Forschungsbericht für das Jahr 2015

Institut für Medizinische Biometrie und Statistik

Stefan-Meier-Strasse 26
79104 Freiburg
Tel: 0761 203 6662 Fax: 0761 203 6680

Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. M. Schumacher
  • Prof. Dr. J. Schulte Mönting
  • Arthur Allignol
  • Dr. G. Antes
  • Dr. J. Beyersmann
  • Dr. H. Binder
  • Dr. Anette Blümle
  • D. Booker
  • Dipl.-Stat. Anika Buchholz
  • Dr. A. Caputo
  • Dr. J. Carpenter
  • Dr. Erik von Elm
  • Dipl.-Math. C. Gall
  • Dr. T. Gerds
  • Dipl.-Stat. A. Gerlach
  • Dr. E. Graf
  • Prof. Dr. Dieter Hauschke
  • Dr. G. Ihorst
  • Dr. B. Lang
  • Dr. Jörg Meerpohl
  • Dipl.-Stat. M. Olschewski
  • Dipl.-Stat. Christine Porzelius
  • Dipl.-Math. G. Rücker
  • PD Dr. W. Sauerbrei
  • Dr. C. Schmoor
  • Dr. Christine Schmucker
  • Dipl.-Math.Oec. R. Schoop
  • Dr. G. Schwarzer
  • Dipl.-Math. P. Sekula
  • Dipl.-Stat. S. Stampf
  • PD Dr. A. Timmer
  • Robert Wolff
  • Dr. M. Wolkewitz
Einträge in der Rubrik "Who is Who"


  • Biometrische Methodologie
  • Epidemiologische Studien
  • Klinische Studien
  • Multizentrische Therapiestudien

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Al-Ahmad A, Bucher M, Anderson AC, Tennert C, Hellwig E, Wittmer A, Vach K, Karygianni L: Antimicrobial Photoinactivation Using Visible Light Plus Water-Filtered Infrared-A (VIS + wIRA) Alters In Situ Oral Biofilms. Plos One, 2015; 10 (online): e0132107. :
  • Aldegheishem A, Alfaer A, Brezavšček M, Vach K, Eliades G, Att W: Wear behavior of zirconia substrates against different antagonist materials. International Journal of Esthetic Dentistry, 2015; 10: 468-485.
  • Arezzo A, Passera R, Salvai A, Arolfo S, Allaix ME, Schwarzer G, Morino M: Laparoscopy for rectal cancer is oncologically adequate: a systematic review and meta-analysis of the literature. Surg Endosc, 2015; 29: 334-348. :
  • Baghai M, Heilmann C, Beyersdorf F, Nakamura L, Geisen U, Olschewski M, Zieger B: Platelet dysfunction and acquired von Willebrand syndrome in patients with left ventricular assist devices. Eur J Cardio-thorac, 2015; 48: 421-427. :
  • Callizo J, Feltgen N, Pantenburg S, Wolf A, Neubauer AS, Jurklies B, Wachter R, Schmoor C, Schumacher M, Junker B, Pielen A, for the European Assessment Group for Lysis in the Eye: Cardiovascular risk factors in central retinal artery occlusion: results of a prospective and standardized medical examination. Ophthalmology, 2015; 122: 1881-1888. :
  • Conrad A, Grotejohann B, Schmoor C, Cosic D, Dettenkofer M: Safety and tolerability of virucidal hand rubs: a randomized, double-blind, cross-over trial with healthy volunteers. Antimicrobial Resistance and Infection Control, 2015; 4 (online): 37. :
  • Dittrich S, Tuerk M, Haaker G, Greim V, Buchholz A, Burkhardt B, Fujak A, Trollmann R, Schmid A, Schroeder R: Cardiomyopathy in Duchenne Muscular Dystrophy: Current Value of Clinical, Electrophysiological and Imaging Findings in Children and Teenagers. Klin Padiatr, 2015; 227: 225-231. :
  • Dreher M, Ekkernkamp E, Schmoor C, Schoenheit-Kenn U, Winterkamp S, Kenn K: Pulmonary rehabilitation and noninvasive ventilation in patients with hypercapnic interstitial lung disease. Respiration, 2015; 89 (3): 208-213. :
  • Ekkernkamp E, Welte L, Schmoor C, Huttmann SE, Dreher M, Windisch W, Storre JH: Spot check analysis of gas exchange: invasive versus noninvasive methods. Respiration, 2015; 89 (4): 294-303. :
  • Engelhardt M, Ihorst G, Landgren O, Pantic M, Reinhardt H, Waldschmidt J, May AM, Schumacher M, Kleber M, Wäsch R: Large registry analysis to accurately define second malignancy rates and risks in a well-characterized cohort of 744 consecutive multiple myeloma patients followed-up for 25 years. Haematologica, 2015; 100: 1340-1349. :
  • Erbes T, Hirschfeld M, Rücker G, Jaeger M, Boas J, Iborra S, Mayer S, Gitsch G, Stickeler E: Feasibility of urinary microRNA detection in breast cancer patients and its potential as an innovative non-invasive biomarker. Bmc Cancer, 2015; 15 (online): 193. :
  • Fleck K, Jacob C, Philipsen A, Matthies S, Graf E, Hennighausen K, Haack-Dees B, Weyers P, Warnke A, Rösler M, Retz W, von Gontard A, Hänig S, Freitag C, Sobanski E, Schumacher-Stien M, Poustka L, Bliznak L, Becker K, Holtmann M, Colla M, Gentschow L, Kappel V, Jaite C, Jans T: Child impact on family functioning: a multivariate analysis in multiplex families with children and mothers both affected by attention-deficit/hyperactivity disorder (ADHD). ADHD Attention Deficit and Hyperactivity Disorders, 2015; 7 (online): 211-223. :
  • Green N, Johnson AP, Henderson KL, Muller-Pebody B, Thelwall S, Robotham JV, Sharland M, Wolkewitz M, Deeny SR: Quantifying the burden of hHospital-acquired bloodstream infection in children in England by estimating excess length of hospital stay and mortality using a multistate analysis of linked, routinely collected data. Pediatr Infect Dis J, 2015; 4: 305-312. :
  • Grishina O, Schmoor C, Döhner K, Hackanson B, Lubrich B, May AM, Cieslik C, Müller MJ, Lübbert M: DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients >60 years with acute myeloid leukemia who are ineligible for induction chemotherapy. Bmc Cancer, 2015; 15 (online): 430. :
  • Hieke S, Kleber M, König C, Engelhardt M, Schumacher M: Conditional Survival: A Useful Concept to Provide Information on How Prognosis Evolves over Time. Clin Cancer Res, 2015; 21: 1530-1536. :
  • Jander N, Sommer H, Pingpoh C, Kienzle R-P, Martin G, Zeh W, Pache G, Siepe M, Beyersdorf F, Schumacher M, Neumann F-J, Minners J: The porcine valve type predicts obstructive thrombosis beyond the first three postoperative months in bioprostheses in the aortic position. Int J Cardiol, 2015; 199: 90-95. :
  • Jans T, Jacob C, Warnke A, Zwanzger U, Groß-Lesch S, Matthies S, Borel P, Hennighausen K, Haack-Dees B, Rösler M, Retz W, von Gontard A, Hänig S, Sobanski E, Alm B, Poustka L, Hohmann S, Colla M, Gentschow L, Jaite C, Kappel V, Becker K, Holtmann M, Freitag C, Graf E, Ihorst G, Philipsen A: Does intensive multimodal treatment for maternal ADHD improve the efficacy of parent training for children with ADHD? A randomized controlled multicenter trial. J Child Psychol Psyc, 2015; 56: 1298-1313. :
  • Jeserich M, Merkely B, Olschewski M, Kimmel S, Pavlik G, Bode C: Patients with exercise-associated ventricular ectopy present evidence of myocarditis. J Cardiovasc Magn R, 2015; 17 (online): 100. :
  • Kohal RJ, Gubik S, StrohlC, Stampf S, Bächle M, Hurrle AA, Patzelt SBM: Effect of two different healing times on the mineralization of newly formed bone using a bovine bone substitute in sinus floor augmentation: A randomized, controlled, clinical and histological investigation. J Clin Periodontol, 2015; 42 (11): 1052-1059. :
  • Kohal RJ, Straub LM, Wolkewitz M, Bächle M, Patzelt SBM: Evaluation of Guided Bone Regeneration around Oral Implants over Different Healing Times Using Two Different Bovine Bone Materials: A Randomized, Controlled Clinical and Histological Investigation: Clin Implant Dent R, 2015; 17: 957-971. :
  • Leisser C, Kaufmann TA, Feltgen N, Schumacher M, Schmoor C, Meckel S: Distribution of internal carotid artery plaque locations among patients with central retinal artery occlusion in the Eagle study population. Graef Arch Clin Exp, 2015; 253 (8): 1227-1230. :
  • Münch C, Dragoi D, Frey A-V, Thurig K, Lübbert M, Wäsch R, Bogatyreva L, Hauschke D, Lassmann S, Werner M, May AM: Therapeutic polo-like kinase 1 inhibition results in mitotic arrest and subsequent cell death of blasts in the bone marrow of AML patients and has similar effects in non-neoplastic cell lines. Leukemia Res, 2015; 39: 462-470. :
  • Naegele M, Leppla L, Kiote-Schmidt C, Ihorst G, Rebafka A, Koller A, M. May AM, Hasemann M, Duyster J, Wäsch R, Engelhardt M: Trained clinical nurse specialists proficiently obtain bone marrow aspirates and trephine biopsies in a nearly painless procedure—a prospective evaluation study. Ann Hematol, 2015; 94: 1577-1584. (download:
  • Ohneberg K, Wolkewitz M, Beyersmann J, Palomar-Martinez M, Olaechea-Astigarraga P, Alvarez-Lerma F, Schumacher M: Analysis of Clinical Cohort Data Using Nested Case-control and Case-cohort Sampling Designs: A Powerful and Economical Tool. Method Inform Med, 2015; 54: 505-514. :
  • Philipsen A, Jans T, Graf E, Matthies S, Borel P, Colla M, Gentschow L, Langner D, Jacob C, Groß-Lesch S, Sobanski E, Alm B, Schumacher-Stien M, Roesler M, Retz W, Retz-Junginger P, Kis B, Abdel-Hamid M, Heinrich V, Huss M, Kornmann C, Bürger A, Perlov E, Ihorst G, Schlander M, Berger M, van Elst LT, for the Comparison of Methylphenidate, Psychotherapy in Adult ADHD Study (COMPAS) Consortium: Effects of Group Psychotherapy, Individual Counseling, Methylphenidate, and Placebo in the Treatment of Adult Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial. Jama Psychiat, 2015; 72: 1199-1210. :
  • Pielen A, Pantenburg S, Schmoor C, Schumacher M, Feltgen N, Junker B, Callizo J, for the EAGLE Study Group: Predictors of prognosis and treatment outcome in central retinal artery occlusion: local intra-arterial fibrinolysis vs. conservative treatment. Neuroradiology, 2015; 57: 1055-1062. :
  • Schimek-Jasch T, Troost EGC, Rücker G, Prokic V, Avlar M, Duncker-Rohr V, Mix M, Doll C, Grosu A-L, Nestle U: A teaching intervention in a contouring dummy run improved target volume delineation in locally advanced non-small cell lung cancer. Strahlenther Onkol, 2015; 191: 525-533. :
  • Sijare F, Geißler A-L, Fichter CD, Hergeth SP, Bogatyreva L, Hauschke D, Schneider R, Werner M, Lassmann S: Aurora B expression and histone variant H1.4S27 phosphorylation are no longer coordinated during metaphase in aneuploid colorectal carcinomas. Virchows Arch, 2015; 466 (5): 503-515. :
  • Speckmann C, Uhlmann A, Doerken S, Wolkewitz M, Ehl S: A prospective outcome study on patients with profound combined immunodeficiency. LymphoSign Journal, 2015; 2: 91-106. :
  • Spies BC, Balmer M, Patzelt SBM, Vach K, Kohal RJ: Clinical and Patient-reported Outcomes of a Zirconia Oral Implant: Three-year Results of a Prospective Cohort Investigation. J Dent Res, 2015; 94: 1385-1391. :
  • Spies BC, Sauter C, Wolkewitz M, Kohal R-J: Alumina reinforced zirconia implants: Effects of cyclic loading and abutment modification on fracture resistance. Dent Mater, 2015; 31: 262-272. :
  • Tchorz JP, Brandl M, Ganter PA, Karygianni L, Polydorou O, Vach K, Hellwig E, Altenburger MJ: Pre-clinical endodontic training with artificial instead of extracted human teeth: does the type of exercise have an influence on clinical endodontic outcomes? Int Endod J, 2015; 48: 888-893. :
  • Woelber JP, Bienas H, Fabry G, Silbernagel W, Giesler M, Tennert C, Stampf S, Ratka-Kruger P, Hellwig E: Oral hygiene-related self-efficacy as a predictor of oral hygiene behavior. A prospective cohort study. J Clin Periodontol, 2015; 42: 142-149. :
  • Zeiser R, Burchert A, Lengerke C, Verbeek M, Maas-Bauer K, Metzelder SK, Spoerl S, Ditschkowski M, Ecsedi M, Sockel K, Ayuk F, Ajib S, de Fontbrune FS, Na I-K, Penter L, Holtick U, Wolf D, Schuler E, Meyer E, Apostolova P, Bertz H, Marks R, Lübbert M, Wäsch R, Scheid C, Stölzel F, Ordemann R, Bug G, Kobbe G, Negrin R, Brune M, Spyridonidis A, Schmitt-Gräff A, van der Velden W, Huls G, Mielke S, Grigoleit GU, Kuball J, Flynn R, Ihorst G, Du J, Blazar BR, Arnold R, Kröger N, Passweg J, Halter J, Socié G, Beelen D, Peschel C, Neubauer A, Finke J, Duyster J, von Bubnoff N: Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multi-center survey. Leukemia, 2015; 29: 2062-2068. :
  • Binder H, Gerds T, Schumacher M: Sirivival Risk Prediction Using High-Dimensional Molecular Data. In: Shigeyuki Matsui, Marc Buyse, Richard Simon (Hrsg.): Design and Analysis of Clinical Trials for Predicitive Medicine. New York: Chapman & Hall/CRC Biostatistics Series, 2015; 271-294.
Kurzbeiträge / short communications:
  • Binder N, Schumacher M, Joly P: Re: “Incidence of Dementia Among Participants and Nonparticipants in a Longitudinal Study of Cognitive Aging” Am J Epidemiol, 2015; 181: 290-292. :
  • Ihorst G, Waldschmidt J, Schumacher M, Wäsch R, Engelhardt M: Analysis of survival by tumor response: have we learnt any better? Ann Hematol, 2015; 94: 1615-1616. :
  • Wolkewitz M: Estimating the Risk of Ventilator-associated Pneumonia as a Function of Time. American Journal of Respiratory and Critical Care Medicine, 2015; 192: 640-641. :
  • Muth C, Aksamit N, von Büdingen F, Motschall E, van Den Akker M, Blom JW, Beyer M, Kühlein T, Lang B: Patientenpräferenzen bei Multimorbidität und Multimedikation – Pilotierung einer Evidence Map. GMS German Medical Science, 2015 (online): Doc15 (49. Kongress für Allgemeinmedizin und Familienmedizin, 17. - 19.09.2015, Bozen, Italien. Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin (DEGAM)). :

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