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 Forschungsbericht für das Jahr 2018

Klinik für Allgemein- und Viszeralchirurgie

Hugstetterstrasse 55
79106 Freiburg
Tel: +49 761 270 28060 Fax: + 49 761 270 28040
Email maria.schierenberg@uniklinik-freiburg.de
http://www.uniklinik-freiburg.de/chirurgie/live/index.html


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Stefan Fichtner-Feigl, Ärztlicher Direktor
  • Prof. Dr. med. Sven A. Lang, Leitender Oberarzt
  • Prof. Dr. med. Jens Höppner, Geschäftsführender Oberarzt
  • PD Dr. Rebecca Kesselring, Leitender wissenschaftlicher Mitarbeiter (m/w)
  • PD Dr. med. Hannes Neeff, Geschäftsführender Oberarzt
  • Prof. Dr. med. Przemyslaw Pisarski, Leiter Sektion Transplantationschirurgie
  • Dr. med. Andrea Proneth, Oberärztin
  • Dr. med. Jochen Rädecke, Komm. Leiter der Sektion Kinderchirurgie, Oberarzt
  • Prof. Dr. med. Oliver Thomusch, Geschäftsführender Oberarzt
  • Prof. Dr. med. Uwe Wittel, Geschäftsführender Oberarzt
  • Prof. Dr. med. Goran Marjanovic, Leiter Zentrum für Metabolische Chirurgie, Obearzt
  • Prof. Dr. med. Stefan Utzolino, Leiter Chirurgische Intensivstation, Oberarzt
  • Dr. med. Carolin Kayser, Funktionsoberärztin
  • Dr. med. Lampros Kousoulas, Funktionsoberarzt
  • Dr. med. Ruth-Sybille Mayer, Funktionsoberäztin
  • Dr. med. Sophia Chikhladze, Fachärztin
  • PD Dr. med. Jodok Fink, Facharzt
  • Dr. med. univ. Philip Holzner, Facharzt
  • Dr. med. Joachim Schönberger, Facharzt
  • Dr. med. Gabriel Seifert, Facharzt
  • Christopher Berlin, Assistenzarzt
  • Dr. med. Esther Biesel, Assistenzärztin
  • Dr. med. Torben Glatz, Assistenzarzt
  • Dr. med. Ulrike Grundmann, Assistenzärztin
  • Daniel Heller, Assistenzarzt
  • Julian Hipp, Assistenzarzt
  • Dr. med. Dominik Jauch, Assistenzarzt
  • Katharina Jöchle, Assistenzärztin
  • Andreas Jud, Assistenzarzt
  • Marius Kamps, Assistenzarzt
  • Dr. med. Christian Kühlbrey, Assistenzarzt
  • Dr. med. Birte Kulemann, Fachärztin
  • Dr. med. Jasmina Kuvendjiska, Assistenzärztin
  • Dr. med. Claudia Läßle, Assistenzärztin
  • Verena Martini, Assistenzärztin
  • Dr. med. Madalena Menzel, Assistenzärztin
  • Gergana Nenova, Assistenzärztin
  • Jost Pott, Assistenzarzt
  • Dr. med. Dietrich Rueß, Assistenzarzt
  • Dr. rer. nat. Andrea Klock
  • Dipl. Biol. Maria Schierenberg
  • Dipl. Biol. Olivia Sick
  • Dr. rer. nat. Guido Wolff-Vorbeck
Einträge in der Rubrik "Who is Who"

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Blazquez-Navarro A, Dang-Heine C, Wittenbrink N, Bauer C, Wolk K, Sabat R, Westhoff TH, Sawitzki B, Reinke P, Thomusch O, Hugo C, Or-Guil M, Babel N: BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Ebiomedicine, 2018; 34: 113-121. : http://dx.doi.org/10.1016/j.ebiom.2018.07.017
  • Ettrich TJ, Berger AW, Perkhofer L, Daum S, Konig A, Dickhut A, Wittel U, Wille K, Geissler M, Algul H, Gallmeier E, Atzpodien J, Kornmann M, Muche R, Prasnikar N, Tannapfel A, Reinacher-Schick A, Uhl W, Seufferlein T: Neoadjuvant plus adjuvant or only adjuvant nab-paclitaxel plus gemcitabine for resectable pancreatic cancer - the NEONAX trial (AIO-PAK-0313), a prospective, randomized, controlled, phase II study of the AIO pancreatic cancer group. Bmc Cancer, 2018; 18 (1): 1298-1298. : http://dx.doi.org/10.1186/s12885-018-5183-y
  • Fink JM, Martini V, Seifert G, Marjanovic G: Left Gastric Artery Embolization for Weight Loss-a Dead-End Procedure. Obes Surg, 2018; 28 (11): 3623-3624. : http://dx.doi.org/10.1007/s11695-018-3427-1
  • Gkika E, Strouthos I, Kirste S, Adebahr S, Schultheiss M, Bettinger D, Fritsch R, Brass V, Maruschke L, Neeff HP, Lang SA, Nestle U, Grosu AL, Brunner TB: Repeated SBRT for in- and out-of-field recurrences in the liver. Strahlenther Onkol, 2018. : http://dx.doi.org/10.1007/s00066-018-1385-0 (in Druck)
  • Glatz T, Neeff H, Holzner P, Fichtner-Feigl S, Thomusch O: Repair of a Grynfeltt-Lesshaft hernia with the PROCEED VENTRAL PATCH: a case report. Surg Case Rep, 2018; 4 (1) (online). : http://dx.doi.org/10.1186/s40792-018-0456-x
  • Holzner PA, Makowiec F, Klock A, Glatz T, Fichtner-Feigl S, Lang SA, Neeff HP: Outcome after hepatic resection for isolated non-colorectal, non-neuroendocrine liver metastases in 100 patients - the role of the embryologic origin of the primary tumor. Bmc Surg, 2018; 18 (1) (online): 89-89. : http://dx.doi.org/10.1186/s12893-018-0424-1
  • Hulsdunker J, Ottmuller KJ, Neeff HP, Koyama M, Gao Z, Thomas OS, Follo M, Al-Ahmad A, Prinz G, Duquesne S, Dierbach H, Kirschnek S, Lammermann T, Blaser MJ, Fife BT, Blazar BR, Beilhack A, Hill GR, Hacker G, Zeiser R: Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset. Blood, 2018; 131 (16): 1858-1869. : http://dx.doi.org/10.1182/blood-2017-10-812891
  • Klett H, Fuellgraf H, Levit-Zerdoun E, Hussung S, Kowar S, Kusters S, Bronsert P, Werner M, Wittel U, Fritsch R, Busch H, Boerries M: Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma. Front Genet, 2018; 9: 108-108. : http://dx.doi.org/10.3389/fgene.2018.00108
  • Klompmaker S, van Hilst J, Wellner UF, Busch OR, Coratti A, D'Hondt M, Dokmak S, Festen S, Kerem M, Khatkov I, Lips DJ, Lombardo C, Luyer M, Manzoni A, Molenaar IQ, Rosso E, Saint-Marc O, Vansteenkiste F, Wittel UA, Bonsing B, Groot Koerkamp B, Abu Hilal M, Fuks D, Poves I, Keck T, Boggi U, Besselink MG: Outcomes After Minimally-invasive Versus Open Pancreatoduodenectomy: A Pan-European Propensity Score Matched Study. Ann Surg, 2018. : http://dx.doi.org/10.1097/SLA.0000000000002850 (in Druck)
  • Kousoulas L, Wittel U, Fichtner-Feigl S, Utzolino S: Hemoadsorption in a Case of Severe Septic Shock and Necrotizing Fasciitis Caused by Nontraumatic Renal Rupture due to Pyelonephritis with Obstructive Uropathy. Case Rep Crit Care, 2018; 2018 (online): 5248901-5248901. : http://dx.doi.org/10.1155/2018/5248901
  • Kousoulas L, Fink JM, Glatz T, Läßle C, Bohlmann IJ, Fichtner-Feigl S, Utzolino S: Pilot trial evaluating Mid-Regional Pro-Atrial Natriuretic Peptide as a marker of sepsis after abdominal surgery Hellenic Journal of Surgery, 2018; 90 (5): 232-238.
  • Kuesters S, Chikhladze S, Makowiec F, Sick O, Fichtner-Feigl S, Hopt UT, Wittel UA: Oncological outcome of laparoscopically assisted pancreatoduodenectomy for ductal adenocarcinoma in a retrospective cohort study. Int J Surg, 2018; 55: 162-166. : http://dx.doi.org/10.1016/j.ijsu.2018.05.026
  • Kuhlbrey CM, Kasper S, Chikhladze S, Seifert G, Hopt UT, Fichtner-Feigl S, Wittel UA: Bio-absorbable sealants for reinforcing the pancreatic stump after distal pancreatectomy are critical. J Hepato-bil-pan Sci, 2018. : http://dx.doi.org/10.1002/jhbp.604 (in Druck)
  • Laessle C, Nenova G, Marjanovic G, Seifert G, Kousoulas L, Jaenigen B, Fichtner-Feigl S, Fink JM: Duodenal Exclusion but Not Sleeve Gastrectomy Preserves Insulin Secretion, Making It the More Effective Metabolic Procedure. Obes Surg, 2018; 28 (5): 1408-1416. : http://dx.doi.org/10.1007/s11695-017-3045-3
  • Lederer A, Schmucker C, Kousoulas L, Fichtner-Feigl S, Huber R: Naturopathic treatment and complementary medicine in surgical practice. A systematic review. Dtsch Arztebl Int, 2018; 115 (49): 815-821.
  • Makowiec F, Bronsert P, Klock A, Hopt UT, Neeff HP: Prognostic influence of hepatic margin after resection of colorectal liver metastasis: role of modern preoperative chemotherapy. Int J Colorectal Dis, 2018; 33 (1): 71-78. : http://dx.doi.org/10.1007/s00384-017-2916-3
  • Makowiec F, Menzel M, Bronsert P, Holzner PA, Klock A, Lang SA, Fichtner-Feigl S, Neeff HP: Does the site of primary colorectal cancer influence the outcome after resection of isolated liver metastases? Digest Liver Dis, 2018; 50: 1088-1092. : http://dx.doi.org/10.1016/j.dld.2018.06.019
  • Manegold P, Lai KKY, Wu Y, Teo JL, Lenz HJ, Genyk YS, Pandol SJ, Wu K, Lin DP, Chen Y, Nguyen C, Zhao Y, Kahn M: Differentiation Therapy Targeting the beta-Catenin/CBP Interaction in Pancreatic Cancer. Cancers, 2018; 10 (4) (online). : http://dx.doi.org/10.3390/cancers10040095
  • Marjanovic G, Seifert G, Läßle C, Nenova G, Höppner J, Fichtner-Feigl S, J. M. Fink: Der deutsche Schneeball-Effekt - Ein zunehmendes Nachsorgeproblem in der bariatrischen Therapie Chirurg, 2018. (in Druck)
  • Martynov I, Raedecke J, Klima-Frysch J, Kluwe W, Schoenberger J: Outcome of landmark-guided percutaneously inserted tunneled central venous catheters in infants and children under 3 years with cancer. Pediatr Blood Cancer, 2018; 65 (10): e27295-e27295. : http://dx.doi.org/10.1002/pbc.27295
  • Monig S, Chevallay M, Niclauss N, Zilli T, Fang W, Bansal A, Hoeppner J: Early esophageal cancer: the significance of surgery, endoscopy, and chemoradiation. Ann Ny Acad Sci, 2018 (online). : http://dx.doi.org/10.1111/nyas.13955
  • Muessig JM, Nia AM, Masyuk M, Lauten A, Sacher AL, Brenner T, Franz M, Bloos F, Ebelt H, Schaller SJ, Fuest K, Rabe C, Dieck T, Steiner S, Graf T, Janosi RA, Meybohm P, Simon P, Utzolino S, Rahmel T, Barth E, Schuster M, Kelm M, Jung C: Clinical Frailty Scale (CFS) reliably stratifies octogenarians in German ICUs: a multicentre prospective cohort study. Bmc Geriatr, 2018; 18 (1) (online): 162-162. : http://dx.doi.org/10.1186/s12877-018-0847-7
  • Munker S, Gerken M, Fest P, Ott C, Schnoy E, Fichtner-Feigl S, Wiggermann P, Vogelhuber M, Herr W, Stroszczynski C, Schlitt HJ, Evert M, Reng M, Klinkhammer-Schalke M, Teufel A: Chemotherapy for metastatic colon cancer: No effect on survival when the dose is reduced due to side effects. Bmc Cancer, 2018; 18 (1): 455-455. : http://dx.doi.org/10.1186/s12885-018-4380-z
  • Mycielska ME, Dettmer K, Rummele P, Schmidt K, Prehn C, Milenkovic VM, Jagla W, Madej GM, Lantow M, Schladt M, Cecil A, Koehl GE, Eggenhofer E, Wachsmuth CJ, Ganapathy V, Schlitt HJ, Kunzelmann K, Ziegler C, Wetzel CH, Gaumann A, Lang SA, Adamski J, Oefner PJ, Geissler EK: Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo. Cancer Res, 2018; 78 (10): 2513-2523. : http://dx.doi.org/10.1158/0008-5472.CAN-17-2959
  • Neeff HP, Holzner PA, Menzel M, Bronsert P, Klock A, Lang SA, Fichtner-Feigl S, Hopt UT, Makowiec F: [Intrahepatic cholangiocarcinoma : Results after 84 resections]. Chirurg, 2018; 89 (5): 374-380. : http://dx.doi.org/10.1007/s00104-018-0609-2
  • Oria VO, Lopatta P, Schmitz T, Preca BT, Nystrom A, Conrad C, Bartsch JW, Kulemann B, Hoeppner J, Maurer J, Bronsert P, Schilling O: ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma. Mol Oncol, 2018. : http://dx.doi.org/10.1002/1878-0261.12426 (in Druck)
  • Ott C, Gerken M, Hirsch D, Fest P, Fichtner-Feigl S, Munker S, Schnoy E, Stroszczynski C, Vogelhuber M, Herr W, Evert M, Reng M, Schlitt HJ, Klinkhammer-Schalke M, Teufel A: Advanced Mucinous Colorectal Cancer: Epidemiology, Prognosis and Efficacy of Chemotherapeutic Treatment. Digestion, 2018; 98 (3): 143-152. : http://dx.doi.org/10.1159/000487710
  • Petrova E, Lapshyn H, Bausch D, D'Haese J, Werner J, Klier T, Nussler NC, Gaedcke J, Ghadimi M, Uhl W, Belyaev O, Kantor O, Baker M, Fichtner-Feigl S, Keck T, Wellner UF: Risk stratification for postoperative pancreatic fistula using the pancreatic surgery registry StuDoQ|Pancreas of the German Society for General and Visceral Surgery. Pancreatology, 2018. : http://dx.doi.org/10.1016/j.pan.2018.11.008 (in Druck)
  • Pisarski P, Schmid A, Schiffer M, Pape L, Budde K, Halleck F, Staeck O: Digitalisierung in der Transplantationsnachsorge Nieren- und Hochdruckkrankheiten, 2018; 47 (5): 255-271.
  • Proneth A, Schnitzbauer AA, Schenker P, Wunsch A, Rauchfuss F, Arbogast H, Manekeller S, Nadalin S, Heise M, Strohlein MA, Banas B, Schemmer P, Becker T, Bechstein WO, Pascher A, Viebahn R, Geissler EK, Schlitt HJ, Farkas SA: Extended Pancreas Donor Program-The EXPAND Study: A Prospective Multicenter Trial Testing the Use of Pancreas Donors Older Than 50 Years. Transplantation, 2018; 102 (8): 1330-1337. : http://dx.doi.org/10.1097/TP.0000000000002122
  • Reuken PA, Kruis W, Maaser C, Teich N, Buning J, Preiss JC, Schmelz R, Bruns T, Fichtner-Feigl S, Stallmach A: Microbial Spectrum of Intra-Abdominal Abscesses in Perforating Crohn's Disease: Results from a Prospective German Registry. J Crohns Colitis, 2018; 12 (6): 695-701. : http://dx.doi.org/10.1093/ecco-jcc/jjy017
  • Ruess DA, Heynen GJ, Ciecielski KJ, Ai J, Berninger A, Kabacaoglu D, Gorgulu K, Dantes Z, Wormann SM, Diakopoulos KN, Karpathaki AF, Kowalska M, Kaya-Aksoy E, Song L, van der Laan EAZ, Lopez-Alberca MP, Nazare M, Reichert M, Saur D, Erkan MM, Hopt UT, Sainz B Jr, Birchmeier W, Schmid RM, Lesina M, Algul H: Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med, 2018; 24 (7): 954-960. : http://dx.doi.org/10.1038/s41591-018-0024-8
  • Schmidt KM, Dietrich P, Hackl C, Guenzle J, Bronsert P, Wagner C, Fichtner-Feigl S, Schlitt HJ, Geissler EK, Hellerbrand C, Lang SA: Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis. Neoplasia, 2018; 20 (12): 1198-1208. : http://dx.doi.org/10.1016/j.neo.2018.10.001
  • Schultheiss M, Bettinger D, Fichtner-Feigl S, Thimme R: [Hepatocellular Carcinoma: New multimodal therapy concepts]. Deut Med Wochenschr, 2018; 143 (11): 815-819. : http://dx.doi.org/10.1055/s-0043-124158
  • Seifert GJ, Leithold G, Kulemann B, Holzner PA, Glatz T, Hoeppner J, Kirste S, Marjanovic G, Laessle C: The effect of pasireotide on intestinal anastomotic healing with and without whole-body irradiation in a rat model. Int J Colorectal Dis, 2018 (online). : http://dx.doi.org/10.1007/s00384-018-3193-5
  • Simunovic F, Wittel U, Passlick B, Wiesemann S, Czerny M, Sudkamp M, Stark GB, Bannasch H: [The use of Deep Inferior Epigastric Vessels to Revascularise Free Flaps for Reconstruction of Complex Oncosurgical Defects of the Thigh and the Abdomen]. Handchir Mikrochir P, 2018; 50 (4): 259-268. : http://dx.doi.org/10.1055/s-0043-124187
  • Thomusch O, Sekulla C, Billmann F, Seifert G, Dralle H, Lorenz K: Risk profile analysis and complications after surgery for autoimmune thyroid disease. Brit J Surg, 2018; 105: 677-685.
  • Tillmann FP, Grotz W, Rump LC, Pisarski P: Impact of monocyte-macrophage inhibition by ibandronate on graft function and survival after kidney transplantation: a single-centre follow-up study over 15 years. Clin Exp Nephrol, 2018; 22 (2): 474-480. : http://dx.doi.org/10.1007/s10157-017-1470-1
  • Timme-Bronsert S, Bronsert P, Werner M, Kulemann B, Höppner J: [Circulating tumor cells in pancreatic cancer : Results of morphological and molecular analyses and comparisons with the primary tumor]. Pathologe, 2018; 39: 311-314. : http://dx.doi.org/10.1007/s00292-018-0550-7
  • Utzolino S, Kousoulas L: The patient with acute abdomen in a critical care setting Anasth Intensivmed, 2018; 59: 640-653.
Fallbeispiele:
  • Tautz E, Wagner D, Wiesemann S, Jonaszik A, Bode C, Wengenmayer T, Staudacher D, Biever P, Hoeppner J, Duerschmied D: Treatment of a broncho-esophageal fistula complicated by severe ARDS. Infection, 2018. : http://dx.doi.org/10.1007/s15010-018-1247-9 (in Druck)
Kurzbeiträge / short communications:

Besondere wissenschaftliche Aktivitäten

Wissenschaftliche Beratung / Gutachtertätigkeiten:
  • Pisarski P: Dr. med. Przemyslaw Pisarski, Leiter der Sektion Transplantation der Chirurgischen Universitätsklinik Freiburg, Abteilung Allgemein- und Viszeralchirurgie, Preis zur Förderung der Organspende für das wissenschaftliche Projekt "German AB0i-Register" (GABOiR), Deutsche Transplantationsgesellschaft, seit 06.10.2011.

Abschlussarbeiten