Institut für Molekulare Medizin und Zellforschung (IMMZ)

Zentrum für Biochemie und Molekulare Zellforschung (ZBMZ)

Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

Wissenschaftliche Publikationen

• Arampatzidou M, Mayer K, Iolyeva ME, Asrat SG, Ravichandran M, Gunther T, Schule R, Reinheckel T, Brix K: Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP. Biol Chem, 2011; 392 (11): 983-993. : http://dx.doi.org/10.1515/BC.2011.096
• Aumann K, Lassmann S, Schopflin A, May AM, Wohrle FU, Zeiser R, Waller CF, Hauschke D, Werner M, Brummer T: The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemia. Hum Pathol, 2011; 42 (5): 719-726. : http://dx.doi.org/10.1016/j.humpath.2010.09.012
• Becker-Pauly C, Barre O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schutte A, Kappelhoff R, Stocker W, Overall CM: Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Mol Cell Proteomics, 2011; 10 (9): M111.009233-M111.009233. : http://dx.doi.org/10.1074/mcp.M111.009233
• Biniossek ML, Nagler DK, Becker-Pauly C, Schilling O: Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S. J Proteome Res, 2011; 10 (12): 5363-5373. : http://dx.doi.org/10.1021/pr200621z
• Blazquez C, Chiarlone A, Sagredo O, Aguado T, Pazos MR, Resel E, Palazuelos J, Julien B, Salazar M, Borner C, Benito C, Carrasco C, Diez-Zaera M, Paoletti P, Diaz-Hernandez M, Ruiz C, Sendtner M, Lucas JJ, de Yebenes JG, Marsicano G, Monory K, Lutz B, Romero J, Alberch J, Gines S, Kraus J, Fernandez-Ruiz J, Galve-Roperh I, Guzman M: Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease. Brain, 2011; 134 (Pt 1): 119-136. : http://dx.doi.org/10.1093/brain/awq278
• Brummer TH, Jalkanen J, Fraser J, Heikkinen AM, Kauko M, Makinen J, Seppala T, Sjoberg J, Tomas E, Harkki P: FINHYST, a prospective study of 5279 hysterectomies: complications and their risk factors. Hum Reprod, 2011; 26 (7): 1741-1751. : http://dx.doi.org/10.1093/humrep/der116
• Buhling F, Kouadio M, Chwieralski CE, Kern U, Hohlfeld JM, Klemm N, Friedrichs N, Roth W, Deussing JM, Peters C, Reinheckel T: Gene targeting of the cysteine peptidase cathepsin h impairs lung surfactant in mice. Plos One, 2011; 6 (10) (online): e26247-e26247. : http://dx.doi.org/10.1371/journal.pone.0026247
• Carrasco-Marin E, Fernandez-Prieto L, Rodriguez-Del Rio E, Madrazo-Toca F, Reinheckel T, Saftig P, Alvarez-Dominguez C: LIMP-2 links late phagosomal trafficking with the onset of the innate immune response to Listeria monocytogenes: a role in macrophage activation. J Biol Chem, 2011; 286 (5): 3332-3341. : http://dx.doi.org/10.1074/jbc.M110.146761
• Charvet C, Wissler M, Brauns-Schubert P, Wang SJ, Tang Y, Sigloch FC, Mellert H, Brandenburg M, Lindner SE, Breit B, Green DR, McMahon SB, Borner C, Gu W, Maurer U: Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53. Mol Cell, 2011; 42 (5): 584-596. : http://dx.doi.org/10.1016/j.molcel.2011.03.033
• Charvet C, Wissler M, Brauns-Schubert P, Wang SJ, Tang Y, Sigloch FC, Mellert H, Brandenburg M, Lindner SE, Breit B, Green DR, McMahon SB, Borner C, Gu W, Maurer U: Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell, 2011; 42 (5): 584-596. : http://dx.doi.org/10.1016/j.molcel.2011.03.033
• Cin H, Meyer C, Herr R, Janzarik WG, Lambert S, Jones DT, Jacob K, Benner A, Witt H, Remke M, Bender S, Falkenstein F, Van Anh TN, Olbrich H, von Deimling A, Pekrun A, Kulozik AE, Gnekow A, Scheurlen W, Witt O, Omran H, Jabado N, Collins VP, Brummer T, Marschalek R, Lichter P, Korshunov A, Pfister SM: Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma. Acta Neuropathol, 2011; 121 (6): 763-774. : http://dx.doi.org/10.1007/s00401-011-0817-z
• Czibere L, Baur LA, Wittmann A, Gemmeke K, Steiner A, Weber P, Putz B, Ahmad N, Bunck M, Graf C, Widner R, Kuhne C, Panhuysen M, Hambsch B, Rieder G, Reinheckel T, Peters C, Holsboer F, Landgraf R, Deussing JM: Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. Plos One, 2011; 6 (8) (online): e23604-e23604. : http://dx.doi.org/10.1371/journal.pone.0023604
• Eisenhardt AE, Olbrich H, Roring M, Janzarik W, Anh TN, Cin H, Remke M, Witt H, Korshunov A, Pfister SM, Omran H, Brummer T: Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma. Int J Cancer, 2011; 129 (9): 2297-2303. : http://dx.doi.org/10.1002/ijc.25893
• Fritsche-Guenther R, Witzel F, Sieber A, Herr R, Schmidt N, Braun S, Brummer T, Sers C, Bluthgen N: Strong negative feedback from Erk to Raf confers robustness to MAPK signalling. Mol Syst Biol, 2011; 7: 489-489. : http://dx.doi.org/10.1038/msb.2011.27
• Goz V, Koehler SM, Egorova NN, Moskowitz AJ, Guillerme SA, Hecht AC, Qureshi SA: Kyphoplasty and vertebroplasty: trends in use in ambulatory and inpatient settings. Spine J, 2011; 11 (8): 737-744. : http://dx.doi.org/10.1016/j.spinee.2011.07.002
• Hacker G, Borner C: Preface to Mitochondria: the deadly organelle. Biochim Biophys Acta, 2011; 1813 (4): 507-507. : http://dx.doi.org/10.1016/j.bbamcr.2011.02.013
• Hacker G, Borner C: Preface to Mitochondria: the deadly organelle. Biochim Biophys Acta, 2011; 1813 (4): 507-507. : http://dx.doi.org/10.1016/j.bbamcr.2011.02.013
• Hecht A, Kinnunen P, McNaughton B, Kopelman R: Label-acquired magnetorotation for biosensing: An asynchronous rotation assay. J Magn Magn Mater, 2011; 323 (3-4): 272-278. : http://dx.doi.org/10.1016/j.jmmm.2010.09.014
• Hecht A, Kumar AA, Kopelman R: Label-acquired magnetorotation as a signal transduction method for protein detection: aptamer-based detection of thrombin. Anal Chem, 2011; 83 (18): 7123-7128. : http://dx.doi.org/10.1021/ac2014756
• Hecht A, Seilmaier M, Guggemos W, Loscher T: [Gastroenteritis with fever, headache and rash after travelling in India]. Internist, 2011; 52 (5): 590-594. : http://dx.doi.org/10.1007/s00108-010-2668-4
• Hecht AC, Koehler SM, Laudone JC, Jenkins A, Qureshi S: Is intraoperative CT of posterior cervical spine instrumentation cost-effective and does it reduce complications? Clin Orthop Relat R, 2011; 469 (4): 1035-1041. : http://dx.doi.org/10.1007/s11999-010-1603-2
• Heeg S, Hirt N, Queisser A, Schmieg H, Thaler M, Kunert H, Quante M, Goessel G, von Werder A, Harder J, Beijersbergen R, Blum HE, Nakagawa H, Opitz OG: EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis. Cancer Sci, 2011; 102 (2): 351-360. : http://dx.doi.org/10.1111/j.1349-7006.2010.01796.x
• Herrera Abreu MT, Hughes WE, Mele K, Lyons RJ, Rickwood D, Browne BC, Bennett HL, Vallotton P, Brummer T, Daly RJ: Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation. Mol Biol Cell, 2011; 22 (1): 105-116. : http://dx.doi.org/10.1091/mbc.E10-03-0185
• Herr R, Wohrle FU, Danke C, Berens C, Brummer T: A novel MCF-10A line allowing conditional oncogene expression in 3D culture. Cell Commun Signal, 2011; 9: 17-17. : http://dx.doi.org/10.1186/1478-811X-9-17
• Horkay F, Basser PJ, Hecht AM, Geissler E: Hierarchical organization of cartilage proteoglycans. Macromol Symp, 2011; 306-307 (1): 11-17. : http://dx.doi.org/10.1002/masy.201000115
• Jefferson T, Causevic M, Auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C: Metalloprotease Meprin {beta} Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo. J Biol Chem, 2011; 286 (31): 27741-27750. : http://dx.doi.org/10.1074/jbc.M111.252718
• Joeckel LT, Wallich R, Martin P, Sanchez-Martinez D, Weber FC, Martin SF, Borner C, Pardo J, Froelich C, Simon MM: Mouse granzyme K has pro-inflammatory potential. Cell Death Differ, 2011; 18 (7): 1112-1119. : http://dx.doi.org/10.1038/cdd.2011.5
• Joeckel LT, Wallich R, Martin P, Sanchez-Martinez D, Weber FC, Martin SF, Borner C, Pardo J, Froelich C, Simon MM: Mouse granzyme K has pro-inflammatory potential. Cell Death Differ, 2011; 18 (7): 1112-1119. : http://dx.doi.org/10.1038/cdd.2011.5
• Kraus S, Bunsen T, Schuster S, Cichon MA, Tacke M, Reinheckel T, Sommerhoff CP, Jochum M, Nagler DK: Cellular senescence induced by cathepsin X downregulation. Eur J Cell Biol, 2011; 90 (8): 678-686. : http://dx.doi.org/10.1016/j.ejcb.2011.03.008
• Lindenboim L, Borner C, Stein R: Nuclear proteins acting on mitochondria. Biochim Biophys Acta, 2011; 1813 (4): 584-596. : http://dx.doi.org/10.1016/j.bbamcr.2010.11.016
• Lindenboim L, Borner C, Stein R: Nuclear proteins acting on mitochondria. Biochim Biophys Acta, 2011; 1813 (4): 584-596. : http://dx.doi.org/10.1016/j.bbamcr.2010.11.016
• Luckert K, Gotschel F, Sorger PK, Hecht A, Joos TO, Potz O: Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions. Mol Cell Proteomics, 2011; 10 (5) (online): M110.007377-M110.007377. : http://dx.doi.org/10.1074/mcp.M110.007377
• Luckert K, Gotschel F, Sorger PK, Hecht A, Joos TO, Potz O: Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions. Mol Cell Proteomics, 2011; 10 (5): M110.007377-M110.007377. : http://dx.doi.org/10.1074/mcp.M110.007377
• Masset A, Maillard C, Sounni NE, Jacobs N, Bruyere F, Delvenne P, Tacke M, Reinheckel T, Foidart JM, Coussens LM, Noel A: Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor. Int J Cancer, 2011; 128 (2): 283-293. : http://dx.doi.org/10.1002/ijc.25326
• Mikhaylov G, Mikac U, Magaeva AA, Itin VI, Naiden EP, Psakhye I, Babes L, Reinheckel T, Peters C, Zeiser R, Bogyo M, Turk V, Psakhye SG, Turk B, Vasiljeva O: Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol, 2011; 6 (9): 594-602. : http://dx.doi.org/10.1038/nnano.2011.112
• Miller G, Matthews SP, Reinheckel T, Fleming S, Watts C: Asparagine endopeptidase is required for normal kidney physiology and homeostasis. Faseb J, 2011; 25 (5): 1606-1617. : http://dx.doi.org/10.1096/fj.10-172312
• Ronsch K, Jager M, Schopflin A, Danciu M, Lassmann S, Hecht A: Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer. Epigenetics, 2011; 6 (5): 610-622.
• Ronsch K, Jager M, Schopflin A, Danciu M, Lassmann S, Hecht A: Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer. Epigenetics, 2011; 6 (5): 610-622.
• Savalas LR, Gasnier B, Damme M, Lubke T, Wrocklage C, Debacker C, Jezegou A, Reinheckel T, Hasilik A, Saftig P, Schroder B: Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L. Biochem J, 2011; 439 (1): 113-128. : http://dx.doi.org/10.1042/BJ20110166
• Schilling O, auf dem Keller U, Overall CM: Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites. Biol Chem, 2011; 392 (11): 1031-1037. : http://dx.doi.org/10.1515/BC.2011.158
• Schilling O, auf dem Keller U, Overall CM: Protease specificity profiling by tandem mass spectrometry using proteome-derived Peptide libraries. Methods Mol Biol, 2011; 753: 257-272. : http://dx.doi.org/10.1007/978-1-61779-148-2_17
• Schilling O, Huesgen PF, Barre O, Auf dem Keller U, Overall CM: Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry. Nat Protoc, 2011; 6 (1): 111-120. : http://dx.doi.org/10.1038/nprot.2010.178
• Schilling O, Huesgen PF, Barre O, Overall CM: Identification and relative quantification of native and proteolytically generated protein C-termini from complex proteomes: C-terminome analysis. Methods Mol Biol, 2011; 781: 59-69. : http://dx.doi.org/10.1007/978-1-61779-276-2_4
• Schlatter R, Philippi N, Wangorsch G, Pick R, Sawodny O, Borner C, Timmer J, Ederer M, Dandekar T: Integration of Boolean models exemplified on hepatocyte signal transduction. Brief Bioinform, 2011. : http://dx.doi.org/10.1093/bib/bbr065 (in Druck)
• Schmich K, Schlatter R, Corazza N, Sa Ferreira K, Ederer M, Brunner T, Borner C, Merfort I: Tumor necrosis factor alpha sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner. Hepatology, 2011; 53 (1): 282-292. : http://dx.doi.org/10.1002/hep.23987
• Schmich K, Schlatter R, Corazza N, Sa Ferreira K, Ederer M, Brunner T, Borner C, Merfort I: Tumor necrosis factor alpha sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner. Hepatology, 2011; 53 (1): 282-292. : http://dx.doi.org/10.1002/hep.23987
• Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Muller S, Follo M, Peters C, Reinheckel T: Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice. Oncogene, 2011; 30 (1): 54-64. : http://dx.doi.org/10.1038/onc.2010.387
• Sun J, Sukhova GK, Zhang J, Chen H, Sjoberg S, Libby P, Xiang M, Wang J, Peters C, Reinheckel T, Shi GP: Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscl Throm Vas, 2011; 31 (11): 2500-2508. : http://dx.doi.org/10.1161/ATVBAHA.111.230201
• Tholen S, Biniossek ML, Gessler AL, Muller S, Weisser J, Kizhakkedathu JN, Reinheckel T, Schilling O: Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts. Biol Chem, 2011; 392 (11): 961-971. : http://dx.doi.org/10.1515/BC.2011.162
• vor dem Esche U, Huber M, Zgaga-Griesz A, Grunow R, Beyer W, Hahn U, Bessler WG: Passive vaccination with a human monoclonal antibody: generation of antibodies and studies for efficacy in Bacillus anthracis infections. Immunobiology, 2011; 216 (7): 847-853. : http://dx.doi.org/10.1016/j.imbio.2010.12.001
• Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Moller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohmuller T, Reinheckel T, Gu C, Huber TB, Ju W, Bitzer M, Rastaldi MP, Ruiz P, Tryggvason K, Shaw AS, Faul C, Sever S, Reiser J: CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest, 2011; 121 (10): 3965-3980. : http://dx.doi.org/10.1172/JCI58552
• Zacharias C, Linnau KF, Golub JS, Meyer TK, Hecht AS, Mannelli L: Crack cocaine-induced supraglottitis. Emerg Radiol, 2011; 18 (5): 445-447. : http://dx.doi.org/10.1007/s10140-011-0960-9

• Leprivier G, Rufini A, Garcia-Saez AJ, Borner C, Rotblat B: 7th Tuscany Retreat on Cancer Research: Genetic profiling, resistance mechanism and novel treatment concepts in cancer. Cell Death Differ, 2011. : http://dx.doi.org/10.1038/cdd.2011.186 (in Druck)
• Loffek S, Schilling O, Franzke CW: Series "matrix metalloproteinases in lung health and disease": Biological role of matrix metalloproteinases: a critical balance. Eur Respir J, 2011; 38 (1): 191-208. : http://dx.doi.org/10.1183/09031936.00146510

• Charvet C, Maurer U: GSK-3 turns p53 deadly. Cell Cycle, 2011; 10 (21) : 3621-3622. : http://dx.doi.org/10.4161/cc.10.21.17852

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten

• Kiefer, Thomas: Isolierung physiologischer Bindungspartner von Bcl-2 - ein Überlebensprotein in der Lymphomgenese (Erstgutachter/in Prof. Dr. Christoph Borner), 2011.