Research Report for the year 2016

Scientific publications

• Binder H, Kurz T, Teschner S, Kreutz C, Geyer M, Donauer J, Kraemer-Guth A, Timmer J, Schumacher M, Walz G: Dealing with prognostic signature instability: a strategy illustrated for cardiovascular events in patients with end-stage renal disease. Bmc Med Genomics, 2016; 9 (online): 43. : http://dx.doi.org/10.1186/s12920-016-0210-9
• Cattaneo G, Schumacher M, Maurer C, Wolfertz J, Jost T, Büchert M, Keuler A, Boos L, Shah MJ, Foerster K, Niesen W-D, Ihorst G, Urbach H, Meckel S: Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance. Am J Neuroradiol, 2016; 37: 885-891. : http://dx.doi.org/10.3174/ajnr.A4625
• Chevalier N, Mueller M, Mougiakakos D, Ihorst G, Marks R, Schmitt-Graeff A, Veelken H: Analysis of dendritic cell subpopulations in follicular lymphoma with respect to the tumor immune microenvironment. Leukemia Lymphoma, 2016; 57: 2150-2160. : http://dx.doi.org/10.3109/10428194.2016.1143150
• Dersch E, Sommer H, Rauer S, Meerpohl JJ: Prevalence and spectrum of residual symptoms in Lyme neuroborreliosis after pharmacological treatment: a systematic review. J Neurol, 2016; 263: 17-24. : http://dx.doi.org/10.1007/s00415-015-7923-0
• Dersch R, Hottenrott T, Schmidt S, Sommer H, Huppertz HI, Rauer S, Meerpohl JJ: Efficacy and safety of pharmacological treatments for Lyme neuroborreliosis in children: a systematic review. Bmc Neurol, 2016; 16 (1) (online): 189. : http://dx.doi.org/10.1186/s12883-016-0708-y
• Dettenkofer M, Humphreys H, Saenz H, Carlet J, Hanberger H, Ruef C, Widmer A, Wolkewitz M, Cookson B: Key priorities in the prevention and control of healthcare-associated infection: a survey of European and other international infection prevention experts. Infection, 2016; 44: 719-724. : https://dx.doi.org/10.1007/s15010-016-0904-0
• Engelhardt M, Dold SM, Ihorst G, Zober A, Möller M, Reinhardt H, Hieke S, Schumacher M, Wäsch: Geriatric assessment in multiple myeloma patients: validation of the International Myeloma Working Group (IMWG) score and comparison with other common comorbidity scores. Haematologica, 2016; 101: 1110-1119. : http://dx.doi.org/10.3324/haematol.2016.148189
• Finke J, Schmoor C, Bertz H, Marks R, Wäsch R, Zeiser R, Hackanson B: Long-term follow-up of therapy-related myelodysplasia and AML patients treated with allogeneic hematopoietic cell transplantation. Bone Marrow Transpl, 2016; 51: 771-777. : http://dx.doi.org/10.1038/bmt.2015.338
• Goebel U, Gebele N, Ebner W, Dettenkofer M, Bürkle H, Hauschke D, Schulz-Stübner S: Bacterial Contamination of the Anesthesia Workplace and Efficiency of Routine Cleaning Procedures: A Prospective Cohort Study. Anesth Analg, 2016; 122: 1444-1447. : http://dx.doi.org/10.1213/ANE.0000000000001220
• Hamprecht A, Rohde AM, Behnke M, Feihl S, Gastmeier P, Gebhardt F, Kern WV, Knobloch JK, Mischnik A, Obermann B, Querbach C, Peter S, Schneider C, Schroder W, Schwab F, Tacconelli E, Wiese-Posselt M, Wille T, Willmann M, Seifert H, Zweigner J, DZIF-ATHOS Study Group: Colonization with third-generation cephalosporin-resistant Enterobacteriaceae on hospital admission: prevalence and risk factors. J Antimicrob Chemoth, 2016; 71 (10): 2957-2963. : http://dx.doi.org/10.1093/jac/dkw216
• Heiland DH *, Mader I *, Schlosser P, Pfeifer D, Carro MS, Lange T, Schwarzwald R, Vasilikos I, Urbach H, Weyerbrock A: Integrative Network-based Analysis of Magnetic Resonance Spectroscopy and Genome Wide Expression in Glioblastoma multiforme. Sci Rep-uk, 2016; 6 (online): 29052. : http://dx.doi.org/10.1038/srep29052
• Hieke S, Benner A, Schlenk RF, Schumacher M, Bullinger L, Binder H: Identifying Prognostic SNPs in Clinical Cohorts: Complementing Univariate Analyses by Resampling and Multivariable Modeling. Plos One, 2016; 11 (online): e0155226. : http://dx.doi.org/10.1371/journal.pone.0155226
• Hieke S, Benner A, Schlenl RF, Schumacher M, Bullinger L, Binder H: Integrating multiple molecular sources into a clinical risk prediction signature by extracting complementary information: Bmc Bioinformatics, 2016; 17 (online): 327. : http://dx.doi.org/10.1186/s12859-016-1183-6
• Illerhaus G, Kasenda B, Ihorst G, Egerer G, Lamprecht M, Keller U, Wolf H-H, Hirt C, Stilgenbauer S, Binder M, Hau P, Edinger M, Frickhofen N, Bentz M, Möhle R, Röth A, Pfreundschuh M, von Baumgarten L, Deckert M, Hader C, Fricker H, Valk E, Schorb E, Fritsch K, Finke J: High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial. Lancet Haematol, 2016; 3 (online): e388-e397. : http://dx.doi.org/10.1016/S2352-3026(16)30050-3
• Janda A, Schwarz K, van der Burg M, Vach W, Ijspeert H, Lorenz MR, Elgizouli M, Pieper K, Fisch P, Hagel J, Lorenzetti R, Seidl M, Roesler J, Hauck F, Traggiai E, Speckmann C, Rensing-Ehl A, Ehl S, Eibel H, Rizzi M: Disturbed B-lymphocyte selection in autoimmune lymphoproliferative syndrome. Blood, 2016; 127 (18): 2193-2202. : http://dx.doi.org/10.1182/blood-2015-04-642488
• Jenkner C, Lorenz E, Becher H, Sauerbrei W: Modeling continuous covariates with a “spike” at zero: Bivariate approaches. Biometrical J, 2016; 58: 783-796. : http://dx.doi.org/10.1002/bimj.201400112
• Kaier K, Gutmann A, Baumbach H, von Zur Mühlen C, Hehn P, Vach W, Beyersdorf F, Zehender M, Bode C, Reinöhl J: Quality of life among elderly patients undergoing transcatheter or surgical aortic valve replacement- a model-based longitudinal data analysis. Health Qual Life Out, 2016; 14 (1) (online): 109. : http://dx.doi.org/10.1186/s12955-016-0512-9
• Lübbert M, Suciu S, Hagemeijer A, Rüter B, Platzbecker U, Giagounidis A, Selleslag D, Labar B, Germing U, Salih HR, Muus P, Pflüger K-H, Schaefer H-E, Bogatyreva L, AulC, de Witte T, Ganser A, Becker H, Huls G, van der Helm L, Vellenga E, Baron F, Marie J-P, Wijermans PW, on behalf of the EORTC Leukemia Group, the German MDS Study Grou: Decitabine improves progression-free survival in older high-risk MDS patients with multiple autosomal monosomies: results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group. Ann Hematol, 2016; 95: 191-199. : http://dx.doi.org/10.1007/s00277-015-2547-0
• Mittag O, Kampling H, Baumeister H: Epidemiologie psychischer Störungen bei chronisch körperlich Kranken Psychotherapie im Dialog, 2016; 17 (01): 34-37.
• Mittag O, Kampling H, Farin E, Tully PJ: Trajectories of depressive symptoms after a major cardiac event Health Psychology Open, 2016; 3 (1) (online). : http://dx.doi.org/10.1177/2055102915624873
• Reinohl J, Kaier K, Reinecke H, Frankenstein L, Zirlik A, Zehender M, von Zur Muhlen C, Bode C, Stachon P: Transcatheter Aortic Valve Replacement: The New Standard in Patients With Previous Coronary Bypass Grafting? Jacc-cardiovasc Inte, 2016; 9 (20): 2137-2143. : http://dx.doi.org/10.1016/j.jcin.2016.07.035
• Sajonz BEA, Amtage F, Reinacher PC, Jenkner C, Piroth T, Kätzler J, Urbach H, Coenen VA: Deep brain stimulation for tremor tractographic versus traditional (DISTINCT): Study protocol of a randomized controlled feasibility trial. JMIR Research Protocols, 2016; 5 (online): e244. : http://dx.doi.org/10.2196/resprot.6885
• Schlöffel M, Funke W, Pollmann H, Köhler J, Sellmer S, Mittag O: Gegenwärtige Praxis des Umgangs mit komorbiden problematischen Suchtmittelkonsum in nicht auf Sucht spezialisierten Rehabilitationseinrichtungen - Ergebnisse einer deutschlandweiten Befragung Rehabilitation, 2016; 55 (2): 95-101.
• Schorb E, Finke J, Ferreri AJM, Ihorst G, Mikesch K, Kasenda B, Fritsch K, Fricker H, Burger E, Grishina O, Valk E, Zucca E, Illerhaus G: High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma—a randomized phase III trial (MATRix). Bmc Cancer, 2016; 16 (online): 282. : http://dx.doi.org/10.1186/s12885-016-2311-4
• Schröder W, Sommer H, Gladstone BP, Foschi F, Hellman J, Evengard B, Tacconelli E: Gender differences in antibiotic prescribing in the community: a systematic review and meta-analysis. J Antimicrob Chemoth, 2016; 71: 1800-1806. : http://dx.doi.org/10.1093/jac/dkw054
• Simonsen JA, Johansen A, Gerke O, Mickley H, Thomassen A, Hess S, Rask CK, Tamadoni M, Jensen LO, Hallas J, Vach W, Hoilund-Carlsen PF: Outcome with invasive versus medical treatment of stable coronary artery disease: influence of perfusion defect size, ischaemia, and ejection fraction. Eurointervention, 2016; 11 (10): 1118-1124. : http://dx.doi.org/10.4244/EIJV11I10A226
• Stewardson AJ, Allignol A, Beyersmann J, Graves N, Schumacher M, Meyer R, Tacconelli E, De Angelis G, Farina C, Pezzoli F, Bertrand X, Gbaguidi-Haore H, Edgeworth J, Tosas O, Martinez JA, Ayala-Blanco MP, Pan A, Zoncada A, Marwick CA, Nathwani D, Seifert H, Hos N, Hagel S, Pletz M, Harbarth S, the TIMBER Study Group 18: The health and economic burden of bloodstream infections caused by antimicrobial-susceptible and non-susceptible Enterobacteriaceae and Staphylococcus aureus in European hospitals, 2010 and 2011: a multicentre retrospective cohort study. Eurosurveillance, 2016; 21 (online): 30319. : http://dx.doi.org/10.2807/1560-7917.ES.2016.21.33.30319
• Stochkendahl MJ, Sørensen J, Vach W, Wulff Christensen H, Høilund-Carlsen PF, Hartvigsen J: Cost-effectiveness of chiropractic care versus self-management in patients with musculoskeletal chest pain. Open Heart, 2016; 3 (1) (online). : http://dx.doi.org/10.1136/openhrt-2015-000334
• Sun H, Bretz F, Gerke O, Vach W: Comparing a stratified treatment strategy with the standard treatment in randomized clinical trials. Stat Med, 2016; 35 (29): 5325-5337. : http://dx.doi.org/10.1002/sim.7091
• Sun H, Vach W: A Framework to Assess the Value of Subgroup Analyses When the Overall Treatment Effect is Significant. J Biopharm Stat, 2016; 26 (3): 565-578. : http://dx.doi.org/10.1080/10543406.2015.1052484
• Taschner CA, Chapot R, Costalat V, Machi P, Courthéoux, Barreau X, Berge J, Pierot L, Kadziolka K, Jean B, Blanc, Biondi A, Brunel H, Gallas S, Berlis A, Herbreteau D, Berkefeld J, Urbach H, El Shikh S, Fiehler J, Desal H, Graf E, Bonafé A: GREAT—a randomized controlled trial comparing HydroSoft/HydroFrame and bare platinum coils for endovascular aneurysm treatment: procedural safety and core-lab-assessedangiographic results. Neuroradiology, 2016; 58: 777-786. : http://dx.doi.org/10.1007/s00234-016-1693-y
• Torbahn G, Hofmann H, Allert R, Freitag MH, Dersch R, Fingerle V, Sommer H, Motschall E, Meerpohl JJ, Schmucker C: Efficacy and safety of pharmacological agents in the treatment of erythema migrans in early Lyme borreliosis—systematic review protocol. Systematic Reviews, 2016; 5 (online): 73. : http://dx.doi.org/10.1186/s13643-016-0251-3
• Urbain P, Ihorst G, Finke J, Bertz H: The impact of pre-transplant body weight on short- and long-term outcomes after allogeneic hematopoietic cell transplantation in adults using different weight classification tools. Bone Marrow Transpl, 2016; 51: 144-147. : http://dx.doi.org/10.1038/bmt.2015.219
• Vry J, Gramsch K, Rodger S, Thompson R, Steffensen BF, Rahbek J, Doerken S, Tassoni A, Beytía, MdlA, Guergueltcheva V, Chamova T, Tournev I, Kostera-Pruszczyk A, Kaminska A, Lusakowska A, Mrazova L, Pavlovska L, Strenkova J, Vondráček P, Garami M, Karcagi V, Herczegfalvi Á, Bushby K, Lochmüller H, Kirschner J: European cross-sectional survey of current care practices for duchenne muscular dystrophy reveals regional and age-dependent differences. Journal of Neuromuscular Diseases, 2016; 3: 517-527. : http://dx.doi.org/10.3233/JND-160185
• Weber S, von Cube M, Sommer H, Wolkewitz M: Necessity of a competing risk approach in risk factor analysis of central line–associated bloodstream infection. Infect Cont Hosp Ep, 2016; 37: 1255-1257. : http://dx.doi.org/10.1017/ice.2016.166

• Bertz H, Lübbert M, Ohneberg K, Zeiser R, Wäsch R, Marks R, Finke J: Allogeneic hematopoietic cell transplantation with double alkylating agents containing reduced-intensity conditioning for patients greater than or equal to60 years with advanced AML/MDS. Leukemia, 2016; 30: 2426-2429. : https://dx.doi.org/10.1038/leu.2016.248
• Mittag O, Kampling H, Farin-Glattacker E, Herpertz S, Petrak F: Trajectories of depression in an onset cohort of adults with type I diabetes: Six year follow up Psychosom Med, 2016; 77 (3): A-121.

• Kampling H, Petrak F, Farin E, Herpertz S, Mittag O: Depressionsverläufe bei Erwachsenen mit neu diagnostiziertem Typ 1 Diabetes: Längsschnittdaten über fünf Jahre Deutscher Kongress für psychosomatische Medizin und Psychotherapie. Beziehung und Gesundheit - Fortschritte in der Psychosomatischen Medizin, 2016: 6 (Deutscher Kongress für Psychosomatische Medizin und Psychothearpie / Potsdam / Deutsche Gesellschaft für Psychosomatische Medizin und Ärztliche Psychotherapie), Deutsche Gesellschaft für Psychosomatische medizinische und ärztliche Psychotherapie & Deutsche Kollegium für Psychosomatische Medizin (Hrsg).
• Kampling H, Reese C, Mittag O: Praxisempfehlungen für psychologische Interventionen in der neurologischen Rehabilitation von Patienten nach Schlaganfall: Ergebnisse der Anwenderbefragung DRV-Schriften, 2016; 109: 364-366 (25. Reha-Wissenschaftliches Kolloquium: Gesundheitssystem im Wandel - Perspektiven der Rehabilitation / Aachen / DRV Bund), Deutsche Rentenversicherung Bund (Hrsg).
• Mittag O, Kampling H, Herpertz S, Petrak F: Long Term Predictors of Glycemic Control in a Cohort of Adults with Newly Diagnosed Type 1 Diabetes: Is It Depression, Anxiety or Distress? Psychosom Med, 2016; 78 (3): A-75 (74th Annual Scientific Meeting of the American Psychosomatic Society (APS) / Denver, CO (USA) / APS)).
• Mittag O, Pollmann H: Über den Umgang mit Alkoholkonsum in der Rehabilitation DRV-Schriften, 2016; 109: 7 (25. Reha-Wissenschaftliches Kolloquium: Gesundheitssystem im Wandel - Perspektiven der Rehabilitation / Aachen / Deutsche Rentenversicherung), DRV Bund (Hrsg).
• Schlöffel M, Funke W, Pollmann H, Köhler J, Mittag O: Praxisempfehlungen zum Umgang mit komorbiden Suchtproblemen in der somatischen und psychosomatischen Rehabilitation - Entwicklung und Konsentierung DRV-Schriften, 2016; 109: 161-163 (25. Reha-Wissenschaftliches Kolloquium: Gesundheitssystem im Wandel - Perspektiven der Rehabilitation / Aachen / Deutsche Rentenversicherung), DRV Bund (Hrsg).
• Schlöffel M, Pollmann H, Sellmer S, Mittag O: Über den Umgang mit Alkohol in der medizinischen Rehabilitation - Perspektive der Rehabilitanden DRV-Schriften, 2016; 109: 425-427 (25. Reha-Wissenschaftliches Kolloquium: Gesundheitssystem im Wandel - Perspektiven der Rehabilitation / Aachen / Deutsche Rentenversicherung), DRV Bund (Hrsg).