Forschungsbericht für das Jahr 2019

Institut für Medizinische Biometrie und Statistik

Stefan-Meier-Strasse 26
79104 Freiburg
Tel: 0761 203 6662 Fax: 0761 203 6680

Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. M. Schumacher
  • Prof. Dr. J. Schulte Mönting
  • Arthur Allignol
  • Dr. G. Antes
  • Dr. J. Beyersmann
  • Dr. H. Binder
  • Dr. Anette Blümle
  • D. Booker
  • Dipl.-Stat. Anika Buchholz
  • Dr. A. Caputo
  • Dr. J. Carpenter
  • Dr. Erik von Elm
  • Dipl.-Math. C. Gall
  • Dr. T. Gerds
  • Dipl.-Stat. A. Gerlach
  • Dr. E. Graf
  • Prof. Dr. Dieter Hauschke
  • Dr. G. Ihorst
  • Dr. B. Lang
  • Dr. Jörg Meerpohl
  • Dipl.-Stat. M. Olschewski
  • Dipl.-Stat. Christine Porzelius
  • Dipl.-Math. G. Rücker
  • PD Dr. W. Sauerbrei
  • Dr. C. Schmoor
  • Dr. Christine Schmucker
  • Dipl.-Math.Oec. R. Schoop
  • Dr. G. Schwarzer
  • Dipl.-Math. P. Sekula
  • Dipl.-Stat. S. Stampf
  • PD Dr. A. Timmer
  • Robert Wolff
  • Dr. M. Wolkewitz
Einträge in der Rubrik "Who is Who"


  • Biometrische Methodologie
  • Epidemiologische Studien
  • Klinische Studien
  • Multizentrische Therapiestudien

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Adebahr S, Hechtner M, Schräder N, Schimek-Jasch T, Kaier K, Rohr VD, Gkika E, Momm F, Gärtner J, Becker G, Grosu AL, Nestle U: Early impact of pulmonary stereotactic fractionated body radiotherapy (SBRT) on Quality of Life (QoL): Benefit for patients with low initial scores (STRIPE trial). J Thorac Oncol, 2019; 14: 708-419. :
  • Binder N, Balmford J, Schumacher M: A multi-state model based reanalysis of the Framingham Heart Study: Is dementia incidence really declining? Eur J Epidemiol, 2019; 34: 1075-1083. :
  • Binder N, Blümle A, Balmford J, Motschall E, Oeller P, Schumacher M: Cohort studies were found to be frequently biased by missing disease information due to death. J Clin Epidemiol, 2019; 105: 68-79. :
  • Brühmann BA, Reese C, Kaier K, Ott M, Maurer C, Kunert S, Saurer BR, Farin E: A complex health services intervention to improve medical care in long-term care homes: study protocol of the controlled coordinated medical care (CoCare) study. Bmc Health Serv Res, 2019; 19 (online): 332. :
  • Chaabane S, Harfouche M, Chemaitelly H, Schwarzer G, Abu-Raddad LJ: Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions. Sci Rep-uk, 2019; 9 (online): 1136. :
  • Dammann P, Wittek P, Darkwah Oppong M, Hütter BO, Jabbarli R, Wrede K, Wanke I, Mönninghoff C, Kaier K, Frank B, Müller O, Kleinschnitz C, Forsting M, Sure U: Relative health-related quality of life after treatment of unruptured intracranial aneurysms: long-term outcomes and influencing factors. Ther Adv Neurol Diso, 2019; 12 (online). :
  • Darkwah Oppong M, Gembruch O, Pierscianek D, Köhrmann M, Kleinschnitz C, Deuschl C, Mönninghoff C, Kaier K, Forsting M, Sure U, Jabbarli R: Post-treatment Antiplatelet Therapy Reduces Risk for Delayed Cerebral Ischemia due to Aneurysmal Subarachnoid Hemorrhage. Neurosurgery, 2019; 85: 827-833. :
  • Dittrich S, Graf E, Trollmann R, Neudorf U, Schara U, Heilmann A, von der Hagen M, Stiller B, Kirschner J, Pozza RD, Müller-Felber W, Weiss K, von Au K, Khalil M, Motz R, Korenke C, Lange M, Wilichowski E, Pattathu J, Ebinger F, Wiechmann N, Schröder R, German Competence Network for Congenital Heart Defects, the Treat-NMD Neuromuscular Network Investigators list of additional local Investigators, co-workers of the German Competence Network for Congenital Heart Defects and the Treat-NMD Neuromuscular Network.: Effect and safety of treatment with ACEinhibitor Enalapril and β-blocker metoprolol on the onset of left ventricular dysfunction in Duchenne muscular dystrophy - a randomized, double-blind, placebocontrolled trial. Orphanet J Rare Dis, 2019; 14 (online): 105. :
  • Doerken S, Avalos M, Lagarde E, Schumacher M: Penalized logistic regression with low prevalence exposures beyond high dimensional settings. Plos One, 2019; 14 (online): e0217057. :
  • Eckert M, Vach W: Constructing treatment selection rules based on an estimated treatment effect function: different approaches to take stochastic uncertainty into account have a substantial effect on performance. Bmc Med Res Methodol, 2019; 19 (online): 168. :
  • Efthimiou O, Mavridis D, Nikolakopoulou A, Rücker G, Trelle S, Egger M, Salanti G: A model for meta-analysis ofcorrelated binary outcomes:The case of split-body interventions. Stat Methods Med Res, 2019; 28: 1998-2014. :
  • Efthimiou O, Rücker G, Schwarzer G, Higgins JPT, Egger M, Salanti G: Network meta-analysis of rare events using the Mantel-Haenszel method. Stat Med, 2019; 38: 2992-3012. :
  • Essi R, Spraul M, Vach K, Hahn P: Influence of delayed light curing on the cuspal deflection and microleakage of a dual-cured composite resin in Class 2 restorations. Quintessence Int, 2019; 50: 94-102. :
  • Fecker J, Schumacher M, Ohneberg K, Wolkewitz M: Correction of Survival Bias in a Study About Increased Mortality of Heads of Government. Am Stat, 2019 (online): 1537-2731. :
  • Gomila A, Carratalà J, Eliakim-Raz N, Shaw E, Tebé C, Wolkewitz M, Wiegand I, Grier S, Vank C, Cuperus N, Van den Heuvel L, Vuong C, MacGowan A, Leibovici L, Addy I, Pujol M, & on behalf of RESCUING Study Group, Study Sites: Clinical outcomes of hospitalised patients with catheter-associated urinary tract infection in countries with a high rate of multidrug-resistance: the COMBACTE-MAGNET RESCUING study. Antimicrob Resist in, 2019; 8 (online): 198. :
  • Gonzalez AI, Schmucker C, Nothacker J, Motschall E, Nguyen TS, Brueckle MS, Blom J, van den Akker M, Rottger K, Wegwarth O, Hoffmann T, Straus SE, Gerlach FM, Meerpohl JJ, Muth C: Health-related preferences of older patients with multimorbidity: an evidence map. Bmj Open, 2019; 9 (12) (online): e034485-e034485. :
  • Graetz C, Gröger A, Luessi F, Salmen A, Zöller D, Schultz J, Siller N, Fleischer V, Bellenberg B, Berthele A, Biberacher V, Havla J, Hecker M, Hohlfeld R, Infante-Duarte C, Kirschke JS, Kümpfel T, Linker R, Paul F, Pfeuffer S, Sämann P, Toenges G, Weber F, Zettl UK, Jahn-Eimermacher A, Antony G, Groppa S, Wiendl H, Hemmer B, Mühlau M, Lukas C, Gold R, Lill CM, Zipp F: Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis. Mult Scler J, 2019; 25: 661-668. :
  • Groß V, Lücke C, Graf E, Lam AP, Matthies S, Borel P, Sobanski E, Rösler M, Retz W, Jacob C, Colla M, Huss M, Jans T, Kis B, Abdel-Hamid M, van Elst LT, Philipsen A, Comparison of Methylphenidate, Psychotherapy in Adult ADHD Study (COMPAS) Consortium: Effectiveness of Psychotherapy in Adult ADHD: What Do Patients Think? Results of the COMPAS Study. J Atten Disord, 2019; 23: 1047-1058. :
  • Hagel S, Ludewig K, Pletz MW, Frosinski J, Moeser A, Wolkewitz M, Gastmeier P, Harbarth S, Brunkhorst FM, Kesselmeier M, Scherag A: Effectiveness of a hospital-wide infection control programme on the incidence of healthcare-associated infections and associated severe sepsis and septic shock: a prospective interventional study. Clin Microbiol Infec, 2019; 25: 462-468. :
  • Heister T, Wolkewitz M, Hehn P, Wolff J, Dettenkofer M, Grundmann H, Kaier K: Costs of hospital-acquired Clostridium difficile infections: an analysis on the effect of time-dependent exposures using routine and surveillance data. Cost Effectiveness and Resource Allocation, 2019; 17: 16. :
  • Hertenstein E, Feige B, Gmeiner T, Kienzler C, Spiegelhalder K, Johann A, Jansson-Fröjmark M, Palagini L, Rücker G, Riemann D, Baglioni C: Insomnia as a predictor of mental disorders: A systematic review and meta-analysis. Sleep Med Rev, 2019; 43: 96-105. :
  • Jabbarli R, Dinger TF, Pierscianek D, Oppong MD, Chen B, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Sure U: Intracranial aneurysms in sickle cell disease: A systematic review and case-control study. Curr Neurovasc Res, 2019; 16: 63-76. :
  • Jabbarli R, Pierscianek D, Darkwah Oppong M, Sato T, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Roos A, Sure U: Laboratory biomarkers of delayed cerebral ischemia after subarachnoid hemorrhage: a systematic review. Neurosurg Rev, 2019 (online). :
  • Jabbarli R, Pierscianek D, Rölz R, Darkwah Oppong M, Kaier K, Shah M, Taschner C, Mönninghoff C, Urbach H, Beck J, Sure U, Forsting M: Endovascular treatment of cerebral vasospasm after subarachnoid hemorrhage: More is more. Neurology, 2019; 93 (online): e1-e9. :
  • Jaite C, van Noort BM, Vloet TD, Graf E, Kappel V, Geissler J, Warnke A, Jacob C, Groß-Lesch S, Hennighausen K, Haack-Dees B, Schneider-Momm K, Philipsen A, Matthies S, Rösler M, Retz W, Hänig S, von Gontard A, Sobanski E, Alm B, Hohmann S, Häge A, Poustka L, Colla M, Gentschow L, Freitag CM, Becker K, Jans T: A multicentre randomized controlled trial on trans-generational attention deficit/hyperactivity disorder (ADHD) in mothers and children (AIMAC): an exploratory analysis of predictors and moderators of treatment outcome. Z Kinder Jug-psych, 2019; 47: 49-65. :
  • Jilg CA, Drendel V, Rischke HC, Beck TI, Reichel K, Kronig M, Wetterauer U, Schultze-Seemann W, Meyer PT, Vach W: Detection Rate of (18)F-Choline PET/CT and (68)Ga-PSMA-HBED-CC PET/CT for Prostate Cancer Lymph Node Metastases with Direct Link from PET to Histopathology: Dependence on the Size of Tumor Deposits in Lymph Nodes. J Nucl Med, 2019; 60 (7): 971-977. :
  • Kaier K, Heister T, Götting T, Wolkewitz M, Mutters NT: Measuring the in-hospital costs of Pseudomonas aeruginosa pneumonia: methodology and results from a German teaching hospital. Bmc Infect Dis, 2019; 19 (online): 1028. :
  • Kaier K, Heister T, Motschall E, Hehn P, Bluhmki T, Wolkewitz M: Impact of mechanical ventilation on the daily costs of ICU care: a systematic review and meta regression. Epidemiol Infect, 2019; 147 (online): e314. :
  • Kaier K, von Zur Mühlen C, Zirlik A, Bothe W, Hehn P, Zehender M, Bode C, Stachon P: Estimating the additional costs per life saved due to transcatheter aortic valve replacement: a secondary data analysis of electronic health records in Germany. Eur J Health Econ, 2019; 20: 625-632. :
  • Kaier K, Wolkewitz M, Hehn P, Mutters NT, Heister T: The impact of hospital-acquired infections on the patient-level reimbursement-cost relationship in a DRG-based hospital payment system. Int J Health Econ Ma, 2019. : (in Druck)
  • Khadr L, Harfouche M, Omori R, Schwarzer G, Chemaitelly H, Abu-Raddad LJ: The Epidemiology of Herpes Simplex Virus Type 1 in Asia: Systematic Review, Meta-analyses, and Meta-regressions. Clin Infect Dis, 2019; 68: 757-772. :
  • Lam AP, Matthies S, Graf E, Colla M, Jacob C, Sobanski E, Alm B, Rösler M, Retz W, Retz-Junginger P, Kis B, Abdel-Hamid M, Müller HHO, Lücke C, Huss M, Jans T, Berger M, van Elst LT, Philipsen A, for the Comparison of Methylphenidate, Psychotherapy in Adult ADHD Study (COMPAS) Consortium: Long-term Effects of Multimodal Treatment on Adult Attention-Deficit/Hyperactivity Disorder Symptoms. Follow-up Analysis of the COMPAS Trial JAMA Netw Open, 2019; 2: e194980. :
  • Mockenhaupt M, Wang CW, Hung SI, Sekula P, Schmidt AH, Pan RY, Chen CB, Dunant A, Gouvello SL, Schumacher M, Valeyrie-Allanore L, Bellon T, Kardaun SH, Jan YS, Chung WH, Roujeau JC, RegiSCAR group: HLA-B*57:01 confers genetic susceptibility to carbamazepine-induced SJS/TEN in Europeans. Allergy, 2019; 74: 2227-2230. :
  • Ohneberg K, Beyersmann J, Schumacher M: Exposure density sampling: Dynamic matching with respect to a time-dependent exposure. Stat Med, 2019; 38: 4390-4403. :
  • Olivier M, Boeker M, Hanser S, Hehn P, Kaier K: Der Pflegekomplexmaßnahmen-Score: Paradigmenwechsel im G-DRG System oder Tropfen auf den heißen Stein? Eine Sekundäranalyse auf Basis von Abrechnungsdaten. Gesundheitsökonomie & Qualitätsmanagement, 2019; 24: 191-196. :
  • Peikert A, Kaier K, Merz J, Manhart L, Schäfer I, Hilgendorf I, Hehn P, Wolf D, Willecke F, Sheng X, Clemens A, Zehender M, von Zur Mühlen C, Bode C, Zirlik A, Stachon P: Residual inflammatory risk in coronary heart disease: incidence of elevated high-sensitive CRP in a real-world cohort. Clin Res Cardiol, 2019 (online). :
  • Prasse A, Binder H, Schupp JC, Kayser G, Bargagli E, Jaeger B, Hess M, Rittinghausen S, Vuga L, Lynn H, Violette S, Jung B, Quast K, Vanaudenaerde B, Xu Y, Hohlfeld JM, Krug N, Herazo-Maya JD, Rottoli P, Wuyts WA, Kaminski N: BAL Cell Gene Expression is Indicative of Outcome and Airway Basal Cell Involvement in IPF. Am J Resp Crit Care, 2019; 199: 622-630. :
  • Rieg S, von Cube M, Kaasch A, Bonaventura B, Bothe W, Wolkewitz M, Peyerl-Hoffmann G, Deppe AC, Wahlers T, Beyersdorf F, Seifert H, Kern WV: Investigating the impact of early valve surgery on survival in Staphylococcus aureus infective endocarditis using a marginal structural model approach - results of a large prospectively evaluated cohort. Clin Infect Dis, 2019; 69: 487-494. :
  • Ritter A, Hirschfeld M, Berner K, Rücker G, Jäger M, Weiss D, Medl M, Nöthling C, Gassner S, Asberger J, Erbes T: Circulating non‑coding RNA‑biomarker potential in neoadjuvant chemotherapy of triple negative breast cancer? Int J Oncol, 2019 (online): 47-68. :
  • Rücker G, Petropoulou M, Schwarzer G: Network meta-analysis of multicomponent interventions. Biometrical J, 2019. : (in Druck)
  • Schubert I, Siegel A, Graf E, Farin-Glattacker E, Ihle P, Köster I, Stelzer D, Mehl C, Schmitz J, Dröge P, Günster C, Klöss A, Vach W, Geraedts M: Study protocol for a quasi-experimental claims-based study evaluating 10-year results of the population-based integrated healthcare model ‘Gesundes Kinzigtal’ (Healthy Kinzigtal): the INTEGRAL study. Bmj Open, 2019; 9: e025945. :
  • Schumacher M, Hieke S, Ihorst G, Engelhardt M: Dynamic prediction: A challenge for biostatisticians, but greatly needed by patients, physicians and the public. Biometrical J, 2019. : (in Druck)
  • Schwingshackl L, Krause M, Schmucker C, Hoffmann G, Rücker G, Meerpohl JJ: Impact of different types of olive oil on cardiovascular risk factors: A systematic review and network meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases, 2019; 29: 1030-1039. :
  • Spies BC, Balmer M, Jung RE, Sailer I, Vach K, Kohal RJ: All-ceramic single crowns supported by zirconia implants: 5-year results of a prospective multicenter study. Clin Oral Implan Res, 2019; 30: 466-475. :
  • Sprinzl MF, Kirstein MM, Koch S, Seib M-L, Weinmann-Menke J, Lang H, Düber C, Toenges G, Zöller D, Marquardt JU, Wörns M-A, Galle PR, Vogel A, Pinter M, Weinmann A: Improved Prediction of Survival by a Risk Factor-Integrating Inflammatory Score in Sorafenib-Treated Hepatocellular Carcinoma. Liver Cancer, 2019 (online). :
  • Stachon P, Kaier K, Heidt T, Bothe W, Zirlik A, Zehender M, Bode C, von Zur Mühlen C: Nationwide outcomes of aortic valve replacement for pure aortic regurgitation in Germany 2008-2015. Catheter Cardio Inte, 2019. : (in Druck)
  • Stachon P, Kaier K, Zirlik A, Bothe W, Heidt T, Zehender M, Bode C, von Zur Mühlen C: Risk-Adjusted Comparison of In-Hospital Outcomes of Transcatheter and Surgical Aortic Valve Replacement. J Am Heart Assoc, 2019; 8 (online): e011504. :
  • Stelzer A-S, Maccioni L, Gerhold-Ay A, Smedby KE, Schumacher M, Nieters A, Binder H: A multivariable approach for riskmarkers from pooled molecular data withonly partial overlap. Bmc Med Genet, 2019; 20 (online): 128. :
  • Tacconelli E, Sifakis F, Harbarth S, Schrijver R, van Mourik M, Voss A, Sharland M, Rajendran NB, Rodriguez-Bano, Wolkewitz M, J Group Author(s): EPI-Net COMBACTE-MAGNET. Surveillance for control of antimicrobial resistance. Lancet Infect Dis, 2019; 18 (online): E99-E106. :
  • Tibubos AN, Ernst M, Brähler E, Fischbeck S, Hinz A, Blettner M, Zeissig SR, Weyer V, Imruck BH, Binder H, Beutel ME: Fatigue in survivors of malignant melanoma and its determinants: a register-based cohort study. Support Care Cancer, 2019; 27: 2809-2818. :
  • Voigt-Radloff S, Schöpf AC, Boeker M, Frank L, Farin E, Kaier K, Körner M, Wollmann K, Lang B, Meerpohl JJ, Möhler R, Niebling W, Serong J, Lange R, van der Keylen P, Maun A: Well informed physician-patient communication in consultations on back pain - study protocol of the cluster randomized GAP trial. Bmc Fam Pract, 2019; 20 (online): 33. :
  • von Cube M, Schumacher M, Bailly S, Timsit JF, Lepape A, Savey A, Machut A, Wolkewitz M: The population-attributable fraction for time-dependent exposures and competing risks-A discussion on estimands. Stat Med, 2019; 38: 3880-3895. :
  • von Cube M, Schumacher M, Putter H, Timsit JF, van de Velde C, Wolkewitz M: The population-attributable fraction for time-dependent exposures using dynamic prediction and landmarking. Biometrical J, 2019. : (in Druck)
  • von Cube M, Schumacher M, Wolkewitz M: Causal inference with multistate models—estimands and estimators of the population attributable fraction. J R Stat Soc A Stat, 2019. : (in Druck)
  • Wengenmayer T, Duerschmied D, Graf E, Chiabudini M, Benk C, Mühlschlegel S, Philipp A, Lubnow M, Bode C, Staudacher DL: Development and validation of a prognostic model for survival in patients treated with venoarterial extracorporeal membrane oxygenation: the PREDICT VA-ECMO score. European Heart Journal: Acute Cardiovascular Care, 2019; 8: 350-359. :
  • Woelber JP, Gärtner M, Breuninger L, Anderson A, König D, Hellwig E, Al-Ahmad A, Vach K, Dötsch A, Ratka-Krüger P, Tennert C: The influence of an anti-inflammatory diet on gingivitis. A randomized controlled trial. J Clin Periodontol, 2019; 46: 481-490. :
  • Wolkewitz M, Palomar-Martinez M, Alvarez-Lerma F, Olaechea-Astigarraga P, Schumacher M: Analyzing the impact of duration of ventilation, hospitalization, and ventilation episodes on the risk of pneumonia. Infect Cont Hosp Ep, 2019; 40: 301-306. :
  • Wolkewitz M, Schumacher M, Rücker G, Harbarth S, Beyersmann J: Estimands to quantify prolonged hospital stay associated with nosocomial infections. Bmc Med Res Methodol, 2019; 19 (online): 111. :
Kurzbeiträge / short communications:
  • Kaier K, Mutters NT, Wolkewitz M: Measuring the financial burden of resistance: What should be compared? Clin Infect Dis, 2019; 69: 1082. :
  • Ohneberg K, Wolkewitz M, Schumacher M: RE: "Risk Set Matching to Assess the Impact of Hospital-Acquired Bloodstream Infections." Am J Epidemiol, 2019; 188: 1192-1193. :
  • von Cube MK, Schumacher M, Wolkewitz M: Follow-on rifaximin for the prevention of recurrence following standard treatment of infection with Clostridium difficile: a competing risks analysis provides a full picture of possible treatment effects. Gut, 2019. : (in Druck)
Sonstige Publikationen:
  • Blümle A, Sow D, Nothacker M, Schaefer C, Motschall E, Boeker M, Lang B, Kopp I, Meerpohl JJ: Manual systematische Recherche für Evidenzsynthesen und Leitlinien. Version 2.0 vom 01.04.2019 2019. :

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