Research Report for the year 2019

Scientific publications

Journal Articles:
  • Adebahr S, Hechtner M, Schräder N, Schimek-Jasch T, Kaier K, Rohr VD, Gkika E, Momm F, Gärtner J, Becker G, Grosu AL, Nestle U: Early impact of pulmonary stereotactic fractionated body radiotherapy (SBRT) on Quality of Life (QoL): Benefit for patients with low initial scores (STRIPE trial). J Thorac Oncol, 2019; 14: 708-419. : https://doi.org/10.1016/j.jtho.2018.10.170
  • Al Said S, Alabed S, Kaier K, Bode C, Meerpohl JJ, Duerschmied D: Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis. Cochrane Db Syst Rev, 2019 ( 1) (online): CD013252. : https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013252
  • Bayrhuber M, Tinsel I, Goldacker S, Farin E, Warnatz K, Nieters A: Entwicklung einer Schulung zur Förderung der Gesundheitskompetenz von Patienten mit variablem Immundefekt (CVID) Gesundheitswesen, 2019. (in Druck)
  • Bayrhuber M, Tinsel I, Goldacker S, Kindle G, Warnatz K, Farin E, Nieters A: Perceived health of patients with common variable immunodeficiency – a cluster analysis Clin Exp Immunol, 2019; 196: 76-85. : http://dx.doi.org/10.1111/cei.13252
  • Borde JP, Kaier K, Hehn P, Böhmer MM, Kreusch TM, Dobler G: Tick-borne encephalitis virus infections in Germany. Seasonality and in-year patterns. A retrospective analysis from 2001-2018. Plos One, 2019; 14 (online): e0224044. : https://doi.org/10.1371/journal.pone.0224044
  • Brühmann B, Reese C, Kaier K, Ott M, Maurer C, Kunert S, Saurer B, Farin E: A complex health services intervention to improve medical care in long-term care homes: study protocol of the controlled coordinated medical care (CoCare) study Bmc Health Serv Res, 2019 (online). : https://doi.org/10.1186/s12913-019-4156-4
  • Brühmann BA, Reese C, Kaier K, Ott M, Maurer C, Kunert S, Saurer BR, Farin E: A complex health services intervention to improve medical care in long-term care homes: study protocol of the controlled coordinated medical care (CoCare) study. Bmc Health Serv Res, 2019; 19 (online): 332. : https://doi.org/10.1186/s12913-019-4156-4
  • Dammann P, Wittek P, Darkwah Oppong M, Hütter BO, Jabbarli R, Wrede K, Wanke I, Mönninghoff C, Kaier K, Frank B, Müller O, Kleinschnitz C, Forsting M, Sure U: Relative health-related quality of life after treatment of unruptured intracranial aneurysms: long-term outcomes and influencing factors. Ther Adv Neurol Diso, 2019; 12 (online). : https://doi.org/10.1177/1756286419833492
  • Darkwah Oppong M, Gembruch O, Pierscianek D, Köhrmann M, Kleinschnitz C, Deuschl C, Mönninghoff C, Kaier K, Forsting M, Sure U, Jabbarli R: Post-treatment Antiplatelet Therapy Reduces Risk for Delayed Cerebral Ischemia due to Aneurysmal Subarachnoid Hemorrhage. Neurosurgery, 2019; 85: 827-833. : https://doi.org/10.1093/neuros/nyy550
  • Dittrich S, Graf E, Trollmann R, Neudorf U, Schara U, Heilmann A, von der Hagen M, Stiller B, Kirschner J, Pozza RD, Müller-Felber W, Weiss K, von Au K, Khalil M, Motz R, Korenke C, Lange M, Wilichowski E, Pattathu J, Ebinger F, Wiechmann N, Schröder R, German Competence Network for Congenital Heart Defects, the Treat-NMD Neuromuscular Network Investigators list of additional local Investigators, co-workers of the German Competence Network for Congenital Heart Defects and the Treat-NMD Neuromuscular Network.: Effect and safety of treatment with ACEinhibitor Enalapril and β-blocker metoprolol on the onset of left ventricular dysfunction in Duchenne muscular dystrophy - a randomized, double-blind, placebocontrolled trial. Orphanet J Rare Dis, 2019; 14 (online): 105. : https://doi.org/10.1186/s13023-019-1066-9
  • El-Helou SM, Biegner AK, Bode S, Ehl SR, Heeg M, Maccari ME, Ritterbusch H, Speckmann C, Rusch S, Scheible R, Warnatz K, Atschekzei F, Beider R, Ernst D, Gerschmann S, Jablonka A, Mielke G, Schmidt RE, Schurmann G, Sogkas G, Baumann UH, Klemann C, Viemann D, von Bernuth H, Kruger R, Hanitsch LG, Scheibenbogen CM, Wittke K, Albert MH, Eichinger A, Hauck F, Klein C, Rack-Hoch A, Sollinger FM, Avila A, Borte M, Borte S, Fasshauer M, Hauenherm A, Kellner N, Muller AH, Ulzen A, Bader P, Bakhtiar S, Lee JY, Hess U, Schubert R, Wolke S, Zielen S, Ghosh S, Laws HJ, Neubert J, Oommen PT, Honig M, Schulz A, Steinmann S, Schwarz K, Duckers G, Lamers B, Langemeyer V, Niehues T, Shai S, Graf D, Muglich C, Schmalzing MT, Schwaneck EC, Tony HP, Dirks J, Haase G, Liese JG, Morbach H, Foell D, Hellige A, Wittkowski H, Masjosthusmann K, Mohr M, Geberzahn L, Hedrich CM, Muller C, Rosen-Wolff A, Roesler J, Zimmermann A, Behrends U, Rieber N, Schauer U, Handgretinger R, Holzer U, Henes J, Kanz L, Boesecke C, Rockstroh JK, Schwarze-Zander C, Wasmuth JC, Dilloo D, Hulsmann B, Schonberger S, Schreiber S, Zeuner R, Ankermann T, von Bismarck P, Huppertz HI, Kaiser-Labusch P, Greil J, Jakoby D, Kulozik AE, Metzler M, Naumann-Bartsch N, Sobik B, Graf N, Heine S, Kobbe R, Lehmberg K, Muller I, Herrmann F, Horneff G, Klein A, Peitz J, Schmidt N, Bielack S, Gross-Wieltsch U, Classen CF, Klasen J, Deutz P, Kamitz D, Lassay L, Tenbrock K, Wagner N, Bernbeck B, Brummel B, Lara-Villacanas E, Munstermann E, Schneider DT, Tietsch N, Westkemper M, Weiss M, Kramm C, Kuhnle I, Kullmann S, Girschick H, Specker C, Vinnemeier-Laubenthal E, Haenicke H, Schulz C, Schweigerer L, Muller TG, Stiefel M, Belohradsky BH, Soetedjo V, Kindle G, Grimbacher B: The German National Registry of Primary Immunodeficiencies (2012-2017). Front Immunol, 2019; 10 (online): 1272-1272. : http://dx.doi.org/10.3389/fimmu.2019.01272
  • Essi R, Spraul M, Vach K, Hahn P: Influence of delayed light curing on the cuspal deflection and microleakage of a dual-cured composite resin in Class 2 restorations. Quintessence Int, 2019; 50: 94-102. : https://doi.org/10.3290/j.qi.a41706
  • Farin E, Heyduck K, Frye B C, Birring S S, Müller-Quernheim J, Schupp J C: Translation and psychometric properties of the King's Sarcoidosis Questionnaire (KSQ) in German language Health Qual Life Out, 2019. (in Druck)
  • Fecker J, Schumacher M, Ohneberg K, Wolkewitz M: Correction of Survival Bias in a Study About Increased Mortality of Heads of Government. Am Stat, 2019 (online): 1537-2731. : https://doi.org/10.1080/00031305.2019.1638831
  • Frank F, Bjeergaard F, Bengel J, Bitzer EM, Heimbach B, Kaier K, Kiekert J, Krämer L, Kricheldorff C, Laubner K, Maun A, Metzner G, Niebling W, Salm C, Schütter S, Seufert J, Farin E, Voigt-Radloff S: Local, collaborative, stepped and personalised care management for older people with chronic diseases (LoChro): study protocol of a randomised comparative effectiveness trial Bmc Geriatr, 2019. : http://doi.org/10.1186/s12877-019-1088-0 (in Druck)
  • Frank F, Bjerregaard F, Bengel J, Bitzer EM, Heimbach B, Kaier K, Kiekert J, Krämer L, Kricheldorff C, Laubner K, Maun A, Metzner G, Niebling W, Salm C, Schütter S, Seufert J, Farin E, Voigt-Radloff S: Local, collaborative, stepped and personalised care management for older people with chronic diseases (LoChro): study protocol of a randomised comparative effectiveness trial. Bmc Geriatr, 2019; 19 (online): 64. : https://doi.org/10.1186/s12877-019-1088-0
  • Gerke O, Ehlers K, Motschall E, Hoilund-Carlsen PF, Vach W: PET/CT-Based Response Evaluation in Cancer-a Systematic Review of Design Issues. Mol Imaging Biol, 2019 (online). : http://dx.doi.org/10.1007/s11307-019-01351-4
  • Geschke K, Weyer-Elberich V2, Mueller AK, Binder H, Fellgiebel A: Feasibility and utility of a cognitive screening for risk stratification in hospitalized older patients. Int J Geriatr Psych, 2019; 34: 588-593. : https://doi.org/10.1002/gps.5056
  • Giesler JM, Klindtworth K, Nebe A, Glattacker M: Medizinische Rehabilitation bei MS: Barrieren und Facilitatoren der Inanspruchnahme aus Patientensicht Rehabilitation, 2019. (in Druck)
  • Gonzalez AI, Schmucker C, Nothacker J, Motschall E, Nguyen TS, Brueckle MS, Blom J, van den Akker M, Rottger K, Wegwarth O, Hoffmann T, Straus SE, Gerlach FM, Meerpohl JJ, Muth C: Health-related preferences of older patients with multimorbidity: an evidence map. Bmj Open, 2019; 9 (12) (online): e034485-e034485. : http://dx.doi.org/10.1136/bmjopen-2019-034485
  • Hagel S, Ludewig K, Pletz MW, Frosinski J, Moeser A, Wolkewitz M, Gastmeier P, Harbarth S, Brunkhorst FM, Kesselmeier M, Scherag A: Effectiveness of a hospital-wide infection control programme on the incidence of healthcare-associated infections and associated severe sepsis and septic shock: a prospective interventional study. Clin Microbiol Infec, 2019; 25: 462-468. : https://doi.org/10.1016/j.cmi.2018.07.010
  • Hasselblatt H, Andrae J, Tassoni A, Fitzer K, Bahls T, Prokosch HU, Boeker M: Establishing an Interoperable Clinical Trial Information System Within MIRACUM. Stud Health Technol Inform, 2019; 258: 216-220.
  • Heister T, Wolkewitz M, Hehn P, Wolff J, Dettenkofer M, Grundmann H, Kaier K: Costs of hospital-acquired Clostridium difficile infections: an analysis on the effect of time-dependent exposures using routine and surveillance data. Cost Effectiveness and Resource Allocation, 2019; 17: 16. : https://doi.org/10.1186/s12962-019-0184-5
  • Hertenstein E, Feige B, Gmeiner T, Kienzler C, Spiegelhalder K, Johann A, Jansson-Fröjmark M, Palagini L, Rücker G, Riemann D, Baglioni C: Insomnia as a predictor of mental disorders: A systematic review and meta-analysis. Sleep Med Rev, 2019; 43: 96-105. : https://doi.org/10.1016/j.smrv.2018.10.006
  • Jabbarli R, Dinger TF, Pierscianek D, Oppong MD, Chen B, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Sure U: Intracranial aneurysms in sickle cell disease: A systematic review and case-control study. Curr Neurovasc Res, 2019; 16: 63-76. : https://doi.org/10.2174/1567202616666190131160847
  • Jabbarli R, Pierscianek D, Darkwah Oppong M, Sato T, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Roos A, Sure U: Laboratory biomarkers of delayed cerebral ischemia after subarachnoid hemorrhage: a systematic review. Neurosurg Rev, 2019 (online). : https://doi.org/10.1007/s10143-018-1037-y
  • Jabbarli R, Pierscianek D, Rölz R, Darkwah Oppong M, Kaier K, Shah M, Taschner C, Mönninghoff C, Urbach H, Beck J, Sure U, Forsting M: Endovascular treatment of cerebral vasospasm after subarachnoid hemorrhage: More is more. Neurology, 2019; 93 (online): e1-e9. : https://doi.org/10.1212/WNL.0000000000007862
  • Jaite C, van Noort BM, Vloet TD, Graf E, Kappel V, Geissler J, Warnke A, Jacob C, Groß-Lesch S, Hennighausen K, Haack-Dees B, Schneider-Momm K, Philipsen A, Matthies S, Rösler M, Retz W, Hänig S, von Gontard A, Sobanski E, Alm B, Hohmann S, Häge A, Poustka L, Colla M, Gentschow L, Freitag CM, Becker K, Jans T: A multicentre randomized controlled trial on trans-generational attention deficit/hyperactivity disorder (ADHD) in mothers and children (AIMAC): an exploratory analysis of predictors and moderators of treatment outcome. Z Kinder Jug-psych, 2019; 47: 49-65. : https://doi.org/10.1024/1422-4917/a000602
  • Jilg CA, Drendel V, Rischke HC, Beck TI, Reichel K, Kronig M, Wetterauer U, Schultze-Seemann W, Meyer PT, Vach W: Detection Rate of (18)F-Choline PET/CT and (68)Ga-PSMA-HBED-CC PET/CT for Prostate Cancer Lymph Node Metastases with Direct Link from PET to Histopathology: Dependence on the Size of Tumor Deposits in Lymph Nodes. J Nucl Med, 2019; 60 (7): 971-977. : http://dx.doi.org/10.2967/jnumed.118.220541
  • Kaier K, Heister T, Götting T, Wolkewitz M, Mutters NT: Measuring the in-hospital costs of Pseudomonas aeruginosa pneumonia: methodology and results from a German teaching hospital. Bmc Infect Dis, 2019; 19 (online): 1028. : https://doi.org/10.1186/s12879-019-4660-5
  • Kaier K, Heister T, Motschall E, Hehn P, Bluhmki T, Wolkewitz M: Impact of mechanical ventilation on the daily costs of ICU care: a systematic review and meta regression. Epidemiol Infect, 2019; 147 (online): e314. : https://doi.org/10.1017/S0950268819001900
  • Kaier K, von Zur Mühlen C, Zirlik A, Bothe W, Hehn P, Zehender M, Bode C, Stachon P: Estimating the additional costs per life saved due to transcatheter aortic valve replacement: a secondary data analysis of electronic health records in Germany. Eur J Health Econ, 2019; 20: 625-632. : https://doi.org/10.1007/s10198-018-1023-x
  • Kaier K, Wolkewitz M, Hehn P, Mutters NT, Heister T: The impact of hospital-acquired infections on the patient-level reimbursement-cost relationship in a DRG-based hospital payment system. Int J Health Econ Ma, 2019. : https://doi.org/10.1007/s10754-019-09267-w (in Druck)
  • Kitzmann J, Ratka-Krueger P, Vach K, Woelber JP: The impact of motivational interviewing on communication of patients undergoing periodontal therapy. J Clin Periodontol, 2019; 46: 40-750. : https://doi.org/10.1111/jcpe.13132
  • Kruse AB, Akakpo DL, Maamar R, Woelber JP, Al-Ahmad A, Vach K, Ratka-Krueger P: Trehalose powder for subgingival air-polishing during periodontal maintenance therapy: A randomized controlled trial. J Periodontol, 2019; 90: 263-270. : https://doi.org/10.1002/JPER.17-0403
  • Ohneberg K, Beyersmann J, Schumacher M: Exposure density sampling: Dynamic matching with respect to a time-dependent exposure. Stat Med, 2019; 38: 4390-4403. : https://doi.org/10.1002/sim.8305
  • Olivier M, Boeker M, Hanser S, Hehn P, Kaier K: Der Pflegekomplexmaßnahmen-Score: Paradigmenwechsel im G-DRG System oder Tropfen auf den heißen Stein? Eine Sekundäranalyse auf Basis von Abrechnungsdaten. Gesundheitsökonomie & Qualitätsmanagement, 2019; 24: 191-196. : http://dx.doi.org/10.1055/a-0659-1706
  • Peikert A, Kaier K, Merz J, Manhart L, Schäfer I, Hilgendorf I, Hehn P, Wolf D, Willecke F, Sheng X, Clemens A, Zehender M, von Zur Mühlen C, Bode C, Zirlik A, Stachon P: Residual inflammatory risk in coronary heart disease: incidence of elevated high-sensitive CRP in a real-world cohort. Clin Res Cardiol, 2019 (online). : https://doi.org/10.1007/s00392-019-01511-0
  • Peikert S, Spurzem W, Vach K, Frisch E, Ratka-Krüger P, Woelber JP: Association of non-surgical periodontal therapy on patients' oral health related quality-of-life - a multi-center cohort study. J Clin Periodontol, 2019; 46: 529-538. : https://doi.org/10.1111/jcpe.13093
  • Prasse A, Binder H, Schupp JC, Kayser G, Bargagli E, Jaeger B, Hess M, Rittinghausen S, Vuga L, Lynn H, Violette S, Jung B, Quast K, Vanaudenaerde B, Xu Y, Hohlfeld JM, Krug N, Herazo-Maya JD, Rottoli P, Wuyts WA, Kaminski N: BAL Cell Gene Expression is Indicative of Outcome and Airway Basal Cell Involvement in IPF. Am J Resp Crit Care, 2019; 199: 622-630. : https://doi.org/10.1164/rccm.201712-2551OC
  • Proksch S, Kirsch K, Vach K, Hellwig E, Tomakidi P: Comparative differentiation analysis of distinct oral tissue-derived cells in response to osteogenic stimulation. Clin Oral Invest, 2019; 23: 1077-1089. : https://doi.org/10.1007/s00784-018-2529-4
  • Ritter A, Hirschfeld M, Berner K, Rücker G, Jäger M, Weiss D, Medl M, Nöthling C, Gassner S, Asberger J, Erbes T: Circulating non‑coding RNA‑biomarker potential in neoadjuvant chemotherapy of triple negative breast cancer? Int J Oncol, 2019 (online): 47-68. : https://doi.org/10.3892/ijo.2019.4920
  • Spies BC, Balmer M, Jung RE, Sailer I, Vach K, Kohal RJ: All-ceramic single crowns supported by zirconia implants: 5-year results of a prospective multicenter study. Clin Oral Implan Res, 2019; 30: 466-475. : https://doi.org/10.1111/clr.13433
  • Stachon P, Kaier K, Heidt T, Bothe W, Zirlik A, Zehender M, Bode C, von Zur Mühlen C: Nationwide outcomes of aortic valve replacement for pure aortic regurgitation in Germany 2008-2015. Catheter Cardio Inte, 2019. : https://doi.org/10.1002/ccd.28361 (in Druck)
  • Stachon P, Kaier K, Zirlik A, Bothe W, Heidt T, Zehender M, Bode C, von Zur Mühlen C: Risk-Adjusted Comparison of In-Hospital Outcomes of Transcatheter and Surgical Aortic Valve Replacement. J Am Heart Assoc, 2019; 8 (online): e011504. : https://doi.org/10.1161/JAHA.118.011504
  • Voigt-Radloff S, Schöpf AC, Boeker M, Frank L, Farin E, Kaier K, Körner M, Wollmann K, Lang B, Meerpohl JJ, Möhler R, Niebling W, Serong J, Lange R, van der Keylen P, Maun A: Well informed physician-patient communication in consultations on back pain - study protocol of the cluster randomized GAP trial. Bmc Fam Pract, 2019; 20 (online): 33. : https://doi.org/10.1186/s12875-019-0925-8
  • Voigt-Radloff S, Schöpf AC, Boeker M, Frank L, Farin E, Kaier K, Körner M, Wollmann K, Lang B, Meerpohl JJ, Möhler R, Niebling W, Serong J, Lange R, van der Keylen P, Maun A: Well informed physician-patient communication in consultations on back pain – study protocol of the cluster randomized GAP trial Bmc Fam Pract, 2019. : http://doi.org/10.1186/s12875-019-0925-8 (in Druck)
  • Weis J, Gschwendtner K, Giesler JM, Adams L, Wirtz MA: Psychoeducational group intervention for breast cancer survivors. A non-randomized multi-centre pilot-study Support Care Cancer, 2019. : https://doi.org/10.1007/s00520-019-05076-6 (in Druck)
  • Woelber JP, Gärtner M, Breuninger L, Anderson A, König D, Hellwig E, Al-Ahmad A, Vach K, Dötsch A, Ratka-Krüger P, Tennert C: The influence of an anti-inflammatory diet on gingivitis. A randomized controlled trial. J Clin Periodontol, 2019; 46: 481-490. : https://doi.org/10.1111/jcpe.13094
  • Zotzmann V, Rilinger J, Lang CN, Kaier K, Benk C, Duerschmied D, Biever PM, Bode C, Wengenmayer T, Staudacher DL: Epinephrine, inodilator, or no inotrope in venoarterial extracorporeal membrane oxygenation implantation: a single-center experience. Crit Care, 2019; 23 (online): 320. : https://doi.org/10.1186/s13054-019-2605-4
Book Chapters:
  • Soucek R, Pauls N, Schlett C, Moser K, Göritz A: Resilire: Erfassung und Förderung von Resilienz als individuelle und betriebliche Kompetenz In: Heyse V, Erpenbeck J, Ortmann S (Hrsg.): Kompetenzen voll entfaltet – Praxis¬berichte zum Kompetenzmanagement / Kompetenzmanagement in der Praxis, Band 12 Münster: Waxmann Verlag GmbH, 2019; 95-108.
Short Communications:
  • Kaier K, Mutters NT, Wolkewitz M: Measuring the financial burden of resistance: What should be compared? Clin Infect Dis, 2019; 69: 1082. : https://doi.org/10.1093/cid/ciz096
  • Ohneberg K, Wolkewitz M, Schumacher M: RE: "Risk Set Matching to Assess the Impact of Hospital-Acquired Bloodstream Infections." Am J Epidemiol, 2019; 188: 1192-1193. : https://doi.org/10.1093/aje/kwz035
Conference Papers:
  • Giesler JM, Klindtworth K, Nebe A, Glattacker M: Prädiktoren wahrgenommener Barrieren der Reha-Inanspruchnahme bei Patienten mit Multipler Sklerose Rehabilitation - Shaping healthcare for the future, 2019; 117: 314-316 (28. Rehabilitationswissenschaftliches Kolloquium/Berlin/Deutsche Rentenversicherung Bund), Deutsche Rentenversicherung Bund (Hrsg).
  • Maun A, Wollmann K, Serong J, Henke J, van der Keylen P, Voigt-Radloff S: Das evidenzbasierte GAP-Portal zur hausärztlichen Konsultation bei Rückenschmerz – nutzerorientierte Entwicklung und Pilotierung EbM und Digitale Transformation in der Medizin, 2019 (20. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin e.V./Berlin/Deutsches Netzwerk Evidenzbasierte Medizin e.V.).