Forschungsbericht für das Jahr 2020

Institut für Medizinische Biometrie und Statistik

Stefan-Meier-Strasse 26
79104 Freiburg
Tel: 0761 203 6662 Fax: 0761 203 6680

Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. M. Schumacher
  • Prof. Dr. J. Schulte Mönting
  • Arthur Allignol
  • Dr. G. Antes
  • Dr. J. Beyersmann
  • Dr. H. Binder
  • Dr. Anette Blümle
  • D. Booker
  • Dipl.-Stat. Anika Buchholz
  • Dr. A. Caputo
  • Dr. J. Carpenter
  • Dr. Erik von Elm
  • Dipl.-Math. C. Gall
  • Dr. T. Gerds
  • Dipl.-Stat. A. Gerlach
  • Dr. E. Graf
  • Prof. Dr. Dieter Hauschke
  • Dr. G. Ihorst
  • Dr. B. Lang
  • Dr. Jörg Meerpohl
  • Dipl.-Stat. M. Olschewski
  • Dipl.-Stat. Christine Porzelius
  • Dipl.-Math. G. Rücker
  • PD Dr. W. Sauerbrei
  • Dr. C. Schmoor
  • Dr. Christine Schmucker
  • Dipl.-Math.Oec. R. Schoop
  • Dr. G. Schwarzer
  • Dipl.-Math. P. Sekula
  • Dipl.-Stat. S. Stampf
  • PD Dr. A. Timmer
  • Robert Wolff
  • Dr. M. Wolkewitz
Einträge in der Rubrik "Who is Who"


  • Biometrische Methodologie
  • Epidemiologische Studien
  • Klinische Studien
  • Multizentrische Therapiestudien

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Bluhmki T, Schmoor C, Finke J, Schumacher M, Socié G, Beyersmann J: Relapse- and immunosuppression-free survival after hematopoietic stem-cell transplantation: How can we assess treatment success for complex time-to-event endpoints? Biol Blood Marrow Tr, 2020. : (in Druck)
  • Blümle A, Haag T, Balmford J, Rücker G, Schumacher M, Binder N: A multi-state model analysis of the time from ethical approval to publication of clinical research studies. Plos One, 2020; 15 (online): e0230797. :
  • Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, Klein M, Michel C, Radsak MP, Rosigkeit S, Grimminger P, Schild H, Rajalingam K: ERK3/MAPK6 controls IL-8 production and chemotaxis. Elife, 2020 (online): e52511. :
  • Bonofiglio F, Schumacher M, Binder H: Recovery of original individual person data (IPD) inferences from empirical IPD summaries only: Applications to distributed computing under disclosure constraints. Stat Med, 2020; 39: 1183-1198. :
  • Braune J, Keller L, Schiller F, Graf E, Rafei-Shamsabadi D, Wehrle J, Follo M, Philipp U, Hussung S, Pfeifer D, Mix M, Duyster J, Fritsch R, von Bubnoff D, Meiss F, von Bubnoff N: Circulating Tumor DNA Allows Early Treatment Monitoring in BRAF- and NRAS-Mutant Malignant Melanoma. JCO Precision Oncology, 2020; 4: 20-31. :
  • Chiabudini M, Schumacher M, Graf E: Comparison of complex modeling strategies for prediction of a binary outcome based on a few, highly correlated predictors. Biometrical J, 2020. : (in Druck)
  • Denkel LA, Maechler F, Schwab F, Kola A, Weber A, Gastmeier P, Pfäfflin F, Weber S, Werner G, Pfeifer Y, Pietsch M, Leistner R: Infections caused by extended-spectrum β-lactamase-producing Enterobacterales after rectal colonization with ESBL-producing Escherichia coli or Klebsiella pneumoniae. Clin Microbiol Infec, 2020. : (in Druck)
  • Derek Hazard D, Kaier K, von Cube M, Grodd M, Bugiera L, Lambert J, Wolkewitz M: Joint analysis of duration of ventilation, length of intensive care, and mortality of COVID-19 patients: a multistate approach. Bmc Med Res Methodol, 2020. : (in Druck)
  • Derek Hazard D, Kaier K, von Cube M, Grodd M, Bugiera L, Lambert J, Wolkewitz M: Joint analysis of duration of ventilation, length of intensive care, and mortality of COVID-19 patients: a multistate approach. Bmc Med Res Methodol, 2020; 20 (online): 206. :
  • Duerr J, Leitz DHW, Szczygiel M, Dvornikov D, Fraumann SG, Kreutz C, Zadora PK, Seyhan Agircan A, Konietzke P, Engelmann TA, Hegermann J, Mulugeta S, Kawabe H, Knudsen L, Ochs M, Rotin D, Muley T, Kreuter M, Herth FJF, Wielpütz MO, Beers MF, Klingmüller U, Mall MA: Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice. Nat Commun, 2020; 11 (online): 2012. :
  • Duerschmied D, Zotzmann V, Rieder M, Bemtgen X, Biever PM, Kaier K, Trummer G, Benk C, Busch HJ, Bode C, Wengenmayer T, Stachon P, von zur Mühlen C, Staudacher DL: Myocardial Infarction Type 1 Is Frequent in Refractory Out-Of-Hospital Cardiac Arrest (OHCA) Treated With Extracorporeal Cardiopulmonary Resuscitation (ECPR). Sci Rep-uk, 2020; 10 (online): 8423. :
  • Feifel J, Gebauer M, Schumacher M, Beyersmann J: Nested exposure case-control sampling: a sampling scheme to analyze rare time-dependent exposures. Lifetime Data Anal, 2020; 26: 21-44. :
  • Frankenstein L, Kaier K, Katus HA, Bode C, Wengenmayer T, von Zur Mühlen C, Bekeredjian R, Täger T, Zehender M, Fröhlich H, Stachon P: Impact of the Introduction of Percutaneous Edge-To-Edge Mitral Valve Reconstruction on Clinical Practice in Germany Compared to Surgical Valve Repair. Clin Res Cardiol, 2020. : (in Druck)
  • Geissler JM, Vloet TD, Strom N, Jaite C, Graf E, Kappel V, Warnke A, Jacob C, Hennighausen K, Haack-Dees B, Schneider-Momm K, Matthies S, Rösler M, Retz W, Hänig S, von Gontard A, Sobanski E, Alm B, Hohmann S, Poustka L, Colla M, Gentschow L, Freitag CM, Häge A, Holtmann M, Becker K, Philipsen A, Jans T: Does helping mothers in multigenerational ADHD also help children in the long run? 2-year follow-up from baseline of the AIMAC randomized controlled multicentre trial. Eur Child Adoles Psy, 2020. : (in Druck)
  • Geraedts M, Mehl C, Schmitz J, Siegel A, Graf E, Stelzer D, Farin-Glattacker E, Ihle P, Köster I, Dröge P, Günster C, Haas N, Gröne O, Schubert I: Development of an indicator set for the evaluation of the population-based integrated healthcare model 'Gesundes Kinzigtal' (Healthy Kinzigtal). Z Evid Fortbild Qual Gesundhwes, 2020; 150: 54-64. :
  • Hirschfeld M, Rücker G, Weiß D, Berner K, Ritter A, Jäger M, Erbes T: Urinary Exosomal MicroRNAs as Potential Non-invasive Biomarkers in Breast Cancer Detection. Mol Diagn Ther, 2020. (download: (in Druck)
  • Kaier K, Wolkewitz M, Hehn P, Mutters NT, Heister T: The impact of hospital-acquired infections on the patient-level reimbursement-cost relationship in a DRG-based hospital payment system. Int J Health Econ Ma, 2020; 20: 1-11. :
  • Kunzler AM, Helmreich I, Chmitorz A, König J, Binder H, Wessa M, Lieb K: Psychological interventions to foster resilience in healthcare professionals. Cochrane Db Syst Rev, 2020; 7 (online): CD012527. :
  • Lother A, Kaier K, Ahrens I, Bothe W, Wolf D, Zehender M, Bode C, von Zur Mühlen C, Stachon P: Bleeding Complications Drive In-Hospital Mortality of Patients with Atrial Fibrillation after Transcatheter Aortic Valve Replacement. Thromb Haemostasis, 2020. : (in Druck)
  • Maier A, Hammerich B, Humburger F, Brieschal T, Heidt T, Bothe W, Schröfel H, Kaier K, Zehender M, Reinöhl J, Bode C, von Zur Mühlen C, Stachon P: A logistic regression analysis comparing minimalistic approach and intubation anaesthesia in patients undergoing transfemoral transcatheter aortic valve replacement. Plos One, 2020; 15 (online): e0227345. :
  • Nestle U, Adebahr S, Kaier K, Gkika E, Schimek-Jasch T, Hechtner M, Momm F, Gaertner J, Becker G, Grosu AL: Quality of life after pulmonary stereotactic fractionated radiotherapy (SBRT): Results of the phase II STRIPE trial. Radiother Oncol, 2020; 148: 82-88. :
  • Oettinger V, Kaier K, Heidt T, Hortmann M, Wolf D, Zirlik A, Zehender M, Bode C, von Zur Mühlen C, Stachon P: Outcomes of transcatheter aortic valve implantations in high-volume or low-volume centres in Germany. Heart, 2020. : (in Druck)
  • Pierscianek D, Ahmadipour Y, Kaier K, Oppong MD, Michel A, Kebir S, Stuschke M, Glas M, Sure U, Jabbarli R: The SHORT score for preoperative assessment of the risk for short-term survival in glioblastoma. World Neurosurg, 2020. : (in Druck)
  • Rilinger J, Zotzmann V, Bemtgen X, Schumacher C, Biever PM, Duerschmied D, Kaier K, Stachon P, von Zur Mühlen C, Zehender M, Bode C, Staudacher DL, Wengenmayer T: Prone positioning in severe ARDS requiring extracorporeal membrane oxygenation. Crit Care, 2020; 24 (online): 379. :
  • Rohde AM, Zweigner J, Wiese-Posselt M, Schwab F, Behnke M, Kola A, Schröder W, Peter S, Tacconelli E, Wille T, Feihl S, Querbach C, Gebhardt F, Gölz H, Schneider C, Mischnik A, Vehreschild MJGT, Seifert H, Kern WV, Gastmeier P, Hamprecht A, DZIF-ATHOS Study Group.: Prevalence of third-generation cephalosporin-resistant Enterobacterales colonization on hospital admission and ESBL genotype-specific risk factors: a cross-sectional study in six German university hospitals. J Antimicrob Chemoth, 2020. : (in Druck)
  • Rücker G, Petropoulou M, Schwarzer G: Network meta-analysis of multicomponent interventions. Biometrical J, 2020. : (in Druck)
  • San Martin Rodriguez M, Kaier K, Hehn M, Borde JP: Knowledge, habits and attitudes towards TBE and other tick-borne diseases in German forestry trainees. Ticks Tick-borne Dis, 2020; 11: 101307. :
  • Schinke M, Ihorst G, Duyster J, Wäsch R, Schumacher M, Engelhardt M: Risk of disease recurrence and survival in patients with multiple myeloma: A German Study Group analysis using a conditional survival approach with long-term follow-up of 815 patients. Cancer, 2020; 126: 3504-3515. :
  • Schlosser P, Knaus J, Schmutz M, Dohner K, Plass C, Bullinger L, Claus R, Binder H, Lubbert M, Schumacher M: Netboost: Boosting-supported Network Analysis Improves High-Dimensional Omics Prediction in Acute Myeloid Leukemia and Huntington's Disease: IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2020. : (in Druck)
  • Schumacher M, Hieke S, Ihorst G, Engelhardt M: Dynamic prediction: A challenge for biostatisticians, but greatly needed by patients, physicians and the public. Biometrical J, 2020. : (in Druck)
  • Spieler D, Namendorf C, Namendorf T, von Cube M, Uhr M: Donepezil, a cholinesterase inhibitor used in Alzheimer's disease therapy, is actively exported out of the brain by abcb1ab p-glycoproteins in mice. J Psychiatr Res, 2020; 124: 29-33. :
  • Stachon P, Kaier K, Heidt T, Bothe W, Zirlik A, Zehender M, Bode C, von Zur Mühlen C: Nationwide outcomes of aortic valve replacement for pure aortic regurgitation in Germany 2008-2015. Catheter Cardio Inte, 2020. : (in Druck)
  • Sturm L, van Elst LT, Fiebich B, Wolkewitz M, Hornig T: Intra-day variations of blood reelin levels in healthy individuals. Arch Med Sci, 2020; 16: 118-123. :
  • von Cube M, Schumacher M, Putter H, Timsit JF, van de Velde C, Wolkewitz M: The population-attributable fraction for time-dependent exposures using dynamic prediction and landmarking. Biometrical J, 2020. : (in Druck)
  • von Cube M, Schumacher M, Wolkewitz M: Causal inference with multistate models—estimands and estimators of the population attributable fraction. J R Stat Soc A Stat, 2020. : (in Druck)
  • von Cube MK, Schumacher M, Wolkewitz M: Follow-on rifaximin for the prevention of recurrence following standard treatment of infection with Clostridium difficile: a competing risks analysis provides a full picture of possible treatment effects. Gut, 2020; 69: 389-400. :
  • Weber S, Wolkewitz M, on behalf of COMBACTE‐MAGNET Consortium: Accounting for length of hospital stay in regression models in clinical epidemiology. Stat Neerl, 2020; 74: 24-37. :
  • Wolff J, Gary A, Jung D, Normann C, Kaier K, Binder H, Domschke K, Klimke A, Franz M: Predicting patient outcomes in psychiatric hospitals with routine data: a machine learning approach. Bmc Med Inform Decis, 2020; 20 (online): 21. :
  • Wolkewitz M, Puljak L: Methodological challenges of analysing COVID-19 data during the pandemic. Bmc Med Res Methodol, 2020; 20 (online): 81. :
Kurzbeiträge / short communications:

Besondere wissenschaftliche Aktivitäten