Institut für Molekulare Medizin und Zellforschung (IMMZ)

Zentrum für Biochemie und Molekulare Zellforschung (ZBMZ)

Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

Finanzierung

• Deutsche Krebshilfe, 10-6977 Re. "Die Bedeutung lysosomaler Cysteinproteasen für die Progression muriner und humaner epidermaler Karzinome". (Reinheckel)

Wissenschaftliche Projekte und Forschungsvorhaben

• "Die Bedeutung lysosomaler Cysteinproteasen für die Progression muriner und humaner epidermaler Karzinome"
  • Projektleitung: Dr. Thomas Reinheckel
  • Laufzeit: 01.04.2006 bis 31.03.2009
  • Details zum Projekt
• "Mouse organogenesis regulated by apoptosis: the role of serine proteases"
  • Projektleitung: Prof. Dr. Christoph Borner
  • Laufzeit: 01.05.2005 bis 31.12.2009
  • Details zum Projekt

Wissenschaftliche Publikationen

• Ai WZ, Hou JZ, Zeiser R, Czerwinski D, Negrin RS, Levy R: Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells. Int J Cancer, 2009; 124 (1): 239-244. : http://dx.doi.org/10.1002/ijc.23881
• Ajaj KA, Biniossek ML, Kratz F: Development of protein-binding bifunctional linkers for a new generation of Bioconjugate Chem, 2009; 20 (2): 390-396. : http://dx.doi.org/10.1021/bc800429q
• Anel A, Bleackley C, Borner C, Golstein P, Krammer PH, Mullbacher A, Pardo J, Simon MM, Trapani JA: EMBO workshop on cytotoxicity, cell death and the immune system. Cell Death Differ, 2009; 16 (5): 790-793. : http://dx.doi.org/10.1038/cdd.2009.4
• Ataullakhanov R, Bauer H, Holms R, Bessler WG: Immunomax for the therapy of disorders of the urogenital tract: a novel immunstimulatory therapy to obtain relieve in bacterial infections, prostatits and in prostate carcinoma. Journal of Men's Health, 2009; 6 (3): 235.
• Baudot AD, Jeandel PY, Mouska X, Maurer U, Tartare-Deckert S, Raynaud SD, Cassuto JP, Ticchioni M, Deckert M: The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression. Oncogene, 2009; 28 (37): 3261-3273. : http://dx.doi.org/10.1038/onc.2009.179
• Beinfeld MC, Funkelstein L, Foulon T, Cadel S, Kitagawa K, Toneff T, Reinheckel T, Peters C, Hook V: Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides, 2009; 30 (10): 1882-1891. : http://dx.doi.org/10.1016/j.peptides.2009.06.030
• Bessler WG, Puce K, vor dem Esche U, Kirschning C, Huber M: Immunomodulating effects of OM-89, a bacterial extract from Escherichia coli, in murine and human leukocytes. Arzneimittel-forsch, 2009; 59 (11): 571-577.
• Borner C, Smida M, Hollt V, Schraven B, Kraus J: Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling. J Biol Chem, 2009; 284 (51): 35450-35460. : http://dx.doi.org/10.1074/jbc.M109.006338
• Borner C, Warnick B, Smida M, Hartig R, Lindquist JA, Schraven B, Hollt V, Kraus J: Mechanisms of opioid-mediated inhibition of human T cell receptor signaling. J Immunol, 2009; 183 (2): 882-889. : http://dx.doi.org/10.4049/jimmunol.0802763
• Brummer TH, Jalkanen J, Fraser J, Heikkinen AM, Kauko M, Makinen J, Puistola U, Sjoberg J, Tomas E, Harkki P: FINHYST 2006-national prospective 1-year survey of 5,279 hysterectomies. Hum Reprod, 2009; 24 (10): 2515-2522. : http://dx.doi.org/10.1093/humrep/dep229
• Caglic D, Kosec G, Bojic L, Reinheckel T, Turk V, Turk B: Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery. Biol Chem, 2009; 390 (2): 175-179. : http://dx.doi.org/10.1515/BC.2009.021
• Fiksel J, Graedel T, Hecht AD, Rejeski D, Sayler GS, Senge PM, Swackhamer DL, Theis TL: EPA at 40: bringing environmental protection into the 21st century. Environ Sci Technol, 2009; 43 (23): 8716-8720. : http://dx.doi.org/10.1021/es901653f
• Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Jaattela M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nunez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G: Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ, 2009; 16 (8): 1093-1107. : http://dx.doi.org/10.1038/cdd.2009.44
• Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Jaattela M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nunez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G: Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ, 2009; 16 (8): 1093-1107. : http://dx.doi.org/10.1038/cdd.2009.44
• Hecht A, Ma S, Porszasz J, Casaburi R: Methodology for using long-term accelerometry monitoring to describe daily activity patterns in COPD. COPD, 2009; 6 (2): 121-129. : http://dx.doi.org/10.1080/15412550902755044
• Hecht AD, Shaw D, Bruins R, Dale V, Kline K, Chen A: Good policy follows good science: using criteria and indicators for assessing sustainable biofuel production. Ecotoxicology, 2009; 18 (1): 1-4. : http://dx.doi.org/10.1007/s10646-008-0293-y
• Hook VY, Kindy M, Reinheckel T, Peters C, Hook G: Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem Bioph Res Co, 2009; 386 (2): 284-288. : http://dx.doi.org/10.1016/j.bbrc.2009.05.131
• Horkay F, Basser PJ, Londono DJ, Hecht AM, Geissler E: Ions in hyaluronic acid solutions. J Chem Phys, 2009; 131 (18): 184902-184902. : http://dx.doi.org/10.1063/1.3262308
• Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T: XIAP discriminates between type I and type II FAS-induced apoptosis. Nature, 2009; 460 (7258): 1035-1039. : http://dx.doi.org/10.1038/nature08229
• Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T: XIAP discriminates between type I and type II FAS-induced apoptosis. Nature, 2009; 460 (7258): 1035-1039. : http://dx.doi.org/10.1038/nature08229
• Koch T, Seifert A, Wu DF, Rankovic M, Kraus J, Borner C, Brandenburg LO, Schroder H, Hollt V: mu-opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2. J Neurochem, 2009; 110 (4): 1288-1296. : http://dx.doi.org/10.1111/j.1471-4159.2009.06217.x
• Koehler SM, Beasley MB, Chin CS, Wittig JC, Hecht AC, Qureshi SA: Synovial sarcoma of the thoracic spine. Spine J, 2009; 9 (12): e1-e6. : http://dx.doi.org/10.1016/j.spinee.2009.08.448
• Ludeke S, Mahalingam M, Vogel R: Rhodopsin activation switches in a native membrane environment. Photochem Photobiol, 2009; 85 (2): 437-441. : http://dx.doi.org/10.1111/j.1751-1097.2008.00490.x
• Olson JA, Zeiser R, Beilhack A, Goldman JJ, Negrin RS: Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation. J Immunol, 2009; 183 (5): 3219-3228. : http://dx.doi.org/10.4049/jimmunol.0804268
• Pardo J, Aguilo JI, Anel A, Martin P, Joeckel L, Borner C, Wallich R, Mullbacher A, Froelich CJ, Simon MM: The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation. Microbes Infect, 2009; 11 (4): 452-459. : http://dx.doi.org/10.1016/j.micinf.2009.02.004
• Pardo J, Aguilo JI, Anel A, Martin P, Joeckel L, Borner C, Wallich R, Mullbacher A, Froelich CJ, Simon MM: The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation. Microbes Infect, 2009; 11 (4): 452-459. : http://dx.doi.org/10.1016/j.micinf.2009.02.004
• Patterson KI, Brummer T, O'Brien PM, Daly RJ: Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J, 2009; 418 (3): 475-489.
• Philippi N, Walter D, Schlatter R, Ferreira K, Ederer M, Sawodny O, Timmer J, Borner C, Dandekar T: Modeling system states in liver cells: survival, apoptosis and their modifications in response to viral infection. BMC Syst Biol, 2009; 3: 97-97. : http://dx.doi.org/10.1186/1752-0509-3-97
• Philippi N, Walter D, Schlatter R, Ferreira K, Ederer M, Sawodny O, Timmer J, Borner C, Dandekar T: Modeling system states in liver cells: survival, apoptosis and their modifications in response to viral infection. Bmc Syst Biol, 2009; 3: 97-97. : http://dx.doi.org/10.1186/1752-0509-3-97
• Ryppa C, Mann-Steinberg H, Biniossek ML, Satchi-Fainaro R, Kratz F: In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E-[c(RGDfK)2] that targets integrin alpha v beta 3. Int J Pharm, 2009; 368 (1-2): 89-97. : http://dx.doi.org/10.1016/j.ijpharm.2008.09.055
• Schlatter R, Schmich K, Avalos Vizcarra I, Scheurich P, Sauter T, Borner C, Ederer M, Merfort I, Sawodny O: ON/OFF and beyond-a boolean model of apoptosis. Plos Comput Biol, 2009; 5 (12): e1000595-e1000595. : http://dx.doi.org/10.1371/journal.pcbi.1000595
• Schlatter R, Schmich K, Avalos Vizcarra I, Scheurich P, Sauter T, Borner C, Ederer M, Merfort I, Sawodny O: ON/OFF and beyond-a boolean model of apoptosis. Plos Comput Biol, 2009; 5 (12): e1000595-e1000595. : http://dx.doi.org/10.1371/journal.pcbi.1000595
• Schuy S, Schafer E, Yoder NC, Hobe S, Kumar K, Vogel R, Janshoff A: Coiled-coil lipopeptides mimicking the prehairpin intermediate of glycoprotein gp41. Angew Chem Int Edit, 2009; 48 (4): 751-754. : http://dx.doi.org/10.1002/anie.200803080
• Schuy S, Schafer E, Yoder NC, Kumar K, Vogel R, Janshoff A: Lipopeptides derived from HIV and SIV mimicking the prehairpin intermediate of gp41 on solid supported lipid bilayers. J Struct Biol, 2009; 168 (1): 125-136. : http://dx.doi.org/10.1016/j.jsb.2009.04.006
• Schwinte P, Gartner W, Sharda S, Mroginski MA, Hildebrandt P, Siebert F: The photoreactions of recombinant phytochrome CphA from the cyanobacterium Calothrix PCC7601: a low-temperature UV-Vis and FTIR study. Photochem Photobiol, 2009; 85 (1): 239-249. : http://dx.doi.org/10.1111/j.1751-1097.2008.00426.x
• Seilmaier M, Hecht A, Guggemos W, Adorf D, Gehbauer G: [Pancytopenia, hepatosplenomegaly and dry cough after breast cancer]. Deut Med Wochenschr, 2009; 134 (24): 1269-1273. : http://dx.doi.org/10.1055/s-0029-1225274
• Seilmaier M, Hecht A, Guggemos W, Rudisser K: [Cryptococcal meningoencephalitis related to HIV infection with resistance to fluconazole, relapse, and IRIS]. Med Klin, 2009; 104 (1): 58-62. : http://dx.doi.org/10.1007/s00063-009-1007-9
• Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS: The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nat Immunol, 2009; 10 (3): 257-265. : http://dx.doi.org/10.1038/ni.1697
• Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS: The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nat Immunol, 2009; 10 (3): 257-265. : http://dx.doi.org/10.1038/ni.1697
• Singh H, Meyer SA, Hecht AC, Jenkins AL 3rd: Novel fluoroscopic technique for localization at cervicothoracic levels. J Spinal Disord Tech, 2009; 22 (8): 615-618. : http://dx.doi.org/10.1097/BSD.0b013e31818da7ce
• Steinbeck G, Andresen D, Seidl K, Brachmann J, Hoffmann E, Wojciechowski D, Kornacewicz-Jach Z, Sredniawa B, Lupkovics G, Hofgartner F, Lubinski A, Rosenqvist M, Habets A, Wegscheider K, Senges J: Defibrillator implantation early after myocardial infarction. New Engl J Med, 2009; 361 (15): 1427-1436. : http://dx.doi.org/10.1056/NEJMoa0901889
• Sugita S, Horie S, Nakamura O, Maruyama K, Takase H, Usui Y, Takeuchi M, Ishidoh K, Koike M, Uchiyama Y, Peters C, Yamamoto Y, Mochizuki M: Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. J Immunol, 2009; 183 (8): 5013-5022. : http://dx.doi.org/10.4049/jimmunol.0901623
• Vreemann A, Qu H, Mayer K, Andersen LB, Stefana MI, Wehner S, Lysson M, Farcas AM, Peters C, Reinheckel T, Kalff J, Brix K: Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases. Biol Chem, 2009; 390 (5-6): 481-492. : http://dx.doi.org/10.1515/BC.2009.055
• Wilson SR, Peters C, Saftig P, Bromme D: Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. J Biol Chem, 2009; 284 (4): 2584-2592. : http://dx.doi.org/10.1074/jbc.M805280200
• Wohrle FU, Daly RJ, Brummer T: Function, regulation and pathological roles of the Gab/DOS docking proteins. Cell Commun Signal, 2009; 7: 22-22. : http://dx.doi.org/10.1186/1478-811X-7-22
• Wohrle FU, Daly RJ, Brummer T: How to Grb2 a Gab. Struct Fold Des, 2009; 17 (6): 779-781. : http://dx.doi.org/10.1016/j.str.2009.05.003
• Wolf AM, Eller K, Zeiser R, Durr C, Gerlach UV, Sixt M, Markut L, Gastl G, Rosenkranz AR, Wolf D: The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo. J Immunol, 2009; 183 (6): 3751-3760. : http://dx.doi.org/10.4049/jimmunol.0901011
• Xiao K, Jehle F, Peters C, Reinheckel T, Schirmer RH, Dandekar T: CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts--a bioinformatical analysis. Biol Chem, 2009; 390 (11): 1185-1197. : http://dx.doi.org/10.1515/BC.2009.124
• Ye S, Huber T, Vogel R, Sakmar TP: FTIR analysis of GPCR activation using azido probes. Nat Chem Biol, 2009; 5 (6): 397-399. : http://dx.doi.org/10.1038/nchembio.167
• Zeiser R, Maas K, Youssef S, Durr C, Steinman L, Negrin RS: Regulation of different inflammatory diseases by impacting the mevalonate pathway. Immunology, 2009; 127 (1): 18-25. : http://dx.doi.org/10.1111/j.1365-2567.2008.03011.x
• Zeiser R, Zerweck A, Bertz H, Finke J: Allogeneic hematopoietic cell transplantation for t-AML following liver transplantation from the same haploidentical donor. Bone Marrow Transpl, 2009; 43 (7): 589-590. : http://dx.doi.org/10.1038/bmt.2008.361
• Zimmermann S, Biniossek ML, Maurer C, Munzer P, Pantic M, Veelken H, Martens UM: Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction. Proteomics, 2009; 9 (22): 5175-5187. : http://dx.doi.org/10.1002/pmic.200900232
• Zimmermann S, Biniossek ML, Pantic M, Pfeifer D, Veelken H, Martens UM: Proteomic profiling of tumor cells after induction of telomere dysfunction. Proteomics, 2009; 9 (3): 521-534. : http://dx.doi.org/10.1002/pmic.200800471

• Anel A, Bleackley C, Borner C, Golstein P, Krammer PH, Mullbacher A, Pardo J, Simon MM, Trapani JA: EMBO workshop on cytotoxicity, cell death and the immune system. Cell Death Differ, 2009; 16 (5) : 790-793. : http://dx.doi.org/10.1038/cdd.2009.4

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten

• Reisdorf, Sven: FTIR-spektroskopische Untersuchung der Interaktionen zwischen dem Photorezeptor Sensory Rhodopsin II aus Natronobacterium pharaonis und seinem Transducer (Erstgutachter/in Prof. Dr. Friedrich Siebert), 2009.