJ, Dreier JP, Woitzik J: Recurrent spreading depolarizations after subarachnoid hemorrhage decreases oxygen availability in human cerebral cortex. Ann Neurol, 2010; 67 (5): 607-617. : http://dx.doi.org/10.1002/ana.21943
  • Brandis A, Kuder H, Knappe U, Jodicke A, Schonmayr R, Samii M, Walter GF, Nikkhah G: Time-dependent expression of donor- and host-specific major histocompatibility complex class I and II antigens in allogeneic dopamine-rich macro- and micrografts: comparison of two different grafting protocols. Acta Neuropathol, 1998; 95 (1): 85-97.
  • Brandis A, Kuder H, Knappe U, Jodicke A, Schonmayr R, Samii M, Walter GF, Nikkhah G: Time-dependent expression of donor- and host-specific major histocompatibility complex class I and II antigens in allogeneic dopamine-rich macro- and micrografts: comparison of two different grafting protocols. Acta Neuropathol, 1998; 95 (1): 85-97.
  • Brawek B, Löffler M, Wagner K, Huppertz HJ, Wendling AS, Weyerbrock A, Jackisch R, Feuerstein TJ: Reactive oxygen species (ROS) in the human neocortex: role of aging and cognition. Brain Res Bull, 2010; 81 (4-5): 484-490. : http://dx.doi.org/10.1016/j.brainresbull.2009.10.011
  • Brooks S, Fielding S, Dobrossy M, von Horsten S, Dunnett S: Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance. Brain Res Bull, 2009; 79 (5): 310-315. : http://dx.doi.org/10.1016/j.brainresbull.2009.03.003
  • Brundin P, Dunnett S, Bjorklund A, Nikkhah G: Transplanted dopaminergic neurons: more or less? Nat Med, 2001; 7 (5): 512-513. : http://dx.doi.org/10.1038/87796
  • Brundin P, Dunnett S, Bjorklund A, Nikkhah G: Transplanted dopaminergic neurons: more or less? Nat Med, 2001; 7 (5): 512-513. : http://dx.doi.org/10.1038/87796
  • Büchele F, Döbrössy M, Hackl C, Jiang W, Papazoglou A, Nikkhah G: Two-step grafting significantly enhances the survival of foetal dopaminergic transplants and induces graft-derived vascularisation in a 6-OHDA model of Parkinson's disease. Neurobiol Dis, 2014; 68: 112-125. : http://dx.doi.org/10.1016/j.nbd.2014.04.009
  • C.B.Ostertag, K.Weigel, P.Warnke, G.Lombeck, P.Kleihues:: Sequential morphological changes in the dog brain after interstitial iodine-125 irradiation. Neurosurgery, 1983; 13: 523-528.
  • C.B.Ostertag, P.C.Burger, H.K.Leetz, P.Kleihues, P.C.Warnke: Experimentelle Dosiseffekte nach interstitieller Bestrahlung des Gehirns. Zuckschwerdt, 1988.
  • C.B.Ostertag, P.Warnke, P.Kleihues, D.D.Bigner: Iodine-125 interstitial irradiation of virally induced dog brain tumors. Neurological Research, 1984; 6: 176-180.
  • Capetian P, Azmitia L, Pauly MG, Krajka V, Stengel F, Bernhardi EM, Klett M, Meier B, Seibler P, Stanslowsky N, Moser A, Knopp A, Gillessen-Kaesbach G, Nikkhah G, Wegner F, Döbrössy M, Klein C: Plasmid-Based Generation of Induced Neural Stem Cells from Adult Human Fibroblasts. Front Cell Neurosci, 2016 (online). : http://dx.doi.org/10.3389/fncel.2016.00245 (download: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075569/pdf/fncel-10-00245.pdf)
  • Capetian P, Dobrossy M, Winkler C, Prinz M, Nikkhah G: To be or not to be accepted: the role of immunogenicity of neural stem cells following transplantation into the brain in animal and human studies. Semin Immunopathol, 2011; 33 (6): 619-626. : http://dx.doi.org/10.1007/s00281-011-0272-x
  • Capetian P, Knoth R, Maciaczyk J, Pantazis G, Ditter M, Bokla L, Landwehrmeyer GB, Volk B, Nikkhah G: Histological findings on fetal striatal grafts in a Huntington's disease patient early after transplantation. Neuroscience, 2009; 160 (3): 661-675. : http://dx.doi.org/10.1016/j.neuroscience.2009.02.035
  • Carvalho GA, Nikkhah G: Subthalamic nucleus lesions are neuroprotective against terminal 6-OHDA-induced striatal lesions and restore postural balancing reactions. Exp Neurol, 2001; 171 (2): 405-417. : http://dx.doi.org/10.1006/exnr.2001.7742
  • Carvalho GA, Nikkhah G: Subthalamic nucleus lesions are neuroprotective against terminal 6-OHDA-induced striatal lesions and restore postural balancing reactions. Exp Neurol, 2001; 171 (2): 405-417. : http://dx.doi.org/10.1006/exnr.2001.7742
  • Carvalho GA, Nikkhah G, Matthies C, Penkert G, Samii M: Diagnosis of root avulsions in traumatic brachial plexus injuries: value of computerized tomography myelography and magnetic resonance imaging. J Neurosurg, 1997; 86 (1): 69-76. : http://dx.doi.org/10.3171/jns.1997.86.1.0069
  • Carvalho GA, Nikkhah G, Matthies C, Penkert G, Samii M: Diagnosis of root avulsions in traumatic brachial plexus injuries: value of computerized tomography myelography and magnetic resonance imaging. J Neurosurg, 1997; 86 (1): 69-76. : http://dx.doi.org/10.3171/jns.1997.86.1.0069
  • Carvalho GA, Nikkhah G, Samii M: [Diagnosis and surgical indications of traumatic brachial plexus lesions from the neurosurgery viewpoint] Orthopade, 1997; 26 (7): 599-605.
  • Carvalho GA, Nikkhah G, Samii M: [Pain management after post-traumatic brachial plexus lesions. Conservative and surgical therapy possibilities] Orthopade, 1997; 26 (7): 621-625.
  • Carvalho GA, Nikkhah G, Samii M: [Pain management after post-traumatic brachial plexus lesions. Conservative and surgical therapy possibilities]. Orthopade, 1997; 26 (7): 621-625.
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  • Nikkhah G, Schonmayr R, Volkening D, Samii M: Chronic compression of the cervical myelon as complication of anterior interbody fusion (AIF): neurological improvement after late anterior decompression. Case report. Neurosurg Rev, 1993; 16 (1): 61-66.
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  • Nikkhah G, Tonn JC, Hoffmann O, Kraemer HP, Darling JL, Schachenmayr W, Schonmayr R: The MTT assay for chemosensitivity testing of human tumors of the central nervous system. Part II: Evaluation of patient- and drug-specific variables. J Neuro-oncol, 1992; 13 (1): 13-24.
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  • Vesper J, Graf E, Tilgner J, Trippel M, Wille C, Nikkhah G, Ostertag CB: Retrospective analysis of treatment outcome in 315 patients with oligodendroglial brain tumors. Bmc Neurol, 2009; 9 (online): 33. : http://dx.doi.org/10.1186/1471-2377-9-33
  • Vesper J, Graf E, Wille C, Tilgner J, Trippel M, Nikkhah G, Ostertag C: Retrospective analysis of treatment outcome in 315 patients with oligodendroglial brain tumors. Bmc Neurol, 2009; 9: 33-33. : http://dx.doi.org/10.1186/1471-2377-9-33
  • Vesper J, Haak S, Ostertag C, Nikkhah G: Subthalamic nucleus deep brain stimulation in elderly patients-analysis of outcome and complications. Bmc Neurol, 2007; 7: 7-7. : http://dx.doi.org/10.1186/1471-2377-7-7
  • Vesper J, Haak S, Ostertag C, Nikkhah G: Subthalamic nucleus deep brain stimulation in elderly patients-analysis of outcome and complications. Bmc Neurol, 2007; 7: 7-7. : http://dx.doi.org/10.1186/1471-2377-7-7
  • Vesper J, Klostermann F, Wille C, Funk T, Brock M: Long-term suppression of extrapyramidal motor symptoms with deep brain stimulation (DBS). Zbl Neurochir, 2004; 65 (3): 117-122.
  • Vesper J, Steinhoff B, Rona S, Wille C, Bilic S, Nikkhah G, Ostertag C: Chronic high-frequency deep brain stimulation of the STN/SNr for progressive myoclonic epilepsy. Epilepsia, 2007; 48 (10): 1984-1989. : http://dx.doi.org/10.1111/j.1528-1167.2007.01166.x
  • Vesper J, Steinhoff B, Rona S, Wille C, Bilic S, Nikkhah G, Ostertag C: Chronic high-frequency deep brain stimulation of the STN/SNr for progressive myoclonic epilepsy. Epilepsia, 2007; 48 (10): 1984-1989. : http://dx.doi.org/10.1111/j.1528-1167.2007.01166.x
  • Voges J, Kiening K, Krauss JK, Nikkhah G, Vesper J: [Neurosurgical standards in deep brain stimulation : consensus recommendations of the German Deep Brain Stimulation Association] Nervenarzt, 2009; 80 (6): 666-672. : http://dx.doi.org/10.1007/s00115-009-2698-0
  • Voges J, Kiening K, Krauss JK, Nikkhah G, Vesper J: [Neurosurgical standards in deep brain stimulation : consensus recommendations of the German Deep Brain Stimulation Association]. Nervenarzt, 2009; 80 (6): 666-672. : http://dx.doi.org/10.1007/s00115-009-2698-0
  • Völker M, Fiederer LDJ, Berberich S, Hammer J, Behncke J, KrÅ¡ek P, TomáÅ¡ek M, Marusic P, Reinacher PC, Coenen VA, Helias M, Schulze-Bonhage A, Burgard W, Ball T: The dynamics of error processing in the human brain as reflected by high-gamma activity in noninvasive and intracranial EEG. Neuroimage, 2018; 173: 564-579. : http://dx.doi.org/10.1016/j.neuroimage.2018.01.059
  • Volkmann J, Mueller J, Deuschl G, Kühn AA, Krauss JK, Poewe W, Timmermann L, Falk D, Kupsch A, Kivi A, Schneider GH, Schnitzler A, Südmeyer M, Voges J, Wolters A, Wittstock M, Müller JU, Hering S, Eisner W, Vesper J, Prokop T, Pinsker M, Schrader C, Kloss M, Kiening K, Boetzel K, Mehrkens J, Skogseid IM, Ramm-Pettersen J, Kemmler G, Bhatia KP, Vitek JL, Benecke R: Pallidal neurostimulation in patients with medication-refractory cervical dystonia: a randomised, sham-controlled trial. Lancet Neurol, 2014; 13 (9): 875-884. : http://dx.doi.org/10.1016/S1474-4422(14)70143-7
  • Volkmann J, Wolters A, Kupsch A, Müller J, Kühn AA, Schneider GH, Poewe W, Hering S, Eisner W, Müller JU, Deuschl G, Pinsker MO, Skogseid IM, Roeste GK, Krause M, Tronnier V, Schnitzler A, Voges J, Nikkhah G, Vesper J, Classen J, Naumann M, Benecke R: Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomised trial. Lancet Neurol, 2012; 11 (12): 1029-1038. : http://dx.doi.org/10.1016/S1474-4422(12)70257-0
  • Wagner K, Buschmann F, Zentner J, Trippel M, Schulze-Bonhage A: Memory outcome one year after stereotactic interstitial radiosurgery in patients with epilepsy due to hypothalamic hamartomas. Epilepsy Behav, 2014; 37: 204-209. : http://dx.doi.org/10.1016/j.yebeh.2014.06.031
  • Wagner K, Schulze-Bonhage A, Urbach H, Trippel M, Spehl TS, Buschmann F, Metternich B, Ofer I, Meyer PT, Frings L: Reduced glucose metabolism in neocortical network nodes remote from hypothalamic hamartomas reflects cognitive impairment. Epilepsia, 2017; 58 Suppl. 2: 41-49. : http://dx.doi.org/10.1111/epi.13757
  • Wagner K, Wethe JV, Schulze-Bonhage A, Trippel M, Rekate H, Prigatano GP, Kerrigan JF: Cognition in epilepsy patients with hypothalamic hamartomas. Epilepsia, 2017; 58 Suppl. 2: 85-93. : http://dx.doi.org/10.1111/epi.13759
  • Warnke, P.C., Berlis, A., Weyerbrock, A., Ostertag, C.B.: Effect of LINAC radiosurgery on regional cerebral blood flow, glucose metabolism and sodium-potassium ATPase in skull base meningiomas and metastasis. Acta Neurochir (Wien), 1996. (in Druck)
  • Warnke PC: Neuronavigation and surgical neurology: the beginning of a new age or the end of an old age? Surg Neurol. 1999 Jul;52(1):7-8; discussion 8-12. No abstract available. PMID: 10390162 Surg Neurol, 1999; 52 (1): 7-8.
  • Warnke PC, Hans FJ, de Sousa MR, Ronsdorf A, Ostertag CB: Bidirectional capillary permeability, vascular volume, regional blood flow and VEGF-expression in primary cerebral lymphomas. J Cereb Blood Flow Metab, 1995; 15: 735.
  • Warnke PC, Hans FJ, Korst A, Mall C, Ostertag CB: Simultaneous measurement of bidirectional capillary permeability, vascular volume, extracellular space and rCBF in experimental gliomas and surrounding edema. Acta Neurochir., 1994; 60: 341-343.
  • Warnke PC, Hans FJ, Kreth FW, Ostertag CB: Stereotactic-endoscopic therapy of colloid cysts. Advances in Neurosurgery, 1994; 22: 134-139.
  • Warnke PC, Kopitzki K, Ostertag CB: Interstitial stereotactic radiosurgery. Acta Neurochir Suppl, 2003; 88: 45-50.
  • Warnke PC, Kopitzki K, Timmer J, Ostertag CB: Capillary physiology of human medulloblastoma: impact on chemotherapy. Cancer, 2006; 107 (9): 2223-2227.
  • Warnke PC, Kreth FW, Ostertag CB: Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumor and its influence on regrowth and prognosis [letter]. Neurosurgery, 1995; 36: 872-874.
  • Warnke PC, Kreth FW, Scheremet R, Ostertag CB: Response to Drs. Simpson, et al.: Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group clinical trials [letter]. Int. Journal of Rad. Onc., Biol., Phys., 1994; 29: 220.
  • Warnke PC, Molnar P, Lapin GD, Kuruvilla A, Groothuis DR: The effects of dexamethasone on transcapillary transport in experimental brain tumors: II. Canine brain tumors. J Neurooncol, 1995; 25: 29-38.
  • Warnke PC, Timmer J, Ostertag CB, Kopitzki K: Capillary physiology and drug delivery in central nervous system lymphomas. Ann Neurol, 2005; 57 (1): 136-139.
  • Warnke PC, Veling-Warnke G, Hans FJ, Korinthenberg, R, Ostertag CB: Regional cerebral blood flow during migraine attacks in pediatric patients. J Cereb Blood Flow Metab, 1995; 1: 165.
  • Warnke PC.: In vivo Messungen des dynamischen Molekültransports im Gehirn und ihr Eingang in die funktionelle Bildgebung. VDI Tech, 1995: 79-86.
  • Warnke PC.: Neuronavigation and surgical neurology - The beginning of a new age or the end of an old age? SURGICAL NEUROLOGY, 1998. (in Druck)
  • Warnke PC., Berlis A., Weyerbrock A., Ostertag CB.: Effect of LINAC radiosurgery on regional blood flow, glucose metabolism and sodium-potassium ATPase in skull base meningeomas and metastasis. Acta Neurochir Suppl (Wien), 1997; 68: 124-126.
  • Warnke PC., Berlis A., Weyerbrock A., Ostertag CB.: Significant reduction of seizure incidence and increase of benzodiazepine receptor density after interstitial radiosurgery in low-grade gliomas. Acta Neurochir Suppl (Wien), 1997; 68: 90-92.
  • Warnke PC., Machein M, Ostertag CB.: Prognostic significance of prognostic and histological variables in diffuse intrinsic brainstem gliomas. J. Neurosurg., 1996; 84: 340A.
  • Warnke PC., Ostertag CB.: Stereotactic biopsy of CNS lymphomas. J Neurooncol, 1998. (in Druck)
  • Weller M, Berger H, Hartmann C, Schramm J, Westphal M, Simon M, Goldbrunner R, Krex D, Steinbach JP, Ostertag CB, Loeffler M, Pietsch T, von Deimling A, German Glioma Network: Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker? Clin Cancer Res, 2007; 13 (23): 6933-6937.
  • Weller M, Felsberg J, Hartmann C, Berger H, Steinbach JP, Schramm J, Westphal M, Schackert G, Simon M, Tonn JC, Heese O, Krex D, Nikkhah G, Pietsch T, Wiestler O, Reifenberger G, von Deimling A, Loeffler M: Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network. J Clin Oncol, 2009; 27 (34): 5743-5750. : http://dx.doi.org/10.1200/JCO.2009.23.0805
  • Weller M, Felsberg J, Hartmann C, Berger H, Steinbach JP, Schramm J, Westphal M, Schackert G, Simon M, Tonn JC, Heese O, Krex D, Nikkhah G, Pietsch T, Wiestler O, Reifenberger G, von Deimling A, Loeffler M: Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network. J Clin Oncol, 2009; 27 (34): 5743-5750. : http://dx.doi.org/10.1200/JCO.2009.23.0805
  • Weller M, Tabatabai G, Kästner B, Felsberq J, Steinbach JP, Wick A, Schnell O, Hau P, Herrlinqer U, Säbel MC, Wirschinq HG, Ketter R, Bahr O, Platten M, Tonn JC, Schlegel U, Marosi C, Goldbrunner R, Stupp R, Homicsko K, Pichler J, Nikkhah G, Meixensberqer J, Vaikoczy P, Kollias S, Hüsinq J, Reifenberqer G, Wick W: MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefitfrom Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The DIRECTOR Trial. Clin Cancer Res, 2015; 21 (9): 2057-2064. : http://dx.doi.org/10.1158/1078-0432.CCR-14-2737
  • Weyerbrock A, Baumer B, Papazoglou A: Growth inhibition and chemosensitization of exogenous nitric oxide released from NONOates in glioma cells in vitro. J Neurosurg, 2009; 110 (1): 128-136. : http://DOI: 10.3171/2008.6.17607
  • Wick W, Platten M, Meisner C, Felsberg J, Tabatabai G, Simon M, Nikkhah G, Papsdorf K, Steinbach JP, Sabel M, Combs SE, Vesper J, Braun C, Meixensberger J, Ketter R, Mayer-Steinacker R, Reifenberger G, Weller M: Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol, 2012; 13 (7): 707-715. : http://dx.doi.org/10.1016/S1470-2045(12)70164-X
  • Wiestler B, Claus R, Hartlieb SA, Schliesser MG, Weiss EK, Hielscher T, Platten M, Dittmann LM, Meisner C, Felsberg J, Happold C, Simon M, Nikkhah G, Papsdorf K, Steinbach JP, Sabel M, Grimm C, Weichenhan D, Tews B, Reifenberger G, Capper D, Muller W, Plass C, Weller M, Wick W: Malignant astrocytomas of elderly patients lack favorable molecular markers: an analysis of the NOA-08 study collective. Neuro-oncology, 2013; 15 (8): 1017-1026. : http://dx.doi.org/10.1093/neuonc/not043
  • Wille C, Steinhoff BJ, Altenmuller DM, Staack AM, Bilic S, Nikkhah G, Vesper J: Chronic high-frequency deep-brain stimulation in progressive myoclonic epilepsy in adulthood-Report of five cases. Epilepsia, 2011; 52 (3): 489-496. : http://dx.doi.org/10.1111/j.1528-1167.2010.02884.x
  • Winkler C, Bentlage C, Cenci MA, Nikkhah G, Bjorklund A: Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson model. Neuroscience, 2003; 118 (4): 1063-1077.
  • Winkler C, Bentlage C, Cenci MA, Nikkhah G, Bjorklund A: Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson model. Neuroscience, 2003; 118 (4): 1063-1077.
  • Winkler C, Bentlage C, Nikkhah G, Samii M, Bjorklund A: Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants. Exp Neurol, 1999; 155 (2): 165-186. : http://dx.doi.org/10.1006/exnr.1998.6916
  • Winkler C, Bentlage C, Nikkhah G, Samii M, Bjorklund A: Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants. Exp Neurol, 1999; 155 (2): 165-186. : http://dx.doi.org/10.1006/exnr.1998.6916
  • Winkler C, Nikkhah G: Stammzelltransplantation bei Parkinson-Erkrankung Psychiatrie & Neurologie, 2011; 3: 16-18.
  • Winkler C, Reis J, Hoffmann N, Gellner AK, Münkel C, Curado M, Furlanetti L, Garcia J, Dobrossy M, Fritsch B: Anodal transcranial Direct Current Stimulation enhances survival and integration of dopaminergic cell transplants in a rat Parkinson model. eNeuro, 2017; 4 (5) (online): 0063. : http://dx.doi.org/10.1523/ENEURO.0063-17.2017
  • Witt K, Daniels C, Krack P, Volkmann J, Pinsker MO, Kloss M, Tronnier V, Schnitzler A, Wojtecki L, Botzel K, Danek A, Hilker R, Sturm V, Kupsch A, Karner E, Deuschl G: Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's disease. J Neurol Sci, 2011; 310 (1-2): 261-266. : http://dx.doi.org/10.1016/j.jns.2011.06.028
  • Witt K, Daniels C, Reiff J, Krack P, Volkmann J, Pinsker MO, Krause M, Tronnier V, Kloss M, Schnitzler A, Wojtecki L, Botzel K, Danek A, Hilker R, Sturm V, Kupsch A, Karner E, Deuschl G: Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study. Lancet Neurol, 2008; 7 (7): 605-614. : http://dx.doi.org/10.1016/S1474-4422(08)70114-5
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:
  • Coenen VA, Hurwitz TA, Schlaepfer TE: Johann Bernhard Aloys von Gudden: The Unrecognized Role of the Psychiatrist and Neuroanatomist in Modern Stereotactic Neurosurgery. Stereot Funct Neuros, 2020; 98 (1): 65-69. : http://dx.doi.org/10.1159/000505704
  • Coenen VA, Madler B, Schlaepfer TE: Reply to: Medial Forebrain Bundle Stimulation-Speed Access to an Old or Entry into a New Depression Neurocircuit? Biol Psychiat, 2013; 74 (12): e45-e46. : http://dx.doi.org/10.1016/j.biopsych.2013.06.017
  • Coenen VA, Sajonz B, Reisert M, Urbach H, Reinacher P: There’s more to the picture than meets the eye. Reply to: Letter to the editor of Acta Neurochirurgica: Blindmen and the elephant—comment on “The dentato-rubro-thalamic tract as the potential common deep brain stimulation target for tremor of various origin: an observational case series” Acta Neurochir, 2020; 162: 1869-1870. : https://doi.org/10.1007/s00701-020-04348-z
  • Döbrössy MD, Furlanetti LL, Coenen VA: Electrical stimulation of the medial forebrain bundle in pre-clinical studies of psychiatric disorders. Neurosci Biobehav R, 2015; 49 (2): 32-42. : http://dx.doi.org/10.1016/j.neubiorev.2014.11.018
  • Gippert SM, Switala C, Bewernick BH, Kayser S, Bräuer A, Coenen VA, Schlaepfer TE: Deep brain stimulation for bipolar disorder-review and outlook. Cns Spectrums, 2017; 22 (3): 254-257. : http://dx.doi.org/10.1017/S1092852915000577
  • Kahlert UD, Nikkhah G, Maciaczyk J: Epithelial-to-mesenchymal(-like) transition as a relevant molecular event in malignant gliomas. Cancer Lett, 2013; 331 (2): 131-138. : http://dx.doi.org/10.1016/j.canlet.2012.12.010
  • Nikkhah G: Transplantation of embryonic dopamine neurons for severe Parkinson's Disease: Potential and pitfalls. Brain Res Bull, 2001; 56: 509.
  • Ostertag CB., Thomas DGT, Bosch A., Linderoth B, Broggi G, Warnke PC, Cockburn H: Abstracts 13th Congress European Society for Stereotactic and Functional Neurosurgery. Acta Neurochir Suppl (Wien), 1998; 140.
  • Pauly MC, Piroth T, Dobrossy M, Nikkhah G: Restoration of the striatal circuitry: from developmental aspects toward clinical applications. Front Cell Neurosci, 2012; 6 (online): 16. : http://dx.doi.org/10.3389/fncel.2012.00016
  • Schulze-Bonhage A, Coenen VA: Treatment of epilepsy: peripheral and central stimulation techniques. Nervenarzt, 2013; 84 (4): 517-528. : http://dx.doi.org/10.1007/s00115-013-3749-0
  • van Calker D, Biber K, Domschke K, Serchov T: The role of adenosine receptors in mood and anxiety disorders. J Neurochem, 2019; 151 (1): 11-27. : http://dx.doi.org/10.1111/jnc.14841
Monographien:
  • Nikkhah G: Humanmedizin in Gießen. , Gießen: JF Lehmanns, 1990.
  • Nikkhah G: Microtransplantation of nigral dopamine neurons in an rat model of Parkinson's disease. , Lund, Schweden: Grahns, 1994.
  • Nikkhah G: Funktionelle Neurochirurgie für neurodegenerative Erkrankungen im Wandel der Zeit: Von den destruktiven hin zu den rekonstruktiven Verfahren., Würzburg: Königshausen & Neumann, 2008.
Buchbeiträge:
  • Bambery KR, Wood BR, Schültke E, Juurlink BHJ, May T, McNaughton D: Monitoring the effects of cisplatin uptake in rat glioma cells: A preliminary analysis using Fourier transform infrared synchrotron spectroscopy In: Moss D (Hrsg.): Biomedical Applications of Synchrotron Infrared Microspectroscopy: A practical approach London: RSC Publishing, 2011; 339-350.
  • Björklund A, Dunnett SB, Nikkhah G: Functional limitations and strategies to enhance nigrostriatal reconstruction. In: Advances in Neuroscience New York: Raven Press, 1994; 47-70.
  • Brandis A, Nikkhah G, Obermann K: Brennpunkt - Neurotransplantation In: Bock WJ (Hrsg.): Sonderheft Zentralblatt für Neurochirurgie Heidelberg: Johann Ambrosius Barth Verlag, 1995.
  • Döbrössy M, Brooks S, Trueman R, Brasted P, Dunnett S: Operant analysis of fronto-striatal function in rodents In: Buccafusco JJ (Hrsg.): Methods of behaviour analysis in neuroscience, 2. Auflage. Auflage. Boca Raton, Florida, USA: Taylor & Francis Group, 2009; 215-241 (Frontiers in Neuroscience).
  • Döbrössy M, Büchele F, Nikkhah G: Excitotoxic lesions of the rodent striatum In: Lane E, Dunnett SB (Hrsg.): Cotemporary animal models of movement disorders New York, USA: Humana Press (Springer), 2012.
  • Döbrössy MD, Büchele F, Nikkhah G: Excitotoxic lesions of the rodent striatum In: Lane E, Dunnett SB (Hrsg.): Contemporary animal models of movement disorders. Vol II, Part I (Basal Ganglia), Chapter 2 London: Spinger Verlag, 2011; 21-36.
  • Feuerstein T.J., Nikkhah G.: Antiparkinson Drugs In: Offermans S., Rosenthal W. (Hrsg.): Encyclopedic Reference of Molecular Pharmacology Heidelberg: Springer, 2002.
  • Feuerstein TJ, Nikkhah G: Antiparkinson drugs. In: Offermanns S, Rosenthal W (Hrsg.): Encyclopedic reference of molecular pharmacology Heidelberg: Springer-Verlag, 2004; 101-106.
  • Grosu A, Nikkhah G, Pagenstecher A, Spreer J, Lutterbach J, Ostertag CB, Behrens P: Allgemeines: Tumoren des Nervensystems In: Hufschmidt A, Lücking CH, Rauer S (Hrsg.): Neurologie compact, 5. Auflage. Stuttgart: Thieme Verlag, 2009; 217-238.
  • Klein A, Nikkhah G: Neural transplantation and restoration of motor behaviour in Parkinson's disease In: Ricardo Ramina, Paulo Henrique Pires Aguiar, Marcos Tatagiba (Hrsg.): Samii's Essentials in Neurosurgery Heidelberg: Springer-Verlag, 2008; 35-48.
  • Knappe U, Brandis A, Joedicke A, Walter GF, Samii M, Schoenmayr R, Nikkhah G: Allogenic neurografting in the rat model of Parkinson's disease: effect of the grafting technique on the functional and morphological integration of the transplant. In: Bauer BL, Brock M, Klinger M (Hrsg.): Advances in Neurosurgery Berlin: Springer-Verlag, 1994; 313-317.
  • Möllers S, Döbrössy M, Nikkhah G: Transplantation of foetal ventral mesencephalic grafts in Parkinson's disease: A still evolving concept with new regulatory challenges In: InTech Open Access Publisher (Hrsg.): Intech e-Book 4 InTechWeb.org: InTech, 2011; 379-396 (Parkinson's Disease, chapter 17).
  • Nikkhah G: Studium der Humanmedizin. In: Studium der Humanmedizin. Stuttgart: Georg Thieme Verlag, 1991.
  • Nikkhah G: 10th International Conference on Neural Transplantation and Repair, Freiburg In: Regenerative Medizin (Kongressband) München: W. Zuckschwerdt Verlag, 2008.
  • Nikkhah G, Maciaczyk J, Reithmeier T, Trippel M, Pinsker MO: Stereotactic radiosurgery for brain metastases In: Schmidek and Sweet’s Operative Neurosurgical Techniques: Indications, Methods, and Results. Sixth Edition Philadelphia, USA: W B Saunders, 2012. (in Druck)
  • Nikkhah G, Samii M: Principles of neural transplantation in the central nervous system. In: Hellwig, Bauer (Hrsg.): Minimally invasive techniques for neurosurgery Heidelberg: Springer-Verlag, 1998.
  • Nikkhah G, Winkler C, Roedter A, Samii M: Microtransplantation of nigral dopamine neurons: a "step-by-step" recipe. In: Dunnett SB, Baker G (Hrsg.): Cell and tissue transplantation in the CNS Totowa: Humana Press, 2000; 207-231.
  • Penkert G, Carvalho GA, Nikkhah G, Samii M: Reinnervation bei Wurzelausrissen des Plexus brachialis mittels des N. accessorius als Spendernerv. In: Kongressband zur 33. Jahrestagung der Deutschen Gesellschaft für Plastische und Wiederherstellungschirurgie. Hannover: Kongressband, 1996; 468-470.
  • Pinsker MO, Nikkhah G: Wie funktioniert Tiefe Hirnstimulation? In: Müller O, Maio G, Boldt J, Mackert J (Hrsg.): Das Gehirn als Projekt Freiburg: Rombach Verlag, 2011; 59-64.
  • Pruszak J, Döbrössy M, Kieninger J, Aravindalochanan K, Urban GA, Nikkhah G: Neural stem cells: From cell fate and metabolic monitoring towards clinical applications In: Stem Cells Engineering Heidelberg: Spinger Verlag, 2011.
  • Samii M, Carvalho GA, Nikkhah G, Penkert G: Neurotization des Plexus brachialis: Interkostalnervenanastomose mit dem N. musculocutaneus. In: Kongressband zur 33. Jahrestagung der Deutschen Gesellschaft für Plastische und Wiederherstellungschirurgie Hannover: Kongressband, 1996; 471-472.
  • Samii M, Nikkhah G, Carvalho GA: Operative Versorgung peripherer Nervenläsionen. In: Wirth CJ (Hrsg.): Praxis der Orthopädie Stuttgart: Georg Thieme Verlag, 2001; 117-129.
  • Samii M, Nikkhah G, Carvalho GA, Penkert G: Periphere Nerventransplantation zur Rekonstruktion des N. musculocutaneus bei traumatischen Armplexusläsionen. In: Kongressband zur 33. Jahrestagung der Deutschen Gesellschaft für Plastische und Wiederherstellungschirurgie Hannover: Kongressband, 1996; 464-467 .
  • Samii M, Tatagiba M, Nikkhah G, Carvalho GA, Penkert G: Zur funktionellen Rekonstruktion des N. axilliaris bei traumatischen Armplexus-Läsionen. In: Kongressband zur 33. Jahrestagung der Deutschen Gesellschaft für Plastische und Wiederherstellungschirurgie Hannover: Kongressband, 1996; 466-467.
  • Schuhmann M, Nikkhah G, Luedemann W, Carvalho GA, Matthies C, Penkert G, Samii M: Die Behandlung traumatischer Läsionen de N. ulnaris: Indikation, Technik und Ergebnisse. In: Kongressband zur 33. Jahrestagung der Deutschen Gesellschaft für Plastische und Wiederherstellungschirurgie Hannover: Kongressband, 1996; 462-463.
  • Tonn J, Nikkhah G, Roosen K, Schachenmayr W: MTT assay for in vitro chemosensitivity testing of malignant intracranial tumors. In: Piscol K, Brock M (Hrsg.): Advances in Neurosurgery Berlin: Springer-Verlag, 1992; 281-285.
  • Vesper J, Nikkhah G: Potential and limitations of chronic high frequency deep brain stimulation in Parkinson's disease. In: Ramina R, Pires A, Paulo H, Tatagiba M (Hrsg.): Samii's essentials in neurosurgery Heidelberg: Springer-Verlag, 2007; 21-26.
  • Warnke PC, Ostertag CB: Physiology of stereotactic interstitial radiosurgery. In: Amaldi U, Larsson B (Hrsg.): Hadrontherapy in Oncology. Elsevier Publishers, 1994; 657-663.
  • Warnke PC., Ostertag CB.: Stereotaktische Biopsie. In: Schlegel, V, Westphal, M (Hrsg.): Neuro-Onkologie. Thieme, 1998; 75-84.
  • Warnke PC., Schlegel V: Chemotherapie. In: Schlegel U, Westphal M (Hrsg.): Neuro-Onkologie. Thieme, 1998; 158-168.
Fallbeispiele:
  • Allert N, Jin W, Toulaki X, Coenen VA: DBS dysfunction mimicking transient ischemic attacks - a case report. Acta Neurochir, 2020; 162 (5): 1077-1079. : http://dx.doi.org/10.1007/s00701-020-04246-4
  • Furlanetti LL, Monaco BA, Cordeiro JG, Lopez WO, Trippel M: Frame-based stereotactic neurosurgery in children under the age of seven: Freiburg University's experience from 99 consecutive cases. Clin Neurol Neurosur, 2015; 130: 42-47. : http://dx.doi.org/10.1016/j.clineuro.2014.12.011
  • Roelz R, Egger K, Reinacher P: Giant perivascular spaces causing hemiparesis successfully treated by cystoventriculoperitoneal shunt. Brit J Neurosurg, 2015; 29 (1): 100-102. : http://dx.doi.org/10.3109/02688697.2014.957160
  • Roelz R, Erny D, Shah MJ, Egger K, Thiel J, Seufert J, Laubner K, Reinacher P: Case Report: Isolated Pauci-immune Vasculitis of the Pituitary Gland Revealed by Stereotactic Biopsy. Exp Clin Endocr Diab, 2015; 02 (01): e4-e7. : http://dx.doi.org/10.1055/s-0035-1548827
  • Taschner C, Staszewski O, Trippel M, Meckel S, Prinz M: A haemorrhagic, contrast-enhancing lesion of the basal ganglia. Clin Neuroradiol, 2012; 22 (3): 269-273. : http://dx.doi.org/10.1007/s00062-012-0161-2
  • Taschner CA, Baumgartner S, Sackmann S, Trippel M, Treier M, Treier M: Freiburg Neuropathology Case Conference: a Hypothalamic Lesion. Klin Neuroradiol, 2009; 19 (4): 306-308. : http://dx.doi.org/10.1007/s00062-009-4013-7
  • Taschner CA, Brendecke S, Trippel M, Keuler A, Prinz M: Freiburg neuropathology case conference: contrast-enhancing white matter lesion adjacent to the lateral ventricle. Clin Neuroradiol, 2013; 23 (2): 165-168. : http://dx.doi.org/10.1007/s00062-013-0226-x
  • Taschner CA, Doostkam S, Reinacher PC, Urbach H, Rau A, Prinz M: Freiburg Neuropathology Case Conference : A Progressive Lesion of the Optic Tract, Brainstem, Hypothalamus and Basal Ganglia. Clin Neuroradiol, 2019; 29 (4): 797-804. : http://dx.doi.org/10.1007/s00062-019-00849-2
  • Taschner CA, Erny D, Sajonz B, Urbach H, Guggenberger K, Prinz M: Freiburg Neuropathology Case Conference: A Cystic Lesion of the Cerebellum in an Adolescent. Clin Neuroradiol, 2017; 27 (1): 121-126. : http://dx.doi.org/10.1007/s00062-017-0562-3
  • Taschner CA, Staszewski O, Pinsker MO, El Shikh S, Prinz M: Freiburg neuropathology case conference: cystic mass lesions of the temporal and occipital lobes in an elderly patient. Clin Neuroradiol, 2011; 21 (4): 251-255. : http://dx.doi.org/10.1007/s00062-011-0112-3
  • Taschner CA, Staszewski O, Reinacher P, Urbach H, Mader I, Prinz M: Freiburg Neuropathology Case Conference: Ring Enhancing Lesion in an Immunocompromised Patient. Clin Neuroradiol, 2015; 25 (3): 321-325.
  • Taschner CA, Staszewski O, Reinacher P, Urbach H, Simon-Gabriel CP, Prinz M: Freiburg neuropathology case conference : Brainstem tumor in a child. Clin Neuroradiol, 2016; 26 (3): 377-383. : http://dx.doi.org/10.1007/s00062-016-0535-y
  • Taschner CA, Süß P, Sajonz B, Urbach H, Simon-Gabriel CP, Prinz M: Freiburg Neuropathology Case Conference: Widespread White Matter Lesions in a Patient with Progressive Paraparesis and Cortical Blindness. Clin Neuroradiol, 2017; 27 (2): 245-250. : http://dx.doi.org/10.1007/s00062-017-0589-5
  • Weber J, Piroth T, Rijntjes M, Jung B, Reinacher PC, Weiller C, Coenen VA, Klebe S: Atypical Presentation of Rapid-onset Dystonia-parkinsonism (DYT12) Unresponsive to Deep Brain Stimulation of the Subthalamic Nucleus. Mov Disord Clin Pract, 2018; 5 (4): 427-429. : http://dx.doi.org/10.1002/mdc3.12605
Kurzbeiträge / short communications:
  • Coenen VA, Kieselbach K, Mader I, Reinacher PC: Diffusion tensor magnetic resonance imaging (DTI) tractography-guided deep brain stimulation in neuropathic pain. Acta Neurochir, 2015; 157 (4): 739-741. : http://dx.doi.org/10.1007/s00701-015-2356-1
  • Coenen VA, McIntyre CC: Letter to the Editor: Correlation of diffusion tensor imaging and intraoperative macrostimulation. J Neurosurg, 2015; 123 (1): 291-292. : http://dx.doi.org/10.3171/2014.12.JNS142690
  • Coenen VA, Sajonz BE, Reisert M, Urbach H, Reinacher PC: There's more to the picture than meets the eye: Reply to: Letter to the editor of Acta Neurochirurgica: Blind men and the elephant-comment on "The dentato-rubro-thalamic tract as the potential common deep brain stimulation target for tremor of various origin: an observational case series". Acta Neurochir, 2020. : http://dx.doi.org/10.1007/s00701-020-04348-z (in Druck)
  • Maurer CJ, Trippel M, Korinthenberg R, Urbach H: Teaching Neuroimages: Basal Ganglia Germinoma with Hemiatrophy. Clin Neuroradiol, 2016; 26 (1): 97-98. : http://dx.doi.org/10.1007/s00062-015-0380-4
  • Obermann K, Brandis A, Nikkhah G: Neurotransplantation in Parkinson's Disease (news). Lancet, 1995; 345: 443-444.
  • Reese R, Steigerwald F, Potter M, Herzog J, Deuschl G, Volkmann J, Pinsker MO, Mehdorn HM: High-frequency stimulation of the subthalamic nucleus increases pallidal neuronal firing rate in a patient with Parkinson's disease. Movement Disord, 2008; 23 (13): 1945-1947. : http://dx.doi.org/10.1002/mds.22225
  • Reithmeier T, Pinsker MO, Piroth T, Trippel M, Prokop T, Nikkhah G: Epidural stimulation of the motor cortex for neuropathic pain: future directions Biomed Tech, 2008; 53 (3) Suppl. 1: 121.
  • Sajonz BE, Mädler B, Herberhold S, Paus S, Allert N, Coenen VA: Stimulation induced hypogeusia in thalamic deep brain stimulation for tremor: an underestimated yet common side effect. J Neurol Neurosur Ps, 2016; 87: 565-567. : http://dx.doi.org/10.1136/jnnp-2015-310368
Vorträge:
  • Ashouri Vajari D: Medial Forebrain Bundle DBS differentially modulates Dopamine release in the Nucleus Accumbens in a rodent model of Depression. 2019 (NeuroModulBasics Kick-off Meeting, Sept 2019, Medizinische Fakultät, Freiburg).
  • Castaño-Candamil S, Coenen VA, Reinacher P,, Piroth T, Tangermann M: DBS-Induced Alpha Desynchronization in the Subthalamic Nucleus of PD Patients. 2016 (II. International Conference on Deep Brain Stimulation (DBS) 2016, Düsseldorf).
  • Castaño-Candamil S, Reinacher P, Coenen VA, Tangermann M: Dynamics of Stn low-frequency components upon DBS. 2016 (XXIInd Congress of the European Society for Stereotactic and Functional Neurosurgery, 28.09.-01.10.16 Madrid, Spanien).
  • Coenen VA: How much Imaging is needed? 2016 (II. International Conference on Deep Brain Stimulation (DBS) 2016, Düsseldorf).
  • Coenen VA: Keynote Lecture: "Fiber tracking assisted deep brain stimulation – gadget or valuable tool?" 2016 (67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie DGNC, Frankfurt/Main).
  • Coenen VA: MR- und CT-basierte Tiefe Hirnstimulation und Stellenwert der Traktographie. 2016 (51. Jahrestagung der Deutschen Gesellschaft für Neuroradiologie e.V., Köln).
  • Coenen VA: Neurointervention: "MRT und CT basierte Tiefenhirnstimulation" 2016 (Forum Neuroradiologicum 2016, Mannheim).
  • Coenen VA: Emerging indications: Which new indications for DBS will be coming next? "Depression". 2016 (Expert Summit on the Future of Deep Brain Stimulation, Würzburg).
  • Coenen VA: Behandlung des Morbus Parkinson mit der Tiefen Hirnstimulation. 2017 (Jung und Parkinson (JUP) e.V. Symposium 2017, Saarlouis). : https://www.youtube.com/watch?v=azuoD1KaGl0&feature=youtu.be
  • Coenen VA: Impulse fürs Gehirn. 2017 („Medizin trifft Technologie“, Publikumsveranstaltung des Universitätsklinikums Freiburg, Freiburg). : https://www.youtube.com/watch?v=IsJ7Uhnj95E
  • Coenen VA: Tiefe Hirnstimulation für alle? 2019 (Patiententag Morbus Parkinson, Neurozentrum, Freiburg).
  • Coenen VA: Moderne Operationsverfahren bei Hirntumoren. 2019 (Patientenveranstaltung Hirntumore, Neurozentrum, Uniklinik Freiburg).
  • Coenen VA: Tiefe Hirnstimulation bei atypischen Bewegungsstörungen? 2019 (6. KOBE Workshop KOmplexe BEwegungsstörung, Neurozentrum, Freiburg).
  • Coenen VA: Kortikale und subkortikale Netzwerke der Emotionen: Kartographie mittels Tiefer Hirnstimulation. 2020 (Mittwochs-Kolloquium (05.02.2020) der Klinik für Neurologie und Neurophysiologie, Universitätsklinikum Freiburg).
  • Coenen VA, Prokop T, Allert N, Sajonz B, Maedler B, Urbach H, Reinacher PC: Diffusion tensor imaging tractography assisted direct targeting of the cerebello-thalamo-cortical network for deep brain stimulationin tremor - surgical strategy and intra-operative effects. 2016 (XXIInd Congress of the European Society for Stereotactic and Functional Neurosurgery, 28.09.-01.10.16 Madrid, Spanien).
  • Coenen VA, Schlaepfer TE, Bewernick BH, Bostroem J, Urbach H, Hattingen E, Li M: Diffusion tensor magnetic resonance imaging tractographic analysis of slMfB DBS in major depression. 2016 (XXIInd Congress of the European Society for Stereotactic and Functional Neurosurgery, 28.09.-01.10.16 Madrid, Spanien).
  • Cook A, Selesnew L, Thiele S, Coenen VA, Döbrössy MD: Olfactory memory deficits in the flinders Sensitive line rodent model of depression. 2016 (XXIInd Congress of the European Society for Stereotactic and Functional Neurosurgery, 28.09.-01.10.16 Madrid, Spanien).
  • Döbrössy MD: Deep Brain Stimulation in Depression: Medial Forebrain Bundle DBS in Pre-clinical studies. 2019 (Eberhard Karls University Tübingen (Sept 2019)).
  • Döbrössy MD: Deep Brain Stimulation of the Medial Forebrain Bundle in Rodent Models of Depression: Exploring Dopaminergic Mechanisms. 2019 (Society of Biological Psychiatry (May 2019), Chicago, USA).
  • Döbrössy MD: Neuromodulation in Rodent Models of Depression: Overview of the Research Strategy. 2019 (NeuroModulBasics Kick-off Meeting, Sept 2019, Medizinische Fakultät, Freiburg).
  • Döbrössy MD, Thiele S, Selesnew L, Furlanetti LL, Coenen VA: Behavioral and histological impact of bilateral high frequency stimulation of the medial forebrain bundle following partial dopamine lesions in a rodent model of depression. 2016 (XXIInd Congress of the European Society for Stereotactic and Functional Neurosurgery, 28.09.-01.10.16 Madrid, Spanien).
  • Gardner W: Sleep deficits in a rodent model of depression and the effects of medial-forebrain bundle deep-brain stimulation. 2019 (NeuroModulBasics Kick-off Meeting, Sept 2019, Medizinische Fakultät, Freiburg).
  • Gardner W: The effect of deep-brain stimulation of the medial forebrain bundle on sleep in the FSL rat model of depression. 2019 (German Neuroscience Meeting, März 2019, Göttingen).
  • Lehtimäki K, Coenen VA, Gonçalves-Ferreira A, Boon P, Elger C, Taylor RS, Ryvlin P, Gil-Nagel A, Gielen F, Brionne T, Abouihia A, Beth G: The Surgical approach to the anterior nucleus of thalamus in patients with refractory epilepsy: experience from the european multicenter registry. 2016 (XXIInd Congress of the European Society for Stereotactic and Functional Neurosurgery, 28.09.-01.10.16 Madrid, Spanien).
  • Nakagawa JM, Hammen ET, Reisert M, Kellner E, Mader I, Reinacher P: Functional and structural connectivity of ictal epileptic activity in stereo-EEG recording and quantitative global fiber tracktography. 2018 (69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Münster.).
  • Nakagawa JM, Hammen ET, Reisert M, Kellner E, Mader I, Reinacher P: Funktionelle und strukturelle Konnektivität entlang iktaler Propagationswege mittels Stereo-EEG und globaler Fasertraktographie. 2018 (54. Jahrestagung der Deutschen Gesellschaft für Epileptologie (DGfE), Fürth).
  • Reinacher P: Mehr als nur eine Biopsie: Einsatzmöglichkeiten der Stereotaxie 2019 (2. Neurochirurgischer Themenabend - Neuroonkologie, Bibliothek der Frauenklinik, Uniklinik Freiburg).
  • Reinacher P, Piroth T: Neue Technologien bei der THS 2019 (Patiententag Morbus Parkinson, Neurozentrum, Freiburg).
  • Roelz R: Stereotactic Catheter Ventriculocisternostomy and Cisternal Lavage Reduces Delayed Cerebral Infarction and Improves Outcome in Patients with Poor Grade Subarachnoid Hemorrhage. A Before and After Study. 2019 (15th Int. Conf. on SubArachnoid Hemorrhage, 25. - 28. Juni 2019 in Amsterdam, Niederlande).
  • Roelz R, Scheiwe C, Csok I, Steiert C, Egger K, Niesen WD, Beck J, Coenen V, Reinacher P: Stereotactic Catheter Ventriculocisternostomy and Cisternal Lavage Reduces Delayed Cerebral Infarction and Improves Outcome in Patients with Poor Grade Subarachnoid Hemorrhage. A Before and After Study. 2019 (70. Jahrestagung der DGNC, Joint Meeting mit der Skand. Ges. für Neurochiurgie, 12.-15.05.2019 in Würzburg).
  • Roohisefat L, Mottaghi S, Li M, Hofmann UG, Coenen VA: Simulation of DBS Selective field deformation in the proximity of white matter pathways. 2016 (Europäische COMSOL Konferenz 2016, München).
  • Selesnew L, Thiele S, Coenen VA, Döbrössy MD: Characterization of pre- and post-weaning behavior in a rodent model of depression: Early affective dysfunction reflected in Vocalization. 2016 (XXIInd Congress of the European Society for Stereotactic and Functional Neurosurgery, 28.09.-01.10.16 Madrid, Spanien).
  • Serchov T: Peripheral application of cell-membrane permeable HIV-1 TAT-fused peptides modulates glutamatergic signaling and promotes rapid antidepressant effects. 2019 (NeuroModulBasics Kick-off Meeting, Sept 2019, Medizinische Fakultät, Freiburg).
  • Tadros A: Deep Brain Stimulation (DBS) of the Medial Forebrain Bundle in a Female Rodent Model of Depression: Interaction between anhedonia-like behaviour and the estrous cycle. 2019 (Medical Research Day, Universitätsklinikum, Nov 2019, Freiburg).
  • Thiele S, Selesnew L, Cremer M, Weis J, Coenen VA, Döbrössy MD: Bilateral High frequency Stimulation of the medial forebrain bundle in the flinders Sensitive line rodent model of depression. 2016 (XXIInd Congress of the European Society for Stereotactic and Functional Neurosurgery, 28.09.-01.10.16 Madrid, Spanien).
  • Tong Y: Optogenetic stimulation of VTA dopaminergic neurons in a rodent model of depression. 2019 (German Neuroscience Meeting, März 2019, Göttingen).
  • Tong Y: Long-term Optogenetic Stimulation of Dopaminergic Neurons at Medial Forebrain Bundle (MFB) in a rodent model of Depression. 2019 (NeuroModulBasics Kick-off Meeting, Sept 2019, Medizinische Fakultät, Freiburg).
  • Trippel M, Korinthenberg R, Coenen VA: Stereotaktische Brachytherapie mit Jod-125- Seeds zur Behandlung von kindlichen Hirntumoren 2013 (Tagung der Sektion Pädiatrische Neurochirurgie der DGNC in Heidelberg).
Konferenzbeiträge:
  • Coenen VA, Kieselbach K, Mader I,, Reinacher PC: Poster: Diffusion tensor magnetic resonance imaging (DTI) tractography-guided deep brain stimulation in neuropathic pain. Acta Neurochir, 2014; 156 (online) (21. Congress of the European Society of Stereotactic and Functional Neurosurgery, Maastricht, The Netherlands, on 17-20 September 2014).
  • Contreras Lopez WO, Espinoza Martinez JA, Escalante Higuera CA: PRACTICAL USE OF AN AUDITORY DEVICE TO IMPROVE GAIT IN PATIENTS WITH PARKINSON’S DISEASE. Stereotact Funct Neurosurg, 2012; 90 Suppl. 1: 22-22 (Vortrag bei der European Society for Stereotactic and Functional Neurosurgery (ESSFN) , Lissabon, Portugal).
  • Contreras Lopez WO, Pinsker M, Arango G, Escobar O, Nikkhah G, Espinoza J: EVALUATION AND TREATMENT OF DYSTONIA: CASE SERIES OF 101 PATIENTS. Stereotact Funct Neurosurg, 2012; 90 Suppl. 1: 156-156 (Poster bei der European Society for Stereotactic and Functional Neurosurgery (ESSFN) , Lissabon, Portugal).
  • Contreras Lopez WO, Pinsker M, Nikkhah G, Trippel M, Reithmeier T: INTERSTITIAL BRACHYTHERAPY WITH IODINE-125 SEEDS FOR LOW-GRADE GLIOMAS OF THE BRAINSTEM IN ADULTS. Stereotact Funct Neurosurg, 2012; 90 Suppl. 1: 177-177 (Poster bei der European Society for Stereotactic and Functional Neurosurgery (ESSFN) , Lissabon, Portugal).
  • Contreras Lopez WO, Spehl TS, Nguyen T, Mader I, Nikkhah G, Pinsker M, Reithmeier T.4.: BEVACIZUMAB AS SALVAGE THERAPY FOR PROGRESSIVE BRAIN STEM GLIOMAS. Stereotact Funct Neurosurg, 2012; 90 Suppl. 1: 130-130 (Poster bei der European Society for Stereotactic and Functional Neurosurgery (ESSFN) , Lissabon, Portugal).
  • Cordeiro JG, Aertsen A, Somerlik KH, Cordeiro KK, Araújo JC, Schulze Bonhage A: Evaluation of Desynchronizing Continuous Low- and High- Frequency Stimulation in Fully Hippocampal Kindled Rats Acta Neurochir, 2011; 153 (3): 667-761.
  • Cordeiro JG, Cordeiro KK, Garcia J, Winkler C, Döbrössy M, Nikkhah G: THE EFFECT OF SUBTHALAMIC NUCLEUS INHIBITION IN THE SURVIVAL OF DOPAMINERGIC VENTRAL MESENCEPHALIC GRAFT IN A RAT MODEL OF PARKINSON´S DISEASE Stereotact Funct Neurosurg, 2012; 90 Suppl. 1: 7-7 (Vortrag bei der European Society for Stereotactic and Functional Neurosurgery (ESSFN) , Lissabon, Portugal).
  • Cordeiro JG, Rottenburger C, Pinsker M, Trippel M, Weber W, Nikkhah G, Reithmeier T: (1) Value of 18F-FET PET in comparison to stereotactic serial biopsy in the diagnosis of brain lesions Acta Neurochir, 2011; 153 (3): 735-735.
  • Cordeiro JG, Rottenburger C, Pinsker M, Trippel M, Weber W, Nikkhah G, Reithmeier T: (2) Value of 18F-FET PET in comparison to stereotactic serial biopsy to evaluate the follow up of brain gliomas 2011; 153 (3): 735-735 (19th Congress of the European Society Stereotaxic and Functional Neurosurgery 2010 in Athens).
  • Defer GL, Widner H, Marié RM, Rémy P, Levivier M, et. al. (Nikkhah G): Core assessment program for surgical interventional therapies in Parkinson's Disease (CAPSIT-PD). Movement Disord, 1999; 14: 572-584.
  • Döbrössy M: CRITICAL PRE-CLINICAL STUDIES TOWARDS ESTABLISHING THE FINAL PROTOCOL FOR THE TRANSEURO CLINICAL TRIAL OF NEURAL TRANSPLANTATION IN THE TREATMENT OF PD. Stereotact Funct Neurosurg, 2012; 90 Suppl. 1: 74-74 (Vortrag bei der European Society for Stereotactic and Functional Neurosurgery (ESSFN) , Lissabonn, Portugal).
  • Hall C, Sturm E, Schültke E, Arfelli F, Menk RH, Astolfo A, Juurlink BHJ: Progress in cell marking for synchrotron X-ray computed tomography American Institute of Physics (AIP) Conference Proceedings, 2010; 1266: 51-56.
  • Kopitzki K., Timmer J., Warnke PC.: Spatial Measurement of Blood-Brain Barrier Permeability. Acta Neurochir (Wien), 1998; 140: 871.
  • Lopes Furlanetti L, Monaco BA, Cordeiro JG, Nikkhah G, Trippel M: IS FRAME-BASED SURGERY IN PATIENTS UNDER SEVEN YEARS OLD SAFE? EXPERIENCE OF THE FREIBURG UNIVERSITY FROM 99 CASES. Stereotact Funct Neurosurg, 2012; 90 Suppl. 1: 180-180 (Poster bei der European Society for Stereotactic and Functional Neurosurgery (ESSFN) , Lissabon, Portugal).
  • Michael Trippel, M. Neuburger, Rudolf Korinthenberg, Volker A. Coenen: Interstitial radiosurgery (IRS) with I-125 seeds in children with brain tumors in eloquent areas. Child Nerv Syst, 2013; 29 (9): 1733-1733 (41st Annual Meeting of the International Society for Pediatric Neurosurgery, Mainz, Germany, Sept 29-Oct 3, 2013).
  • Nikkhah G, Prokop T, Maciaczyk J, Piroth T, Landwehrmeyer B, Trippel M: Neural transplantation in patients with Huntington's disease: preliminary risk and outcome assessment (P 096) Poster-Abstract zur DGNC Jahrestagung, 2011 (62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)), German Medical Science GMS Publishing House (Hrsg).
  • Reinshagen G, Martin P., Gilsbach J, Zentner J, Warnke PC, Ostertag CB.: Stereotactic Hippocampectomy in Bilateral Mesio-Temporal Lobe Epilepsy. Acta Neurochir (Wien), 1998; 140: 855.
  • Sajonz B, Blazhenets G, Walz I, Frommer M, Thurow J, Maurer C, Rijntjes M, Meyer P, Coenen VA: Turn ’em off – to identify stimulation-induced cerebellar syndrome in VIM/DRT-DBS for essential tremor Ausschalten und Aufdecken – stimulationsinduziertes zerebelläres Syndrom unter VIM/DRT-THS bei essentiellem Tremor 2020 (online) (71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 21.06. - 24.06.2020.).
  • Schültke E, Brian Bewer, Tomasz Wysokinski, Dean Chapman, Guido Nikkhah: Bystander effects during synchrotron imaging procedures American Institute of Physics (AIP) Conference Proceedings, 2010; 1266: 111-114.
  • Trippel M, Hefft S, Cordeiro J, Reithmeier T, Pinsker M, Schulze-Bonhage A, Nikkhah G: Stereotactic implantation of depth electrodes in epileptology Acta Neurochir, 2011; 153 (3): 667-761.
  • Trippel M, Hefft S, Cordeiro JG, Reithmeier T, Pinsker MO, Schulze-Bonhage A, Nikkhah G: Safety and efficacy of microwire implantations in the setting of invasive monitoring in patients suffering from therapy-resistant epilepsy Poster-Abstract zur DGNC Jahrestagung, 2011 (62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)), German Medical Science GMS Publishing House (Hrsg).
  • Trippel M, Reithmeier T, Pinsker M, Cordeiro J, Nikkhah G: INTERSTITIAL RADIOSURGERY WITH IODINE-125 SEEDS IN THE TREATMENT OF BRAIN METASTASES AND BRAIN TUMORS. Stereotact Funct Neurosurg, 2012; 90 Suppl. 1: 176-176 (Poster bei der European Society for Stereotactic and Functional Neurosurgery (ESSFN) , Lissabon, Portugal).
  • Warnke PC.: Effect of the Synthetic Bradykinine Cereport on Capillary Permeability in Untreated Glioblastoma Multiforme. Acta Neurochir (Wien), 1998; 140: 872.
  • Warnke PC., Schumacher U., Kopitzki K., Ostertag CB., Warnke PC.: The Effect of Interstitial Radiosurgery on Tumoural Lesional Epilepsy. Acta Neurochir (Wien), 1998; 140: 856.
Festschriften:
  • Nikkhah G: Reisen zum Mittelpunkt des Gehirns. 60 Jahre stereotaktische Neurochirurgie am Universitätsklinikum Freiburg. (Journeys to the center of the brain. 60 years of stereotactic neurosurgery at the University Hospital Freiburg) Freiburg, 2011.
Sonstige Publikationen:

Besondere wissenschaftliche Aktivitäten

Veranstaltung:
  • Prof. Dr. Volker A. Coenen: Veranstalter des 3. KOBE Workshop - Kompetenznetzwerk Komplexer Bewegungsstörungen. , Universitätsklinikum Freiburg - Neurozentrum, 12.05.2016 bis 14.05.2016.
  • Prof. Dr. Volker A. Coenen: 2. Patiententag Morbus Parkinson am 13. April 2019, Leitung der Veranstaltung, 13.04.2019.
  • Prof. Dr. Volker A. Coenen: 6. KOBE-Workshop am 18. und 19. Oktober 2019, Leitung der Veranstaltung, 18.10.2019 bis 19.10.2019.
Öffentlichkeitsarbeit:
  • Prof. Dr. Volker A. Coenen, Dr. Thomas Prokop, Dr. Peter Reinacher, Dr. Bastian Sajonz, Dr. Michael Trippel: Regelmäßige, landesweite Vorlesungen für die Selbsthilfegruppen der Deutschen Parkinson Gesellschaft DPV, 2016.
Wissenschaftliche Beratung / Gutachtertätigkeiten:
  • Prof. Dr. Volker A. Coenen: Project Proposal Evaluation Board, BrainLinks – BrainTools Freiburg, 2016.
  • Prof. Dr. Volker A. Coenen: Zweitgutachter in Promotionsverfahren, der Medizinischen Fakultät der Universität Freiburg, 2016.
Fakultaet:
  • Dr. Bastian Sajonz: Lehre an der Medizinischen Fakultät - Humanmedizin, Tutor, Neurochirurgie, Wintersemester 2016, 2016.
  • Dr. Bastian Sajonz: Lehre an der Medizinischen Fakultät - Humanmedizin, Tutor, Neurologie, Wintersemester 2016, 2016.
  • Dr. Máté Döbrössy: Lehre an der Medizinischen Fakultät – Molekulare Medizin, MSc. Molekulare Medizin, Modul Biomedizin, Universität Freiburg , Seminar Jan-Feb: "Neuromodulation in Neuro-degenerative and Psychiatric Disorders", 2016.
  • Dr. Máté Döbrössy: Lehre an der Medizinischen Fakultät – Molekulare Medizin, MSc. Molekulare Medizin, Modul Biomedizin, Universität Freiburg , Vorlesung Juni: "Novel therapies in Parkinson´s disease and Depression: Neurotransplantation and Deep Brain Stimulation", 2016.
  • Dr. Máté Döbrössy: Lehre an der Medizinischen Fakultät – Molekulare Medizin, MSc. Molekulare Medizin, Modul Biomedizin, Universität Freiburg , Vorlesung November: "Novel therapies in Parkinson´s disease and Depression: Neurotransplantation and Deep Brain Stimulation", 2016.
  • Dr. Máté Döbrössy: Lehre an der Medizinischen Fakultät – Molekulare Medizin, MSc. Molekulare Medizin, Modul Biomedizin, Universität Freiburg , Seminar Dez 2016 – Jan 2017: "Neuromodulation in Neuro-degenerative and Psychiatric Disorders", 01.12.2016 bis 31.01.2017.
  • Dr. Peter Reinacher: Lehre an der Medizinischen Fakultät – Zahn- Mund- und Kieferheilkunde, Vorlesung im Dezember, 2016.
  • Dr. Peter Reinacher: Lehre an der Medizinischen Fakultät - Humanmedizin, , Tutor, Neurologie, Sommersemester 2016 und Wintersemester 2016, 2016.
  • Dr. Peter Reinacher: Lehre an der Medizinischen Fakultät - Humanmedizin, , Tutor, Neurochirurgie, Sommersemester 2016 und Wintersemester 2016, 2016.
  • Stephanie Thiele: Tutorat an der Medizinischen Fakultät – Molekulare Medizin, MSc. Molekulare Medizin, Modul Biomedizin, Universität Freiburg , Modul November 2016: "Molekulare Mechanismen und Techniken der Entwicklungsbiologie"., 01.11.2016 bis 30.11.2016.

Abschlussarbeiten

Promotionen
  • Büchele F: Two-step grafting – a new method to study cell survival and graft development in a 6-OHDA rat model of Parkinson’s disease (PD)., 2012.
  • Ganser, Claudia: In Vitro Characterisation of Neuroprotective Agents and Cell Sources for Cell Replacement Therapies for Parkinson's Disease, 2008.
  • Garcia J: L-DOPA- and graft-induced dyskinesias after cell replacement therapy in a rat model of Parkinson´s disease., 2012.
  • Hackl, Christina: Towards a cell-based organotypic reconstruction of the dopaminergic pathway in rat models of Parkinson's disease. The influence of the developmental stage of the host, of the transplantation technique and of donor cell properties on morphologic reconstruction and functional recovery by embryonic ventral mesencephalic transplants, 2007.
  • Jiang, Wei: Anatomical and functional analysis of intrastriatal striatal transplants in a rodent model of Huntington’s disease. Studies using the micro-transplantation approach in an excitotoxically leasioned rat striatum, 2008.
  • Kahlert U: Characterization of Brain Tumor Stem Cells - a novel concept for the origin and propagation of adult malignant glial tumors., 2012.
  • Klein, Alexander: Stammzellbasierte Restauration komplex sensomotorischer Funktionen im dopaminergen Projektionssystem (in Zusammenarbeit mit Prof. W. Driever, Entwicklungsneurobiologie), 2006.
  • Kloth, Verena: Studien zu Anatomie und Verhalten im Tiermodell der Parkinsonschen Erkrankung, 2006.
  • Knust, U: Einfluß von kapillärer Permeabilität, regionaler Durchblutung und vaskulärem Volumen auf die Anreicherung des monoklonalen Antikörpers 81C6 in malignen Gliomen, 1995.
  • Lepski, Guilherme: A comparative analysis of human adult mesenchymal and fetal neuronal stem cells with regard to their neurogenic potential, 2009.
  • Liu, Jung-Tung: Quantitative Messung der regionalen Hirndurchblutung mittels Xenon-Computertomographie und SPECT bei intrakraniellen Tumoren, 1995.
  • Löttrich, David: Xenotransplantation of L1 overexpressing mouse embryonic stem cells in an animal model of Parkinson’s disease, 2009.
  • Maciaczyk, Jaroslaw: Human fetal neural precursor cells: a putative cell source for neurorestorative strategies, 2006.
  • Pantazis, Georgios: Einzeitige interstitielle stereotaktische Radiochirurgie mit dem Photon Radiosurgery System (PRS) zur Behandlung maligner Gliome und zerebraler Metastasen, 2007.
  • Pfeiffer, Lisa-Marie, geb. Selesnew: Optogenetic Neuromodulation in a Rodent Model of Depression., 2019.
  • Pruszak, Jan: Identification, differentiation and selection of specific neural cell lineages from embryonic stem cells , 2009.
  • Savas, Ali: Die Wirkung kontinuierlicher und Einzeit-Bestrahlung auf die Cholin-Aufnahme von organotypischen Gewebeschnittkulturen des Hypocampus des Kaninchens, 1995.
  • Scheidecker,Anne: Diagnostik und Therapie maligner Hirntumoren bei älteren Patienten, 2007.
  • Thiele, Stephanie: Electrical stimulation in animal models of psychiatric diseases., 2019.
Diplomarbeiten
  • Jäger J: Gene expression analysis during striatal development in transgenic rat models of Huntington's Disease., 2012.
Master
  • Alexander Cook: Olfactory Discrimination and Memory Deficits in the Flinder`s Sensitive Line Model of Depression,, 2016.
  • Ramanathan, Chockalingam: Assessment of Dopamine release induced by Deep Brain Stimulation of Medial Forebrain Bundle in anaesthetized rats. , 2019.
Bachelor
  • Ramelow, Christian: Assessing Neurostimulation Induced Changes in Gene Expression in a Model of Depression., 2019.




Gastwissenschaftler:

  • Aliaksandr Zabaronak, Weißrussland, 23.07.2008 bis 05.09.2008
  • Diogo Ribeiro, Portugal, 23.10.2008 bis 08.12.2008
  • Dr. Cielo Cantillo, Kolumbien, 30.03.2009 bis 03.04.2009
  • Dr. Marcos Perocco Luiz da Costa, Univ. Presidente Prudente, Sao Paulo, Brasilien, 02.03.2009 bis 08.03.2009
  • Dr. Paresh Doshi, India, 30.03.2009 bis 01.04.2009
  • Gökay Orhan, Türkei, 15.12.2008 bis 19.12.2008
  • Luis Manuel Azmitia, Universidad de San Carlos de Guatemala Medical School, Guatemala, Hospitant, 15.06.2010 bis 16.08.2010
  • Marilia Grando Sória, Curitiba, Brasilien, 07.10.2010 bis 23.03.2011
  • Miroslaw Janowski, Polen, 15.09.2008 bis 26.09.2008
  • William Omar Contreras Lopez, Bucarramanga, Kolumbien, 01.10.2009 bis 30.09.2012