[Zurück]
 
Bitte auswählen
Jahr
Details
Sprache
Sortierung
Ausgabe
neu: RTF !
 Forschungsbericht für das Jahr 2014

Institut für Molekulare Medizin und Zellforschung (IMMZ)

Zentrum für Biochemie und Molekulare Zellforschung (ZBMZ)

Stefan-Meier-Str. 17
79104 Freiburg i. Br.
Tel: +49-761-203-9600/9601 Fax: +49-761-203-9602
Email christoph.peters@mol-med.uni-freiburg.de
http://www.mol-med.uni-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Christoph Peters, Institutsleiter
  • Dr. Martin Biniossek, Gruppenleiter
  • Prof. Dr. Dr. h.c. Christoph Borner, Gruppenleiter
  • Dr. Dr. Melanie Börries, Gruppenleiterin
  • Prof. Dr. Tilman Brummer, Gruppenleiter
  • Dr. Hauke Busch, Gruppenleiter
  • Prof. Dr. Andreas Hecht, Gruppenleiter
  • PD Dr. Ulrich Maurer, Gruppenleiter
  • Prof. Dr. Thomas Reinheckel, Gruppenleiter
  • Prof. Dr. Oliver Schilling, Gruppenleiter
  • Dr. Geoffroy Andrieux, Wissenschaftlicher Mitarbeiter
  • Dr. Lars Nilse, Wissenschaftlicher Mitarbeiter
  • Dr. Ulrike Burk, Wissenschaftliche Mitarbeiterin
  • Dr. Ursula Kern, Wissenschaftlicher Mitarbeiter (m/w)
  • Dr. Anett Ketscher, Wissenschaftliche Mitarbeiterin
  • Dr. Martin Klose, Postdoc
  • Dr. Maria Koczorowska, Wissenschaftliche Mitarbeiterin
  • Dr. Simon Neumann, Postdoc
  • Dr. Agnese Petrera, Postdoc
  • Dr. Giuseppe Facchetti, Postdoc
  • Dr. Ursula Kern, Postdoc
  • Dr. Zon Weng Lai, Wissenschaftlicher Mitarbeiter (m/w)
  • Dr. Kathrin Sachse, Postdoc
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Funktion der Bcl-2 Familie und Identifikation von neuen Komponenten der Caspase-unabhängigen Zelltodwege
  • In vivo Funktionen von Proteasen
  • Massenspektrometrie
  • Modulation von Signaltransduktionsprozessen in der Embryonalentwicklung und Tumorigenese
  • Protease Degradomik
  • Signaltransduktion in Tumorentwicklung und Medikamentenresistenz
  • Signaltransduktion in Zelltod und -überleben
  • Systembiologie und Systemmedizin
  • Tumorinvasion und Metastasierung

Finanzierung

  • siehe: www.mol-med.uni-freiburg.de

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T, Joyce JA: Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Gene Dev, 2014; 28 (19): 2134-2150. : http://dx.doi.org/10.1101/gad.249599.114
  • Avci D, Fuchs S, Schrul B, Fukumori A, Breker M, Frumkin I, Chen CY, Biniossek ML, Kremmer E, Schilling O, Steiner H, Schuldiner M, Lemberg MK: The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance. Mol Cell, 2014; 56 (5): 630-640. : http://dx.doi.org/10.1016/j.molcel.2014.10.012
  • Baird EO, Brietzke SC, Weinberg AD, McAnany SJ, Qureshi SA, Cho SK, Hecht AC: Ambulatory spine surgery: a survey study. Global Spine J, 2014; 4 (3): 157-160. : http://dx.doi.org/10.1055/s-0034-1378142
  • Baird EO, Egorova NN, McAnany SJ, Qureshi SA, Hecht AC, Cho SK: National trends in outpatient surgical treatment of degenerative cervical spine disease. Global Spine J, 2014; 4 (3): 143-150. : http://dx.doi.org/10.1055/s-0034-1376917
  • Bengsch F, Buck A, Gunther SC, Seiz JR, Tacke M, Pfeifer D, von Elverfeldt D, Sevenich L, Hillebrand LE, Kern U, Sameni M, Peters C, Sloane BF, Reinheckel T: Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression. Oncogene, 2014; 33 (36): 4474-4484. : http://dx.doi.org/10.1038/onc.2013.395
  • Bischoff A, Huck B, Keller B, Strotbek M, Schmid S, Boerries M, Busch H, Muller D, Olayioye MA: miR149 Functions as a Tumor Suppressor by Controlling Breast Epithelial Cell Migration and Invasion. Cancer Res, 2014; 74 (18): 5256-5265. : http://dx.doi.org/10.1158/0008-5472.CAN-13-3319
  • Bronsert P, Enderle-Ammour K, Bader M, Timme S, Kuehs M, Csanadi A, Kayser G, Kohler I, Bausch D, Hoeppner J, Hopt U, Keck T, Stickeler E, Passlick B, Schilling O, Reiss C, Vashist Y, Brabletz T, Berger J, Lotz J, Olesch J, Werner M, Wellner U: Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface. J Pathol, 2014; 234 (3): 410-422. : http://dx.doi.org/10.1002/path.4416
  • Bronsert P, Kohler I, Timme S, Kiefer S, Werner M, Schilling O, Vashist Y, Makowiec F, Brabletz T, Hopt UT, Bausch D, Kulemann B, Keck T, Wellner UF: Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer. Surgery, 2014; 156 (1): 97-108. : http://dx.doi.org/10.1016/j.surg.2014.02.018
  • Bronsert P, Weisser J, Biniossek ML, Kuehs M, Mayer B, Drendel V, Timme S, Shahinian H, Kusters S, Wellner UF, Lassmann S, Werner M, Schilling O: Impact of routinely employed procedures for tissue processing on the proteomic analysis of formalin-fixed paraffin-embedded tissue. Proteom Clin Appl, 2014; 8 (10): 796-804. : http://dx.doi.org/10.1002/prca.201300082
  • Brummer T, Harkki P: Authors' reply: There must be more to surgical wound infection prevention than antibiotic prophylaxis alone. Bjog-int J Obstet Gy, 2014; 121 (12): 1576-1576. : http://dx.doi.org/10.1111/1471-0528.12645
  • Butinar M, Prebanda MT, Rajkovic J, Jeric B, Stoka V, Peters C, Reinheckel T, Kruger A, Turk V, Turk B, Vasiljeva O: Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model. Oncogene, 2014; 33 (26): 3392-3400. : http://dx.doi.org/10.1038/onc.2013.314
  • Deiner S, Chu I, Mahanian M, Lin HM, Hecht AC, Silverstein JH: Prone position is associated with mild cerebral oxygen desaturation in elderly surgical patients. Plos One, 2014; 9 (9): e106387-e106387. : http://dx.doi.org/10.1371/journal.pone.0106387
  • Dias da Cunha KM, Henderson H, Thomson BM, Hecht AA: Ground water contamination with (238)U, (234)U, (235)U, (226)Ra and (210)Pb from past uranium mining: cove wash, Arizona. Environ Geochem Hlth, 2014; 36 (3): 477-487. : http://dx.doi.org/10.1007/s10653-013-9575-2
  • Ebeling S, Naumann K, Pollok S, Wardecki T, Vidal-Y-Sy S, Nascimento JM, Boerries M, Schmidt G, Brandner JM, Merfort I: From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract. Plos One, 2014; 9 (1) (online): e86147. : http://dx.doi.org/10.1371/journal.pone.0086147
  • El Maadidi S, Faletti L, Berg B, Wenzl C, Wieland K, Chen ZJ, Maurer U, Borner C: A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis. J Immunol, 2014; 192 (3): 1171-1183. : http://dx.doi.org/10.4049/jimmunol.1300842
  • Floyel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsen CH, Friedrichsen M, Overgaard AJ, Berchtold LA, Wiberg A, Poulsen P, Hansen L, Rosinger S, Boehm BO, Ram R, Nguyen Q, Mehta M, Morahan G, Concannon P, Bergholdt R, Nielsen JH, Reinheckel T, von Herrath M, Vaag A, Eizirik DL, Mortensen HB, Storling J, Pociot F: CTSH regulates beta-cell function and disease progression in newly diagnosed type 1 diabetes patients. P Natl Acad Sci Usa, 2014; 111 (28): 10305-10310. : http://dx.doi.org/10.1073/pnas.1402571111
  • Gonzalez-Leal IJ, Roger B, Schwarz A, Schirmeister T, Reinheckel T, Lutz MB, Moll H: Cathepsin B in Antigen-Presenting Cells Controls Mediators of the Th1 Immune Response during Leishmania major Infection. Plos Neglect Trop D, 2014; 8 (9) (online): e3194-e3194. : http://dx.doi.org/10.1371/journal.pntd.0003194
  • Grahammer F, Haenisch N, Steinhardt F, Sander L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber TB: mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. P Natl Acad Sci Usa, 2014; 111 (27): E2817-E2826. : http://dx.doi.org/10.1073/pnas.1402352111
  • Guterl CC, Torre OM, Purmessur D, Dave K, Likhitpanichkul M, Hecht AC, Nicoll SB, Iatridis JC: Characterization of mechanics and cytocompatibility of fibrin-genipin annulus fibrosus sealant with the addition of cell adhesion molecules. Tissue Eng Part B, 2014; 20 (17-18): 2536-2545. : http://dx.doi.org/10.1089/ten.TEA.2012.0714
  • Guzman JZ, Baird EO, Fields AC, McAnany SJ, Qureshi SA, Hecht AC, Cho SK: C5 nerve root palsy following decompression of the cervical spine: a systematic evaluation of the literature. Bone Joint J, 2014; 96-B (7): 950-955. : http://dx.doi.org/10.1302/0301-620X.96B7.33665
  • Guzman JZ, Iatridis JC, Skovrlj B, Cutler HS, Hecht AC, Qureshi SA, Cho SK: Outcomes and complications of diabetes mellitus on patients undergoing degenerative lumbar spine surgery. Spine, 2014; 39 (19): 1596-1604. : http://dx.doi.org/10.1097/BRS.0000000000000482
  • Guzman JZ, Skovrlj B, Shin J, Hecht AC, Qureshi SA, Iatridis JC, Cho SK: The impact of diabetes mellitus on patients undergoing degenerative cervical spine surgery. Spine, 2014; 39 (20): 1656-1665. : http://dx.doi.org/10.1097/BRS.0000000000000498
  • Hayashi Y, Koga Y, Zhang X, Peters C, Yanagawa Y, Wu Z, Yokoyama T, Nakanishi H: Autophagy in superficial spinal dorsal horn accelerates the cathepsin B-dependent morphine antinociceptive tolerance. Neuroscience, 2014; 275: 384-394. : http://dx.doi.org/10.1016/j.neuroscience.2014.06.037
  • Hecht A, Commiskey P, Lazaridis F, Argyrakis P, Kopelman R: Fractal dimension of microbead assemblies used for protein detection. Chemphyschem, 2014; 15 (16): 3444-3446. : http://dx.doi.org/10.1002/cphc.201402048
  • Illien-Junger S, Lu Y, Purmessur D, Mayer JE, Walter BA, Roughley PJ, Qureshi SA, Hecht AC, Iatridis JC: Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model. Spine J, 2014; 14 (11): 2724-2732. : http://dx.doi.org/10.1016/j.spinee.2014.04.017
  • Jagle S, Ronsch K, Timme S, Andrlova H, Bertrand M, Jager M, Proske A, Schrempp M, Yousaf A, Michoel T, Zeiser R, Werner M, Lassmann S, Hecht A: Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer. P Natl Acad Sci Usa, 2014; 111 (13): 4886-4891. : http://dx.doi.org/10.1073/pnas.1314523111
  • Kalfalah F, Sobek S, Bornholz B, Gotz-Rosch C, Tigges J, Fritsche E, Krutmann J, Kohrer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F: Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation. Exp Gerontol, 2014; 56: 59-68. : http://dx.doi.org/10.1016/j.exger.2014.03.017
  • Koehler SM, Rosario-Quinones F, Mayer J, McAnany S, Schiller AL, Qureshi S, Hecht AC: Understanding acute apophyseal spinous process avulsion injuries. Orthopedics, 2014; 37 (3): e317-e321. : http://dx.doi.org/10.3928/01477447-20140225-68
  • Kowalewski B, Lubke T, Kollmann K, Braulke T, Reinheckel T, Dierks T, Damme M: Molecular Characterization of Arylsulfatase G: EXPRESSION, PROCESSING, GLYCOSYLATION, TRANSPORT, AND ACTIVITY. J Biol Chem, 2014; 289 (40): 27992-28005. : http://dx.doi.org/10.1074/jbc.M114.584144
  • Lai ZW, Petrera A, Schilling O: The emerging role of the peptidome in biomarker discovery and degradome profiling. Biol Chem, 2014. : http://dx.doi.org/10.1515/hsz-2014-0207 (in Druck)
  • Likhitpanichkul M, Dreischarf M, Illien-Junger S, Walter BA, Nukaga T, Long RG, Sakai D, Hecht AC, Iatridis JC: Fibrin-genipin adhesive hydrogel for annulus fibrosus repair: performance evaluation with large animal organ culture, in situ biomechanics, and in vivo degradation tests. Eur Cells Mater, 2014; 28: 25-37; discussion 37.
  • Lindenboim L, Sasson T, Worman HJ, Borner C, Stein R: Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release. Nucleus-austin, 2014; 5 (6) (online): 527-541. : http://dx.doi.org/10.4161/19491034.2014.970105
  • Liu JJ, Chan GC, Hecht AS, Storm DR, Davis GE: Comparison of two nasal cell collection methods in determining cyclic adenosine monophosphate levels and its association with olfaction: A feasibility study. Allergy Rhinol (Providence), 2014; 5 (1): 17-21. : http://dx.doi.org/10.2500/ar.2014.5.0079
  • Liu JJ, Chan GC, Hecht AS, Storm DR, Davis GE: Nasal saline irrigation has no effect on normal olfaction: a prospective randomized trial. Int Forum Allergy Rhinol, 2014; 4 (1): 39-42. : http://dx.doi.org/10.1002/alr.21235
  • Löffek S, Hurskainen T, Jackow J, Sigloch FC, Schilling O, Tasanen K, Bruckner-Tuderman L, Franzke CW: Transmembrane Collagen XVII Modulates Integrin Dependent Keratinocyte Migration via PI3K/Rac1 Signaling. Plos One, 2014; 9 (2) (online): e87263. : http://dx.doi.org/10.1371/journal.pone.0087263
  • Lutz A, Sanwald J, Thomas M, Feuer R, Sawodny O, Ederer M, Borner C, Humar M, Merfort I: Interleukin-1beta Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes. Plos One, 2014; 9 (12) (online): e115603-e115603. : http://dx.doi.org/10.1371/journal.pone.0115603
  • Lu Y, Guzman JZ, Purmessur D, Iatridis JC, Hecht AC, Qureshi SA, Cho SK: Nonoperative management of discogenic back pain: a systematic review. Spine, 2014; 39 (16): 1314-1324. : http://dx.doi.org/10.1097/BRS.0000000000000401
  • Lu Y, McAnany SJ, Hecht AC, Cho SK, Qureshi SA: Utilization trends of cervical artificial disc replacement after FDA approval compared with anterior cervical fusion: adoption of new technology. Spine, 2014; 39 (3): 249-255. : http://dx.doi.org/10.1097/BRS.0000000000000113
  • Maurer U, Preiss F, Brauns-Schubert P, Schlicher L, Charvet C: GSK-3 - at the crossroads of cell death and survival. J Cell Sci, 2014; 127 (Pt 7): 1369-1378. : http://dx.doi.org/10.1242/jcs.138057
  • Mayer JE, Dang RP, Duarte Prieto GF, Cho SK, Qureshi SA, Hecht AC: Analysis of the techniques for thoracic- and lumbar-level localization during posterior spine surgery and the occurrence of wrong-level surgery: results from a national survey. Spine J, 2014; 14 (5): 741-748. : http://dx.doi.org/10.1016/j.spinee.2013.06.068
  • McAnany S, Cho S, Qureshi S, Hecht AC: A commentary on cervical spondylolysis in the contact athlete. Spine J, 2014; 14 (6): e7-e8. : http://dx.doi.org/10.1016/j.spinee.2014.02.026
  • McAnany SJ, Overley S, Baird EO, Cho SK, Hecht AC, Zigler JE, Qureshi SA: The 5-year cost-effectiveness of anterior cervical discectomy and fusion and cervical disc replacement: a Markov analysis. Spine, 2014; 39 (23): 1924-1933. : http://dx.doi.org/10.1097/BRS.0000000000000562
  • McAteer JP, Hecht A, De Roos AJ, Goldin AB: Maternal medical and behavioral risk factors for congenital diaphragmatic hernia. J Pediatr Surg, 2014; 49 (1): 34-8; discussion 38. : http://dx.doi.org/10.1016/j.jpedsurg.2013.09.025
  • Mckie J, Qureshi S, Iatridis J, Egorova N, Cho S, Hecht A: Trends in Bone Morphogenetic Protein Usage since the U.S. Food and Drug Administration Advisory in 2008: What Happens to Physician Practices When the Food and Drug Administration Issues an Advisory? Global Spine J, 2014; 4 (2): 71-76. : http://dx.doi.org/10.1055/s-0033-1363515
  • Moller Y, Siegemund M, Beyes S, Herr R, Lecis D, Delia D, Kontermann R, Brummer T, Pfizenmaier K, Olayioye MA: EGFR-Targeted TRAIL and a Smac Mimetic Synergize to Overcome Apoptosis Resistance in KRAS Mutant Colorectal Cancer Cells. Plos One, 2014; 9 (9) (online): e107165-e107165. : http://dx.doi.org/10.1371/journal.pone.0107165
  • Moller Y, Siegemund M, Beyes S, Herr R, Lecis D, Delia D, Kontermann R, Brummer T, Pfizenmaier K, Olayioye MA: EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells. Plos One, 2014; 9 (9): e107165-e107165. : http://dx.doi.org/10.1371/journal.pone.0107165
  • Muller S, Faulhaber A, Sieber C, Pfeifer D, Hochberg T, Gansz M, Deshmukh SD, Dauth S, Brix K, Saftig P, Peters C, Henneke P, Reinheckel T: The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction. Faseb J, 2014; 28 (1): 162-175. : http://dx.doi.org/10.1096/fj.13-232272
  • Neumann J, Boerries M, Kohler R, Giaisi M, Krammer PH, Busch H, Li-Weber M: The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints. Int J Cancer, 2014; 134 (8): 1991-2002. : http://dx.doi.org/10.1002/ijc.28521
  • Pensa S, Neoh K, Resemann HK, Kreuzaler PA, Abell K, Clarke NJ, Reinheckel T, Kahn CR, Watson CJ: The PI3K regulatory subunits p55alpha and p50alpha regulate cell death in vivo. Cell Death Differ, 2014; 21 (9): 1442-1450. : http://dx.doi.org/10.1038/cdd.2014.59
  • Qureshi S, Goz V, McAnany S, Cho SK, Hecht AC, Delamarter RB, Fehlings MG: Health state utility of patients with single-level cervical degenerative disc disease: comparison of anterior cervical discectomy and fusion with cervical disc arthroplasty. J Neurosurg Spine, 2014; 20 (5): 475-479. : http://dx.doi.org/10.3171/2014.1.SPINE13718
  • Rohde D, Schon C, Boerries M, Didrihsone I, Ritterhoff J, Kubatzky KF, Volkers M, Herzog N, Mahler M, Tsoporis JN, Parker TG, Linke B, Giannitsis E, Gao E, Peppel K, Katus HA, Most P: S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Embo Mol Med, 2014; 6 (6): 778-794. : http://dx.doi.org/10.15252/emmm.201303498
  • Schmidt Y, Biniossek M, Stark GB, Finkenzeller G, Simunovic F: Osteoblastic alkaline phosphatase mRNA is stabilized by binding to vimentin intermediary filaments. Biol Chem, 2014. : http://dx.doi.org/10.1515/hsz-2014-0274 (in Druck)
  • Scholzel K, Schildberg FA, Welz M, Borner C, Geiger S, Kurts C, Heikenwalder M, Knolle PA, Wohlleber D: Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance. J Hepatol, 2014; 61 (3): 600-608. : http://dx.doi.org/10.1016/j.jhep.2014.04.028
  • Shahinian H, Loessner D, Biniossek ML, Kizhakkedathu JN, Clements JA, Magdolen V, Schilling O: Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFbeta-1 signaling in ovarian cancer cells. Mol Oncol, 2014; 8 (1): 68-82. : http://dx.doi.org/10.1016/j.molonc.2013.09.003
  • Silvestre J, Guzman JZ, Skovrlj B, Overley SC, Cho SK, Qureshi SA, Hecht AC: The Internet as a communication tool for orthopedic spine fellowships in the United States. Spine J, 2014. : http://dx.doi.org/10.1016/j.spinee.2014.11.024
  • Sprissler C, Belenki D, Maurer H, Aumann K, Pfeifer D, Klein C, Muller TA, Kissel S, Hulsdunker J, Alexandrovski J, Brummer T, Jumaa H, Duyster J, Dierks C: Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice. Blood Cancer J, 2014; 4 (online): e240-e240. : http://dx.doi.org/10.1038/bcj.2014.53
  • Sprissler C, Belenki D, Maurer H, Aumann K, Pfeifer D, Klein C, Muller TA, Kissel S, Hulsdunker J, Alexandrovski J, Brummer T, Jumaa H, Duyster J, Dierks C: Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice. Blood Cancer J, 2014; 4: e240-e240. : http://dx.doi.org/10.1038/bcj.2014.53
  • Tamhane T, Arampatzidou M, Gerganova V, Tacke M, Illukkumbura R, Dauth S, Schaschke N, Peters C, Reinheckel T, Brix K: The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biol Chem, 2014; 395 (10): 1201-1219. : http://dx.doi.org/10.1515/hsz-2014-0151
  • Tholen M, Hillebrand LE, Tholen S, Sedelmeier O, Arnold SJ, Reinheckel T: Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo. Nat Commun, 2014; 5 (online): 4931-4931. : http://dx.doi.org/10.1038/ncomms5931
  • Tholen S, Biniossek ML, Gansz M, Ahrens TD, Schlimpert M, Kizhakkedathu JN, Reinheckel T, Schilling O: Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis. Cell Mol Life Sci, 2014; 71 (5): 899-916. : http://dx.doi.org/10.1007/s00018-013-1406-1
  • Timme S, Ihde S, Fichter CD, Waehle V, Bogatyreva L, Atanasov K, Kohler I, Schopflin A, Geddert H, Faller G, Klimstra D, Tang L, Reinheckel T, Hauschke D, Busch H, Boerries M, Werner M, Lassmann S: STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas. Oncogene, 2014; 33 (25): 3256-3266. : http://dx.doi.org/10.1038/onc.2013.298
  • Videm P, Gunasekaran D, Schroder B, Mayer B, Biniossek ML, Schilling O: Automated peptide mapping and protein-topographical annotation of proteomics data. Bmc Bioinformatics, 2014; 15 (online): 207-207. : http://dx.doi.org/10.1186/1471-2105-15-207
  • Volceanov L, Herbst K, Biniossek M, Schilling O, Haller D, Nolke T, Subbarayal P, Rudel T, Zieger B, Hacker G: Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion. Mbio, 2014; 5 (5): 1802-1814. : http://dx.doi.org/10.1128/mBio.01802-14
  • Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stuhler K: Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts. Aging-us, 2014; 6 (10): 856-878.
  • Walter BA, Illien-Junger S, Nasser PR, Hecht AC, Iatridis JC: Development and validation of a bioreactor system for dynamic loading and mechanical characterization of whole human intervertebral discs in organ culture. J Biomech, 2014; 47 (9): 2095-2101. : http://dx.doi.org/10.1016/j.jbiomech.2014.03.015
  • Walter BA, Torre OM, Laudier D, Naidich TP, Hecht AC, Iatridis JC: Form and function of the intervertebral disc in health and disease: a morphological and stain comparison study. J Anat, 2014. : http://dx.doi.org/10.1111/joa.12258
  • Weber E, Barbulescu E, Medek R, Reinheckel T, Sameni M, Anbalagan A, Moin K, Sloane BF: Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies. Biol Chem, 2014. : http://dx.doi.org/10.1515/hsz-2014-0191 (in Druck)
  • Weinberg F, Schulze E, Fatouros C, Schmidt E, Baumeister R, Brummer T: Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans. Gene Expr Patterns, 2014; 15 (2): 124-134. : http://dx.doi.org/10.1016/j.gep.2014.05.005
  • Yaktapour N, Meiss F, Mastroianni J, Zenz T, Andrlova H, Mathew NR, Claus R, Hutter B, Frohling S, Brors B, Pfeifer D, Pantic M, Bartsch I, Spehl TS, Meyer PT, Duyster J, Zirlik K, Brummer T, Zeiser R: BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia. J Clin Invest, 2014; 124 (11): 5074-5084. : http://dx.doi.org/10.1172/JCI76539
  • Yaktapour N *, Meiss F *, Mastroianni J, Zenz T, Andrlova H, Mathew NR, Claus R, Hutter B, Frohling S, Brors B, Pfeifer D, Pantic M, Bartsch I, Spehl TS, Meyer PT, Duyster J *, Zirlik K *, Brummer T *, Zeiser R *: BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia. J Clin Invest, 2014; 124 (11): 5074-5084. : http://dx.doi.org/10.1172/JCI76539
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:
  • Hamson EJ, Keane FM, Tholen S, Schilling O, Gorrell MD: Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy. Proteom Clin Appl, 2014; 8 (5-6): 454-463. : http://dx.doi.org/10.1002/prca.201300095
  • Petrera A, Lai ZW, Schilling O: Carboxyterminal protein processing in health and disease: key actors and emerging technologies. J Proteome Res, 2014; 13 (11): 4497-4504. : http://dx.doi.org/10.1021/pr5005746
Kurzbeiträge / short communications:
  • Lindner SE, Wissler M, Grunder A, Aumann K, Ottina E, Peintner L, Brauns-Schubert P, Preiss F, Herzog S, Borner C, Charvet C, Villunger A, Pahl HL, Maurer U: Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation. Oncogene, 2014; 33 (44): 5221-5224. : http://dx.doi.org/10.1038/onc.2013.469
Sonstige Publikationen:

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten

Promotionen
  • Ursula Kern: Endosomal/lysosomal proteases in epithelial to mesenchymal transition (EMT) and invasion of normal and malignant mammary epithelium, 2014.