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 Forschungsbericht für das Jahr 2019

Klinik für Allgemein- und Viszeralchirurgie

Hugstetterstrasse 55
79106 Freiburg
Tel: +49 761 270 28060 Fax: + 49 761 270 28040
Email maria.schierenberg@uniklinik-freiburg.de
http://www.uniklinik-freiburg.de/chirurgie/live/index.html


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Stefan Fichtner-Feigl, Ärztlicher Direktor
  • Prof. Dr. med. Sven Arke Lang, Leitender Oberarzt
  • Prof. Dr. med. Jens Höppner, Geschäftsführender Oberarzt
  • PD Dr. med. Hannes Neeff, Geschäftsführender Oberarzt
  • Prof. Dr. med. Oliver Thomusch, Geschäftsführender Oberarzt
  • Prof. Dr. med. Uwe Wittel, Geschäftsführender Oberarzt
  • PD Dr. Rebecca Kesselring, Leitender wissenschaftlicher Mitarbeiter (m/w)
  • Prof. Dr. med. Goran Marjanovic, Leiter Zentrum für Metabolische Chirurgie, Obearzt
  • Prof. Dr. med. Przemyslaw Pisarski, Leiter Sektion Transplantationschirurgie
  • Dr. med. Andrea Proneth, Oberärztin
  • Dr. med. Jochen Rädecke, Oberarzt Kinderchirurgie
  • Prof. Dr. med. Stefan Utzolino, Leiter Chirurgische Intensivstation, Oberarzt
  • Dr. med. Lampros Kousoulas, Funktionsoberarzt
  • Dr. med. Esther Biesel, Fachärztin
  • Dr. med. Sophia Chikhladze, Fachärztin
  • PD Dr. med. Jodok Fink, Facharzt
  • PD Dr. med. Torben Glatz, Facharzt
  • Dr. med. univ. Philip Holzner, Facharzt
  • Dr. med. Carolin Kayser, Funktionsoberärztin
  • PD Dr. med. Birte Kulemann, Fachärztin
  • Dr. med. Susanne Lagrèze, Fachärztin, Kinderchirurgie
  • Dr. med. Ruth-Sybille Mayer, Funktionsoberäztin
  • Dr. med. Catharina Ruf, Fachärztin
  • Dr. med. Joachim Schönberger, Facharzt
  • PD Dr. med. Gabriel Seifert, Facharzt
  • Dr. med. Sandra Weih, Fachärztin, Kinderchirurgie
  • Dr. med. Christopher Berlin, Assistenzarzt
  • Dr. med. Chiara Erdle, Ärztin
  • Emma Sophia Hartmann Roca, Ärztin
  • Nancy Heidler, Ärztin
  • Dr. med. Stephan Herrmann, Arzt
  • Dr. med. Julian Hipp, Assistenzarzt
  • Dr. med. Dominik Jauch, Assistenzarzt
  • Dr. med. Katharina Jöchle, Ärztin
  • Andreas Jud, Arzt
  • Jessica Klima-Frysch, Ärztin, Kinderchirurgie
  • Dr. med. Christian Kühlbrey, Facharzt
  • Dr. med. Jasmina Kuvendjiska, Ärztin
  • Dr. med. Claudia Läßle, Assistenzärztin
  • Dr. med. Jost Lünstedt, Assistenzarzt
  • Verena Martini, Assistenzärztin
  • Laura Matuschik, Ärztin
  • Dr. med. Madalena Menzel, Fachärztin
  • Gergana Nenova, Assistenzärztin
  • Dr. med. Dietrich Rueß, Assistenzarzt
  • Mira Runkel, Ärztin
  • Giuseppe Rusignuolo, Arzt
  • Dr. med. Julia Spiegelberg, Ärztin
  • Gabriel Stöger
  • Dr. rer. nat. Andrea Klock, Studienassistentin
  • Dipl. Biol. Maria Schierenberg, Organisation Fortbildungen / Wissenschaft
  • Dipl. Biol. Olivia Sick, Studienassistentin
Einträge in der Rubrik "Who is Who"

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Bolm L, Petrova E, Weitz J, Ruckert F, Wittel UA, Makowiec F, Lapshyn H, Bronsert P, Rau BM, Khatkov IE, Bausch D, Keck T, Wellner UF, Distler M: Prognostic relevance of preoperative bilirubin-adjusted serum carbohydrate antigen 19-9 in a multicenter subset analysis of 179 patients with distal cholangiocarcinoma. Hpb, 2019. : http://dx.doi.org/10.1016/j.hpb.2019.03.363 (in Druck)
  • Chikhladze S, Kupreishvili S, Korsake K, Sick O, Fink J, Seifert G, Lassle C, Nenova G, Hoppner J, Glatz T, Fichtner-Feigl S, Marjanovic G: Recurring Anastomotic Leak-A Prospective Clinicopathological Investigation of a Distinct Disease Pattern. J Surg Res, 2019; 239: 201-207. : http://dx.doi.org/10.1016/j.jss.2019.02.013
  • Chikhladze S, Makowiec F, Kusters S, Riediger H, Sick O, Fichtner-Feigl S, Hopt UT, Wittel UA: The rate of postoperative pancreatic fistula after distal pancreatectomy is independent of the pancreatic stump closure technique - A retrospective analysis of 284 cases. Asian J Surg, 2019 (online). : http://dx.doi.org/10.1016/j.asjsur.2019.03.009
  • Fink JM, von Pigenot A, Seifert G, Laessle C, Fichtner-Feigl S, Marjanovic G: Banded versus nonbanded sleeve gastrectomy: 5-year results of a matched-pair analysis. Surg Obes Relat Dis, 2019; 15: 1233-1238. : http://dx.doi.org/10.1016/j.soard.2019.05.023
  • Gkika E, Strouthos I, Kirste S, Adebahr S, Schultheiss M, Bettinger D, Fritsch R, Brass V, Maruschke L, Neeff HP, Lang SA, Nestle U, Grosu AL, Brunner TB: Repeated SBRT for in- and out-of-field recurrences in the liver. Strahlenther Onkol, 2019; 195 (3): 246-253. : http://dx.doi.org/10.1007/s00066-018-1385-0
  • Glatz T, Horvath P, Lang SA, Archid R, Nadiradze G: Staging laparoscopy and Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for peritoneal metastasis: safe access to the abdomen. Pleura Peritoneum, 2019; 4 (1): 20190004-20190004. : http://dx.doi.org/10.1515/pp-2019-0004
  • Gorgulu K, Diakopoulos KN, Ai J, Schoeps B, Kabacaoglu D, Karpathaki AF, Ciecielski KJ, Kaya-Aksoy E, Ruess DA, Berninger A, Kowalska M, Stevanovic M, Wormann SM, Wartmann T, Zhao Y, Halangk W, Voronina S, Tepikin A, Schlitter AM, Steiger K, Artati A, Adamski J, Aichler M, Walch A, Jastroch M, Hartleben G, Mantzoros CS, Weichert W, Schmid RM, Herzig S, Kruger A, Sainz B Jr, Lesina M, Algul H: Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice. Gastroenterology, 2019; 156 (1): 203-217.e20. : http://dx.doi.org/10.1053/j.gastro.2018.09.053
  • Hipp J, Mohamed S, Pott J, Sick O, Makowiec F, Hopt UT, Fichtner-Feigl S, Wittel UA: Management and outcomes of intraductal papillary mucinous neoplasms. BJS Open, 2019; 3 (4): 490-499. : http://dx.doi.org/10.1002/bjs5.50156
  • Holmer C, Benz S, Fichtner-Feigl S, Jehle EC, Kienle P, Post S, Schiedeck T, Weitz J, Kreis ME: Transanale totale mesorektale Exzision – eine kritische Standortbestimmung. Chirurg, 2019; 90 (6): 478-486. : http://dx.doi.org/10.1007/s00104-019-0945-x
  • Jänigen BM, Salabe C, Glatz T, Thomusch O, Laessle C, Fichtner-Feigl S, Zschiedrich S, Pisarski P: Single cohort study: ABO-incompatible kidney transplant recipients have a higher risk of lymphocele formation. Langenbeck Arch Surg, 2019. : http://dx.doi.org/10.1007/s00423-019-01812-y (in Druck)
  • Jöchle K, Goumard C, Vega EA, Okuno M, Chun YS, Tzeng CD, Vauthey JN, Conrad C: Long-term survival after post-hepatectomy liver failure for colorectal liver metastases. Hpb, 2019; 21 (3): 361-369. : http://dx.doi.org/10.1016/j.hpb.2018.07.019
  • Jöchle K, Vega EA, Okuno M, Simoneau E, Ogiso S, Newhook TE, Ramirez DL, Holmes AA, Soliz JM, Chun YS, Tzeng CD, Lee JE, Vauthey JN, Conrad C: Middle Hepatic Vein Roadmap for a Safe Laparoscopic Right Hepatectomy. Ann Surg Oncol, 2019; 26 (1): 296-296. : http://dx.doi.org/10.1245/s10434-018-7034-0
  • Kabacaoglu D, Ruess DA, Ai J, Algul H: NF-kappaB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB. Cancers, 2019; 11 (7) (online). : http://dx.doi.org/10.3390/cancers11070937
  • Kirste S, Landenberger N, Scholber J, Henne K, Wittel UA, Grosu AL: Retroperitoneal soft tissue sarcoma: low-dose neoadjuvant radiation therapy followed by surgery with or without intraoperative radiotherapy and adjuvant radiation therapy. Strahlenther Onkol, 2019; 195 (6): 558-565. : http://dx.doi.org/10.1007/s00066-019-01464-3
  • Koulaxouzidis G, Penna V, Bannasch H, Neeff HP, Manegold P, Aigner F, Witzel C, Kreis ME, Pratschke J, Stark GB, Lampert FM: The adipofasciocutaneous gluteal fold perforator flap a versatile alternative choice for covering perineal defects. Int J Colorectal Dis, 2019; 34 (3): 501-511. : http://dx.doi.org/10.1007/s00384-018-03222-w
  • Kühlbrey CM, Kasper S, Chikhladze S, Seifert G, Hopt UT, Fichtner-Feigl S, Wittel UA: Bio-absorbable sealants for reinforcing the pancreatic stump after distal pancreatectomy are critical. J Hepato-bil-pan Sci, 2019; 26 (3): 96-103. : http://dx.doi.org/10.1002/jhbp.604
  • Kuvendjiska J, Bronsert P, Martini V, Lang S, Pitman MB, Hoeppner J, Kulemann B: Non-Metastatic Esophageal Adenocarcinoma: Circulating Tumor Cells in the Course of Multimodal Tumor Treatment. Cancers, 2019; 11 (3) (online). : http://dx.doi.org/10.3390/cancers11030397
  • Kuvendjiska J, Marjanovic G, Glatz T, Kulemann B, Hoeppner J: Hybrid Minimally Invasive Esophagectomy-Surgical Technique and Results. J Clin Med, 2019; 8 (7) (online). : http://dx.doi.org/10.3390/jcm8070978
  • Laessle C, Jin K, Seifert GJ, Timme-Bronsert S, Fichtner-Feigl S, Marjanovic G, Fink JM: Putting the Hindgut Hypothesis to the Test in a Diabetic Zucker Rat Model. Obes Surg, 2019 (online). : http://dx.doi.org/10.1007/s11695-019-04079-w
  • Lagies S, Schlimpert M, Braun LM, Kather M, Plagge J, Erbes T, Wittel UA, Kammerer B: Unraveling altered RNA metabolism in pancreatic cancer cells by liquid-chromatography coupling to ion mobility mass spectrometry. Anal Bioanal Chem, 2019 (online). : http://dx.doi.org/10.1007/s00216-019-01814-1
  • Lederer AK, Haffa D, Felgendreff P, Makowiec F, Fichtner-Feigl S, Huber R, Kousoulas L: The impact of immunosuppression on postoperative graft function after graft-unrelated surgery: a retrospective controlled cohort study. Bmc Nephrol, 2019; 20 (1): 170-170. : http://dx.doi.org/10.1186/s12882-019-1358-2
  • Lederer AK, Haffa D Martini V, Huber R, Makowiec F, Fichtner-Feigl S, Kousoulas L: Surgical outcomes of renal transplant recipients after abdominal surgery not connected with transplantation: A retrospective case-control study Int J Surg, 2019; 61: 53-59.
  • Manegold P, Taukert J, Neeff H, Fichtner-Feigl S, Thomusch O: The minimum distal resection margin in rectal cancer surgery and its impact on local recurrence - a retrospective cohort analysis. Int J Surg, 2019; 69: 77-83. : http://dx.doi.org/10.1016/j.ijsu.2019.07.029
  • Martynov I, Rädecke J, Klima-Frysch J, Kluwe W, Schönberger J: The outcome of Bishop-Koop procedure compared to divided stoma in neonates with meconium ileus, congenital intestinal atresia and necrotizing enterocolitis. Medicine, 2019; 98 (27): e16304-e16304. : http://dx.doi.org/10.1097/MD.0000000000016304
  • Mintziras I, Keck T, Werner J, Fichtner-Feigl S, Wittel U, Senninger N, Vowinkel T, Koninger J, Anthuber M, Geissler B, Bartsch DK: Implementation of Current ENETS Guidelines for Surgery of Small (</=2 cm) Pancreatic Neuroendocrine Neoplasms in the German Surgical Community: An Analysis of the Prospective DGAV StuDoQ|Pancreas Registry. World J Surg, 2019; 43: 175-182. : http://dx.doi.org/10.1007/s00268-018-4751-2
  • Mintziras I, Keck T, Werner J, Fichtner-Feigl S, Wittel U, Senninger N, Vowinkel T, Koninger J, Anthuber M, Geissler B, Bartsch DK: Indications for resection and perioperative outcomes of surgery for pancreatic neuroendocrine neoplasms in Germany: an analysis of the prospective DGAV StuDoQ|Pancreas registry. Surg Today, 2019 (online). : http://dx.doi.org/10.1007/s00595-019-01838-1
  • Mungroop TH, Klompmaker S, Wellner UF, Steyerberg EW, Coratti A, D'Hondt M, de Pastena M, Dokmak S, Khatov I, Saint-Marc O, Wittel U, Abu Hilal M, Fuks D, Poves I, Keck T, Boggi U, Besselink MG: Updated Alternative Fistula Risk Score (ua-FRS) to Include Minimally Invasive Pancreatoduodenectomy: Pan-European Validation. Ann Surg, 2019. : http://dx.doi.org/10.1097/SLA.0000000000003234 (in Druck)
  • Okuno M, Goumard C, Kopetz S, Vega EA, Jöchle K, Mizuno T, Tzeng CD, Chun YS, Lee JE, Vauthey JN, Aloia TA, Conrad C: Loss of muscle mass during preoperative chemotherapy as a prognosticator for poor survival in patients with colorectal liver metastases. Surgery, 2019; 165 (2): 329-336. : http://dx.doi.org/10.1016/j.surg.2018.07.031
  • Schardey J, Globig AM, Janssen C, Hofmann M, Manegold P, Thimme R, Hasselblatt P: Vitamin D inhibits pro-inflammatory T cell function in patients with inflammatory bowel disease. J Crohns Colitis, 2019. : http://dx.doi.org/10.1093/ecco-jcc/jjz090 (in Druck)
  • Seifert GJ, Leithold G, Kulemann B, Holzner PA, Glatz T, Hoeppner J, Kirste S, Marjanovic G, Laessle C: The effect of pasireotide on intestinal anastomotic healing with and without whole-body irradiation in a rat model. Int J Colorectal Dis, 2019; 34 (2): 337-345. : http://dx.doi.org/10.1007/s00384-018-3193-5
  • van Hilst J, de Rooij T, Klompmaker S, Rawashdeh M, Aleotti F, Al-Sarireh B, Alseidi A, Ateeb Z, Balzano G, Berrevoet F, Bjornsson B, Boggi U, Busch OR, Butturini G, Casadei R, Del Chiaro M, Chikhladze S, Cipriani F, van Dam R, Damoli I, van Dieren S, Dokmak S, Edwin B, van Eijck C, Fabre JM, Falconi M, Farges O, Fernandez-Cruz L, Forgione A, Frigerio I, Fuks D, Gavazzi F, Gayet B, Giardino A, Bas Groot K, Hackert T, Hassenpflug M, Kabir I, Keck T, Khatkov I, Kusar M, Lombardo C, Marchegiani G, Marshall R, Menon KV, Montorsi M, Orville M, de Pastena M, Pietrabissa A, Poves I, Primrose J, Pugliese R, Ricci C, Roberts K, Rosok B, Sahakyan MA, Sanchez-Cabus S, Sandstrom P, Scovel L, Solaini L, Soonawalla Z, Souche FR, Sutcliffe RP, Tiberio GA, Tomazic A, Troisi R, Wellner U, White S, Wittel UA, Zerbi A, Bassi C, Besselink MG, Abu Hilal M: Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA): A Pan-European Propensity Score Matched Study. Ann Surg, 2019; 269 (1): 10-17. : http://dx.doi.org/10.1097/SLA.0000000000002561
  • Vega EA, Kutlu OC, Jöchle K, De La Cruz N, Ko D, Conrad C: Preoperative Prognosticators of Safe Laparoscopic Hepatocellular Carcinoma Resection in Advanced Cirrhosis: a Propensity Score Matching Population-Based Analysis of 1799 Western Patients. J Gastrointest Surg, 2019; 23 (6): 1157-1165. : http://dx.doi.org/10.1007/s11605-019-04139-7
  • Vega EA, Vinuela E, Okuno M, Joechle K, Sanhueza M, Diaz C, Jarufe N, Martinez J, Troncoso A, Diaz A, Chun YS, Tzeng CD, Lee JE, Vauthey JN, Conrad C: Incidental versus non-incidental gallbladder cancer: index cholecystectomy before oncologic re-resection negatively impacts survival in T2b tumors. Hpb, 2019. : http://dx.doi.org/10.1016/j.hpb.2018.12.006 (in Druck)
  • Vega EA, Vinuela E, Sanhueza M, Mege R, Caracci M, Diaz C, Diaz A, Okuno M, Jöchle K, Goumard C, Chun YS, Tzeng CD, Lee JE, Vauthey JN, Conrad C: Positive cystic duct margin at index cholecystectomy in incidental gallbladder cancer is an important negative prognosticator. Eur J Surg Oncol, 2019; 45 (6): 1061-1068. : http://dx.doi.org/10.1016/j.ejso.2019.01.013
  • Wicha SG, Mundkowski RG, Klock A, Hopt UT, Drewelow B, Kloft C, Wellner UF, Keck T, Wittel UA: Is Moxifloxacin a Treatment Option for Pancreatic Infections? A Pharmacometric Analysis of Serum and Pancreatic Juice. J Clin Pharmacol, 2019. : http://dx.doi.org/10.1002/jcph.1445 (in Druck)
  • Wittenbrink N, Herrmann S, Blazquez-Navarro A, Bauer C, Lindberg E, Wolk K, Sabat R, Reinke P, Sawitzki B, Thomusch O, Hugo C, Babel N, Seitz H, Or-Guil M: A novel approach reveals that HLA class 1 single antigen bead-signatures provide a means of high-accuracy pre-transplant risk assessment of acute cellular rejection in renal transplantation. Bmc Immunol, 2019; 20 (1): 11-11. : http://dx.doi.org/10.1186/s12865-019-0291-2

Besondere wissenschaftliche Aktivitäten

Wissenschaftliche Beratung / Gutachtertätigkeiten:
  • Pisarski P: Dr. med. Przemyslaw Pisarski, Leiter der Sektion Transplantation der Chirurgischen Universitätsklinik Freiburg, Abteilung Allgemein- und Viszeralchirurgie, Preis zur Förderung der Organspende für das wissenschaftliche Projekt "German AB0i-Register" (GABOiR), Deutsche Transplantationsgesellschaft, seit 06.10.2011.

Abschlussarbeiten