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 Forschungsbericht für das Jahr 2019

Physiologisches Institut

Hermann-Herder-Str. 7
79104 Freiburg i. Br.
Tel: +49 761 203-5176/5150 Fax: +49 761 203-5191/5204
http://www.physiologie.uni-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Bernd Fakler
  • Prof. Dr. emer. Hermann Antoni
  • Prof. Dr. Jan Behrends
  • Prof. Dr. Gisa Fleckenstein-Grün
  • PD Dr. Jörg Weirich
  • Dr. Detlef Bentrop
  • Dr. Henrike Berkefeld
  • Dr. Wolfgang Bildl
  • PD Dr. Akos Kulik
  • Dr. Uwe Schulte
  • Dr. Gerd Zolles
  • Dr. Jochen Schwenk
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Direct recordings from presynaptic elements and dendrites
  • Excitatory and inhibitory synaptic transmission in the mammalian central nervous system
  • Functional significance of K+ channels in various types of cell (neurons, sensory hair cells in the inner ear)
  • GABAergic interneurons
  • Glutamate receptors of the AMPA and NMDA subtype
  • Ion channels
  • Ion transport
  • Mechanisms of transmitter release
  • Molecular mechanisms underlying function and regulation of ion channels (K+, Ca2+) and other membrane proteins (prestin)
  • NMR-based structure analysis of functional domains of membrane proteins (in particular ion channel proteins)
  • Protein-protein interaction in ion channels
  • Proteom analysis of the microdomains associated with membrane proteins including ion channels, transporters and GPCRs
  • Somatodendritic integration of synaptic signals
  • Voltage-gated ion channels (Na+, K+, Ca2+)

Finanzierung

  • Fördermittel der Tinnitus GmbH

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Dinamarca MC, Raveh A, Schneider A, Fritzius T, Früh S, Rem PD, Stawarski M, Lalanne T, Turecek R, Choo M, Besseyrias V, Bildl W, Bentrop D, Staufenbiel M, Gassmann M, Fakler B, Schwenk J, Bettler B: Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing Nat Commun, 2019; 10 (1): 1331. : http://dx.doi.org/10.1038/s41467-019-09164-3
  • Makrynitsa G, Ntonti D, Marousis KD, Birkou M, Matsoukas MT, Asami S, Bentrop D, Papageorgiou N, Canard B, Coutard B, Spyroulias GA: Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose J Struct Biol, 2019; 206 (1): 119-127. : http://dx.doi.org/10.1016/j.jsb.2019.02.008
  • Müller CS, Bildl W, Klugbauer N, Haupt A, Fakler B, Schulte U: High-Resolution Complexome Profiling by Cryoslicing BN-MS Analysis Jove-j Vis Exp, 2019; 152: 1-10.
  • Schewe M, Sun H, Mert1 Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde1 DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter DP, Tucker ST, Baukrowitz T: A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels Science, 2019; 363: 875-880.
  • Schwenk J, Boudkkazi S, Kocylowski M, Brechet A, Zolles G, Bus T, Costa K, Kollewe A, Jordan J, Bank J, Bildl W, SprengelR, Kulik A, Roeper J, Schulte U, Fakler B: An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity Neuron, 2019; 104: 1-13.
  • Tsika AC, Melekis E, Tsatsouli SA, Papageorgiou N, Maté MJ, Canard B, Coutard B, Bentrop D, Spyroulias GA: Deciphering the Nucleotide and RNA Binding Selectivity of the Mayaro Virus Macro Domain J Mol Biol, 2019; 431 (12): 2283-2297. : http://dx.doi.org/10.1016/j.jmb.2019.04.013

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten