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 Forschungsbericht für das Jahr 2006

Institut für Molekulare Medizin und Zellforschung (IMMZ)

Zentrum für Biochemie und Molekulare Zellforschung (ZBMZ)

Stefan-Meier-Str. 17
79104 Freiburg i. Br.
Tel: +49-761-203-9600/9601 Fax: +49-761-203-9602
Email christoph.peters@mol-med.uni-freiburg.de
http://www.mol-med.uni-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Christoph Peters, Institutsleiter
  • Prof. Dr. Wolfgang Bessler, Gruppenleiter
  • Dr. Martin Biniossek, Gruppenleiter
  • Prof. Dr. Dr. h.c. Christoph Borner, Gruppenleiter
  • Prof. Dr. Andreas Hecht, Gruppenleiter
  • PD Dr. Ulrich Maurer, Gruppenleiter
  • Prof. Dr. Friedrich Siebert, Gruppenleiter
  • PD Dr. med. Oliver Opitz, Gruppenleiter
  • Dr. Felix Beuschlein, Gruppenleiter
  • Dr. Céline Charvet
  • Dr. Hanno Glimm, Gruppenleiter
  • Dr. Thomas Reinheckel, Gruppenleiter
  • Dr. Marlene Tacke (geb. Fischer)
  • Dr. Martin Trepel, Gruppenleiter
  • Dr. Ulrich vor dem Esche, AG Bessler
  • Dr. Jan Harder, AG Opitz
  • Dr. Maria Huber, AG Bessler
  • Dr. Klaus Mittenbühler, AG Bessler
  • Dr. Carolin Oberle, AG Borner
  • Dr. Robert Pick
  • Dr. Uta Schurigt
  • Dr. Olga Vasiljeva, AG Peters
  • Dr. Reiner Vogel, AG Siebert
  • Dr. Andreas Weise
Einträge in der Rubrik "Who is Who"

Finanzierung

  • BMBF. "A Systems Biology Approach to Native and Regenerating Hepatocytes". (Hecht)
  • BMBF. "Sysbio regenerierender Hepatozyten: Teilprojekte B6" (Borner)
  • Deutsche Krebshilfe, 10-6977 Re. "Die Bedeutung lysosomaler Cysteinproteasen für die Progression muriner und humaner epidermaler Karzinome". (Reinheckel)
  • DFG, He 2004/4-1/4-2. "Molekulare Mechanismen der differentiellen Genregulation durch den Wnt/beta-Catenin-Signalweg". (Hecht)
  • DFG, He 2004/6-1, He 2004/6-2. "Funktionelle Diversifizierung von Signaltransduktionsmechanismen: Ausmaß und molekulare Grundlagen des genspezifischen regulatorischen Potentials von 'T-Cell Factor' DNA-Bindungsproteinen". (Hecht)
  • DFG, Re 1584/2-2 "Untersuchungen zur Pathogenese einer dilatativen Kardiomyopathie bei Cathepsin L defizienten Mäusen". (Reinheckel)
  • DFG. "Stammzelltransplantation und Immunmodulation – molekulare Therapieansätze in der Pädiatrie. Möglichkeiten und Grenzen der Selektion blutbildender Stammzellklone durch genetische Modifikation". (von Kalle)
  • DFG. Re 1584/3-1 "Untersuchungen zu Funktionen der lysosomalen Proteasen Cathepsin H, Cathepsin E und Napsin in Lunge und Immunsystem". (Reinheckel)
  • EU, Framework 6, "Creation and biological analysis of tumors in novel protease gene knockout models." (Workpackage 2.1) "Detailed spatio-temporal examination of specific proteases and inhibitors in spontaneous mouse cancer models." (Workpackage 2.2)(Peters, Reinheckel)
  • EU. "Concerted Safety and Efficiency Evaluation of Retroviral Transgenesis for Gene Therapy of Inherited Diseases (Consert)". (von Kalle)
  • Mittel der Industrie. "BioDisk: Autonomes Bioanalysesystem für diagnostische Anwendungen auf Basis eines Zentrifugalantriebs" (Bessler)
  • MWK, "Protease-selektive Inhibitor-basierte NMR-Marker". (Reinheckel, Peters)
  • MWK. "Bedeutung von Cathepsin B aus Stromazellen für die Metastasenbildung". (Peters, Reinheckel)
  • OM Pharma Projekt. "In vivo assessment of the activity of Broncho-Vaxom" (Bessler)

Wissenschaftliche Projekte und Forschungsvorhaben


  • "A Systems Biology Approach to Native and Regenerating Hepatocytes"
  • "Bedeutung von Cathepsin B aus Stromazellen für die Metastasenbildung." im Rahmen des Forschungsschwerpunktprogrammes BW: "Molekulare Mechanismen von Migration, Invasion und Metastasierung."
    • Projektleitung: Prof. Dr. Christoph Peters, Dr. Thomas Reinheckel
    • Laufzeit: 01.09.2004 bis 31.08.2006
    • Details zum Projekt
  • "BioDisk: Autonomes Bioanalysesystem für diagnostische Anwendungen auf Basis eines Zentrifugalantriebs"
    • Projektleitung: Prof. Dr. Wolfgang G. Bessler
    • Laufzeit: 01.03.2003 bis 28.02.2006
    • Details zum Projekt
  • "Concerted Safety and Efficiency Evaluation of Retroviral Transgenesis for Gene Therapy of Inherited Diseases (Consert)"
    • Projektleitung: Prof. Dr. Christof von Kalle
    • Laufzeit: 01.11.2004 bis 31.10.2008
    • Details zum Projekt
  • "Creation and biological analysis of tumors in novel protease gene knockout models." (Workpackage 2.1) "Detailed spatio-temporal examination of specific proteases and inhibitors in spontaneous mouse cancer models." (Workpackage 2.2) Project full title: "Extracellular Proteases and the Caner Degradome: Innovative Diagnostic Markers, Therapeutic Targets and Tumour Imaging Agents."
  • "Die Bedeutung lysosomaler Cysteinproteasen für die Progression muriner und humaner epidermaler Karzinome"
    • Projektleitung: Dr. Thomas Reinheckel
    • Laufzeit: 01.04.2006 bis 31.03.2009
    • Details zum Projekt
  • "Funktionelle Diversifizierung von Signaltransduktionsmechanismen: Ausmaß und molekulare Grundlagen des genspezifischen regulatorischen Potentials von 'T-Cell Factor' DNA-Bindungsproteinen"
  • "In vivo assessment of the activity of Broncho-Vaxom"
  • "Mathematical modeling of the FasL/CD95L signaling pathway in primary hepatocytes"
  • "Molekulare Mechanismen der differentiellen Genregulation durch den Wnt/beta-Catenin-Signalweg"
  • "Mouse organogenesis regulated by apoptosis: the role of serine proteases"
    • Projektleitung: Prof. Dr. Christoph Borner
    • Laufzeit: 01.05.2005 bis 31.12.2009
    • Details zum Projekt
  • "Protease-selektive Inhibitor-basierte NMR-Marker"
    • Projektleitung: Dr. Thomas Reinheckel, Prof. Dr. Christoph Peters
    • Laufzeit: 01.05.2006 bis 30.04.2008
    • Details zum Projekt
  • "Stammzelltransplantation und Immunmodulation – molekulare Therapieansätze in der Pädiatrie. Möglichkeiten und Grenzen der Selektion blutbildender Stammzellklone durch genetische Modifikation"
  • "Understanding the mode of action of Bcl-2 family members on mitochondria: Identification of inhibitors and activators by proteomics strategies"
    • Projektleitung: Prof. Dr. Christoph Borner
    • Laufzeit: 01.10.2003 bis 30.09.2006
    • Details zum Projekt
  • "Untersuchungen zu Funktionen der lysosomalen Proteasen Cathepsin H, Cathepsin E und Napsin in Lunge und Immunsystem"
    • Projektleitung: Dr. Thomas Reinheckel
    • Laufzeit: 01.05.2004 bis 31.12.2007
    • Details zum Projekt
  • "Untersuchungen zur Pathogenese einer dilatativen Kardiomyopathie bei Cathepsin L defizienten Mäusen"
    • Projektleitung: Dr. Thomas Reinheckel
    • Laufzeit: 01.11.2002 bis 31.12.2006
    • Details zum Projekt

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Baran K, Ciccone A, Peters C, Yagita H, Bird PI, Villadangos JA, Trapani JA: Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. J Biol Chem, 2006; 281 (41): 30485-30491.
  • Bester AC, Schwartz M, Schmidt M, Garrigue A, Hacein-Bey-Abina S, Cavazzana-Calvo M, Ben-Porat N, Von Kalle C, Fischer A, Kerem B: Fragile sites are preferential targets for integrations of MLV vectors in gene therapy. Gene Ther, 2006; 13 (13): 1057-1059.
  • Beuschlein F, Reincke M: Adrenocortical tumorigenesis. Ann Ny Acad Sci, 2006; 1088: 319-334.
  • Binder M, Otto F, Mertelsmann R, Veelken H, Trepel M: The epitope recognized by rituximab. Blood, 2006; 108 (6): 1975-1978.
  • Bohnsack M, Hehl S, Moller H, Borner C, Wirth CJ, Ruhmann O: [Influence of the postoperative activity level on tibial bone tunnel enlargement and functional treatment results following anterior cruciate ligament reconstruction using a patellar tendon autograft]. Z Orthop Grenzgeb, 2006; 144 (4): 373-379. : http://dx.doi.org/10.1055/s-2006-942122
  • Bohnsack M, Lekkos K, Borner CE, Wirth CJ, Ruhmann O: [Results of hip arthroscopy in sports related groin pain]. Sportverletz Sportsc, 2006; 20 (2): 86-90. : http://dx.doi.org/10.1055/s-2006-926816
  • Borner C: In memoriam of a prominent composer of the Bcl-2 family symphony. Cell Death Differ, 2006; 13 (8): 1248-1249.
  • Borner C: In memoriam of a prominent composer of the Bcl-2 family symphony. Cell Death Differ, 2006; 13 (8): 1248-1249. : http://dx.doi.org/10.1038/sj.cdd.4401998
  • Borner C, Hollt V, Kraus J: Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells. Mol Pharmacol, 2006; 69 (4): 1486-1491. : http://dx.doi.org/10.1124/mol.105.018325
  • Brummer T, Martin P, Herzog S, Misawa Y, Daly RJ, Reth M: Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein. Oncogene, 2006; 25 (47): 6262-6276. : http://dx.doi.org/10.1038/sj.onc.1209640
  • Brummer T, Schramek D, Hayes VM, Bennett HL, Caldon CE, Musgrove EA, Daly RJ: Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J Biol Chem, 2006; 281 (1): 626-637. : http://dx.doi.org/10.1074/jbc.M509567200
  • Charvet C, Canonigo AJ, Becart S, Maurer U, Miletic AV, Swat W, Deckert M, Altman A: Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol, 2006; 177 (8): 5024-5031.
  • Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL: Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem, 2006; 281 (23): 15893-15899.
  • Coll AP, Fassnacht M, Klammer S, Hahner S, Schulte DM, Piper S, Tung YC, Challis BG, Weinstein Y, Allolio B, O'Rahilly S, Beuschlein F: Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production. J Endocrinol, 2006; 190 (2): 515-525.
  • Deibert P, Schumacher YO, Ruecker G, Opitz OG, Blum HE, Rossle M, Kreisel W: Effect of vardenafil, an inhibitor of phosphodiesterase-5, on portal haemodynamics in normal and cirrhotic liver -- results of a pilot study. Aliment Pharm Therap, 2006; 23 (1): 121-128.
  • Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL: Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood, 2006; 108 (5): 1461-1468.
  • Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL: Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood, 2006; 108 (5): 1461-1468. : http://dx.doi.org/10.1182/blood-2006-03-014209
  • Everts V, Korper W, Hoeben KA, Jansen ID, Bromme D, Cleutjens KB, Heeneman S, Peters C, Reinheckel T, Saftig P, Beertsen W: Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone. J Bone Miner Res, 2006; 21 (9): 1399-1408.
  • Fischer M, Schmidt M, Klingenberg S, Eaves CJ, von Kalle C, Glimm H: Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype. Blood, 2006; 108 (6): 2121-2123.
  • Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA: Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Gene Dev, 2006; 20 (5): 543-556.
  • Gorczynski RM, Alexander C, Bessler W, Brandenburg K, Fournier K, Hoffmann P, Mach JP, Mueller S, Rietschel ET, Terzioglu E, Ulmer AJ, Waelli T, Zahringer U, Khatri I: Role of MIF and glutathione, in association with fetal ovine globin chain (Hbgamma) and LPS, in induction of TNFalpha from cells of young and aged mice, and PBL from healthy human populations. Immunol Lett, 2006; 105 (2): 140-149.
  • Guijarro J, Engelhard M, Siebert F: Anion uptake in halorhodopsin from Natromonas pharaonis studied by FTIR spectroscopy: consequences for the anion transport mechanism. Biochemistry, 2006; 45 (38): 11578-11588.
  • Hajitou A, Trepel M, Lilley CE, Soghomonyan S, Alauddin MM, Marini FC 3rd, Restel BH, Ozawa MG, Moya CA, Rangel R, Sun Y, Zaoui K, Schmidt M, von Kalle C, Weitzman MD, Gelovani JG, Pasqualini R, Arap W: A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell, 2006; 125 (2): 385-398.
  • Harder J, Opitz OG: [Gastric cancer-risk factors and medical therapy] Schweiz Rundsch Med Prax, 2006; 95 (25-2): 1021-1028.
  • Harder J, Riecken B, Kummer O, Lohrmann C, Otto F, Usadel H, Geissler M, Opitz O, Henss H: Outpatient chemotherapy with gemcitabine and oxaliplatin in patients with biliary tract cancer. Brit J Cancer, 2006; 95 (7): 848-852.
  • Hayes AB, Cline D, Wu CY, Ai J, Amro H, Beausang C, Casten RF, Gerl J, Hecht AA, Heinz A, Hughes R, Janssens RV, Lister CJ, Macchiavelli AO, Meyer DA, Moore EF, Napiorkowski P, Pardo RC, Schlegel Ch, Seweryniak D, Simon MW, Srebrny J, Teng R, Vetter K, Wollersheim HJ: Breakdown of K selection in 178Hf. Phys Rev Lett, 2006; 96 (4): 042505-042505.
  • Heeg S, Doebele M, von Werder A, Opitz OG: In vitro transformation models: modeling human cancer. Cell Cycle, 2006; 5 (6): 630-634.
  • Hershkovitz L, Beuschlein F, Klammer S, Krup M, Weinstein Y: Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone. Endocrinology, 2006; Epub ahead of print. (in Druck)
  • Honegger JB, Psaras T, Petrick M, Beuschlein F, Reincke M: Spontaneous cerebrospinal fluid rhinorrhea in untreated macroprolactinoma--an indication for primary surgical therapy. Zbl Neurochir, 2006; 67 (3): 149-154.
  • Horkay F, Hecht AM, Rochas C, Basser PJ, Geissler E: Anomalous small angle x-ray scattering determination of ion distribution around a polyelectrolyte biopolymer in salt solution. J Chem Phys, 2006; 125 (23): 234904-234904. : http://dx.doi.org/10.1063/1.2402921
  • Jeffrey KL, Brummer T, Rolph MS, Liu SM, Callejas NA, Grumont RJ, Gillieron C, Mackay F, Grey S, Camps M, Rommel C, Gerondakis SD, Mackay CR: Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. Nat Immunol, 2006; 7 (3): 274-283. : http://dx.doi.org/10.1038/ni1310
  • Johnsen IK, Slawik M, Shapiro I, Hartmann MF, Wudy SA, Looyenga BD, Hammer GD, Reincke M, Beuschlein F: Gonadectomy in mice of the inbred strain CE/J induces proliferation of sub-capsular adrenal cells expressing gonadal marker genes. J Endocrinol, 2006; 190 (1): 47-57.
  • Kim S, Xu X, Hecht A, Boyer TG: Mediator is a transducer of Wnt/beta-catenin signaling. J Biol Chem, 2006; 281 (20): 14066-14075.
  • Kim S, Xu X, Hecht A, Boyer TG: Mediator is a transducer of Wnt/beta-catenin signaling. J Biol Chem, 2006; 281 (20): 14066-14075. : http://dx.doi.org/10.1074/jbc.M602696200
  • Klingmuller U, Bauer A, Bohl S, Nickel PJ, Breitkopf K, Dooley S, Zellmer S, Kern C, Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C, Hermes M, Gotschel F, Hecht A, Walter D, Egger L, Neubert K, Borner C, Brulport M, Schormann W, Sauer C, Baumann F, Preiss R, MacNelly S, Godoy P, Wiercinska E, Ciuclan L, Edelmann J, Zeilinger K, Heinrich M, Zanger UM, Gebhardt R, Maiwald T, Heinrich R, Timmer J, von Weizsacker F, Hengstler JG: Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. Systems Biol, 2006; 153 (6): 433-447.
  • Klingmuller U, Bauer A, Bohl S, Nickel PJ, Breitkopf K, Dooley S, Zellmer S, Kern C, Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C, Hermes M, Gotschel F, Hecht A, Walter D, Egger L, Neubert K, Borner C, Brulport M, Schormann W, Sauer C, Baumann F, Preiss R, MacNelly S, Godoy P, Wiercinska E, Ciuclan L, Edelmann J, Zeilinger K, Heinrich M, Zanger UM, Gebhardt R, Maiwald T, Heinrich R, Timmer J, von Weizsacker F, Hengstler JG: Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. Systems Biol, 2006; 153 (6): 433-447.
  • Klingmüller U, Bauer A, Bohl S, Nickel PJ, Breitkopf K, Dooley S, Zellmer S, Kern C, Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C, Hermes M, Götschel F, Hecht A, Walter D, Egger L, Neubert K, Borner C, Brulport M, Schormann W, Sauer C, Baumann F, Preiss R, MacNelly S, Godoy P, Wiercinska E, Ciuclan L, Edelmann J, Zeilinger K, Heinrich M, Zanger UM, Gebhardt R, Maiwald T, Heinrich R, Timmer J, von Weizsäcker F, Hengstler JG: Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. IEE Proc Syst Biol, 2006; 153 (6): 433-447.
  • Kraus J, Borner C, Lendeckel U, Hollt V: Interferon-gamma down-regulates transcription of the mu-opioid receptor gene in neuronal and immune cells. J Neuroimmunol, 2006; 181 (1-2): 13-18. : http://dx.doi.org/10.1016/j.jneuroim.2006.07.012
  • Liddick SN, Grzywacz R, Mazzocchi C, Page RD, Rykaczewski KP, Batchelder JC, Bingham CR, Darby IG, Drafta G, Goodin C, Gross CJ, Hamilton JH, Hecht AA, Hwang JK, Ilyushkin S, Joss DT, Korgul A, Krolas W, Lagergren K, Li K, Tantawy MN, Thomson J, Winger JA: Discovery of 109Xe and 105Te: superallowed alpha decay near doubly magic 100Sn. Phys Rev Lett, 2006; 97 (8): 082501-082501.
  • Lüdeke S, Fonfria VA, Siebert F, Vogel R: Time-resolved rapid-scan Fourier transform infrared difference spectroscopy on a noncyclic photosystem: rhodopsin photointermediates from Lumi to Meta II. Biopolymers, 2006; 83 (2): 159-169.
  • Mahalingam M, Vogel R: The All-trans-15-syn-Retinal Chromophore of Metarhodopsin III Is a Partial Agonist and Not an Inverse Agonist. Biochemistry, 2006; 45 (51): 15624-15632.
  • Manoharan A, Kiefer T, Leist S, Schrader K, Urban C, Walter D, Maurer U, Borner C: Identification of a 'genuine' mammalian homolog of nematodal CED-4: is the hunt over or do we need better guns? Cell Death Differ, 2006; 13 (8): 1310-1317.
  • Manoharan A, Kiefer T, Leist S, Schrader K, Urban C, Walter D, Maurer U, Borner C: Identification of a 'genuine' mammalian homolog of nematodal CED-4: is the hunt over or do we need better guns? Cell Death Differ, 2006; 13 (8): 1310-1317. : http://dx.doi.org/10.1038/sj.cdd.4401948
  • Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR: Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell, 2006; 21 (6): 749-760.
  • Modlich U, Bohne J, Schmidt M, von Kalle C, Knoss S, Schambach A, Baum C: Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity. Blood, 2006; 108 (8): 2545-2553.
  • Mollmann H, Nef HM, Kostin S, von Kalle C, Pilz I, Weber M, Schaper J, Hamm CW, Elsasser A: Bone marrow-derived cells contribute to infarct remodelling. Cardiovasc Res, 2006; 71 (4): 661-671.
  • Montini E, Cesana D, Schmidt M, Sanvito F, Ponzoni M, Bartholomae C, Sergi Sergi L, Benedicenti F, Ambrosi A, Di Serio C, Doglioni C, von Kalle C, Naldini L: Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol, 2006; 24 (6): 687-696.
  • Nowrouzi A, Dittrich M, Klanke C, Heinkelein M, Rammling M, Dandekar T, von Kalle C, Rethwilm A: Genome-wide mapping of foamy virus vector integrations into a human cell line. J Gen Virol, 2006; 87 (Pt 5): 1339-1347.
  • Ott MG, Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U, Glimm H, Kuhlcke K, Schilz A, Kunkel H, Naundorf S, Brinkmann A, Deichmann A, Fischer M, Ball C, Pilz I, Dunbar C, Du Y, Jenkins NA, Copeland NG, Luthi U, Hassan M, Thrasher AJ, Hoelzer D, von Kalle C, Seger R, Grez M: Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med, 2006; 12 (4): 401-409.
  • Pantic M, Zimmermann S, El Daly H, Opitz OG, Popp S, Boukamp P, Martens UM: Telomere dysfunction and loss of p53 cooperate in defective mitotic segregation of chromosomes in cancer cells. Oncogene, 2006; 25 (32): 4413-4420.
  • Pardo J, Urban C, Galvez EM, Ekert PG, Muller U, Kwon-Chung J, Lobigs M, Mullbacher A, Wallich R, Borner C, Simon MM: The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. J Cell Biol, 2006; 174 (4): 509-519.
  • Pardo J, Urban C, Galvez EM, Ekert PG, Muller U, Kwon-Chung J, Lobigs M, Mullbacher A, Wallich R, Borner C, Simon MM: The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. J Cell Biol, 2006; 174 (4): 509-519. : http://dx.doi.org/10.1083/jcb.200604044
  • Perez-Amodio S, Jansen DC, Schoenmaker T, Vogels IM, Reinheckel T, Hayman AR, Cox TM, Saftig P, Beertsen W, Everts V: Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity. Calcified Tissue Int, 2006; 79 (4): 245-254.
  • Petermann I, Mayer C, Stypmann J, Biniossek ML, Tobin DJ, Engelen MA, Dandekar T, Grune T, Schild L, Peters C, Reinheckel T: Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J, 2006; 20 (8): 1266-1268.
  • Reincke M, Beuschlein F, Slawik M: [Obesity 2006] MMW Fortschr Med, 2006; 148 (33-3): 20-24.
  • Rocken C, Fandrich M, Stix B, Tannert A, Hortschansky P, Reinheckel T, Saftig P, Kahne T, Menard R, Ancsin JB, Buhling F: Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis. J Pathol, 2006; 210 (4): 478-487.
  • Ruhmann O, Borner C, von Lewinski G, Bohnsack M: [Lig. capitis femoris. Arthroscopic diagnosis and treatment of degenerative and traumatic disorders]. Orthopade, 2006; 35 (1): 59, 61-54, 65. : http://dx.doi.org/10.1007/s00132-005-0893-7
  • Schambach A, Galla M, Modlich U, Will E, Chandra S, Reeves L, Colbert M, Williams DA, von Kalle C, Baum C: Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research. Exp Hematol, 2006; 34 (5): 588-592.
  • Schepsky A, Bruser K, Gunnarsson GJ, Goodall J, Hallsson JH, Goding CR, Steingrimsson E, Hecht A: The microphthalmia-associated transcription factor Mitf interacts with Mol Cell Biol, 2006; 26 (23): 8914-8927.
  • Schepsky A, Bruser K, Gunnarsson GJ, Goodall J, Hallsson JH, Goding CR, Steingrimsson E, Hecht A: The microphthalmia-associated transcription factor Mitf interacts with Mol Cell Biol, 2006; 26 (23): 8914-8927. : http://dx.doi.org/10.1128/MCB.02299-05
  • Schirpenbach C, Seiler L, Maser-Gluth C, Beuschlein F, Reincke M, Bidlingmaier M: Automated chemiluminescence-immunoassay for aldosterone during dynamic testing: comparison to radioimmunoassays with and without extraction steps. Clin Chem, 2006; 52 (9): 1749-1755.
  • Schirpenbach C, Seiler L, Maser-Gluth C, Rudiger F, Nickel C, Beuschlein F, Reincke M: Confirmatory testing in normokalaemic primary aldosteronism: the value of the saline infusion test and urinary aldosterone metabolites. Eur J Endocrinol, 2006; 154 (6): 865-873.
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  • Sevenich L, Pennacchio LA, Peters C, Reinheckel T: Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol Chem, 2006; 387 (7): 885-891.
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Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten

Promotionen
  • Lohmüller, Tobias: Rolle der lysosomalen Protease Cathepsin L bei experimentell-induzierter epidermaler Karzinogenese (Erstgutachter/in Prof. Dr. Christoph Peters), 2006.
  • Pilz, Ingo Hinrich: Evaluation der Beteiligung retroviral markierter Knochenmarktransplantate an der Leberzellregeneration im murinen MOdell chronischer Leberschädigung C57BL/6J TGN(ALB 1 HBV) 44BRI (Erstgutachter/in Prof. Dr. Christoph Peters), 2006.
  • Spira, Daniel: Genetische Analyse zellspezifischer Funktionen der lysosomalen Cysteinprotease Cathepsin L im Mausherz (Erstgutachter/in Prof. Dr. Christoph Peters), 2006.