Institut für Molekulare Medizin und Zellforschung (IMMZ)

Zentrum für Biochemie und Molekulare Zellforschung (ZBMZ)

Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

Wissenschaftliche Publikationen

• auf dem Keller U, Schilling O: Proteomic techniques and activity-based probes for the system-wide study of proteolysis. Biochimie, 2010; 92 (11): 1705-1714. : http://dx.doi.org/10.1016/j.biochi.2010.04.027
• Bernhardt A, Kuester D, Roessner A, Reinheckel T, Krueger S: Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after Helicobacter pylori infection. J Biol Chem, 2010; 285 (44): 33691-33700. : http://dx.doi.org/10.1074/jbc.M110.146183
• Bessler WG, Vogler M, Stormer H, Gerthsen D, Utz A, Weber A, Ivers-Tiffee E: Model anodes and anode models for understanding the mechanism of hydrogen oxidation in solid oxide fuel cells. Phys Chem Chem Phys, 2010; 12 (42): 13888-13903. : http://dx.doi.org/10.1039/c0cp00541j
• Bessler WG, vor dem Esche U, Zgaga-Griesz A, Ataullakhanov R: Immunostimulatory properties of the bacterial extract OM-89 in vitro and in vivo. Arzneimittel-forsch, 2010; 60 (6): 324-329.
• Bessler WG, Vor dem Esche U, Masihi N: The bacterial extract OM-85 BV protects mice against influenza and Salmonella infection. Int Immunopharmacol, 2010; 10 (9): 1086-1090. : http://dx.doi.org/10.1016/j.intimp.2010.06.009
• Bronson WH, Koehler SM, Qureshi SA, Hecht AC: The importance of plain radiography in the evaluation of radiculopathy after failed diskectomy. Orthopedics, 2010; 33 (5). : http://dx.doi.org/10.3928/01477447-20100329-23
• Brummer T, Schmitz-Peiffer C, Daly RJ: Docking proteins. Febs J, 2010; 277 (21): 4356-4369. : http://dx.doi.org/10.1111/j.1742-4658.2010.07865.x
• D'Angelo ME, Bird PI, Peters C, Reinheckel T, Trapani JA, Sutton VR: Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem, 2010; 285 (27): 20514-20519. : http://dx.doi.org/10.1074/jbc.M109.094573
• Dennemarker J, Lohmuller T, Mayerle J, Tacke M, Lerch MM, Coussens LM, Peters C, Reinheckel T: Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis. Oncogene, 2010; 29 (11): 1611-1621. : http://dx.doi.org/10.1038/onc.2009.466
• Dennemarker J, Lohmuller T, Muller S, Aguilar SV, Tobin DJ, Peters C, Reinheckel T: Impaired turnover of autophagolysosomes in cathepsin L deficiency. Biol Chem, 2010; 391 (8): 913-922. : http://dx.doi.org/10.1515/BC.2010.097
• Dierks A *, Lichtenauer U *, Sackmann S *, Spyroglou A, Shapiro I, Geyer M, Manopoulou J, Reincke M, Hantel C, Beuschlein F: Identification of adrenal genes regulates in a postassium dependent manner. J Mol Endocrinol, 2010; 45 (4): 193-206. : http://dx.doi.org/10.1677/JME-09-0171
• Fleuren ED, O'Toole S, Millar EK, McNeil C, Lopez-Knowles E, Boulghourjian A, Croucher DR, Schramek D, Brummer T, Penninger JM, Sutherland RL, Daly RJ: Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development. Int J Cancer, 2010; 127 (6): 1486-1492. : http://dx.doi.org/10.1002/ijc.25172
• Gebhardt R, Lerche KS, Gotschel F, Gunther R, Kolander J, Teich L, Zellmer S, Hofmann HJ, Eger K, Hecht A, Gaunitz F: 4-aminoethylamino-emodin-a novel potent inhibitor of GSK-3beta-acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin. J Cell Mol Med, 2010; 14 (6A): 1276-1293. : http://dx.doi.org/10.1111/j.1582-4934.2009.00701.x
• Gebhardt R, Lerche KS, Gotschel F, Gunther R, Kolander J, Teich L, Zellmer S, Hofmann HJ, Eger K, Hecht A, Gaunitz F: 4-Aminoethylamino-emodin-a novel potent inhibitor of GSK-3beta-acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin. J Cell Mol Med, 2010; 14 (6A): 1276-1293. : http://dx.doi.org/10.1111/j.1582-4934.2009.00701.x
• Geissler E, Hecht AM, Horkay F: Scaling behaviour of hyaluronic acid in solution with mono- and divalent ions. Macromol Symp, 2010; 291-292 (1): 362-370. : http://dx.doi.org/10.1002/masy.201050543
• Gocheva V, Chen X, Peters C, Reinheckel T, Joyce JA: Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer. Biol Chem, 2010; 391 (8): 937-945. : http://dx.doi.org/10.1515/BC.2010.080
• Goldmann O, Hertzen E, Hecht A, Schmidt H, Lehne S, Norrby-Teglund A, Medina E: Inducible cyclooxygenase released prostaglandin E2 modulates the severity of infection caused by Streptococcus pyogenes. J Immunol, 2010; 185 (4): 2372-2381. : http://dx.doi.org/10.4049/jimmunol.1000838
• Goncalves JA, South K, Ahuja S, Zaitseva E, Opefi CA, Eilers M, Vogel R, Reeves PJ, Smith SO: Highly conserved tyrosine stabilizes the active state of rhodopsin. P Natl Acad Sci Usa, 2010; 107 (46): 19861-19866. : http://dx.doi.org/10.1073/pnas.1009405107
• Grimm S, Ernst L, Grotzinger N, Hohn A, Breusing N, Reinheckel T, Grune T: Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins. Free Radical Res, 2010; 44 (9): 1013-1026. : http://dx.doi.org/10.3109/10715762.2010.495127
• Hecht AH, Sommer GJ, Durland RH, Yang X, Singh AK, Hatch AV: Aptamers as affinity reagents in an integrated electrophoretic lab-on-a-chip platform. Anal Chem, 2010; 82 (21): 8813-8820. : http://dx.doi.org/10.1021/ac101106m
• Horkay F, Basser PJ, Hecht AM, Geissler E: Counterion and pH-Mediated Structural Changes in Charged Biopolymer Gels. Macromol Symp, 2010; 291-292 (1): 354-361. : http://dx.doi.org/10.1002/masy.201050542
• Horkay F, Falus P, Hecht AM, Geissler E: Length scale dependence of the dynamic properties of hyaluronic acid solutions in the presence of salt. J Phys Chem B, 2010; 114 (47): 15445-15450. : http://dx.doi.org/10.1021/jp106578f
• Huai J, Jockel L, Schrader K, Borner C: Role of caspases and non-caspase proteases in cell death. F1000 Biol Rep, 2010; 2 (online). : http://dx.doi.org/10.3410/B2-48
• Huai J, Jockel L, Schrader K, Borner C: Role of caspases and non-caspase proteases in cell death. F1000 Biol Rep, 2010; 2. : http://dx.doi.org/10.3410/B2-48
• Jabbour AM, Daunt CP, Green BD, Vogel S, Gordon L, Lee RS, Silke N, Pearson RB, Vandenberg CJ, Kelly PN, Nutt SL, Strasser A, Borner C, Ekert PG: Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood, 2010; 115 (2): 344-352. : http://dx.doi.org/10.1182/blood-2009-07-230730
• Jabbour AM, Daunt CP, Green BD, Vogel S, Gordon L, Lee RS, Silke N, Pearson RB, Vandenberg CJ, Kelly PN, Nutt SL, Strasser A, Borner C, Ekert PG: Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood, 2010; 115 (2): 344-352. : http://dx.doi.org/10.1182/blood-2009-07-230730
• Kleifeld O, Doucet A, auf dem Keller U, Prudova A, Schilling O, Kainthan RK, Starr AE, Foster LJ, Kizhakkedathu JN, Overall CM: Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products. Nat Biotechnol, 2010; 28 (3): 281-288. : http://dx.doi.org/10.1038/nbt.1611
• Koehler SM, Lin JD, Stets KC, Qureshi SA, Martins DA, Hecht AC: Lumbar spinous process avulsion fracture in an adolescent dancer. Clin J Sport Med, 2010; 20 (3): 213-214. : http://dx.doi.org/10.1097/JSM.0b013e3181df6116
• Konjar S, Sutton VR, Hoves S, Repnik U, Yagita H, Reinheckel T, Peters C, Turk V, Turk B, Trapani JA, Kopitar-Jerala N: Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology, 2010; 131 (2): 257-267. : http://dx.doi.org/10.1111/j.1365-2567.2010.03299.x
• Krane V, Berger M, Lilienthal J, Winkler K, Schambeck C, Wanner C: Antibodies to platelet factor 4-heparin complex and outcome in hemodialysis patients with diabetes. Clin J Am Soc Nephro, 2010; 5 (5): 874-881. : http://dx.doi.org/10.2215/CJN.01170209
• Kraus J, Lehmann L, Borner C, Hollt V: Epigenetic mechanisms involved in the induction of the mu opioid receptor gene in Jurkat T cells in response to interleukin-4. Mol Immunol, 2010; 48 (1-3): 257-263. : http://dx.doi.org/10.1016/j.molimm.2010.08.002
• Lindenboim L, Blacher E, Borner C, Stein R: Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L). Cell Death Differ, 2010; 17 (2): 346-359. : http://dx.doi.org/10.1038/cdd.2009.145
• Lindenboim L, Blacher E, Borner C, Stein R: Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L). Cell Death Differ, 2010; 17 (2): 346-359. : http://dx.doi.org/10.1038/cdd.2009.145
• Ma S, Hecht A, Varga J, Rambod M, Morford S, Goto S, Casaburi R, Porszasz J: Breath-by-breath quantification of progressive airflow limitation during exercise in COPD: a new method. Resp Med, 2010; 104 (3): 389-396. : http://dx.doi.org/10.1016/j.rmed.2009.10.014
• Matthews SP, Werber I, Deussing J, Peters C, Reinheckel T, Watts C: Distinct protease requirements for antigen presentation in vitro and in vivo. J Immunol, 2010; 184 (5): 2423-2431. : http://dx.doi.org/10.4049/jimmunol.0901486
• Minokadeh A, Funkelstein L, Toneff T, Hwang SR, Beinfeld M, Reinheckel T, Peters C, Zadina J, Hook V: Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression. Mol Cell Neurosci, 2010; 43 (1): 98-107. : http://dx.doi.org/10.1016/j.mcn.2009.10.001
• Oberle C, Huai J, Reinheckel T, Tacke M, Rassner M, Ekert PG, Buellesbach J, Borner C: Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes. Cell Death Differ, 2010; 17 (7): 1167-1178. : http://dx.doi.org/10.1038/cdd.2009.214
• Oberle C, Huai J, Reinheckel T, Tacke M, Rassner M, Ekert PG, Buellesbach J, Borner C: Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes. Cell Death Differ, 2010; 17 (7): 1167-1178. : http://dx.doi.org/10.1038/cdd.2009.214
• Patterson KI, Brummer T, Daly RJ, O'Brien PM: DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs. Biochim Biophys Acta, 2010; 1803 (9): 1003-1012. : http://dx.doi.org/10.1016/j.bbamcr.2010.03.014
• Reiser J, Adair B, Reinheckel T: Specialized roles for cysteine cathepsins in health and disease. J Clin Invest, 2010; 120 (10): 3421-3431. : http://dx.doi.org/10.1172/JCI42918
• Schilling O, Barre O, Huesgen PF, Overall CM: Proteome-wide analysis of protein carboxy termini: C terminomics. Nat Methods, 2010; 7 (7): 508-511. : http://dx.doi.org/10.1038/nmeth.1467
• Schrader K, Huai J, Jockel L, Oberle C, Borner C: Non-caspase proteases: triggers or amplifiers of apoptosis? Cell Mol Life Sci, 2010; 67 (10): 1607-1618. : http://dx.doi.org/10.1007/s00018-010-0287-9
• Schrader K, Huai J, Jockel L, Oberle C, Borner C: Non-caspase proteases: triggers or amplifiers of apoptosis? Cell Mol Life Sci, 2010; 67 (10): 1607-1618. : http://dx.doi.org/10.1007/s00018-010-0287-9
• Sevenich L, Hagemann S, Stoeckle C, Tolosa E, Peters C, Reinheckel T: Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice. Biochimie, 2010; 92 (11): 1674-1680. : http://dx.doi.org/10.1016/j.biochi.2010.03.014
• Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Muller S, Vasiljeva O, Schwinde A, Klemm N, Deussing J, Peters C, Reinheckel T: Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. P Natl Acad Sci Usa, 2010; 107 (6): 2497-2502. : http://dx.doi.org/10.1073/pnas.0907240107
• Shimada N, Ohno-Matsui K, Iseki S, Koike M, Uchiyama Y, Wang J, Yoshida T, Sato T, Peters C, Mochizuki M, Morita I: Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization. Am J Pathol, 2010; 176 (5): 2571-2580. : http://dx.doi.org/10.2353/ajpath.2010.091027
• Sprenger A, Kuttner V, Biniossek ML, Gretzmeier C, Boerries M, Mack C, Has C, Bruckner-Tuderman L, Dengjel J: Comparative quantitation of proteome alterations induced by aging or immortalization in primary human fibroblasts and keratinocytes for clinical applications. Mol Biosyst, 2010; 6 (9): 1579-1582. : http://dx.doi.org/10.1039/c003962d
• Sun L, Wu Z, Baba M, Peters C, Uchiyama Y, Nakanishi H: Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse. Biochem Bioph Res Co, 2010; 399 (3): 391-395. : http://dx.doi.org/10.1016/j.bbrc.2010.07.084
• Tacke M, Ball CR, Schmidt M, Klingenberg S, Maurer B, Fessler S, Eaves CJ, von Kalle C, Glimm H: The inherent differentiation program of short-term hematopoietic repopulating cells changes during human ontogeny. Stem Cells Dev, 2010; 19 (5): 621-628. : http://dx.doi.org/10.1089/scd.2009.0202
• Terada K, Yamada J, Hayashi Y, Wu Z, Uchiyama Y, Peters C, Nakanishi H: Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia. Glia, 2010; 58 (1): 114-124. : http://dx.doi.org/10.1002/glia.20906
• Wartmann T, Mayerle J, Kahne T, Sahin-Toth M, Ruthenburger M, Matthias R, Kruse A, Reinheckel T, Peters C, Weiss FU, Sendler M, Lippert H, Schulz HU, Aghdassi A, Dummer A, Teller S, Halangk W, Lerch MM: Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice. Gastroenterology, 2010; 138 (2): 726-737. : http://dx.doi.org/10.1053/j.gastro.2009.10.048
• Weise A, Bruser K, Elfert S, Wallmen B, Wittel Y, Wohrle S, Hecht A: Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets. Nucleic Acids Res, 2010; 38 (6): 1964-1981. : http://dx.doi.org/10.1093/nar/gkp1197
• Weise A, Bruser K, Elfert S, Wallmen B, Wittel Y, Wohrle S, Hecht A: Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets. Nucleic Acids Res, 2010; 38 (6): 1964-1981. : http://dx.doi.org/10.1093/nar/gkp1197
• Ye S, Zaitseva E, Caltabiano G, Schertler GF, Sakmar TP, Deupi X, Vogel R: Tracking G-protein-coupled receptor activation using genetically encoded infrared probes. Nature, 2010; 464 (7293): 1386-1389. : http://dx.doi.org/10.1038/nature08948
• Zaitseva E, Brown MF, Vogel R: Sequential rearrangement of interhelical networks upon rhodopsin activation in membranes: the Meta II(a) conformational substate. J Am Chem Soc, 2010; 132 (13): 4815-4821. : http://dx.doi.org/10.1021/ja910317a
• Zaitseva E, Saavedra M, Banerjee S, Sakmar TP, Vogel R: SEIRA spectroscopy on a membrane receptor monolayer using lipoprotein particles as carriers. Biophys J, 2010; 99 (7): 2327-2335. : http://dx.doi.org/10.1016/j.bpj.2010.06.054
• Zeeuwen PL, van Vlijmen-Willems IM, Cheng T, Rodijk-Olthuis D, Hitomi K, Hara-Nishimura I, John S, Smyth N, Reinheckel T, Hendriks WJ, Schalkwijk J: The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea. Faseb J, 2010; 24 (10): 3744-3755. : http://dx.doi.org/10.1096/fj.10-155879

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten

• Kunert, Heike: Mechanismen der Invasion und Metastasierung in einem genetisch definierten Karzinogenesemodell (Erstgutachter/in Prof. Dr. Christoph Peters), 2010.
• Queisser, Angela: Induktion eines alternativen Telomererhaltungsmechanismus in humanen Tumoren durch genetische Inhibition der Telomerase (Erstgutachter/in Prof. Dr. Christoph Peters), 2010.
• Vogel,Sandra: Apoptosis regulation by Bax binding proteins , 2010.