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 Forschungsbericht für das Jahr 2018

Department Innere Medizin

Klinik für Innere Medizin I

Hugstetter Str. 55
79106 Freiburg
Tel: 0761/270-34060 Fax: 0761/270-32060
https://www.uniklinik-freiburg.de/medizin1.html


Einträge in der Rubrik "Who is Who"

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Arends J: How to feed patients with gastrointestinal mucositis. Curr Opin Support Pa, 2018; 12 (2): 168-173. : http://dx.doi.org/10.1097/SPC.0000000000000345
  • Arends J: Struggling with nutrition in patients with advanced cancer: nutrition and nourishment-focusing on metabolism and supportive care. Ann Oncol, 2018; 29 (suppl_2): ii27-ii34. : http://dx.doi.org/10.1093/annonc/mdy093
  • Brandt LP, Albers J, Hejhal T, Pfundstein S, Goncalves AF, Catalano A, Wild PJ, Frew IJ: Mouse genetic background influences whether Hras(G12V) expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma. Oncotarget, 2018; 9 (28): 19753-19766. : http://dx.doi.org/10.18632/oncotarget.24831
  • Caers J, Paiva B, Zamagni E, Leleu X, Blade J, Kristinsson SY, Touzeau C, Abildgaard N, Terpos E, Heusschen R, Ocio E, Delforge M, Sezer O, Beksac M, Ludwig H, Merlini G, Moreau P, Zweegman S, Engelhardt M, Rosinol L: Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel. J Hematol Oncol, 2018; 11 (1): 10-10. : http://dx.doi.org/10.1186/s13045-017-0549-1
  • Chen S, Zeiser R: The Role of MicroRNAs in Myeloid Cells during Graft-versus-Host Disease. Front Immunol, 2018; 9: 4-4. : http://dx.doi.org/10.3389/fimmu.2018.00004
  • de van der Schueren MAE, Laviano A, Blanchard H, Jourdan M, Arends J, Baracos VE: Systematic review and meta-analysis of the evidence for oral nutritional intervention on nutritional and clinical outcomes during chemo(radio)therapy: current evidence and guidance for design of future trials. Ann Oncol, 2018; 29 (5): 1141-1153. : http://dx.doi.org/10.1093/annonc/mdy114
  • Duque-Afonso J, Ihorst G, Waterhouse M, Zeiser R, Wasch R, Bertz H, Muller-Quernheim J, Finke J, Marks R, Prasse A: Impact of lung function on bronchiolitis obliterans syndrome and outcome after allogeneic hematopoietic cell transplantation with reduced intensity conditioning. Biol Blood Marrow Tr, 2018 (online). : http://dx.doi.org/10.1016/j.bbmt.2018.06.024
  • Duque-Afonso J, Waterhouse M, Pfeifer D, Follo M, Duyster J, Bertz H, Finke J: Cell-free DNA characteristics and chimerism analysis in patients after allogeneic cell transplantation. Clin Biochem, 2018; 52: 137-141. : http://dx.doi.org/10.1016/j.clinbiochem.2017.11.015
  • Engelhardt M, Herget GW, Graziani G, Ihorst G, Reinhardt H, Ajayi S, Knop S, Wasch R: Osteoprotective medication in the era of novel agents: a European perspective on values, risks and future solutions. Haematologica, 2018; 103 (5): 755-758. : http://dx.doi.org/10.3324/haematol.2018.188516
  • Felip E, Hirsh V, Popat S, Cobo M, Fulop A, Dayen C, Trigo JM, Gregg R, Waller CF, Soria JC, Goss GD, Gordon J, Wang B, Palmer M, Ehrnrooth E, Gadgeel SM: Symptom and Quality of Life Improvement in LUX-Lung 8, an Open-Label Phase III Study of Second-Line Afatinib Versus Erlotinib in Patients With Advanced Squamous Cell Carcinoma of the Lung After First-Line Platinum-Based Chemotherapy. Clin Lung Cancer, 2018; 19 (1): 74-83e11. : http://dx.doi.org/10.1016/j.cllc.2017.06.002
  • Gay F, Engelhardt M, Terpos E, Wasch R, Giaccone L, Auner HW, Caers J, Gramatzki M, van de Donk N, Oliva S, Zamagni E, Garderet L, Straka C, Hajek R, Ludwig H, Einsele H, Dimopoulos M, Boccadoro M, Kroger N, Cavo M, Goldschmidt H, Bruno B, Sonneveld P: From transplant to novel cellular therapies in multiple myeloma: European Myeloma Network guidelines and future perspectives. Haematologica, 2018; 103 (2): 197-211. : http://dx.doi.org/10.3324/haematol.2017.174573
  • Gengenbach L, Reinhardt H, Ihorst G, Ajayi S, Dold SM, Kohler M, Einsele H, Duyster J, Wasch R, Engelhardt M: Navigating the changing multiple myeloma treatment landscape: clinical practice patterns of MM patients treated in- and outside German DSMM study group trials(). Leukemia Lymphoma, 2018 (online): 1-8. : http://dx.doi.org/10.1080/10428194.2018.1448084
  • Greil C, Ihorst G, Kiote-Schmidt C, Hildenbeutel S, Kuhbach K, Bosse R, Duyster J, Engelhardt M, Wasch R: Stem cell mobilization in poor mobilizers with multiple myeloma or lymphoma before and after introduction of plerixafor: a single-center comparative analysis using a cost-efficient single fixed-dose schedule. Leukemia Lymphoma, 2018; 59 (7): 1722-1725. : http://dx.doi.org/10.1080/10428194.2017.1393673
  • Hottenrott T, Schorb E, Fritsch K, Dersch R, Berger B, Huzly D, Rauer S, Tebartz van Elst L, Endres D, Stich O: The MRZ reaction and a quantitative intrathecal IgG synthesis may be helpful to differentiate between primary central nervous system lymphoma and multiple sclerosis. J Neurol, 2018; 265 (5): 1106-1114. : http://dx.doi.org/10.1007/s00415-018-8779-x
  • Hulsdunker J, Ottmuller KJ, Neeff HP, Koyama M, Gao Z, Thomas OS, Follo M, Al-Ahmad A, Prinz G, Duquesne S, Dierbach H, Kirschnek S, Lammermann T, Blaser MJ, Fife BT, Blazar BR, Beilhack A, Hill GR, Hacker G, Zeiser R: Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset. Blood, 2018; 131 (16): 1858-1869. : http://dx.doi.org/10.1182/blood-2017-10-812891
  • Jagasia M, Zeiser R, Arbushites M, Delaite P, Gadbaw B, Bubnoff NV: Ruxolitinib for the treatment of patients with steroid-refractory GVHD: an introduction to the REACH trials. Immunotherapy-uk, 2018; 10 (5): 391-402. : http://dx.doi.org/10.2217/imt-2017-0156
  • Kohler M, Greil C, Hudecek M, Lonial S, Raje N, Wasch R, Engelhardt M: Current developments in immunotherapy in the treatment of multiple myeloma. Cancer Cytopathol, 2018; 124 (10): 2075-2085. : http://dx.doi.org/10.1002/cncr.31243
  • Lin CH, Wong SH, Kurzer JH, Schneidawind C, Wei MC, Duque-Afonso J, Jeong J, Feng X, Cleary ML: SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression. Cell Rep, 2018; 23 (4): 1166-1177. : http://dx.doi.org/10.1016/j.celrep.2018.03.124
  • Marks R, Engelhardt M, Hager S, Fullgraf H, Sudkamp NP, Herget GW: Diffuse large B cell lymphoma (DLBCL): bilateral vanishing tibiae. Ann Hematol, 2018; 97 (8): 1497-1500. : http://dx.doi.org/10.1007/s00277-018-3308-7
  • Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Muller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lubbert M, Rummelt C, Bertz H, Wasch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rosler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stolzel F, Ordemann R, Muller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kroger N, Ayuk F, Vago L, Ciceri F, Muller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dorfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Borries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Shah O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socie G, Caligiuri MA, Ruggiero E, Bonini C, Hacker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nat Med, 2018; 24 (3): 282-291. : http://dx.doi.org/10.1038/nm.4484
  • Naegele M, Kirsch M, Ihorst G, Fierz K, Engelhardt M, De Geest S: Symptom experience of multiple myeloma (syMMex) patients treated with autologous stem cell transplantation following high-dose melphalan: a descriptive longitudinal study. Support Care Cancer, 2018; 26 (3): 833-841. : http://dx.doi.org/10.1007/s00520-017-3897-z
  • Pankratz F, Hohnloser C, Bemtgen X, Jaenich C, Kreuzaler S, Hoefer I, Pasterkamp G, Mastroianni J, Zeiser R, Smolka C, Schneider L, Martin J, Juschkat M, Helbing T, Moser M, Bode C, Grundmann S: MicroRNA-100 Suppresses Chronic Vascular Inflammation by Stimulation of Endothelial Autophagy. Circ Res, 2018; 122 (3): 417-432. : http://dx.doi.org/10.1161/CIRCRESAHA.117.311428
  • Peeken JC, Jutzi JS, Wehrle J, Koellerer C, Staehle HF, Becker H, Schoenwandt E, Seeger TS, Schanne DH, Gothwal M, Ott CJ, Grunder A, Pahl HL: Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms. Blood, 2018; 131 (18): 2065-2073. : http://dx.doi.org/10.1182/blood-2017-10-810622
  • Pfeifer H, Raum K, Markovic S, Nowak V, Fey S, Oblander J, Pressler J, Bohm V, Bruggemann M, Wunderle L, Huttmann A, Wasch R, Beck J, Stelljes M, Viardot A, Lang F, Hoelzer D, Hofmann WK, Serve H, Weiss C, Goekbuget N, Ottmann OG, Nowak D: Genomic CDKN2A/2B deletions in adult Ph(+) ALL are adverse despite allogeneic stem cell transplantation. Blood, 2018; 131 (13): 1464-1475. : http://dx.doi.org/10.1182/blood-2017-07-796862
  • Prestipino A, Emhardt AJ, Aumann K, O'Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholoma M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kroger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R: Oncogenic JAK2(V617F) causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Sci Transl Med, 2018; 10 (429): ?-?. : http://dx.doi.org/10.1126/scitranslmed.aam7729
  • Rassner MP, Seidl M, Salzer U, Rajkumar SV, Epting T, Wasch R, Neumann-Haefelin E, Engelhardt M: Cast Nephropathy and Deceptively Low Absolute Serum Free Light Chain Levels: Resolution of a Challenging Case and Systematic Review of the Literature. Cl Lymph Myelom Leuk, 2018; 8 (1): e1-e7. : http://dx.doi.org/10.1016/j.clml.2017.09.019
  • Scheller E, Schumacher LV, Peter J, Lahr J, Wehrle J, Kaller CP, Gaser C, Kloppel S: Brain Aging and APOE epsilon4 Interact to Reveal Potential Neuronal Compensation in Healthy Older Adults. Front Aging Neurosci, 2018; 10: 74-74. : http://dx.doi.org/10.3389/fnagi.2018.00074
  • Schneidawind C, Jeong J, Schneidawind D, Kim IS, Duque-Afonso J, Wong SHK, Iwasaki M, Breese EH, Zehnder JL, Porteus M, Cleary ML: MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing. Blood Advances, 2018; 2 (8): 832-845. : http://dx.doi.org/10.1182/bloodadvances.2017013748
  • Schulz-Fincke J, Hau M, Barth J, Robaa D, Willmann D, Kurner A, Haas J, Greve G, Haydn T, Fulda S, Lubbert M, Ludeke S, Berg T, Sippl W, Schule R, Jung M: Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation. Eur J Med Chem, 2018; 144: 52-67. : http://dx.doi.org/10.1016/j.ejmech.2017.12.001
  • Simon-Gabriel CP, Foerster K, Saleem S, Bleckmann D, Benkisser-Petersen M, Thornton N, Umezawa K, Decker S, Burger M, Veelken H, Claus R, Dierks C, Duyster J, Zirlik K: Microenvironmental stromal cells abrogate NF-kappaB inhibitor-induced apoptosis in chronic lymphocytic leukemia. Haematologica, 2018; 103 (1): 136-147. : http://dx.doi.org/10.3324/haematol.2017.165381
  • Stosch JM, Heumuller A, Niemoller C, Bleul S, Rothenberg-Thurley M, Riba J, Renz N, Szarc Vel Szic K, Pfeifer D, Follo M, Pahl HL, Zimmermann S, Duyster J, Wehrle J, Lubbert M, Metzeler KH, Claus R, Becker H: Gene mutations and clonal architecture in myelodysplastic syndromes and changes upon progression to acute myeloid leukaemia and under treatment. Brit J Haematol, 2018. : http://dx.doi.org/10.1111/bjh.15461 (in Druck)
  • Thomsen AR, Aldrian C, Bronsert P, Thomann Y, Nanko N, Melin N, Rucker G, Follo M, Grosu AL, Niedermann G, Layer PG, Heselich A, Lund PG: A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement. Lab Chip, 2018; 18 (1): 179-189. : http://dx.doi.org/10.1039/c7lc00832e
  • Waller CF, Tiessen RG, Lawrence TE, Shaw A, Liu MS, Sharma R, Baczkowski M, Kothekar MA, Micales CE, Barve A, Ranganna GM, Pennella EJ: A pharmacokinetics and pharmacodynamics equivalence trial of the proposed pegfilgrastim biosimilar, MYL-1401H, versus reference pegfilgrastim. J Cancer Res Clin, 2018; 144 (6): 1087-1095. : http://dx.doi.org/10.1007/s00432-018-2643-3
  • Zeiser R: Immune modulatory effects of statins. Immunology, 2018; 154 (1): 69-75. : http://dx.doi.org/10.1111/imm.12902
  • Zeiser R: Introduction to a review series on strategies to improve GVL effects. Blood, 2018; 131 (10): 1039-1039. : http://dx.doi.org/10.1182/blood-2017-11-814467
  • Zeiser R, Sarantopoulos S, Blazar BR: B-cell targeting in chronic graft-versus-host disease. Blood, 2018; 131 (13): 1399-1405. : http://dx.doi.org/10.1182/blood-2017-11-784017
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:
  • Ludwig H, Delforge M, Facon T, Einsele H, Gay F, Moreau P, Avet-Loiseau H, Boccadoro M, Hajek R, Mohty M, Cavo M, Dimopoulos MA, San-Miguel JF, Terpos E, Zweegman S, Garderet L, Mateos MV, Cook G, Leleu X, Goldschmidt H, Jackson G, Kaiser M, Weisel K, van de Donk NWCJ, Waage A, Beksac M, Mellqvist UH, Engelhardt M, Caers J, Driessen C, Blade J, Sonneveld P: Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network. Leukemia, 2018 (online). : http://dx.doi.org/10.1038/s41375-018-0040-1

Besondere wissenschaftliche Aktivitäten

Preise / Ehrungen:
  • Dr. Verena Klämbt: Albrecht-Fleckenstein-Preis, für Ihre Promotionsarbeit (AG Zeiser), 22.08.2016.

Abschlussarbeiten