Forschungsbericht für das Jahr 2018

Institut für Medizinische Biometrie und Statistik

Stefan-Meier-Strasse 26
79104 Freiburg
Tel: 0761 203 6662 Fax: 0761 203 6680
Email sec@imbi.uni-freiburg.de
http://www.imbi.uni-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. M. Schumacher
  • Prof. Dr. J. Schulte Mönting
  • Arthur Allignol
  • Dr. G. Antes
  • Dr. J. Beyersmann
  • Dr. H. Binder
  • Dr. Anette Blümle
  • D. Booker
  • Dipl.-Stat. Anika Buchholz
  • Dr. A. Caputo
  • Dr. J. Carpenter
  • Dr. Erik von Elm
  • Dipl.-Math. C. Gall
  • Dr. T. Gerds
  • Dipl.-Stat. A. Gerlach
  • Dr. E. Graf
  • Prof. Dr. Dieter Hauschke
  • Dr. G. Ihorst
  • Dr. B. Lang
  • Dr. Jörg Meerpohl
  • Dipl.-Stat. M. Olschewski
  • Dipl.-Stat. Christine Porzelius
  • Dipl.-Math. G. Rücker
  • PD Dr. W. Sauerbrei
  • Dr. C. Schmoor
  • Dr. Christine Schmucker
  • Dipl.-Math.Oec. R. Schoop
  • Dr. G. Schwarzer
  • Dipl.-Math. P. Sekula
  • Dipl.-Stat. S. Stampf
  • PD Dr. A. Timmer
  • Robert Wolff
  • Dr. M. Wolkewitz
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Biometrische Methodologie
  • Epidemiologische Studien
  • Klinische Studien
  • Multizentrische Therapiestudien

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Adánez MH, Brezavšček M, Vach K, Fonseca M, Att W: Clinical and Radiographic Evaluation of Short Implants Placed in the Posterior Mandible: A 1-Year Pilot Split-Mouth Study. J Oral Implantol, 2018; 44 (4): 250-259. : https://doi.org/10.1563/aaid-joi-D-18-00037
  • Balmer M, Spies BC, Vach K, Kohal RJ, Hammerle CHF, Jung RE: Three-year analysis of zirconia implants used for single-tooth replacement and three-unit fixed dental prostheses: A prospective multicenter study. Clin Oral Implan Res, 2018; 29 (3): 290-299. : http://dx.doi.org/10.1111/clr.13115
  • Becker E, Orellana Rios CL, Lahmann C, Rücker G, Bauer J, Boeker M: Anxiety as a risk factor of Alzheimer's disease and vascular dementia. Brit J Psychiat, 2018; 213 (5): 654-660. : https://doi.org/10.1192/bjp.2018.173
  • Becker K, Bluhm A, Casas-Vila N, Dinges N, Dejung M, Sayols S, Kreutz C, Roignant JY, Butter F, Legewie S: Quantifying post-transcriptional regulation in the development of Drosophila melanogaster. Nat Commun, 2018; 9 (1) (online): 4970-4970. : http://dx.doi.org/10.1038/s41467-018-07455-9
  • Bluhmki T, Allignol A, Ruckly S, Timsit JF, Wolkewitz M, Beyersmann J: Estimation of adjusted expected excess length-of-stay associated with ventilation-acquired pneumonia in intensive care: A multistate approach accounting for time-dependent mechanical ventilation. Biometrical J, 2018; 60 (6): 1135-1150. : http://dx.doi.org/10.1002/bimj.201700242
  • Bluhmki T, Schmoor C, Dobler D, Pauly M, Finke J, Schumacher M, Beyersmann J: A wild bootstrap approach for the Aalen-Johansen estimator. Biometrics, 2018; 74: 977-985. : https://doi.org/10.1111/biom.12861
  • Bollig C, Nothacker M, Lehane C, Motschall E, Lang B, Meerpohl JJ, Schmucker C: Prophylactic antibiotics before cord clamping in cesarean delivery: a systematic review. Acta Obstet Gyn Scan, 2018; 97: 521-535. : http://dx.doi.org/10.1111/aogs.13276
  • Brinster R, Köttgen A, Tayo BO, Schumacher M, Sekula P, CKDGen Consortium: Control procedures and estimators of the false discovery rate and their application in low-dimensional settings: an empirical investigation. Bmc Bioinformatics, 2018; 19 (online): 78-78. : https://doi.org/10.1186/s12859-018-2081-x
  • Byrne J, Grabow D, Campbell H, O'Brien K, Bielack S, Am Zehnhoff-Dinnesen, Calaminus G, Kremer L, Langer T, van den Heuvel-Eibrink MM, van Dulmen-den Broeder E, Baust K, Bautz A, Beck JD, Berger C, Binder H, Borgmann-Staudt A, Broer L, Cario H, Casagranda L, Clemens E, Deuster D, de Vries A, Dirksen U, Falck Winther J, Fosså S, Font-Gonzalez A, Grandage V, Haupt R, Hecker-Nolting S, Hjorth L, Kaiser M, Kenborg L, Kepak T, Kepáková K, Knudsen LE, Krawczuk-Rybak M, Kruseova J, Kuehni CE, Kunstreich M, Kuonen R, Lackner H, Leiper A, Loeffen EAH, Luks A, Modan-Moses D, Mulder R, Parfitt R, Paul NW, Ranft A, Ruud E, Schilling R, Spix C, Stefanowicz J, Strauβ G, Uitterlinden AG, van den Berg M, van der Kooi AL, van Dijk M, van Leeuwen F, Zolk O, Zöller D, Kaatsch P, PanCareLIFE consortium: PanCareLIFE: The scientific basis for a European project to improve long-term care regarding fertility, ototoxicity and health-related quality of life after cancer occurring among children and adolescents. Eur J Cancer, 2018; 103: 227-237. : https://doi.org/10.1016/j.ejca.2018.08.007
  • de Kraker MEA, Sommer H, de Velde F, Gravestock I, Weiss E, McAleenan A, Nikolakopoulos S, Amit O, Ashton T, Beyersmann J, Held L, Lovering AM, MacGowan AP, Mouton JW, Timsit JF, Wilson D, Wolkewitz M, Bettiol E, Dane A, Harbarth S, COMBACTE-NET Consortium: Optimizing the Design and Analysis of Clinical Trials for Antibacterials Against Multidrug-resistant Organisms: A White Paper From COMBACTE's STAT-Net. Clin Infect Dis, 2018; 67: 1922-1931. : https://doi.org/10.1093/cid/ciy516
  • Fischbeck S, Weyer-Elberich V, Zeissig SR, Imruck BH, Blettner M, Binder H, Beutel ME: Determinants of illness-specific social support and its relation to distress in long-term melanoma survivors. Bmc Public Health, 2018; 18 (online): 511. : https://doi.org/10.1186/s12889-018-5401-1
  • Grigioni F, Clavel MA, Vanoverschelde JL, Tribouilloy C, Pizarro R, Huebner M, Avierinos JF, Barbieri A, Suri R, Pasquet A, Rusinaru D, Gargiulo GD, Oberti P, Théron A, Bursi F, Michelena H, Lazam S, Szymanski C, Nkomo VT, Schumacher M, Bacchi-Reggiani L, Enriquez-Sarano M, MIDA Investigators: The MIDA Mortality Risk Score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation. Eur Heart J, 2018; 39: 1281-1291. : https://doi.org/10.1093/eurheartj/ehx465
  • Häge A, Alm B, Banaschewski T, Becker K, Colla M, Freitag C, Geissler J, von Gontard A, Graf E, Haack-Dees B, Hänig S, Hennighausen K, Hohmann S, Jacob C, Jaite C, Jennen-Steinmetz C, Kappel V, Matthies S, Philipsen A, Poustka L, Retz W, Rösler M, Schneider-Momm K, Sobanski E, Vloet TD, Warnke A, Jans T: Does the efficacy of parent-child training depend on maternal symptom improvement? Results from a randomized controlled trial on children and mothers both affected by attention-deficit/hyperactivity disorder (ADHD). Eur Child Adoles Psy, 2018; 27: 1011-1021. : https://doi.org/10.1007/s00787-018-1109-0
  • Hazard D, Schumacher M, Palomar-Martinez M, Alvarez-Lerma F, Olaechea-Astigarraga P, Wolkewitz M: Improving nested case-control studies to conduct a full competing-risks analysis for nosocomial infections. Infect Cont Hosp Ep, 2018; 39 (10): 1196-1201. : https://doi.org/10.1017/ice.2018.186
  • Hickl J, Argyropoulou A, Sakavitsi ME, Halabalaki M, Al-Ahmad A, Hellwig E, Aligiannis N, Skaltsounis AL, Wittmer A, Vach K, Karygianni L: Mediterranean herb extracts inhibit microbial growth of representative oral microorganisms and biofilm formation of Streptococcus mutans. Plos One, 2018; 13 (12) (online): e0207574-e0207574. : http://dx.doi.org/10.1371/journal.pone.0207574
  • Inzucchi SE, Zinman B, Fitchett D, Wanner C, Ferrannini E, Schumacher M, Schmoor C, Ohneberg K, Johansen OE, George JT, Hantel S, Bluhmki E, Lachin JM: How Does Empagliflozin Reduce Cardiovascular Mortality? Insights From a Mediation Analysis of the EMPA-REG OUTCOME Trial. Diabetes Care, 2018; 41: 356-363. : https://doi.org/10.2337/dc17-1096
  • Jabbarli R, Pierscianek D, Rölz R, Reinhard M, Darkwah Oppong M, Scheiwe C, Dammann P, Kaier K, Wrede KH, Shah M, Zentner J, Sure U: Gradual External Ventricular Drainage Weaning Reduces The Risk of Shunt Dependency After Aneurysmal Subarachnoid Hemorrhage: A Pooled Analysis. Oper Neurosurg, 2018; 15 (5): 498-504. : https://doi.org/10.1093/ons/opy009
  • Jenny B, Beyersmann J, Schumacher M: A simulation approach for power calculation in large cohort studies based on multistate models. Biometrical J, 2018; 60: 671-686. : https://doi.org/10.1002/bimj.201700074
  • Jeserich M, Merkely B, Schlosser P, Kimmel S, Pavlik G, Biermann J: Early diastolic septal movement in patients with myocarditis. Clin Radiol, 2018; 73 (2): 219.e9-219.e15. : http://dx.doi.org/10.1016/j.crad.2017.09.008
  • Kaier K, Oettinger V, Reinecke H, Schmoor C, Frankenstein L, Vach W, Hehn P, von Zur Mühlen C, Bode C, Zehender M, Reinöhl J: Volume-outcome relationship in transcatheter aortic valve implantations in Germany 2008-2014: a secondary data analysis of electronic health records. Bmj Open, 2018; 8 (7) (online): e020204-e020204. : https://doi.org/10.1136/bmjopen-2017-020204
  • Kaier K, von zur Mühlen C, Zirlik A, Schmoor C, Roth K, Bothe W, Hehna P, Reinöhl J, Zehender M, Bode C, Stachon P: Sex-specific differences in outcome of transcatheter or surgical aortic valve replacement. Can J Cardiol, 2018; 34: 992-998. : https://doi.org/10.1016/j.cjca.2018.04.009
  • Kempf E, de Beyer JA, Cook J, Holmes J, Mohammed S, Nguyen TL, Simera I, Trivella M, Altman DG, Hopewell S, Moons KGM, Porcher R, Reitsma JB, Sauerbrei W, Collins GS: Overinterpretation and misreporting of prognostic factor studies in oncology: a systematic review. Brit J Cancer, 2018; 119 (10): 1288-1296. : http://dx.doi.org/10.1038/s41416-018-0305-5
  • Kern WV, Weber S, Dettenkofer M, Kaier K, Bertz H, Behnke M, Weisser M, Götting T, Widmer AF, Theilacker C, Hospital Infection Surveillance System for Patients with Haematologic/Oncologic Malignancies Study Group (ONKO-KISS).: Impact of fluoroquinolone prophylaxis during neutropenia on bloodstream infection: Data from a surveillance program in 8,755 patients receiving high-dose chemotherapy for haematologic malignancies between 2009 and 2014. J Infection, 2018; 77: 68-74. : https://doi.org/10.1016/j.jinf.2018.05.004
  • Kowalzik F, Binder H, Zöller D, Riera-Montes M, Clemens R, Verstraeten T, Zepp F: Norovirus Gastroenteritis among Hospitalized Patients, Germany, 2007-2012. Emerg Infect Dis, 2018; 24: 2021-2028. : https://doi.org/10.3201/eid2411.170820
  • Kruse AB, Kuerschner AC, Kunze M, Woelber JP, Al-Ahmad A, Wittmer A, Vach K, Ratka-Krueger P: Association between high risk for preterm birth and changes in gingiva parameters during pregnancy-a prospective cohort study. Clin Oral Invest, 2018; 22: 1263-1271. : https://doi.org/10.1007/s00784-017-2209-9
  • Maccioni L *, Weber S *, Elgizouli M, Stoehlker AS, Geist I, Peter HH, Vach W, Nieters A: Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study. Bmc Public Health, 2018; 18 (1) (online): 271. : http://dx.doi.org/10.1186/s12889-018-5172-8
  • Naegele M, Kirsch M, Ihorst G, Fierz K, Engelhardt M, De Geest S: Symptom experience of multiple myeloma (syMMex) patients treated with autologous stem cell transplantation following high-dose melphalan: a descriptive longitudinal study. Support Care Cancer, 2018; 26: 833-841. : https://doi.org/10.1007/s00520-017-3897-z
  • Nührenberg TG, Cederqvist M, Marini F, Stratz C, Grüning BA, Trenk D, Binder H, Gilsbach R, Neumann F-J, Hein L: Uncontrolled Diabetes Mellitus Has No Major Influence on the Platelet Transcriptome. Biomed Res Int, 2018; 2018 (online): 8989252. : https://doi.org/10.1155/2018/8989252
  • Ogorodnikov A, Levin M, Tattikota S, Tokalov S, Hoque M, Scherzinger D, Marini F, Poetsch A, Binder H, Macher-Goppinger S, Probst HC, Tian B, Schaefer M, Lackner KJ, Westermann F, Danckwardt S: Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma. Nat Commun, 2018; 9 (1) (online): 5331-5331. : http://dx.doi.org/10.1038/s41467-018-07580-5
  • Paling FP, Olsen K, Ohneberg K, Wolkewitz M, Fowler VG Jr, DiNubile MJ, Jafri HS, Sifakis F, Bonten MJM, Harbarth SJ, Kluytmans JAJW: Risk prediction for Staphylococcus aureus surgical site infection following cardiothoracic surgery; A secondary analysis of the V710-P003 trial. Plos One, 2018; 13 (3) (online): e0193445-e0193445. : http://dx.doi.org/10.1371/journal.pone.0193445
  • Papakonstantinou T, Nikolakopoulou A, Rücker G, Chaimani A, Schwarzer G, Egger M, Salanti G: Estimating the contribution of studies in network meta-analysis: paths, flows and streams [version 2; referees: 2 approved, 1 approved with reservations]. F1000 Research, 2018 (online). : http://dx.doi.org/10.12688/f1000research.14770.2
  • Pieralli S, Kohal RJ, Rabel K, von Stein-Lausnitz M, Vach K, Spies BC: Clinical outcomes of partial and full-arch all-ceramic implant-supported fixed dental prostheses. A systematic review and meta-analysis. Clin Oral Implan Res, 2018; 29 Suppl. 18: 224-236. : http://dx.doi.org/10.1111/clr.13345
  • Poguntke I, Schumacher M, Beyersmann J, Wolkewitz M, On Behalf Of Combacte-Magnet Consortium MW: Simulation shows undesirable results for competing risks analysis with time-dependent covariates for clinical outcomes. Bmc Med Res Methodol, 2018; 18 (online): 79. : https://doi.org/10.1186/s12874-018-0535-5
  • Polydorou O, Scheitza S, Spraul M, Vach K, Hellwig E: The effect of long-term use of tooth bleaching products on the human enamel surface. Odontology, 2018; 106: 64-72. : https://doi.org/10.1007/s10266-017-0308-3
  • Prokosch HU, Acker T, Bernarding J, Binder H, Boeker M, Boerries M, Daumke P, Ganslandt T, Hesser J, Höning G, Neumaier M, Marquardt K, Renz H, Rothkötter HJ, Schade-Brittinger C, Schmücker P, Schüttler J, Sedlmayr M, Serve H, Sohrabi K, Storf H: MIRACUM: Medical Informatics in Research and Care in University Medicine. Method Inform Med, 2018; 57 Suppl. 1: e82-e91. : https://doi.org/10.3414/ME17-02-0025
  • Rahman S, von Cube M, Schumacher M, Wolkewitz M: Bias due to censoring of deaths when calculating extra length of stay for patients acquiring a hospital infection. Bmc Med Res Methodol, 2018; 18 (online): 49. : https://doi.org/10.1186/s12874-018-0500-3
  • Rauch G, Kieser M, Binder H, Bayes-Genis A, Jahn-Eimermacher A: Time-to-first-event versus recurrent-event analysis: points to consider for selecting a meaningful analysis strategy in clinical trials with composite endpoints. Clin Res Cardiol, 2018; 107: 437-443. : https://doi.org/10.1007/s00392-018-1205-7
  • Rohde AM, Zweigner J, Wiese-Posselt M, Schwab F, Behnke M, Kola A, Obermann B, Knobloch JK, Feihl S, Querbach C, Gebhardt F, Mischnik A, Ihle V, Schröder W, Armean S, Peter S, Tacconelli E, Hamprecht A, Seifert H, Vehreschild MJGT, Kern WV, Gastmeier P, on behalf of the DZIF-ATHOS study group: Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals. Antimicrob Resist in, 2018; 7 (online): 159-159. : https://doi.org/10.1186/s13756-018-0452-8
  • Schwab C, Gabrysch A, Olbrich P, Patino V, Warnatz K, Wolff D, Hoshino A, Kobayashi M, Imai K, Takagi M, Dybedal I, Haddock JA, Sansom DM, Lucena JM, Seidl M, Schmitt-Graeff A, Reiser V, Emmerich F, Frede N, Bulashevska A, Salzer U, Schubert D, Hayakawa S, Okada S, Kanariou M, Kucuk ZY, Chapdelaine H, Petruzelkova L, Sumnik Z, Sediva A, Slatter M, Arkwright PD, Cant A, Lorenz HM, Giese T, Lougaris V, Plebani A, Price C, Sullivan KE, Moutschen M, Litzman J, Freiberger T, van de Veerdonk FL, Recher M, Albert MH, Hauck F, Seneviratne S, Pachlopnik Schmid J, Kolios A, Unglik G, Klemann C, Speckmann C, Ehl S, Leichtner A, Blumberg R, Franke A, Snapper S, Zeissig S, Cunningham-Rundles C, Giulino-Roth L, Elemento O, Duckers G, Niehues T, Fronkova E, Kanderova V, Platt CD, Chou J, Chatila TA, Geha R, McDermott E, Bunn S, Kurzai M, Schulz A, Alsina L, Casals F, Deya-Martinez A, Hambleton S, Kanegane H, Tasken K, Neth O, Grimbacher B: Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects. J Allergy Clin Immun, 2018; 142 (6): 1932-1946. : http://dx.doi.org/10.1016/j.jaci.2018.02.055
  • Sommer H, Bluhmki T, Beyersmann J, Schumacher M, COMBACTE-NET, COMBACTE-MAGNET consortium.: Assessing non-inferiority in treatment trials regarding severe infectious diseases: An extension to the entire follow-up period using a cure-death multistate model. Antimicrob Agents Ch, 2018; 62 (online): e01691-17. : https://doi.org/10.1128/AAC.01691-17
  • Sommer H, Timsit JF, von Cube M, Schumacher M, Darmon M, Schwebel C, Ruckly S, Wolkewitz M, COMBACTE-MAGNET Consortium.: The Impact of Early Adequate Treatment on Extubation and Discharge Alive of Patients With Pseudomonas aeruginosa-Related Ventilator-Associated Pneumonia. Crit Care Med, 2018; 46: 1643-1648. : https://doi.org/10.1097/CCM.0000000000003305
  • Sommer S, Cruijsen M, Claus R, Bertz H, Wasch R, Marks R, Zeiser R, Bogatyreva L, Blijlevens NMA, May A, Duyster J, Huls G, van der Velden WJFM, Finke J, Lubbert M: Decitabine in combination with donor lymphocyte infusions can induce remissions in relapsed myeloid malignancies with higher leukemic burden after allogeneic hematopoietic cell transplantation. Leukemia Res, 2018; 72: 20-26. : http://dx.doi.org/10.1016/j.leukres.2018.07.005
  • Spies BC, Bateli M, Ben Rahal G, Christmann M, Vach K, Kohal RJ: Does Oral Implant Design Affect Marginal Bone Loss? Results of a Parallel-Group Randomized Controlled Equivalence Trial. Biomed Res Int, 2018; 2018 (online): 8436437. : https://doi.org/10.1155/2018/8436437
  • Stachon P, Kaier K, Zirlik A, Bothe W, Zehender M, Bode C, von zur Mühlen C: [Development and Results of Transcatheter and Surgical Aortic Valve Replacement in Germany 2014 and 2015]. Die Entwicklung und Ergebnisse von TAVI und chirurgischem Aortenklappenersatz in Deutschland 2014 bis 2015. Deut Med Wochenschr, 2018; 143 (online): e206-e212. : http://dx.doi.org/10.1055/a-0655-6218
  • Stachon P, Kaier K, Zirlik A, Reinöhl J, Heidt T, Bothe W, Hehn P, Zehender M, Bode C, von Zur Mühlen C: Risk factors and outcome of postoperative delirium after transcatheter aortic valve replacement. Clin Res Cardiol, 2018; 107: 756-762. : https://doi.org/10.1007/s00392-018-1241-3
  • Thomsen AR, Aldrian C, Bronsert P, Thomann Y, Nanko N, Melin N, Rücker G, Follo M, Grosu AL, Niedermann G, Layer PG, Heselich A, Lund PG: A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement. Lab Chip, 2018; 18: 179-189. : http://dx.doi.org/10.1039/c7lc00832e
  • Treppner M, Lenz S, Binder H, Zöller D: Modeling Activity Tracker Data Using Deep Boltzmann Machines. Studies in Health Technology and Informatics, 2018; 53: 155-159.
  • van der Kooi T, Sax H, Pittet D, van Dissel J, van Benthem B, Walder B, Cartier V, Clack L, de Greeff S, Wolkewitz M, Hieke S, Boshuizen H, van de Kassteele J, Van den Abeele A, Boo TW, Diab-Elschahawi M, Dumpis U, Ghita C, FitzGerald S, Lejko T, Leleu K, Martinez MP, Paniara O, Patyi M, Schab P, Raglio A, Szilágyi E, Ziętkiewicz M, Wu AW, Grundmann H, Zingg W, PROHIBIT consortium: Prevention of hospital infections by intervention and training (PROHIBIT): results of a pan-European cluster-randomized multicentre study to reduce central venous catheter-related bloodstream infections. Intens Care Med, 2018; 44: 48-60. : https://doi.org/10.1007/s00134-017-5007-6
  • Vukovic E, Czerny M, Beyersdorf F, Wolkewitz M, Berezowski M, Siepe M, Blanke P, Rylski B: Abdominal aortic aneurysm neck remodeling after Anaconda stent graft implantation. J Vasc Surg, 2018; 68 (5): 1354-1359.e2. : http://dx.doi.org/10.1016/j.jvs.2018.02.041
  • Wolkewitz M, Mandel M, Palomar-Martinez M, Alvarez-Lerma F, Olaechea-Astigarraga P, Schumacher M.: Methodological challenges in using point-prevalence versus cohort data in risk factor analyses of nosocomial infections. Ann Epidemiol, 2018; 28: 475-480. : https://doi.org/10.1016/j.annepidem.2018.03.017
Kurzbeiträge / short communications:
  • Stachon P, Zehender M, Bode C, von Zur Mühlen C, Kaier K: Development and In-Hospital Mortality of Transcatheter and Surgical Aortic Valve Replacement in 2015 in Germany. J Am Coll Cardiol, 2018; 72: 475-476. : https://doi.org/10.1016/j.jacc.2018.04.077
  • Weber S, Wolkewitz M, Schumacher M: Analyzing the impact of depth of response on survival in patients with metastatic non-small-cell lung cancer. Ann Oncol, 2018; 29: 282-283. : https://doi.org/10.1093/annonc/mdx558
Sonstige Publikationen:
  • Boulesteix AL, Binder H, Abrahamowicz M, Sauerbrei W, Simulation Panel of the STRATOS Initiative: On the necessity and design of studies comparing statistical methods. Biometrical J, 2018; 60: 216-218. : https://doi.org/10.1002/bimj.201700129
  • Doerken S, Mandel M, Zingg W, Wolkewitz M: Use of prevalence data to study sepsis incidence and mortality in intensive care units. Lancet Infect Dis, 2018; 18 (3) : 252-252. : http://dx.doi.org/10.1016/S1473-3099(18)30081-1
  • Heister T, Wolkewitz M, Kaier K: Determining the Attributable Costs of Clostridium difficile Infections When Exposure Time Is Lacking: Be Wary of "Conditioning on the Future". Infect Cont Hosp Ep, 2018; 39: 759-760. : https://doi.org/10.1017/ice.2018.42
  • Heister T, Wolkewitz M, Kaier K: Estimating the additional costs of surgical site infections: length bias, time-dependent bias, and conditioning on the future. J Hosp Infect, 2018; 99: 103-104. : https://doi.org/10.1016/j.jhin.2018.02.012
  • Kaier K, Wolkewitz M, Heister T: Estimating the attributable costs of hospital-acquired infections requires a distinct categorization of cases based on time of infection. Am J Infect Control, 2018; 46: 729. : https://doi.org/10.1016/j.ajic.2018.02.014
  • von Cube MK, Timsit JF, Sommer H, Darmon M, Schwebel C, Bailly S, Souweine B, Wolkewitz M: Relative risk and population-attributable fraction of ICU death caused by susceptible and resistant Pseudomonas aeruginosa ventilator-associated pneumonia: a competing risks approach to investigate the OUTCOMEREA database. Intens Care Med, 2018; 44 (7) : 1177-1179. : http://dx.doi.org/10.1007/s00134-018-5109-9

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten