Forschungsbericht für das Jahr 2016

Institut für Medizinische Biometrie und Statistik

Stefan-Meier-Strasse 26
79104 Freiburg
Tel: 0761 203 6662 Fax: 0761 203 6680
Email sec@imbi.uni-freiburg.de
http://www.imbi.uni-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. M. Schumacher
  • Prof. Dr. J. Schulte Mönting
  • Arthur Allignol
  • Dr. G. Antes
  • Dr. J. Beyersmann
  • Dr. H. Binder
  • Dr. Anette Blümle
  • D. Booker
  • Dipl.-Stat. Anika Buchholz
  • Dr. A. Caputo
  • Dr. J. Carpenter
  • Dr. Erik von Elm
  • Dipl.-Math. C. Gall
  • Dr. T. Gerds
  • Dipl.-Stat. A. Gerlach
  • Dr. E. Graf
  • Prof. Dr. Dieter Hauschke
  • Dr. G. Ihorst
  • Dr. B. Lang
  • Dr. Jörg Meerpohl
  • Dipl.-Stat. M. Olschewski
  • Dipl.-Stat. Christine Porzelius
  • Dipl.-Math. G. Rücker
  • PD Dr. W. Sauerbrei
  • Dr. C. Schmoor
  • Dr. Christine Schmucker
  • Dipl.-Math.Oec. R. Schoop
  • Dr. G. Schwarzer
  • Dipl.-Math. P. Sekula
  • Dipl.-Stat. S. Stampf
  • PD Dr. A. Timmer
  • Robert Wolff
  • Dr. M. Wolkewitz
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Biometrische Methodologie
  • Epidemiologische Studien
  • Klinische Studien
  • Multizentrische Therapiestudien

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Chevalier N, Mueller M, Mougiakakos D, Ihorst G, Marks R, Schmitt-Graeff A, Veelken H: Analysis of dendritic cell subpopulations in follicular lymphoma with respect to the tumor immune microenvironment. Leukemia Lymphoma, 2016; 57: 2150-2160. : http://dx.doi.org/10.3109/10428194.2016.1143150
  • De Bin R, Janitza S, Sauerbrei W, Boulesteix A-L: Subsampling versus bootstrapping in resampling-based model selection for multivariable regression. Biometrics, 2016; 72: 272-280. : http://dx.doi.org/10.1111/biom.12381
  • Dersch R, Hottenrott T, Schmidt S, Sommer H, Huppertz HI, Rauer S, Meerpohl JJ: Efficacy and safety of pharmacological treatments for Lyme neuroborreliosis in children: a systematic review. Bmc Neurol, 2016; 16 (1) (online): 189. : http://dx.doi.org/10.1186/s12883-016-0708-y
  • Diem R, Molnar F, Beisse F, Gross N, Drüschler K, Heinrich SP, Joachimsen L, Rauer S, Pielen A, Sühs K-W, Linker RA, Huchzermeyer C, Albrecht P, Hassenstein A, Aktas O, Guthoff T, Tonagel F, Kernstock C, Hartmann K, Kümpfel T, Hein K, van Oterendorp C, Grotejohann B, Ihorst G, Maurer J, Müller M, Volkmann M, Wildemann B, Platten M, Wick W, Heesen C, Schiefer U, Wolf S, Lagrèze WA: Treatment of optic neuritis with erythropoietin (TONE): a randomised, double-blind, placebo-controlled trial—study protocol. Bmj Open, 2016; 6 (online): e010956. : http://dx.doi.org/10.1136/bmjopen-2015-010956
  • Engelhardt M, Ihorst G, Caers J, Günther A, Wäsch R: Autotransplants in older multiple myeloma patients: hype or hope in the era of novel agents? Haematologica, 2016; 101: 1276-1278. : http://dx.doi.org/10.3324/haematol.2016.154807
  • Finke J, Schmoor C, Bertz H, Marks R, Wäsch R, Zeiser R, Hackanson B: Long-term follow-up of therapy-related myelodysplasia and AML patients treated with allogeneic hematopoietic cell transplantation. Bone Marrow Transpl, 2016; 51: 771-777. : http://dx.doi.org/10.1038/bmt.2015.338
  • Heiland DH *, Mader I *, Schlosser P, Pfeifer D, Carro MS, Lange T, Schwarzwald R, Vasilikos I, Urbach H, Weyerbrock A: Integrative Network-based Analysis of Magnetic Resonance Spectroscopy and Genome Wide Expression in Glioblastoma multiforme. Sci Rep-uk, 2016; 6 (online): 29052. : http://dx.doi.org/10.1038/srep29052
  • Illerhaus G, Kasenda B, Ihorst G, Egerer G, Lamprecht M, Keller U, Wolf H-H, Hirt C, Stilgenbauer S, Binder M, Hau P, Edinger M, Frickhofen N, Bentz M, Möhle R, Röth A, Pfreundschuh M, von Baumgarten L, Deckert M, Hader C, Fricker H, Valk E, Schorb E, Fritsch K, Finke J: High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial. Lancet Haematol, 2016; 3 (online): e388-e397. : http://dx.doi.org/10.1016/S2352-3026(16)30050-3
  • Machado V, Gilsbach R, Das R, Schober A, Bogatyreva L, Hauschke D, Krieglstein K, Unsicker K, Spittau B: Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice. Cell Tissue Res, 2016; 365: 209-223. : http://dx.doi.org/10.1007/s00441-016-2406-x
  • Spielmanns M, Gloeckl R, Schmoor C, Windisch W, Storre JH, Boensch M, Kenn K: Effects on pulmonary rehabilitation in patients with COPD or ILD: A retrospective analysis of clinical and functional predictors with particular emphasis on gender. Resp Med, 2016; 113: 8-14. : http://dx.doi.org/10.1016/j.rmed.2016.02.006
  • Stewardson AJ, Allignol A, Beyersmann J, Graves N, Schumacher M, Meyer R, Tacconelli E, De Angelis G, Farina C, Pezzoli F, Bertrand X, Gbaguidi-Haore H, Edgeworth J, Tosas O, Martinez JA, Ayala-Blanco MP, Pan A, Zoncada A, Marwick CA, Nathwani D, Seifert H, Hos N, Hagel S, Pletz M, Harbarth S, the TIMBER Study Group 18: The health and economic burden of bloodstream infections caused by antimicrobial-susceptible and non-susceptible Enterobacteriaceae and Staphylococcus aureus in European hospitals, 2010 and 2011: a multicentre retrospective cohort study. Eurosurveillance, 2016; 21 (online): 30319. : http://dx.doi.org/10.2807/1560-7917.ES.2016.21.33.30319
  • Taschner CA, Chapot R, Costalat V, Machi P, Courthéoux, Barreau X, Berge J, Pierot L, Kadziolka K, Jean B, Blanc, Biondi A, Brunel H, Gallas S, Berlis A, Herbreteau D, Berkefeld J, Urbach H, El Shikh S, Fiehler J, Desal H, Graf E, Bonafé A: GREAT—a randomized controlled trial comparing HydroSoft/HydroFrame and bare platinum coils for endovascular aneurysm treatment: procedural safety and core-lab-assessedangiographic results. Neuroradiology, 2016; 58: 777-786. : http://dx.doi.org/10.1007/s00234-016-1693-y
  • Torbahn G, Hofmann H, Allert R, Freitag MH, Dersch R, Fingerle V, Sommer H, Motschall E, Meerpohl JJ, Schmucker C: Efficacy and safety of pharmacological agents in the treatment of erythema migrans in early Lyme borreliosis—systematic review protocol. Systematic Reviews, 2016; 5 (online): 73. : http://dx.doi.org/10.1186/s13643-016-0251-3
  • Vry J, Gramsch K, Rodger S, Thompson R, Steffensen BF, Rahbek J, Doerken S, Tassoni A, Beytía, MdlA, Guergueltcheva V, Chamova T, Tournev I, Kostera-Pruszczyk A, Kaminska A, Lusakowska A, Mrazova L, Pavlovska L, Strenkova J, Vondráček P, Garami M, Karcagi V, Herczegfalvi Á, Bushby K, Lochmüller H, Kirschner J: European cross-sectional survey of current care practices for duchenne muscular dystrophy reveals regional and age-dependent differences. Journal of Neuromuscular Diseases, 2016; 3: 517-527. : http://dx.doi.org/10.3233/JND-160185
Buchbeiträge:
Kurzbeiträge / short communications:
  • Bertz H, Lübbert M, Ohneberg K, Zeiser R, Wäsch R, Marks R, Finke J: Allogeneic hematopoietic cell transplantation with double alkylating agents containing reduced-intensity conditioning for patients greater than or equal to60 years with advanced AML/MDS. Leukemia, 2016; 30: 2426-2429. : https://dx.doi.org/10.1038/leu.2016.248
  • Lorenz J, Waldschmidt J, Wider D, Follo M, Ihorst G, Chatterjee M, May AM, Duyster J, Rosenwald A, Wäsch R, Zirlik K, Engelhardt M: From CLL to Multiple Myeloma - Spleen Tyrosine Kinase (SYK) influences multiple myeloma cell survival and migration. Brit J Haematol, 2016; 174: 985-989. : http://dx.doi.org/10.1111/bjh.13825
  • Schmoor C, Bender R, Beyersmann J, Kieser M, Schumacher M: Adverse event development in clinical oncology trials. Lancet Oncol, 2016; 17 (online): e263-e264.

Besondere wissenschaftliche Aktivitäten

Abschlussarbeiten