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Wissenschaftliche Publikationen
Originalarbeiten in wissenschaftlichen
Fachzeitschriften:
- Ahrens TD, Timme S, Hoeppner J, Ostendorp J, Hembach S, Follo M, Hopt UT, Werner M, Busch H, Boerries M, Lassmann S: Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine. Epigenetics, 2015; 10 (5): 431-445. : http://dx.doi.org/10.1080/15592294.2015.1039216
- Bach AS, Derocq D, Laurent-Matha V, Montcourrier P, Sebti S, Orsetti B, Theillet C, Gongora C, Pattingre S, Ibing E, Roger P, Linares LK, Reinheckel T, Meurice G, Kaiser FJ, Gespach C, Liaudet-Coopman E: Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells. Oncotarget, 2015; 6 (29): 28084-28103.
- Benary U, Kofahl B, Hecht A, Wolf J: Mathematical modelling suggests a differential impact of beta-transducin repeat-containing protein paralogues on Wnt/beta-catenin signalling dynamics. Febs J, 2015; 282 (6): 1080-1096. : http://dx.doi.org/10.1111/febs.13204
- Boerries M, Herr R, Brummer T, Busch H: Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines. genom data, 2015; 4: 158-161. : http://dx.doi.org/10.1016/j.gdata.2015.04.015
- Boerries M, Herr R, Brummer T, Busch H: Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines. Genom Data, 2015; 4: 158-161. : http://dx.doi.org/10.1016/j.gdata.2015.04.015
- Dong F, Eibach M, Bartsch JW, Dolga AM, Schlomann U, Conrad C, Schieber S, Schilling O, Biniossek ML, Culmsee C, Strik H, Koller G, Carl B, Nimsky C: The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells. Neuro-oncology, 2015; 17 (11): 1474-1485. : http://dx.doi.org/10.1093/neuonc/nov042
- Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW: Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation. J Exp Med, 2015; 212 (10): 1693-1708. : http://dx.doi.org/10.1084/jem.20141271
- Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW: Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation. J Exp Med, 2015; 212 (10): 1693-1708. : http://dx.doi.org/10.1084/jem.20141271
- Fischer A, Brummer T, Warscheid B, Radziwill G: Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction. Bba-mol Cell Res, 2015; 1853 (11 Pt A): 2847-2855. : http://dx.doi.org/10.1016/j.bbamcr.2015.08.014
- Fischer A, Brummer T, Warscheid B, Radziwill G: Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction. Biochim Biophys Acta, 2015; 1853 (11 Pt A): 2847-2855. : http://dx.doi.org/10.1016/j.bbamcr.2015.08.014
- Haug S, Schnerch D, Halbach S, Mastroianni J, Dumit VI, Follo M, Hasenburg A, Kohler M, Dierbach H, Herzog S, Proske A, Werner M, Dengjel J, Brummer T, Lassmann S, Wasch R, Zeiser R: Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer. Int J Cancer, 2015; 136 (10): 2328-2340. : http://dx.doi.org/10.1002/ijc.29289
- Haug S *, Schnerch D *, Halbach S *, Mastroianni J, Dumit VI, Follo M, Hasenburg A, Kohler M, Dierbach H, Herzog S, Proske A, Werner M, Dengjel J, Brummer T *, Lassmann S *, Wasch R *, Zeiser R *: Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer. Int J Cancer, 2015; 136 (10): 2328-2340. : http://dx.doi.org/10.1002/ijc.29289
- Herr R, Brummer T: BRAF inhibitors in colorectal cancer: Toward a differentiation therapy? Mol Cell Oncol, 2015; 2 (4): e1002709-e1002709. : http://dx.doi.org/10.1080/23723556.2014.1002709
- Herr R, Brummer T: BRAF inhibitors in colorectal cancer: Toward a differentiation therapy? Mol Cell Oncol, 2015; 2 (4): e1002709-e1002709. : http://dx.doi.org/10.1080/23723556.2014.1002709
- Herr R, Kohler M, Andrlova H, Weinberg F, Moller Y, Halbach S, Lutz L, Mastroianni J, Klose M, Bittermann N, Kowar S, Zeiser R, Olayioye MA, Lassmann S, Busch H, Boerries M, Brummer T: B-Raf Inhibitors Induce Epithelial Differentiation in BRAF-Mutant Colorectal Cancer Cells. Cancer Res, 2015; 75 (1): 216-229. : http://dx.doi.org/10.1158/0008-5472.CAN-13-3686
- Herr R, Kohler M, Andrlova H, Weinberg F, Moller Y, Halbach S, Lutz L, Mastroianni J, Klose M, Bittermann N, Kowar S, Zeiser R, Olayioye MA, Lassmann S, Busch H, Boerries M, Brummer T: B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells. Cancer Res, 2015; 75 (1): 216-229. : http://dx.doi.org/10.1158/0008-5472.CAN-13-3686
- Jokinen E, Brummer T, Jalkanen J, Fraser J, Heikkinen AM, Makinen J, Sjoberg J, Tomas E, Mikkola TS, Harkki P: Hysterectomies in Finland in 1990-2012: comparison of outcomes between trainees and specialists. Acta Obstet Gyn Scan, 2015; 94 (7): 701-707. : http://dx.doi.org/10.1111/aogs.12654
- Kalfalah F, Seggewiss S, Walter R, Tigges J, Moreno-Villanueva M, Burkle A, Ohse S, Busch H, Boerries M, Hildebrandt B, Royer-Pokora B, Boege F: Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors. Aging-us, 2015; 7 (2): 110-122.
- Kern U, Wischnewski V, Biniossek ML, Schilling O, Reinheckel T: Lysosomal protein turnover contributes to the acquisition of TGFbeta-1 induced invasive properties of mammary cancer cells. Mol Cancer, 2015; 14 (1) (online): 39-39. : http://dx.doi.org/10.1186/s12943-015-0313-5
- Knopf JD, Tholen S, Koczorowska MM, De Wever O, Biniossek ML, Schilling O: The stromal cell-surface protease fibroblast activation protein-alpha localizes to lipid rafts and is recruited to invadopodia. Bba-mol Cell Res, 2015; 1853 (10 Pt A): 2515-2525. : http://dx.doi.org/10.1016/j.bbamcr.2015.07.013
- Kohler I, Bronsert P, Timme S, Werner M, Brabletz T, Hopt UT, Schilling O, Bausch D, Keck T, Wellner UF: Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma. J Gastroen Hepatol, 2015; 30 Suppl. 1: 78-84. : http://dx.doi.org/10.1111/jgh.12752
- Koszinowski S, Boerries M, Busch H, Krieglstein K: RARbeta regulates neuronal cell death and differentiation in the avian ciliary ganglion. Dev Neurobiol, 2015; 75 (11): 1204-1218. : http://dx.doi.org/10.1002/dneu.22278
- Lai ZW, Gomez-Auli A, Keller EJ, Mayer B, Biniossek ML, Schilling O: Enrichment of protein N-termini by charge reversal of internal peptides. Proteomics, 2015; 15 (14): 2470-2478. : http://dx.doi.org/10.1002/pmic.201500023
- Lim C, Gandhi S, Biniossek ML, Feng L, Schilling O, Urban S, Chen X: An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation. Cell Rep, 2015; 13 (2): 315-325. : http://dx.doi.org/10.1016/j.celrep.2015.09.001
- Mock K, Preca BT, Brummer T, Brabletz S, Stemmler MP, Brabletz T: The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors. Oncotarget, 2015; 6 (16): 14399-14412.
- Mock K, Preca BT, Brummer T, Brabletz S, Stemmler MP, Brabletz T: The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors. Oncotarget, 2015; 6 (16): 14399-14412. : http://dx.doi.org/10.18632/oncotarget.3882
- Nilse L, Sigloch FC, Biniossek ML, Schilling O: Toward improved peptide feature detection in quantitative proteomics using stable isotope labeling. Proteom Clin Appl, 2015; 9 (7-8): 706-714. : http://dx.doi.org/10.1002/prca.201400173
- Okada R, Wu Z, Zhu A, Ni J, Zhang J, Yoshimine Y, Peters C, Saftig P, Nakanishi H: Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier. Mol Cell Neurosci, 2015; 64 (1): 51-60. : http://dx.doi.org/10.1016/j.mcn.2014.12.002
- Papaianni E, El Maadidi S, Schejtman A, Neumann S, Maurer U, Marino-Merlo F, Mastino A, Borner C: Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells. Plos One, 2015; 10 (6) (online): e0126645-e0126645. : http://dx.doi.org/10.1371/journal.pone.0126645
- Preca BT, Bajdak K, Mock K, Sundararajan V, Pfannstiel J, Maurer J, Wellner U, Hopt UT, Brummer T, Brabletz S, Brabletz T, Stemmler MP: A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells. Int J Cancer, 2015; 137 (11): 2566-2577. : http://dx.doi.org/10.1002/ijc.29642
- Preca BT, Bajdak K, Mock K, Sundararajan V, Pfannstiel J, Maurer J, Wellner U, Hopt UT, Brummer T, Brabletz S, Brabletz T, Stemmler MP: A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells. Int J Cancer, 2015; 137 (11): 2566-2577. : http://dx.doi.org/10.1002/ijc.29642
- Rönsch K, Jägle S, Rose K, Seidl M, Baumgartner F, Freihen V, Yousaf A, Metzger E, Lassmann S, Schule R, Zeiser R, Michoel T, Hecht A: SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. Mol Oncol, 2015; 9 (2): 335-354. : http://dx.doi.org/10.1016/j.molonc.2014.08.016
- Schmidt Y, Biniossek M, Stark GB, Finkenzeller G, Simunovic F: Osteoblastic alkaline phosphatase mRNA is stabilized by binding to vimentin intermediary filaments. Biol Chem, 2015; 396 (3): 253-260. : http://dx.doi.org/10.1515/hsz-2014-0274
- Seubert B, Grunwald B, Kobuch J, Cui H, Schelter F, Schaten S, Siveke JT, Lim NH, Nagase H, Simonavicius N, Heikenwalder M, Reinheckel T, Sleeman JP, Janssen KP, Knolle PA, Kruger A: Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. Hepatology, 2015; 61 (1): 238-248. : http://dx.doi.org/10.1002/hep.27378
- Sigloch FC, Burk UC, Biniossek ML, Brabletz T, Schilling O: miR-200c dampens cancer cell migration via regulation of protein kinase A subunits. Oncotarget, 2015; 6 (27): 23874-23889.
- Tholen M, Wolanski J, Stolze B, Chiabudini M, Gajda M, Bronsert P, Stickeler E, Rospert S, Reinheckel T: Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression. J Biol Chem, 2015; 290 (25): 15758-15769. : http://dx.doi.org/10.1074/jbc.M114.624353
- Walter K, Steinwede K, Aly S, Reinheckel T, Bohling J, Maus UA, Ehlers S: Cathepsin G in Experimental Tuberculosis: Relevance for Antibacterial Protection and Potential for Immunotherapy. J Immunol, 2015; 195 (7): 3325-3333. : http://dx.doi.org/10.4049/jimmunol.1501012
- Weber E, Barbulescu E, Medek R, Reinheckel T, Sameni M, Anbalagan A, Moin K, Sloane BF: Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies. Biol Chem, 2015; 396 (3): 277-281. : http://dx.doi.org/10.1515/hsz-2014-0191
- Weisser J, Lai ZW, Bronsert P, Kuehs M, Drendel V, Timme S, Kuesters S, Jilg CA, Wellner UF, Lassmann S, Werner M, Biniossek ML, Schilling O: Quantitative proteomic analysis of formalin-fixed, paraffin-embedded clear cell renal cell carcinoma tissue using stable isotopic dimethylation of primary amines. Bmc Genomics, 2015; 16 (online): 559. : http://dx.doi.org/10.1186/s12864-015-1768-x
- Willmann L, Erbes T, Halbach S, Brummer T, Jager M, Hirschfeld M, Fehm T, Neubauer H, Stickeler E, Kammerer B: Exometabolom analysis of breast cancer cell lines: Metabolic signature. Sci Rep-uk, 2015; 5 (online): 13374. : http://dx.doi.org/10.1038/srep13374
- Willmann L, Erbes T, Halbach S, Brummer T, Jager M, Hirschfeld M, Fehm T, Neubauer H, Stickeler E, Kammerer B: Exometabolom analysis of breast cancer cell lines: Metabolic signature. Sci Rep-uk, 2015; 5: 13374-13374. : http://dx.doi.org/10.1038/srep13374
- Willmann L, Schlimpert M, Halbach S, Erbes T, Stickeler E, Kammerer B: Metabolic profiling of breast cancer: Differences in central metabolism between subtypes of breast cancer cell lines. J Chromatogr B, 2015; 1000: 95-104. : http://dx.doi.org/10.1016/j.jchromb.2015.07.021
- Wunsch D, Hahlbrock A, Heiselmayer C, Backer S, Schrenk C, Benne F, Schilling O, Knauer SK: Evolutionary divergence of Threonine Aspartase1 leads to species-specific substrate recognition. Biol Chem, 2015; 396 (4): 367-376. : http://dx.doi.org/10.1515/hsz-2014-0318
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