Forschungsbericht für das Jahr 2017

Institut für Medizinische Biometrie und Statistik

Stefan-Meier-Strasse 26
79104 Freiburg
Tel: 0761 203 6662 Fax: 0761 203 6680
Email sec@imbi.uni-freiburg.de
http://www.imbi.uni-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. M. Schumacher
  • Prof. Dr. J. Schulte Mönting
  • Arthur Allignol
  • Dr. G. Antes
  • Dr. J. Beyersmann
  • Dr. H. Binder
  • Dr. Anette Blümle
  • D. Booker
  • Dipl.-Stat. Anika Buchholz
  • Dr. A. Caputo
  • Dr. J. Carpenter
  • Dr. Erik von Elm
  • Dipl.-Math. C. Gall
  • Dr. T. Gerds
  • Dipl.-Stat. A. Gerlach
  • Dr. E. Graf
  • Prof. Dr. Dieter Hauschke
  • Dr. G. Ihorst
  • Dr. B. Lang
  • Dr. Jörg Meerpohl
  • Dipl.-Stat. M. Olschewski
  • Dipl.-Stat. Christine Porzelius
  • Dipl.-Math. G. Rücker
  • PD Dr. W. Sauerbrei
  • Dr. C. Schmoor
  • Dr. Christine Schmucker
  • Dipl.-Math.Oec. R. Schoop
  • Dr. G. Schwarzer
  • Dipl.-Math. P. Sekula
  • Dipl.-Stat. S. Stampf
  • PD Dr. A. Timmer
  • Robert Wolff
  • Dr. M. Wolkewitz
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Biometrische Methodologie
  • Epidemiologische Studien
  • Klinische Studien
  • Multizentrische Therapiestudien

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Abou-Ayash S, Strasding M, Rücker G, Att W: Impact of prosthetic material on mid- and long-term outcome of dental implants supporting single crowns and fixed partial dentures: A systematic review and meta-analysis. Eur J Oral Implantol, 2017; 10 Suppl. 1: 47-65. : http://ejoi.quintessenz.de/index.php?doc=abstract&abstractID=39070/
  • Andrlová H, Mastroianni J, Madl J, Kern JS, Melchinger W, Dierbach H, Wernet F, Follo M, Technau-Hafsi K, Has C, Mittapalli VR, Idzko M, Herr R, Brummer T, Ungefroren H, Busch H, Boerries M, Narr A, Ihorst G, Vennin C, Schmitt-Graeff A, Minguet S, Timpson P, Duyster J, Meiss F, Römer W, Zeiser R: Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression. Oncotarget, 2017; 8: 42901-42916. : https://doi.org/10.18632/oncotarget.17160
  • Augustin NH, Kim SW, Uhlig A, Hanser C, Henke M, Schumacher M: A flexible multivariate random effects proportional odds model with application to adverse effects during radiation therapy. Biometrical J, 2017; 59: 1339-1351. : https://doi.org/10.1002/bimj.201600142
  • Binder N, Herrnböck A-S, Schumacher M: Estimating hazard ratios in cohort data with missing disease information due to death. Biometrical J, 2017; 59: 251-269. : http://dx.doi.org/10.1002/bimj.201500167
  • Binder N, Manderscheid L, Schumacher M: The combined association of alcohol consumption with dementia risk is likely biased due to lacking account of death cases. Eur J Epidemiol, 2017; 32: 627-629. : http://dx.doi.org/10.1007/s10654-017-0252-0
  • Böger CA, Gorski M, McMahon GM, Xu H, Chang YC, van der Most PJ, Navis G, Nolte IM, de Borst MH, Zhang W, Lehne B, Loh M, Tan ST, Boerwinkle E, Grams ME, Sekula P, Li M, Wilmot B, Moon JG, Scheet P, Cucca F, Xiao X, Lyytikäinen LP, Delgado G, Grammer TB, Kleber ME, Sedaghat S, Rivadeneira F, Corre T, Kutalik Z, Bergmann S, Nielson CM, Srikanth P, Teumer A, Müller-Nurasyid M, Brockhaus AC, Pfeufer A, Rathmann W, Peters A, Matsumoto M, de Andrade M, Atkinson EJ, Robinson-Cohen C, de Boer IH, Hwang SJ, Heid IM, Gögele M, Concas MP, Tanaka T, Bandinelli S, Nalls MA, Singleton A, Tajuddin SM, Adeyemo A, Zhou J, Doumatey A, McWeeney S, Murabito J, Franceschini N, Flessner M, Shlipak M, Wilson JG, Chen G, Rotimi CN, Zonderman AB, Evans MK, Ferrucci L, Devuyst O, Pirastu M, Shuldiner A, Hicks AA, Pramstaller PP, Kestenbaum B, Kardia SL, Turner ST, LifeLines Cohort Study, Briske TE, Gieger C, Strauch K, Meisinger C, Meitinger T, Völker U, Nauck M, Völzke H, Vollenweider P, Bochud M, Waeber G, Kähönen M, Lehtimäki T, März W, Dehghan A, Franco OH, Uitterlinden AG, Hofman A, Taylor HA, Chambers JC, Kooner JS, Fox CS, Hitzemann R, Orwoll ES, Pattaro C, Schlessinger D, Köttgen A, Snieder H, Parsa A, Cohen DM: NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality. J Am Soc Nephrol, 2017; 28: 2311-2321. : https://doi.org/10.1681/ASN.2016080892
  • Diener MK, Hüttner FJ, Kieser M, Knebel P, Dörr-Harim C, Distler M, Grützmann R, Wittel UA, Schirren R, Hau HM, Kleespies A, Heidecke CD, Tomazic A, Halloran CM, Wilhelm TJ, Bahra M, Beckurts T, Börner T, Glanemann M, Steger U, Treitschke F, Staib L, Thelen K, Bruckner T, Mihaljevic AL, Werner J, Ulrich A, Hackert T, Büchler MW, ChroPac Trial Group.: Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind ChroPac trial. Lancet, 2017; 390: 1027-1037. : https://doi.org/10.1016/S0140-6736(17)31960-8
  • Döpfner M, Hautmann C, Dose C, Banaschewski T, Becker K, Brandeis D, Holtmann M, Jans T, Jenkner C, Millenet S, Renner T, Romanos M, von Wirth E: ESCAschool study: trial protocol of an adaptive treatment approach for school-age children with ADHD including two randomised trials. Bmc Psychiatry, 2017; 17 (1) (online): 269. : http://dx.doi.org/10.1186/s12888-017-1433-9
  • Duttenhoefer F, Probst FA, Vach K, Cornelius CP, Zens M, Schmelzeisen R, Metzger MC: Clinical analysis of MatrixMANDIBLE Preformed Reconstruction Plate design. J Cranio Maxill Surg, 2017; 45: 1521-1525. : https://doi.org/10.1016/j.jcms.2017.05.022
  • Eismann J, Hirschfeld M, Erbes T, Rücker G, Jäger M, Ritter A, Weiss D, Gitsch G, Mayer S: Hypoxia- and acidosis-driven aberrations of secreted microRNAs in endometrial cancer in vitro. Oncol Rep, 2017; 38: 993-1004. : https://doi.org/10.3892/or.2017.5717
  • Engelhardt M, Domm A-S, Dold SM, Ihorst G, Reinhardt H, Zober A, Hieke S, Baayen C, Müller SJ, Einsele H, Sonneveld P, Landgren O, Schumacher M, Wäsch R: A concise revised myeloma comorbidity Index as a valid prognostic instrument in a large cohort of 801 multiple myeloma patients. Haematologica, 2017; 102: 910-921. : http://dx.doi.org/10.3324/haematol.2016.162693
  • Engelhardt M, Selder R, Pandurevic M, Möller M, Ihorst G, Waldschmidt J, Herget G, Wäsch R: Multidisciplinary Tumor Boards: Facts and Satisfaction Analysis of an Indispensable Comprehensive Cancer Center Instrument. Deut Med Wochenschr, 2017; 142 (online): e51-e60. : https://dx.doi.org/10.1055/s-0043-100054
  • Finke J, Schmoor C, Bethge WA, Ottinger H, Stelljes M, Volin L, Heim D, Bertz H, Grishina O, Socie G: Long-term outcomes after standard graft-versus-host disease prophylaxis with or without anti-human-T-lymphocyte immunoglobulin in haemopoietic cell transplantation from matched unrelated donors: final results of a randomised controlled trial. Lancet Haematol, 2017; 4 (6): e293-e301. : https://doi.org/10.1016/S2352-3026(17)30081-9
  • Friedrich F, Beyersmann J, Winterfeld U, Schumacher M, Allignol A: Nonparametric estimation of pregnancy outcome probabilities. Ann Appl Stat, 2017; 11: 840-867. : http://dx.doi.org/10.1214/17-AOAS1020
  • Fritsch K, Kasenda B, Schorb E, Hau P, Bloehdorn J, Möhle R, Löw S, Binder M, Atta J, Keller U, Wolf H-H, Krause SW, Heß G, Naumann R, Sasse S, Hirt C, Lamprecht M, Martens U, Morgner A, Panse J, Frickhofen N, Röth A, Hader C, Deckert M, Fricker H, Ihorst G, Finke J, Illerhaus G: High-dose methotrexate-based immuno-chemotherapy for elderly primary CNS lymphoma patients (PRIMAIN study). Leukemia, 2017; 31: 846-852. : https://dx.doi.org/10.1038/leu.2016.334
  • Greil C, Ihorst G, Gaiser F, Salzer U, Bisse E, Kastritis E, Ludwig H, Wäsch R, Engelhardt M: The serum heavy/light chain immunoassay: A valuable tool for sensitive paraprotein assessment, risk, and disease monitoring in monoclonal gammopathies. Eur J Haematol, 2017; 99: 449-458. : https://doi.org/10.1111/ejh.12958
  • Greil C, Kiote-Schmidt C, Fink G, Ihorst G, Hildenbeutel S, Bosse R, Duyster J, Engelhardt M, Wäsch R: Successful peripheral blood stem cell mobilization with a cost-efficient single fixed-dose plerixafor schedule in poor mobilizers. Leukemia Lymphoma, 2017; 58: 1849-1858. : http://dx.doi.org/10.1080/10428194.2016.1271946
  • Haun MW, Estel S, Rücker G, Friederich HC, Villalobos M, Thomas M, Hartmann M: Early palliative care for adults with advanced cancer. Cochrane Db Syst Rev, 2017; 6 (online): CD011129. : http://dx.doi.org/10.1002/14651858.CD011129.pub2
  • Hess M, Lenz S, Blätte TJ, Bullinger L, Binder H: Partitioned learning of deep Boltzmann machines for SNP data. Bioinformatics, 2017; 33: 3173-3180. : https://doi.org/10.1093/bioinformatics/btx408
  • Hiller JK, Schmoor C, Gaidzik VI, Schmidt-Salzmann C, Yalcin A, Abdelkarim M, Blagitko-Dorfs N, Döhner K, Bullinger L, Duyster J, Lübbert M, Hackanson B: Evaluating the impact of genetic and epigenetic aberrations on survival and response in acute myeloid leukemia patients receiving epigenetic therapy. Ann Hematol, 2017; 96: 559-565. : https://dx.doi.org/10.1007/s00277-016-2912-7
  • Hochholzer W, Kleiner P, Younas I, Valina CM, Löffelhardt N, Amann M, Bömicke T, Ferenc M, Hauschke D, Trenk D, Neumann FJ, Stratz C: Randomized Comparison of Oral P2Y12-Receptor Inhibitor Loading Strategies for Transitioning From Cangrelor: The ExcelsiorLOAD2 Trial. Jacc-cardiovasc Inte, 2017; 10: 121-129. : https://dx.doi.org/10.1016/j.jcin.2016.10.004
  • Huebner M, Wolkewitz M, Enriquez-Sarano M, Schumacher M: Competing risks need to be considered in survival analysis models for cardiovascular outcomes. J Thorac Cardiov Sur, 2017; 153: 1427-1431. : https://doi.org/10.1016/j.jtcvs.2016.12.039
  • Jackson D, Law M, Rücker G, Schwarzer G: The Hartung-Knapp modification for random-effects meta-analysis: A useful refinement but are there any residual concerns? Stat Med, 2017; 36: 3923-3934. : http://dx.doi.org/10.1002/sim.7411
  • Jansen L, Weberpals J, Kuiper JG, Vissers PAJ, Wolkewitz M, Hoffmeister M, Brenner H: Pre- and post-diagnostic beta-blocker use and prognosis after colorectal cancer: Results from a population-based study. Int J Cancer, 2017; 141: 62-71. : http://dx.doi.org/10.1002/ijc.30717
  • Jeserich M, Merkely B, Schlosser P, Kimmel S, Pavlik G, Achenbach S: Assessment of edema using STIR+ via 3D cardiovascular magnetic resonance imaging in patients with suspected myocarditis. Magn Reson Mater Phy, 2017; 30: 309-316. : http://dx.doi.org/10.1007/s10334-016-0603-y
  • Jung M, Wissing M, Motschall E, Türp JC: Time-related quantitative analysis of articles about randomized controlled trials in medicine and dentistry cited in PubMed. [Zeitbezogene Quantitätsanalyse von in PubMed zitierten Artikeln über randomisierte kontrollierte Studien in der Zahnmedizin]. Zeitschrift für Kraniomandibuläre Funktion - Journal of Craniomandibular Function, 2017; 9 (4): 291-302.
  • Kaier K, Reinecke H, Schmoor C, Frankenstein L, Vach W, Hehn P, Zirlik A, Bode C, Zehender M, Reinöhl J: Learning Curves Among All Patients Undergoing Transcatheter Aortic Valve Implantation in Germany: A Retrospective Observational Study. Int J Cardiol, 2017; 235: 17-21. : https://doi.org/10.1016/j.ijcard.2017.02.138
  • Karrasch S, Linde K, Rücker G, Sommer H, Karsch-Völk M, Kleijnen J, Jörres RA, Schneider A: Accuracy of FENO for diagnosing asthma: a systematic review. Thorax, 2017; 72: 109-116. : http://dx.doi.org/10.1136/thoraxjnl-2016-208704
  • Kasenda B, Ihorst G, Schroers R, Korfel A, Schmidt-Wolf I, Egerer G, von Baumgarten L, Röth A, Bloehdorn J, Möhle R, Binder M, Keller U, Lamprecht M, Pfreundschuh M, Valk E, Fricker H, Schorb E, Fritsch K, Finke J, Illerhaus G: High-dose chemotherapy with autologous haematopoietic stem cell support for relapsed or refractory primary CNS lymphoma: a prospective multicentre trial by the German Cooperative PCNSL study group. Leukemia, 2017; 31: 2623-2629. : https://doi.org/10.1038/leu.2017.170
  • Klok FA, Ageno W, Barco S, Binder H, Brenner B, Duerschmied D, Empen K, Faggiano P, Ficker JH, Galie N, Ghuysen A, Held M, Heydenreich N, Huisman MV, Jimenez D, Kozak M, Lang IM, Lankeit M, Munzel T, Petris A, Pruszczyk P, Quitzau K, Schellong S, Schmidt KH, Stefanovic BS, Verschuren F, Wolf-Puetz A, Meyer G, Konstantinides SV: Dabigatran after Short Heparin Anticoagulation for Acute Intermediate-Risk Pulmonary Embolism: Rationale and Design of the Single-Arm PEITHO-2 Study. Thromb Haemostasis, 2017; 117 (12): 2425-2434. : http://dx.doi.org/10.1160/TH17-06-0434
  • Landgrebe M, Hajak G, Wolf S, Padberg F, Klupp P, Fallgatter AJ, Polak T, Höppner J, Haker R, Cordes J, Klenzner T, Schönfeldt-Lecuona C, Kammer T, Graf E, Koller M, Kleinjung T, Lehner A, Schecklmann M, Pöppl TB, Kreuzer P, Frank E, Langguth B: 1-Hz rTMS in the Treatment of Tinnitus: A Sham-controlled, Randomized Multicenter Trial. Brain Stimul, 2017; 10: 1112-1120. : https://doi.org/10.1016/j.brs.2017.08.001
  • Limberger KA, Bogatyreva L, Todorova R, Herde B, Hauschke D, Pahl HL, Werner M, Aumann K: Tissue microarray technique is applicable to bone marrow biopsies of myeloproliferative neoplasms. Histochem Cell Biol, 2017; 147: 75-82. : http://dx.doi.org/10.1007/s00418-016-1476-x
  • Lübbert M, Ihorst G, Sander PN, Bogatyreva L, Becker H, Wijermans PW, Suciu S, Bissé E, Claus R: Elevated fetal haemoglobin is a predictor of better outcome in MDS/AML patients receiving 5-aza-2′-deoxycytidine (Decitabine). Brit J Haematol, 2017; 176: 609-617. : https://dx.doi.org/10.1111/bjh.14463
  • Magnet FS, Callegari J, Dieninghoff D, Spielmanns M, Storre JH, Schmoor C, Windisch W: Impact of Pseudomonas aeruginosa Infection on Respiratory Muscle Function in Adult Cystic Fibrosis Patients. Respiration, 2017; 93: 42-50. : https://dx.doi.org/10.1159/000452893
  • Mayer S, Erbes T, Timme-Bronsert S, Jaeger M, Rücker G, Kuf F, Stickeler E, Gitsch G, Hirschfeld M: Clinical relevance of Cyr61 expression in patients with hormone-dependent breast cancer. Oncol Lett, 2017; 14: 2334-2340. : https://doi.org/10.3892/ol.2017.6406
  • Mayer S, Gabriel B, Erbes T, Timme-Bronsert S, Jäger M, Rücker G, Kuf F, Bouda J, Bartakova A, Hausen AZ, Stickeler E, Gitsch G, Hirschfeld M: Cyr61 Expression Pattern and Association with Clinicopathological Factors in Patients with Cervical Cancer. Anticancer Res, 2017; 37: 2451-2456. : https://doi.org/10.21873/anticanres.11585
  • Mayer S, Kayser G, Rücker G, Bögner D, Hirschfeld M, Hug C, Stickeler E, Gitsch G, Erbes T: Absence of epithelial atypia in B3-lesions of the breast is associated with decreased risk for malignancy. Breast, 2017; 31: 144-149. : http://dx.doi.org/10.1016/j.breast.2016.11.007
  • Ohneberg K, Schumacher M, Beyersmann J: Modelling two cause-specific hazards of competing risks in one cumulative proportional odds model? Stat Med, 2017; 36: 4353-4363. : https://dx.doi.org/10.1002/sim.7437
  • Paling FP, Troeman DPR, Wolkewitz M, Kalyani R, Prins DR, Weber S, Lammens C, Timbermont L, Goossens H, Malhotra-Kumar S, Sifakis F, Bonten MJM, Kluytmans JAJW: Rationale and design of ASPIRE-ICU: a prospective cohort study on the incidence and predictors of Staphylococcus aureus and Pseudomonas aeruginosa pneumonia in the ICU. Bmc Infect Dis, 2017; 17: 643. : https://doi.org/10.1186/s12879-017-2739-4
  • Paling FP, Wolkewitz M, Bode LGM, Klein Klouwenberg PMC, Ong DSY, Depuydt P, de Bus L, Sifakis F, Bonten MJM, Kluytmans JAJW: Staphylococcus aureus colonization at ICU admission as a risk factor for developing S. aureus ICU pneumonia. Clin Microbiol Infec, 2017; 23: 49.e9-49.e14. : http://dx.doi.org/10.1016/j.cmi.2016.09.022
  • Paling FP, Wolkewitz M, Depuydt P, de Bus L, Sifakis F, Bonten MJM, Kluytmans JAJW: P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia. Antimicrob Resist in, 2017; 6 (online): 38. : http://dx.doi.org/10.1186/s13756-017-0197-9
  • Reinacher PC, Kruger MT, Coenen VA, Shah M, Roelz R, Jenkner C, Egger K: Determining the Orientation of Directional Deep Brain Stimulation Electrodes Using 3D Rotational Fluoroscopy. Am J Neuroradiol, 2017; 38 (6): 1111-1116. : http://dx.doi.org/10.3174/ajnr.A5153
  • Rylski B, Hahn N, Beyersdorf F, Kondov S, Wolkewitz M, Plonek T, Czerny M, Siepe M: Fate of the dissected aortic arch after ascending replacement in type A aortic dissection†. Eur J Cardio-thorac, 2017; 51: 1127-1134. : https://doi.org/10.1093/ejcts/ezx062
  • Schmucker CM, Blümle A, Schell LK, Schwarzer G, Oeller P, Cabrera L, von Elm E, Briel M, Meerpohl JJ;, OPEN consortium.: Systematic review finds that study data not published in full text articles have unclear impact on meta-analyses results in medical research. Plos One, 2017; 12 (online): e0176210. : https://doi.org/10.1371/journal.pone.0176210
  • Schulz A, Zoeller D, Nickels S, Beutel ME, Blettner M, Wild PS, Binder H: Simulation of complex data structures for planning of studies with focus on biomarker comparison. Bmc Med Res Methodol, 2017; 17 (1) (online): 90. : http://dx.doi.org/10.1186/s12874-017-0364-y
  • Sekula P, Li Y, Stanescu HC, Wuttke M, Ekici AB, Bockenhauer D, Walz G, Powis SH, Kielstein JT, Brenchley P, GCKD Investigators, Eckardt K-U, Kronenberg F, Kleta R, Köttgen A: Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies. Nephrol Dial Transpl, 2017; 32: 325-332. : http://dx.doi.org/10.1093/ndt/gfw001
  • Sillem M, Timme S, Bronsert P, Bogatyreva L, Hauschke D, Zur Hausen A, Werner M, Stickeler E: Anti-Phosphohistone H3-Positive Mitoses Are Linked to Pathological Response in Neoadjuvantly Treated Breast Cancer. Breast Care, 2017; 12: 244-250. : https://doi.org/10.1159/000463377
  • Sommer H, Wolkewitz M, Schumacher M, COMBACTE-NET consortium: The time-dependent "cure-death" model investigating two equally important endpoints simultaneously in trials treating high-risk patients with resistant pathogens. Pharm Stat, 2017; 16: 267-279. : https://doi.org/10.1002/pst.1809
  • Speckmann C, Doerken S, Aiuti A, Albert MH, Al-Herz W, Allende LM, Scarselli A, Avcin T, Perez-Becker R, Cancrini C, Cant A, Di Cesare S, Finocchi A, Fischer A, Gaspar HB, Ghosh S, Gennery A, Gilmour K, González-Granado LI, Martinez-Gallo M, Hambleton S, Hauck F, Hoenig M, Moshous D, Neven B, Niehues T, Notarangelo L, Picard C, Rieber N, Schulz A, Schwarz K, Seidel MG, Soler-Palacin P, Stepensky P, Strahm B, Vraetz T, Warnatz K, Winterhalter C, Worth A, Fuchs S, Uhlmann A, Ehl S, on behalf of the P-CID study of the Inborn Errors Working Party of the EBMT: A prospective study on the natural history of patients with profound combined immunodeficiency: An interim analysis. J Allergy Clin Immun, 2017; 139: 1302-1310.e4. : https://doi.org/10.1016/j.jaci.2016.07.040
  • Spies BC, Balmer M, Jung RE, Sailer I, Vach K, Kohal RJ: All-ceramic, bi-layered crowns supported by zirconia implants: Three-year results of a prospective multicenter study. J Dent, 2017; 67: 58-65. : https://doi.org/10.1016/j.jdent.2017.09.008
  • Spies BC, Kohal RJ, Balmer M, Vach K, Jung RE: Evaluation of zirconia-based posterior single crowns supported by zirconia implants: preliminary results of a prospective multicenter study. Clin Oral Implan Res, 2017; 28: 613-619. : https://dx.doi.org/10.1111/clr.12842
  • Strüßmann T, Fritsch K, Baumgarten A, Fietz T, Engelhardt M, Mertelsmann R, Ihorst G, Duyster J, Finke J, Marks R: Favourable outcomes of poor prognosis diffuse large B-cell lymphoma patients treated with dose-dense Rituximab, high-dose Methotrexate and six cycles of CHOP-14 compared to first-line autologous transplantation. Brit J Haematol, 2017; 178: 927-935. : https://doi.org/10.1111/bjh.14802
  • Su SC, Mockenhaupt M, Wolkenstein P, Dunant A, Le Gouvello S, Chen CB, Chosidow O, Valeyrie-Allanore L, Bellon T, Sekula P, Wang CW, Schumacher M, Kardaun SH, Hung SI, Roujeau JC, Chung WH: Interleukin-15 is associated with severity and mortality in Stevens-Johnson syndrome/toxic epidermal necrolysis. J Invest Dermatol, 2017; 137: 1065-1073. : http://dx.doi.org/10.1016/j.jid.2016.11.034
  • Timsit J-F, de Kraker MEA, Sommer H, Weiss E, Bettiol E, Wolkewitz M, Nikolakopoulos S, Wilson D, Harbarth S, on behalf of the COMBACTE-NET consortium: Appropriate endpoints for evaluation of new antibiotic therapies for severe infections: a perspective from COMBACTE’s STAT-Net. Intens Care Med, 2017; 43: 1002-1012. : http://dx.doi.org/10.1007/s00134-017-4802-4
  • von Cube M, Schumacher M, Palomar-Martinez M, Olaechea-Astigarraga P, Alvarez-Lerma F, Wolkewitz M: A case-cohort approach for multi-state models in hospital epidemiology: Stat Med, 2017; 36: 481-495. : http://dx.doi.org/10.1002/sim.7146
  • von Cube M, Schumacher M, Wolkewitz M: Basic parametric analysis for a multi-state model in hospital epidemiology. Bmc Med Res Methodol, 2017; 17: 111. : https://doi.org/10.1186/s12874-017-0379-4
  • Waldschmidt JM, Simon A, Wider D, Müller SJ, Follo M, Ihorst G, Decker S, Lorenz J, Chatterjee M, Azab AK, Duyster J, Wäsch R, Engelhardt M: CXCL12 and CXCR7 are relevant targets to reverse cell adhesion-mediated drug resistance in multiple myeloma. Brit J Haematol, 2017; 179: 36-49. : https://doi.org/10.1111/bjh.14807
  • Weberpals J, Jansen L, Haefeli WE, Hoffmeister M, Wolkewitz M, Herk-Sukel MPPV, Vissers PAJ, Brenner H: Pre- and post-diagnostic β-blocker use and lung cancer survival: A population-based cohort study. Sci Rep-uk, 2017; 7 (online): 2911. : https://doi.org/10.1038/s41598-017-02913-8
  • Wolkewitz M, Schumacher M: Survival biases lead to flawed conclusions in observational treatment studies of influenza patients. J Clin Epidemiol, 2017; 84: 121-129. : http://dx.doi.org/10.1016/j.jclinepi.2017.01.008
  • Wolkewitz M, von Cube M, Schumacher M: Multistate Modeling to Analyze Nosocomial Infection Data: An Introduction and Demonstration. Infect Cont Hosp Ep, 2017; 38: 953-959. : https://doi.org/10.1017/ice.2017.107
  • Wolkewitz M, Zortel M, Palomar-Martinez M, Alvarez-Lerma F, Olaechea-Astigarraga P, Schumacher M: Landmark prediction of nosocomial infection risk to disentangle short- and long-stay patients. J Hosp Infect, 2017; 96: 81-84. : https://doi.org/10.1016/j.jhin.2017.01.017
  • Wuensch A, Goelz T, Ihorst G, Terris DD, Bertz H, Bengel J, Wirsching M, Fritzsche K: Effect of individualized communication skills training on physicians’ discussion of clinical trials in oncology: results from a randomized controlled trial. Bmc Cancer, 2017; 17 (online): 264. : https://doi.org/10.1186/s12885-017-3238-0
  • Zimmermann S, Sekula P, Venhoff M, Motschall E, Knaus J, Schumacher M, Mockenhaupt M: Systemic Immunomodulating Therapies for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. A Systematic Review and Meta-analysis Jama Dermatol, 2017; 153 (online): 514-522. : http://dx.doi.org/10.1001/jamadermatol.2016.5668
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:
Kurzbeiträge / short communications:
  • Gerds TA, Schumacher M: Discussion of "A risk-based measure of time-varying prognostic discrimination for survival models," by C. Jason Liang and Patrick J. Heagerty. Biometrics, 2017; 73: 739-741. : https://doi.org/10.1111/biom.12629
  • Haddad C, Chosidow O, Valeyrie-Allanore L, Ghaleh B, Legrand T, Mockenhaupt M, Barau C, Khoudour N, Sekula P, Wolkenstein P, Hulin A: Are Idiopathic Stevens-Johnson syndrome/Toxic Epidermal Necrolysis Related to Drugs in Food? Example of Phenylbutazone. J Invest Dermatol, 2017; 137: 1179-1181. : https://dx.doi.org/10.1016/j.jid.2016.11.041
  • Schumacher M: Norman Edward Breslow–Key figure in the foundation of modern biostatistics. Biometrical J, 2017; 59: 399-404. : http://dx.doi.org/10.1002/bimj.201600196
Konferenzbeiträge:
  • Rücker G, Steinhauser S, Schumacher M: Modelling multiple biomarker thresholds in meta-analysis of diagnostic test accuracy studies: Diagnostic and Prognostic Research, 2017; 1 Suppl. 1 (online): P7 (Methods for Evaluating Medical Tests and Biomarkers Birmingham, UK. 19–20 July 2016). : http://dx.doi.org/10.1186/s41512-016-0001-y
Sonstige Publikationen:
  • Heister T, Kaier K, Wolkewitz M: Estimating the burden of nosocomial infections: Time dependency and cost clustering should be taken into account. Am J Infect Control, 2017; 45: 94-95. : http://dx.doi.org/10.1016/j.ajic.2016.07.030
  • Rücker G, Steinhauser S, Schumacher M: Re: "Selective cutoff reporting in studies of diagnostic test accuracy: A comparison of conventional and individual-patient-data meta-analyses of the patient health questionnaire-9 depression screening toll". Am J Epidemiol, 2017; 186: 894-895. : https://doi.org/10.1093/aje/kwx275
  • Schwarzer G, Schumacher M, Rücker G: Sole reliance on I2 may mislead. Heart, 2017; 103: 1471-1472. : https://doi.org/10.1136/heartjnl-2017-311767
  • Sommer H, Timsit JF, Wolkewitz M, for the COMBACTE-NET Consortium: Bezlotoxumab and Recurrent Clostridium difficile Infection. New Engl J Med, 2017; 376: 1594. : http://dx.doi.org/10.1056/NEJMc1702531
  • Wolkewitz M, Rücker G, Schumacher M: Changes in Rates of Ventilator-Associated Pneumonia. Jama-j Am Med Assoc, 2017; 317: 1580-1581. : http://dx.doi.org/10.1001/jama.2017.2411
  • Wolkewitz M, Schumacher M: Correction: Neuraminidase Inhibitors and Hospital Mortality in British Patients with H1N1 Influenza A: A Re-Analysis of Observational Data. Plos One, 2017; 12: e0175660. : http://dx.doi.org/10.1371/journal.pone.0175660

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