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 Forschungsbericht für das Jahr 2013

Institut für Molekulare Medizin und Zellforschung (IMMZ)

Zentrum für Biochemie und Molekulare Zellforschung (ZBMZ)

Stefan-Meier-Str. 17
79104 Freiburg i. Br.
Tel: +49-761-203-9600/9601 Fax: +49-761-203-9602
Email christoph.peters@mol-med.uni-freiburg.de
http://www.mol-med.uni-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Christoph Peters, Institutsleiter
  • Dr. Martin Biniossek, Gruppenleiter
  • Prof. Dr. Dr. h.c. Christoph Borner, Gruppenleiter
  • Dr. Dr. Melanie Börries, Gruppenleiterin
  • Prof. Dr. Tilman Brummer, Gruppenleiter
  • Dr. Hauke Busch, Gruppenleiter
  • Prof. Dr. Andreas Hecht, Gruppenleiter
  • PD Dr. Ulrich Maurer, Gruppenleiter
  • Prof. Dr. Thomas Reinheckel, Gruppenleiter
  • Prof. Dr. Oliver Schilling, Gruppenleiter
  • Dr. Martin Klose, Postdoc
  • Dr. Maria Koczorowska, Wissenschaftliche Mitarbeiterin
  • Dr. Agnese Petrera, Postdoc
  • Dr. Marlene Tacke (geb. Fischer)
  • Dr. Moritz Buck, Postdoc
  • Dr. Giuseppe Facchetti, Postdoc
  • Dr. Steffen Knauer, Postdoc
  • Dr. Maria Koczorowska, Postdoc
  • Dr. Zon Weng Lai, Wissenschaftlicher Mitarbeiter (m/w)
  • Dr. Juliana Nascimento, Postdoc
  • Dr. Lai Zon Weng, Postdoc
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Funktion der Bcl-2 Familie und Identifikation von neuen Komponenten der Caspase-unabhängigen Zelltodwege
  • In vivo Funktionen von Proteasen
  • Massenspektrometrie
  • Modulation von Signaltransduktionsprozessen in der Embryonalentwicklung und Tumorigenese
  • Protease Degradomik
  • Signaltransduktion in Tumorentwicklung und Medikamentenresistenz
  • Signaltransduktion in Zelltod und -überleben
  • Systembiologie und Systemmedizin
  • Tumorinvasion und Metastasierung

Finanzierung

  • siehe: www.mol-med.uni-freiburg.de

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Aldahmesh MA, Khan AO, Alkuraya H, Adly N, Anazi S, Al-Saleh AA, Mohamed JY, Hijazi H, Prabakaran S, Tacke M, Al-Khrashi A, Hashem M, Reinheckel T, Assiri A, Alkuraya FS: Mutations in LRPAP1 Are Associated with Severe Myopia in Humans. Am J Hum Genet, 2013; 93 (2): 313-320. : http://dx.doi.org/10.1016/j.ajhg.2013.06.002
  • Ansmann EB, Hecht A, Henn DK, Leptien S, Stelzer HG: The future of monitoring in clinical research - a holistic approach: linking Ger Med Sci, 2013; 11: Doc04-Doc04. : http://dx.doi.org/10.3205/000172
  • Benary U, Kofahl B, Hecht A, Wolf J: Modeling Wnt/beta-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions. Front Physiol, 2013; 4 (online): 21-21. : http://dx.doi.org/10.3389/fphys.2013.00021
  • Benary U, Kofahl B, Hecht A, Wolf J: Modeling Wnt/beta-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions. Front Physiol, 2013; 4: 21-21. : http://dx.doi.org/10.3389/fphys.2013.00021
  • Biniossek ML, Lechel A, Rudolph KL, Martens UM, Zimmermann S: Quantitative proteomic profiling of tumor cell response to telomere dysfunction using isotope-coded protein labeling (ICPL) reveals interaction network of candidate senescence markers. J Proteomics, 2013; 91: 515-535. : http://dx.doi.org/10.1016/j.jprot.2013.08.007
  • Borner C, Kraus J: Inhibition of NF-kappaB by opioids in T cells. J Immunol, 2013; 191 (9): 4640-4647. : http://dx.doi.org/10.4049/jimmunol.1300320
  • Borner C, Lanciotti S, Koch T, Hollt V, Kraus J: mu opioid receptor agonist-selective regulation of interleukin-4 in T lymphocytes. J Neuroimmunol, 2013; 263 (1-2): 35-42. : http://dx.doi.org/10.1016/j.jneuroim.2013.07.012
  • Brummer TH, Heikkinen AM, Jalkanen J, Fraser J, Makinen J, Tomas E, Seppala T, Sjoberg J, Harkki P: Antibiotic prophylaxis for hysterectomy, a prospective cohort study: cefuroxime, metronidazole, or both? Bjog-int J Obstet Gy, 2013; 120 (10): 1269-1276. : http://dx.doi.org/10.1111/1471-0528.12178
  • Buhler A, Berger S, Bengsch F, Martin G, Han H, Vierkotten S, Pielen A, Boehringer D, Schlunck G, Fauser S, Agostini HT, Reinheckel T, Stahl A: Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice. Exp Eye Res, 2013; 115: 73-78. : http://dx.doi.org/10.1016/j.exer.2013.06.014
  • Busch H, Boerries M, Bao J, Hanke ST, Hiss M, Tiko T, Rensing SA: Network theory inspired analysis of time-resolved expression data reveals key players guiding P. patens stem cell development. Plos One, 2013; 8 (4) (online): e60494-e60494. : http://dx.doi.org/10.1371/journal.pone.0060494
  • Carneiro GL, Braz D, de Jesus EF, Santos SM, Cardoso K, Hecht AA, Dias da Cunha MK: Radon in indoor concentrations and indoor concentrations of metal dust particles in museums and other public buildings. Environ Geochem Hlth, 2013; 35 (3): 333-340. : http://dx.doi.org/10.1007/s10653-012-9497-4
  • Deswal S, Meyer A, Fiala GJ, Eisenhardt AE, Schmitt LC, Salek M, Brummer T, Acuto O, Schamel WW: Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells. J Immunol, 2013; 190 (5): 1927-1935. : http://dx.doi.org/10.4049/jimmunol.1200653
  • Deswal S, Meyer A, Fiala GJ, Eisenhardt AE, Schmitt LC, Salek M, Brummer T, Acuto O, Schamel WW: Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells. J Immunol, 2013; 190 (5): 1927-1935. : http://dx.doi.org/10.4049/jimmunol.1200653
  • Elfert S, Weise A, Bruser K, Biniossek ML, Jagle S, Senghaas N, Hecht A: Acetylation of human TCF4 (TCF7L2) proteins attenuates inhibition by the HBP1 repressor and induces a conformational change in the TCF4::DNA complex. Plos One, 2013; 8 (4) (online): e61867-e61867. : http://dx.doi.org/10.1371/journal.pone.0061867
  • Elfert S, Weise A, Bruser K, Biniossek ML, Jagle S, Senghaas N, Hecht A: Acetylation of human TCF4 (TCF7L2) proteins attenuates inhibition by the HBP1 repressor and induces a conformational change in the TCF4::DNA complex. Plos One, 2013; 8 (4): e61867-e61867. : http://dx.doi.org/10.1371/journal.pone.0061867
  • Fuellen G, Boerries M, Busch H, de Grey A, Hahn U, Hiller T, Hoeflich A, Jansen L, Janssens GE, Kaleta C, Meinema AC, Schauble S, Simm A, Schofield PN, Smith B, Suhnel J, Vera J, Wagner W, Wonne EC, Wuttke D: In silico approaches and the role of ontologies in aging research. Rejuv Res, 2013; 16 (6): 540-546. : http://dx.doi.org/10.1089/rej.2013.1517
  • Geissler A, Haun F, Frank DO, Wieland K, Simon MM, Idzko M, Davis RJ, Maurer U, Borner C: Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Cell Death Differ, 2013; 20 (10): 1317-1329. : http://dx.doi.org/10.1038/cdd.2013.78
  • Geissler A, Haun F, Frank DO, Wieland K, Simon MM, Idzko M, Davis RJ, Maurer U, Borner C: Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Cell Death Differ, 2013; 20 (10): 1317-1329. : http://dx.doi.org/10.1038/cdd.2013.78
  • Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Bottger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gomez-Lechon MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Haussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhutter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stober R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG: Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol, 2013; 87 (8): 1315-1530. : http://dx.doi.org/10.1007/s00204-013-1078-5
  • Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Bottger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gomez-Lechon MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Haussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhutter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stober R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG: Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol, 2013; 87 (8): 1315-1530. : http://dx.doi.org/10.1007/s00204-013-1078-5
  • Goz V, Errico TJ, Weinreb JH, Koehler SM, Hecht AC, Lafage V, Qureshi SA: Vertebroplasty and kyphoplasty: national outcomes and trends in utilization from 2005 through 2010. Spine J, 2013. : http://dx.doi.org/10.1016/j.spinee.2013.06.032
  • Goz V, Qureshi S, Hecht AC: Arytenoid dislocation as a cause of prolonged hoarseness after cervical discectomy and fusion. Global Spine J, 2013; 3 (1): 47-50. : http://dx.doi.org/10.1055/s-0032-1329890
  • Halbach S, Rigbolt KT, Wohrle FU, Diedrich B, Gretzmeier C, Brummer T, Dengjel J: Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells. Cell Commun Signal, 2013; 11 (1) (online): 30. : http://dx.doi.org/10.1186/1478-811X-11-30
  • Halbach S, Rigbolt KT, Wohrle FU, Diedrich B, Gretzmeier C, Brummer T, Dengjel J: Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells. Cell Commun Signal, 2013; 11 (1): 30-30. : http://dx.doi.org/10.1186/1478-811X-11-30
  • Hecht A, Commiskey P, Shah N, Kopelman R: Bead assembly magnetorotation as a signal transduction method for protein detection. Biosens Bioelectron, 2013; 48: 26-32. : http://dx.doi.org/10.1016/j.bios.2013.03.073
  • Hecht A, Nowak D, Nowak V, Hanfstein B, Faldum A, Buchner T, Spiekermann K, Sauerland C, Lengfelder E, Hofmann WK, Nolte F: High expression of the Ets-related gene (ERG) is an independent prognostic marker for relapse-free survival in patients with acute promyelocytic leukemia. Ann Hematol, 2013; 92 (4): 443-449. : http://dx.doi.org/10.1007/s00277-012-1648-2
  • Horst SA, Linner A, Beineke A, Lehne S, Holtje C, Hecht A, Norrby-Teglund A, Medina E, Goldmann O: Prognostic value and therapeutic potential of TREM-1 in Streptococcus pyogenes induced sepsis. J Innate Immun, 2013; 5 (6): 581-590. : http://dx.doi.org/10.1159/000348283
  • Huai J, Vogtle FN, Jockel L, Li Y, Kiefer T, Ricci JE, Borner C: TNFalpha-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation. J Cell Sci, 2013; 126 (Pt 17): 4015-4025. : http://dx.doi.org/10.1242/jcs.129999
  • Huai J, Vogtle FN, Jockel L, Li Y, Kiefer T, Ricci JE, Borner C: TNFalpha-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation. J Cell Sci, 2013; 126 (Pt 17): 4015-4025. : http://dx.doi.org/10.1242/jcs.129999
  • Kampf B, Makowski T, Weiss H, Henn H, Hoeschen-Luemmen M, Brummer T, Blum R, Wietfeld K: ESGE newsletter. Definition of "endoscope families" as used in EN ISO 15883-4. Endoscopy, 2013; 45 (2): 156-157. : http://dx.doi.org/10.1055/s-0032-1326183
  • Karlsson M, Lienemann PS, Sprossmann N, Heilmann K, Brummer T, Lutolf MP, Ehrbar M, Weber W: A generic strategy for pharmacological caging of growth factors for tissue engineering. Chem Commun, 2013; 49 (53): 5927-5929. : http://dx.doi.org/10.1039/c3cc41616j
  • Karlsson M, Lienemann PS, Sprossmann N, Heilmann K, Brummer T, Lutolf MP, Ehrbar M, Weber W: A generic strategy for pharmacological caging of growth factors for tissue engineering. Chem Commun, 2013; 49 (53): 5927-5929. : http://dx.doi.org/10.1039/c3cc41616j
  • Kienzle C, Eisler SA, Villeneuve J, Brummer T, Olayioye MA, Hausser A: PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. Mol Biol Cell, 2013; 24 (3): 222-233. : http://dx.doi.org/10.1091/mbc.E12-03-0198
  • Kienzle C, Eisler SA, Villeneuve J, Brummer T, Olayioye MA, Hausser A: PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. Mol Biol Cell, 2013; 24 (3): 222-233. : http://dx.doi.org/10.1091/mbc.E12-03-0198
  • Koike M, Shibata M, Ezaki J, Peters C, Saftig P, Kominami E, Uchiyama Y: Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system. Eur J Neurosci, 2013; 37 (5): 816-830. : http://dx.doi.org/10.1111/ejn.12096
  • Krueger S, Bernhardt A, Kalinski T, Baldensperger M, Zeh M, Teller A, Adolf D, Reinheckel T, Roessner A, Kuester D: Induction of premalignant host responses by cathepsin x/z-deficiency in helicobacter pylori-infected mice. Plos One, 2013; 8 (7) (online): e70242-e70242. : http://dx.doi.org/10.1371/journal.pone.0070242
  • Kuttner V, Mack C, Rigbolt KT, Kern JS, Schilling O, Busch H, Bruckner-Tuderman L, Dengjel J: Global remodelling of cellular microenvironment due to loss of collagen VII. Mol Syst Biol, 2013; 9 (online): 657. : http://dx.doi.org/10.1038/msb.2013.17
  • Lavin M, Brummer TJ, Quire R, Maxwell BD, Rew LJ: Physical disturbance shapes vascular plant diversity more profoundly than fire in the sagebrush steppe of southeastern Idaho, U.S.A. Ecol Evol, 2013; 3 (6): 1626-1641. : http://dx.doi.org/10.1002/ece3.574
  • Lindenboim L, Ferrando-May E, Borner C, Stein R: Non-canonical function of Bax in stress-induced nuclear protein redistribution. Cell Mol Life Sci, 2013; 70 (16): 3013-3027. : http://dx.doi.org/10.1007/s00018-013-1306-4
  • Lindenboim L, Ferrando-May E, Borner C, Stein R: Non-canonical function of Bax in stress-induced nuclear protein redistribution. Cell Mol Life Sci, 2013; 70 (16): 3013-3027. : http://dx.doi.org/10.1007/s00018-013-1306-4
  • Liszewski MK, Kolev M, Le Friec G, Leung M, Bertram PG, Fara AF, Subias M, Pickering MC, Drouet C, Meri S, Arstila TP, Pekkarinen PT, Ma M, Cope A, Reinheckel T, Rodriguez de Cordoba S, Afzali B, Atkinson JP, Kemper C: Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation. Immunity, 2013; 39 (6): 1143-1157. : http://dx.doi.org/10.1016/j.immuni.2013.10.018
  • Makinen J, Brummer T, Jalkanen J, Heikkinen AM, Fraser J, Tomas E, Harkki P, Sjoberg J: Ten years of progress-improved hysterectomy outcomes in Finland 1996-2006: a longitudinal observation study. Bmj Open, 2013; 3 (10): e003169-e003169. : http://dx.doi.org/10.1136/bmjopen-2013-003169
  • Mayer JE, Iatridis JC, Chan D, Qureshi SA, Gottesman O, Hecht AC: Genetic polymorphisms associated with intervertebral disc degeneration. Spine J, 2013; 13 (3): 299-317. : http://dx.doi.org/10.1016/j.spinee.2013.01.041
  • Nolte F, Hecht A, Reinwald M, Nowak D, Nowak V, Hanfstein B, Faldum A, Buchner T, Spiekermann K, Sauerland C, Hofmann WK, Lengfelder E: In acute promyelocytic leukemia (APL) low BAALC gene expression identifies a patient group with favorable overall survival and improved relapse free survival. Leukemia Res, 2013; 37 (4): 378-382. : http://dx.doi.org/10.1016/j.leukres.2012.11.018
  • Ohkouchi S, Shibata M, Sasaki M, Koike M, Safig P, Peters C, Nagata S, Uchiyama Y: Biogenesis and Proteolytic Processing of Lysosomal DNase II. Plos One, 2013; 8 (3) (online): e59148-e59148. : http://dx.doi.org/10.1371/journal.pone.0059148
  • Ortiz-Padilla C, Gallego-Ortega D, Browne BC, Hochgrafe F, Caldon CE, Lyons RJ, Croucher DR, Rickwood D, Ormandy CJ, Brummer T, Daly RJ: Functional characterization of cancer-associated Gab1 mutations. Oncogene, 2013; 32 (21): 2696-2702. : http://dx.doi.org/10.1038/onc.2012.271
  • Ortiz-Padilla C, Gallego-Ortega D, Browne BC, Hochgrafe F, Caldon CE, Lyons RJ, Croucher DR, Rickwood D, Ormandy CJ, Brummer T, Daly RJ: Functional characterization of cancer-associated Gab1 mutations. Oncogene, 2013; 32 (21): 2696-2702. : http://dx.doi.org/10.1038/onc.2012.271
  • Ploen D, Hafirassou ML, Himmelsbach K, Sauter D, Biniossek ML, Weiss TS, Baumert TF, Schuster C, Hildt E: TIP47 plays a crucial role in the life cycle of hepatitis C virus. J Hepatol, 2013; 58 (6): 1081-1088. : http://dx.doi.org/10.1016/j.jhep.2013.01.022
  • Purmessur D, Cornejo MC, Cho SK, Hecht AC, Iatridis JC: Notochordal cell-derived therapeutic strategies for discogenic back pain. Global Spine J, 2013; 3 (3): 201-218. : http://dx.doi.org/10.1055/s-0033-1350053
  • Purmessur D, Walter BA, Roughley PJ, Laudier DM, Hecht AC, Iatridis J: A role for TNFalpha in intervertebral disc degeneration: a non-recoverable catabolic shift. Biochem Bioph Res Co, 2013; 433 (1): 151-156. : http://dx.doi.org/10.1016/j.bbrc.2013.02.034
  • Qureshi SA, Koehler SM, Lu Y, Cho S, Hecht AC: Utilization trends of cervical artificial disc replacement during the FDA investigational device exemption clinical trials compared to anterior cervical fusion. J Clin Neurosci, 2013; 20 (12): 1723-1726. : http://dx.doi.org/10.1016/j.jocn.2013.03.002
  • Qureshi SA, McAnany S, Goz V, Koehler SM, Hecht AC: Cost-effectiveness analysis: comparing single-level cervical disc replacement and single-level anterior cervical discectomy and fusion: clinical article. J Neurosurg Spine, 2013; 19 (5): 546-554. : http://dx.doi.org/10.3171/2013.8.SPINE12623
  • Reinheckel T: On the road to inflammation: linking lysosome disruption, lysosomal protease release and necrotic death of immune cells. Cell Cycle, 2013; 12 (13): 1994-1994. : http://dx.doi.org/10.4161/cc.25316
  • Ruffell B, Affara NI, Cottone L, Junankar S, Johansson M, Denardo DG, Korets L, Reinheckel T, Sloane BF, Bogyo M, Coussens LM: Cathepsin C is a tissue-specific regulator of squamous carcinogenesis. Gene Dev, 2013; 27 (19): 2086-2098. : http://dx.doi.org/10.1101/gad.224899.113
  • Sprenger A, Weber S, Zarai M, Engelke R, Nascimento JM, Gretzmeier C, Hilpert M, Boerries M, Has C, Busch H, Bruckner-Tuderman L, Dengjel J: Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin localization. Mol Cell Proteomics, 2013; 12 (9): 2509-2521. : http://dx.doi.org/10.1074/mcp.M112.025478
  • Srinivasan HB, Tjin-A-Tam A, Galang R, Hecht A, Srinivasan G: Migration patterns of peripherally inserted central venous catheters at 24 hours postinsertion in neonates. Am J Perinat, 2013; 30 (10): 871-874. : http://dx.doi.org/10.1055/s-0033-1333672
  • Stevens GB, Silver DA, Zgaga-Griesz A, Bessler WG, Vashist SK, Patel P, Achazi K, Strotmeier J, Worbs S, Dorner MB, Dorner BG, Pauly D, Rummel A, Urban GA, Krueger M: Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity. Analyst, 2013; 138 (20): 6154-6162. : http://dx.doi.org/10.1039/c3an00525a
  • Tholen S, Biniossek ML, Gansz M, Gomez-Auli A, Bengsch F, Noel A, Kizhakkedathu JN, Boerries M, Busch H, Reinheckel T, Schilling O: Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome. Mol Cell Proteomics, 2013; 12 (3): 611-625. : http://dx.doi.org/10.1074/mcp.M112.017962
  • Weber M, Gawanbacht A, Habjan M, Rang A, Borner C, Schmidt AM, Veitinger S, Jacob R, Devignot S, Kochs G, Garcia-Sastre A, Weber F: Incoming RNA Virus Nucleocapsids Containing a 5'-Triphosphorylated Genome Activate RIG-I and Antiviral Signaling. Cell Host Microbe, 2013; 13 (3): 336-346. : http://dx.doi.org/10.1016/j.chom.2013.01.012
  • Weber M, Gawanbacht A, Habjan M, Rang A, Borner C, Schmidt AM, Veitinger S, Jacob R, Devignot S, Kochs G, Garcia-Sastre A, Weber F: Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling. Cell Host Microbe, 2013; 13 (3): 336-346. : http://dx.doi.org/10.1016/j.chom.2013.01.012
  • Wohrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, Lassmann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T: Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors. Leukemia, 2013; 27 (1): 118-129. : http://dx.doi.org/10.1038/leu.2012.222
  • Wohrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, Lassmann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T: Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors. Leukemia, 2013; 27 (1): 118-129. : http://dx.doi.org/10.1038/leu.2012.222
  • Yaktapour N, Ubelhart R, Schuler J, Aumann K, Dierks C, Burger M, Pfeifer D, Jumaa H, Veelken H, Brummer T *, Zirlik K *: Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia. Blood, 2013; 122 (9): 1621-1633. : http://dx.doi.org/10.1182/blood-2013-02-484386
  • Yaktapour N, Ubelhart R, Schuler J, Aumann K, Dierks C, Burger M, Pfeifer D, Jumaa H, Veelken H, Brummer T, Zirlik K: Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia. Blood, 2013; 122 (9): 1621-1633. : http://dx.doi.org/10.1182/blood-2013-02-484386
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten

Promotionen
  • Fee Bengsch: Pathogenic Functions of the Lysosomal Protease Cathepsin B in Murine Invasive Breast Cancer, 2013.