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 Forschungsbericht für das Jahr 2016

Klinik für Allgemein- und Viszeralchirurgie

Hugstetterstrasse 55
79106 Freiburg
Tel: +49 761 270 28060 Fax: + 49 761 270 28040
Email maria.schierenberg@uniklinik-freiburg.de
http://www.uniklinik-freiburg.de/chirurgie/live/index.html


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Stefan Fichtner-Feigl, Ärztlicher Direktor
  • Prof. Dr. med. Sven A. Lang, Leitender Oberarzt
  • Prof. Dr. med. Jens Höppner, Geschäftsführender Oberarzt
  • PD Dr. med. Hannes Neeff, Geschäftsführender Oberarzt
  • Prof. Dr. med. Przemyslaw Pisarski, Leiter Sektion Transplantationschirurgie
  • Dr. med. Andrea Proneth, Oberärztin
  • Dr. med. Jochen Rädecke, Komm. Leiter der Sektion Kinderchirurgie, Oberarzt
  • Prof. Dr. med. Oliver Thomusch, Geschäftsführender Oberarzt
  • Prof. Dr. med. Uwe Wittel, Geschäftsführender Oberarzt
  • PD Dr. med. Simon Küsters, Oberarzt
  • Prof. Dr. med. Frank Makowiec, Oberarzt
  • Prof. Dr. med. Goran Marjanovic, Leiter Zentrum für Metabolische Chirurgie, Obearzt
  • Prof. Dr. med. Stefan Utzolino, Leiter Chirurgische Intensivstation, Oberarzt
  • Dr. med. Carolin Kayser, Funktionsoberärztin
  • Dr. med. Lampros Kousoulas, Funktionsoberarzt
  • Dr. med. Ruth-Sybille Mayer, Funktionsoberäztin
  • Dr. med. Sophia Chikhladze, Fachärztin
  • PD Dr. med. Jodok Fink, Facharzt
  • Dr. med. univ. Philip Holzner, Facharzt
  • Dr. med. Joachim Schönberger, Facharzt
  • Dr. med. Gabriel Seifert, Facharzt
  • Dr. med. Esther Biesel, Assistenzärztin
  • Dr. med. Torben Glatz, Assistenzarzt
  • Dr. med. Ulrike Grundmann, Assistenzärztin
  • Julian Hipp, Assistenzarzt
  • Dr. med. Dominik Jauch, Assistenzarzt
  • Marius Kamps, Assistenzarzt
  • Andreas Kienlein, Assistenzarzt
  • Robin Klewitz, Assistenzarzt
  • Dr. med. Laura Klösges, Assistenzärztin
  • Dr. med. Christian Kühlbrey, Assistenzarzt
  • Dr. med. Birte Kulemann, Assistenzärztin
  • Jasmina Kuvendjiska, Assistenzärztin
  • Dr. med. Claudia Läßle, Assistenzärztin
  • Dr. med. Ann-Kathrin Lederer, Assistenzärztin
  • Verena Martini, Assistenzärztin
  • Markus Medl, Assistenzarzt
  • Dr. med. Madalena Menzel, Assistenzärztin
  • Jost Pott, Assistenzarzt
  • Dr. med. Dietrich Rueß, Assistenzarzt
  • Dr. med. Andrea Schmidt, Assistenzärztin
  • Susanne Wienecke, Assistenzärztin
  • Dr. rer. nat. Andrea Klock
  • Dipl. Biol. Maria Schierenberg
  • Dipl. Biol. Olivia Sick
  • Dr. rer. nat. Guido Wolff-Vorbeck
Einträge in der Rubrik "Who is Who"

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Ahrens TD, Timme S, Ostendorp J, Bogatyreva L, Hoeppner J, Hopt UT, Hauschke D, Werner M, Lassmann S: Response of esophageal cancer cells to epigenetic inhibitors is mediated via altered thioredoxin activity. Lab Invest, 2016; 96 (3): 307-316. : http://dx.doi.org/10.1038/labinvest.2015.148
  • Assfalg V, Huser N, van Meel M, Haller B, Rahmel A, de Boer J, Matevossian E, Novotny A, Knops N, Weekers L, Friess H, Pratschke J, Fugger R, Janko O, Rasoul-Rockenschaub S, Bosmans JL, Broeders N, Peeters P, Mourad M, Kuypers D, Slavicek J, Muehlfeld A, Sommer F, Viebahn R, Pascher A, van der Giet M, Zantvoort F, Woitas RP, Putz J, Grabitz K, Kribben A, Hauser I, Pisarski P, Weimer R, Lorf T, Fornara P, Morath C, Nashan B, Lehner F, Kliem V, Sester U, Grimm MO, Feldkamp T, Kleinert R, Arns W, Monch C, Schoenberg MB, Nitschke M, Kruger B, Thorban S, Arbogast HP, Wolters HH, Maier T, Lutz J, Heller K, Banas B, Hakenberg O, Kalus M, Nadalin S, Keller F, Lopau K, Bemelman FJ, Nurmohamed S, Sanders JS, de Fijter JW, Christiaans M, Hilbrands L, Betjes M, van Zuilen A, Heemann U: High-urgency kidney transplantation in the Eurotransplant Kidney Allocation System: success or waste of organs? The Eurotransplant 15-year all-centre survey. Nephrol Dial Transpl, 2016; 31 (9): 1515-1522. : http://dx.doi.org/10.1093/ndt/gfv446
  • Baier P, Ihorst G, Wolff-Vorbeck G, Hull M, Hopt U, Deschler B: Independence and health related quality of life in 200 onco-geriatric surgical patients within 6 months of follow-up: Who is at risk to lose? Ejso-eur J Surg Onc, 2016; 42 (12): 1890-1897. : http://dx.doi.org/10.1016/j.ejso.2016.07.013
  • Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M: LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. Cell Metab, 2016; 24 (5): 657-671. : http://dx.doi.org/10.1016/j.cmet.2016.08.011
  • Brunner SM, Hahn U, Jeiter T, Kesselring R, Rubner C, Ruemmele P, Sziklavari Z, Hofmann HS, Schlitt HJ, Fichtner-Feigl S: Immune Architecture of Colorectal Lung Metastases and Implications for Patient Survival. Eur Surg Res, 2016; 57 (3-4): 186-196. : http://dx.doi.org/10.1159/000447555
  • Fischer A, Thimme R, Hopt UT, Richter-Schrag HJ: Two-sided sponge (TSS) treatment: Description of a novel device and technique for endoscopic vacuum treatment (EVT) in the upper gastrointestinal tract. Endosc Int Open, 2016; 4 (9): E937-E940. : http://dx.doi.org/10.1055/s-0042-111078
  • Giel KE, Hartmann A, Zeeck A, Jux A, Vuck A, Gierthmuehlen PC, Wetzler-Burmeister E, Sandholz A, Marjanovic G, Joos A: Decreased Emotional Perception in Obesity. Eur Eat Disord Rev, 2016; 24 (4): 341-346. : http://dx.doi.org/10.1002/erv.2444
  • Glatz T, Marjanovic G, Kulemann B, Hipp J, Theodor Hopt U, Fischer A, Richter-Schrag HJ, Hoeppner J: Management and outcome of esophageal stenting for spontaneous esophageal perforations. Dis Esophagus, 2016 (online). : http://dx.doi.org/10.1111/dote.12461 (in Druck)
  • Goos M, Schubach F, Seifert G, Boeker M: Validation of undergraduate medical student script concordance test (SCT) scores on the clinical assessment of the acute abdomen. Bmc Surg, 2016; 16 (1) (online): 57. : http://dx.doi.org/10.1186/s12893-016-0173-y
  • Hoeppner J, Lordick F, Brunner T, Glatz T, Bronsert P, Rothling N, Schmoor C, Lorenz D, Ell C, Hopt UT, Siewert JR: ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286). Bmc Cancer, 2016; 16 (online): 503. : http://dx.doi.org/10.1186/s12885-016-2564-y
  • Honselmann KC, Krauss T, Geserick S, Wellner UF, Wittel U, Hopt UT, Keck T, Bausch D: Cystic lesions of the pancreas-is radical surgery really warranted? Langenbeck Arch Surg, 2016; 401 (4): 449-456. : http://dx.doi.org/10.1007/s00423-016-1416-1
  • Keck T, Wellner UF, Bahra M, Klein F, Sick O, Niedergethmann M, Wilhelm TJ, Farkas SA, Borner T, Bruns C, Kleespies A, Kleeff J, Mihaljevic AL, Uhl W, Chromik A, Fendrich V, Heeger K, Padberg W, Hecker A, Neumann UP, Junge K, Kalff JC, Glowka TR, Werner J, Knebel P, Piso P, Mayr M, Izbicki J, Vashist Y, Bronsert P, Bruckner T, Limprecht R, Diener MK, Rossion I, Wegener I, Hopt UT: Pancreatogastrostomy Versus Pancreatojejunostomy for RECOnstruction After PANCreatoduodenectomy (RECOPANC, DRKS 00000767): Perioperative and Long-term Results of a Multicenter Randomized Controlled Trial. Ann Surg, 2016; 263 (3): 440-449. : http://dx.doi.org/10.1097/SLA.0000000000001240
  • Kovaleva V, Geissler AL, Lutz L, Fritsch R, Makowiec F, Wiesemann S, Hopt UT, Passlick B, Werner M, Lassmann S: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. Mol Cancer, 2016; 15 (1) (online): 63-63. : http://dx.doi.org/10.1186/s12943-016-0549-8
  • Kulemann B, Liss AS, Warshaw AL, Seifert S, Bronsert P, Glatz T, Pitman MB, Hoeppner J: KRAS mutations in pancreatic circulating tumor cells: a pilot study. Tumor Biol, 2016; 37 (6): 7547-7554. : http://dx.doi.org/10.1007/s13277-015-4589-2
  • Lai ZW, Bolm L, Fuellgraf H, Biniossek ML, Makowiec F, Hopt UT, Werner M, Keck T, Bausch D, Sorio C, Scarpa A, Schilling O, Bronsert P, Wellner UF: Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses. Bmc Cancer, 2016; 16 (online): 195-195. : http://dx.doi.org/10.1186/s12885-016-2193-5
  • Lapshyn H *, Bronsert P *, Bolm L, Werner M, Hopt UT, Makowiec F, Wittel UA, Keck T, Wellner UF, Bausch D: Prognostic factors after pancreatoduodenectomy with en bloc portal venous resection for pancreatic cancer. Langenbeck Arch Surg, 2016; 401 (1): 63-69. : http://dx.doi.org/10.1007/s00423-015-1363-2
  • Läßle C, Fink J, Küsters S, Seifert G, Höppner J, Marjanovic G: Innere Hernien nach laparoskopischem Roux-Y-Magenbypass – eine Herausforderung nicht nur für den Allgemeinchirurgen. Zbl Chir, 2016; 141: 1-3. : http://dx.doi.org/10.1055/s-0041-107203
  • Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, Herr R, Brabletz S, Stemmler MP, Brabletz T: ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nat Commun, 2016; 7 (online): 10498. : http://dx.doi.org/10.1038/ncomms10498
  • Lutz L, Fitzner IC, Ahrens T, Geissler AL, Makowiec F, Hopt UT, Bogatyreva L, Hauschke D, Werner M, Lassmann S: Histone modifiers and marks define heterogeneous groups of colorectal carcinomas and affect responses to HDAC inhibitors in vitro. Am J Cancer Res, 2016; 6 (3): 664-676.
  • Pisarski P, Schleicher C, Hauser I, Becker JU: German recommendations for pretransplantation donor kidney biopsies. Langenbeck Arch Surg, 2016; 401 (2): 133-140. : http://dx.doi.org/10.1007/s00423-016-1384-5
  • Richter-Schrag HJ, Glatz T, Walker C, Fischer A, Thimme R: First-line endoscopic treatment with over-the-scope clips significantly improves the primary failure and rebleeding rates in high-risk gastrointestinal bleeding: A single-center experience with 100 cases. World J Gastroentero, 2016; 22 (41): 9162-9171. : http://dx.doi.org/10.3748/wjg.v22.i41.9162
  • Riediger H, Krueger CM, Makowiec F, Adam U, Kruger K: Orthograde Planimetrie der Pankreasschnittfläche anhand der präoperativen Computertomografie zur Risikoeinschätzung einer postoperativen Pankreasfistel nach Pankreaskopfresektion. [Computed Tomography-Based Planimetry of the Pancreatic Transection Line in Risk Evaluation for Postoperative Pancreatic Fistula after Pancreatic Head Resection] Zbl Chir, 2016; 141 (04): 446-453. : http://dx.doi.org/10.1055/s-0035-1546193
  • Riediger H, Kulemann B, Wittel U, Adam U, Sick O, Neeff H, Hoppner J, Hopt UT, Makowiec F: Prognostic Role of Log Odds of Lymph Nodes After Resection of Pancreatic Head Cancer. J Gastrointest Surg, 2016; 20 (10): 1707-1715. : http://dx.doi.org/10.1007/s11605-016-3200-5
  • Ruess DA, Probst M, Marjanovic G, Wittel UA, Hopt UT, Keck T, Bausch D: HDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail to Protect against Warm Hepatic Ischemia-Reperfusion Injury. Plos One, 2016; 11 (8): e0161233-e0161233. : http://dx.doi.org/10.1371/journal.pone.0161233
  • Schluermann CN, Hoeppner J, Benk C, Schmidt R, Loop T, Kalbhenn J: Intraabdominal pressure, cardiac index and vascular resistance during hyperthermic intraperitoneal chemotherapy - a prospective observational study. Minerva Anestesiol, 2016; 82 (2): 160-169. : http://www.minervamedica.it/en/journals/minerva-anestesiologica/article.php?cod=R02Y2016N02A0160
  • Schmid A, Hils S, Kramer-Zucker A, Bogatyreva L, Hauschke D, De Geest S, Pisarski P: Telemedically Supported Case Management of Living-Donor Renal Transplant Recipients to Optimize Routine Evidence-Based Aftercare: A Single-Center Randomized Controlled Trial. Am J Transplant, 2016. : http://dx.doi.org/10.1111/ajt.14138 (in Druck)
  • Seifert M, Seifert G, Wolff-Vorbeck G, Langenmair E, Hopt UT, Wittel UA: Inducing a humoral immune response to pancreatic cancer antigen. Cell Immunol, 2016; 310: 150-155. : http://dx.doi.org/10.1016/j.cellimm.2016.09.002
  • Shahinian JH, Fuellgraf H, Tholen S, Mastroianni J, Knopf JD, Kuehs M, Mayer B, Schlimpert M, Kulemann B, Kuesters S, Hoeppner J, Wellner UF, Werner M, Hopt UT, Zeiser R, Bronsert P, Schilling O: Pregnancy Specific beta-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival. J Cancer, 2016; 7 (14): 2018-2027. : http://dx.doi.org/10.7150/jca.15864
  • Strietz J, Stepputtis SS, Preca BT, Vannier C, Kim MM, Castro DJ, Au Q, Boerries M, Busch H, Aza-Blanc P, Heynen-Genel S, Bronsert P, Kuster B, Stickeler E, Brabletz T, Oshima RG, Maurer J: ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer. Oncotarget, 2016; 7 (50): 83278-83293. : http://dx.doi.org/10.18632/oncotarget.13086
  • Susal C, Dohler B, Ruhenstroth A, Morath C, Slavcev A, Fehr T, Wagner E, Kruger B, Rees M, Balen S, Zivcic-Cosic S, Norman DJ, Kuypers D, Emonds MP, Pisarski P, Bosmuller C, Weimer R, Mytilineos J, Scherer S, Tran TH, Gombos P, Schemmer P, Zeier M, Opelz G: Donor-specific antibodies require preactivated immune system to harm renal transplant. EBioMedicine, 2016; 9: 366-371. : http://dx.doi.org/10.1016/j.ebiom.2016.06.006
  • Thomusch O, Wiesener M, Opgenoorth M, Pascher A, Woitas RP, Witzke O, Jaenigen B, Rentsch M, Wolters H, Rath T, Cingoz T, Benck U, Banas B, Hugo C: Rabbit-ATG or basiliximab induction for rapid steroid withdrawal after renal transplantation (Harmony): an open-label, multicentre, randomised controlled trial. Lancet, 2016; 388 (10063) (online): 3006-3016. : http://dx.doi.org/10.1016/S0140-6736(16)32187-0
  • Wellner UF, Krauss T, Csanadi A, Lapshyn H, Bolm L, Timme S, Kulemann B, Hoeppner J, Kuesters S, Seifert G, Bausch D, Schilling O, Vashist YK, Bruckner T, Langer M, Makowiec F, Hopt UT, Werner M, Keck T, Bronsert P: Mesopancreatic Stromal Clearance Defines Curative Resection of Pancreatic Head Cancer and Can Be Predicted Preoperatively by Radiologic Parameters: A Retrospective Study. Medicine, 2016; 95 (3) (online): e2529-e2529. : http://dx.doi.org/10.1097/MD.0000000000002529
  • Whetstone RD, Wittel UA, Michels NM, Gulizia JM, Gold B: Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate. Mol Carcinogen, 2016; 55 (7): 1187-1195. : http://dx.doi.org/10.1002/mc.22361
  • Zschiedrich S *, Janigen B *, Dimova D, Neumann A, Seidl M, Hils S, Geyer M, Emmerich F, Kirste G, Drognitz O, Hopt UT, Walz G, Huber TB, Pisarski P *, Kramer-Zucker A *: One hundred ABO-incompatible kidney transplantations between 2004 and 2014: a single-centre experience. Nephrol Dial Transpl, 2016; 31 (4): 663-671. : http://dx.doi.org/10.1093/ndt/gfv388
Buchbeiträge:
  • Chang H.-H., Schmidt A, Eibl G: Oncogenic KRAS and the Inflammatory Microenvironment in Pancreatic Cancer. In: Azmi A (Hrsg.): Conquering RAS – From Biology to Cancer Therapy. Elsevier, 2016; 79-95.
Fallbeispiele:
  • Lutz L, Holzner P, Neeff H: An Unusual Cecal Mass in an Otherwise Healthy Young Woman. Gastroenterology, 2016; 150 (5): e5-e6. : http://dx.doi.org/10.1053/j.gastro.2015.12.008
  • Marjanovic G, Hoeppner J: IMAGES IN CLINICAL MEDICINE. Esophagogastric Bypass in Motion. New Engl J Med, 2016; 374 (16): e20-e20. : http://dx.doi.org/10.1056/NEJMicm1509754
  • Perakakis N, Flohr F, Kayser G, Thomusch O, Parsons L, Billmann F, von Dobschuetz E, Rondot S, Seufert J, Laubner K: Multiple endocrine neoplasia type 1 associated with a new germline Men1 mutation in a family with atypical tumor phenotype. Horm-int J Endocrino, 2016; 15 (1): 113-117. : http://dx.doi.org/10.14310/horm.2002.1626
  • Schultheiss M, Neeff HP, Neumann-Haefelin C: Sigmoid Colon Compression Due to Liver Migration and Hypertrophy. Clin Gastroenterol H, 2016; 14 (8): A27-A27. : http://dx.doi.org/10.1016/j.cgh.2016.05.002

Besondere wissenschaftliche Aktivitäten

Wissenschaftliche Beratung / Gutachtertätigkeiten:
  • Pisarski P: Dr. med. Przemyslaw Pisarski, Leiter der Sektion Transplantation der Chirurgischen Universitätsklinik Freiburg, Abteilung Allgemein- und Viszeralchirurgie, Preis zur Förderung der Organspende für das wissenschaftliche Projekt "German AB0i-Register" (GABOiR), Deutsche Transplantationsgesellschaft, seit 06.10.2011.

Abschlussarbeiten