Research Report for the year 1980-2014

Scientific publications

Journal Articles:
  • Antes G, Augustin N, Beyersmann J, Caputo A, Falck-Ytter Y, Gerds T, Gerlach A, Graf E, Holländer N, Ihorst G, Lang B, Meier-Hirmer C, Musio M, Olschewski M, Roßner R, Sauerbrei W, Schlingmann J, Schmoor C, Schulgen G, Schulte Mönting J, Schwarzer G, Schumacher M: Freiburger Beiträge zur Biometrie und Klinischen Epidemiologie. Informatik, Biometrie und Epidemiologie in Medizin und Biologie, 2004; 35: 74-122.
  • Asbach S, Hartmann M, Wengenmayer T, Graf E, Bode C, Biermann J: Vector selection of a quadripolar left ventricular pacing lead affects acute hemodynamic response to cardiac resynchronization therapy: A randomized cross-over trial. Plos One, 2013; 8 (online): e67235. : http://dx.doi.org/10.1371/journal.pone.0067235
  • Christiansen H, Hirsch O, Philipsen A, Oades RD, Matthies S, Hebebrand J, Ueckermann J, Abdel-Hamid M, Kraemer M, Wiltfang J, Graf E, Colla M, Sobanski E, Alm B, Rösler M, Jacob C, Jans T, Huss M, Schimmelmann BG, Kis B: German validation of the conners adult ADHD rating scale–self-report: Confirmation of factor structure in a large sample of participants with ADHD. J Atten Disord, 2013; 17: 690-698. : http://dx.doi.org/10.1177/1087054711435680
  • Christiansen H, Kis B, Hirsch O, Matthies S, Hebebrand J, Uekermann J, Abdel-Hamid M, Kraemer M, Wiltfang J, Graf E, Colla M, Sobanski E, Alm B, Rösler M, Jacob C, Jans T, Huss M, Schimmelmann BG, Philipsen A: German validation of the Conners Adult ADHD Rating Scales (CAARS) II: Reliability, validity, diagnostic sensitivity and specificity. Eur Psychiat, 2012; 27: 321-328. : http://dx.doi.org/10.1016/j.eurpsy.2010.12.010
  • Eiermann W, Graf E, Ataseven B, Conrad B, Hilfrich J, Massinger-Biebl H, Vescia S, Loibl S, von Minckwitz G, Schumacher M, Kaufmannh M, and for the German Adjuvant Breast Cancer Group: Dose-intensified epirubicin versus standard-dose epirubicin/cyclophosphamide followed by CMF in breast cancer patients with 10 or more positive lymph nodes: Results of a randomised trial (GABG-IV E-93) – The German Adjuvant Breast Cancer Groupstar. Eur J Cancer, 2010; 46: 84-94. : http://dx.doi.org/10.1016/j.ejca.2009.10.001
  • Farthmann J, Gabriel B, Niesel A, Fünfgeld C, Krauss A, Lenz F, Augenstein HJ, Graf E, Watermann D: Pelvic floor related quality of life after vaginal mesh implantation. Secondary endpoint of a prospective randomized trial. Pelviperineology, 2014; 33: 74-79. (download: http://www.pelviperineology.org/september-2014/pdf/pelviperineology-september-2014.pdf)
  • Farthmann J, Watermann D, Niesel A, Fünfgeld C, Kraus A, Lenz F, Augenstein HJ, Graf E, Gabriel B: Lower exposure rates of partially absorbable mesh compared to nonabsorbable mesh for cystocele treatment: 3-year follow-up of a prospective randomized trial. Int Urogynecol J, 2013; 24: 749-758. : http://dx.doi.org/10.1007/s00192-012-1929-2
  • Graf E: The propensity score in the analysis of therapeutic studies. Biometrical Journal, 1997; 39: 297-307.
  • Graf E, Schmoor C, Sauerbrei W, Schumacher M: Assessment and comparison of prognostic classification schemes for survival data. Statistics in Medicine, 1999; 18: 2529-2545.
  • Graf E, Schumacher M: An investigation on measures of explained variation in survival analysis. The Statistician, 1995; 44: 497-507.
  • Jans T, Graf E, Jacob C, Zwanzger U, Groß-Lesch S, Matthies S, Perlov E, Hennighausen K, Jung M, Rösler M, Schulte-Altedorneburg M, von Gontard A, Hänig S, Sobanski E, Alm B, Poustka L, Bliznak L, Colla M, Gentschow L, Burghardt R, , Salbach-Andrae H, Becker K, Holtmann M, Freitag C, Warnke A, Philipsen A: A randomized controlled multicentre trial on the treatment for ADHD in mothers and children: enrolment and basic characteristics of the study sample. ADHD Attention Deficit and Hyperactivity Disorders, 2013; 5: 29-40. : http://dx.doi.org/10.1007/s12402-012-0092-4
  • Jans T, Philipsen A, Graf E, Ihorst G, Gerlach M, Warnke A: Does the treatment of maternal attention deficit and hyperactivity disorder (ADHD) enhance the efficacy of a behavioural parent training for the treatment of their children's ADHD? Study protocol of a randomized controlled multicentre trail. ADHD Attention Deficit and Hyperactivity Disorders, 2009; 1: 33-45. : http://dx.doi.org/10.1007/s12402-009-0004-4
  • Jans T, Philipsen A, Graf E, Schwenck C, Gerlach M, Warnke A, and Studiengruppe AIMACKi: Die Bedeutung des Vorliegens einer Aufmerksamkeitsdefizit- und Hyperaktivitätsstörung (ADHS) bei Müttern für die Behandlung ihrer Kinder mit ADHS - Überblick und Skizze des Studienprotokolls einer multizentrischen randomisierten kontrollierten Psychotherapiestudie. Z Kinder Jug-psych, 2008; 36: 335-343.
  • Kaufmann M, Graf E, Jonat W, Eiermann W, Geberth M, Albert U-S, Gademann G, Conrad B, Stahl K, Minckwitz von G, Schumacher M: Tamoxifen versus control after adjuvant, risk-adapted chemotherapy in postmenopausal, receptor-negative patients with breast cancer: A randomized trial (GABG-IV D-93) - The German Adjuvant Breast Cancer Group. J Clin Oncol, 2005; 23: 7842-7848.
  • Kaufmann M, Graf E, Jonat W, Eiermann W, Vescia S, Geberth M, Conrad B, Gademann G, Albert U-S, Loibl S, von Minckwitz G, Schumacher M: A randomised trial of goserelin versus control after adjuvant, risk-adapted chemotherapy in premenopausal patients with primary breast cancer – GABG-IV B-93. Eur J Cancer, 2007; 43: 2351-2358.
  • Landgrebe M, Binder H, Koller M, Eberl Y, Kleinjung T, Eichhammer P, Graf E, Hajak G, Langguth B: Design of a placebo-controlled, randomized study of the efficacy of repetitive transcranial magnetic stimulation for the treatment of chronic tinntius. BMC Psychiatry, 2008; 8: 1-9. : http://www.biomedcentral.com/1471-244X/8/23; doi:10.1186/1471-244X-8-23
  • Lonjou C, Thomas L, Borot N, Ledger N, Toma de C, LeLouet H, Graf E, Schumacher M, Hovnanian A, Mockenhaupt M, Roujeau J-C, (for the RegiSCAR group): A marker for Stevens-Johnson syndrome ...: ethnicity matters. The Pharmacogenomics Journal, 2006; 6: 1-4.
  • Minckwitz von G, Costa SD, Raab G, Blohmer J-U, Eidtmann H, Hilfrich J, Merkle E, Jackisch C, Gademann G, Tulusan AH, Eiermann W, Graf E, Kaufmann M for the German Preoperative Adriamycin-Docetaxel and German Adjuvant Breast Cancer Study Group: Dose-dense Doxorubicin, Docetaxel, and Granulocyte colony-stimulating factor support with or without Tamoxifen as preoperative therapy in patients with operable carcinoma of the breast: A randomized, controlled, open phase IIb study. J Clin Oncol, 2001; 19 (15): 3506-3515.
  • Minckwitz von G, Graf E, Geberth M, Eiermann W, Jonat W, Conrad B, Brunnert K, Gerber B, Vescia S, Wollert J, Kaufmann M: CMF versus goserelin as adjuvant therapy for node-negative, hormone-receptor-positive breast cancer in premenopausal patients: A randomised trial (GABG trial IV-A-93). Eur J Cancer, 2006; 42: 1780-1788.
  • Minckwitz von G, Raab G, Schütte M, Hilfrich J, Blohmer J-U, Gerber B, Costa SD, Merkle E, Eidtmann H, Lampe D, Jackisch C, Bois du A, Tulusan AH, Gademann G, Sinn HP, Caputo A, Graf E, Kaufmann M für die German Preoperative Adriamycin-Docetaxel (GEPARDO), German Adjuvant Breast (GABG)-Studiengruppe: Präoperative Chemotherapie operabler primärer Mammakarzinome mit einer dosisdichten Kombination von Adriamycin und Docetaxel (ADoc). Zentralblatt für Gynäkologie, 2001; 123: 497-504.
  • Philipsen A, Graf E, Jans T, Matthies S, Borel P, Colla M, Gentschow L, Langner D, Jacob C, Groß-Lesch S, Sobanski E, Alm B, Schumacher-Stien M, Roesler M, Retz W, Retz-Junginger P, Kis B, Abdel-Hamid M, Heinrich V, Huss M, Kornmann C, Bürger A, Tebartz van Elst L, Berger M: A randomized controlled multicenter trial on the multimodal treatment of adult attention-deficit hyperactivity disorder: enrollment and characteristics of the study sample. ADHD Attention Deficit and Hyperactivity Disorders, 2014; 6: 35-47. : http://dx.doi.org/10.1007/s12402-013-0120-z
  • Philipsen A, Graf E, van Elst LT, Jans T, Warnke A, Hesslinger B, Ebert D, Gerlach M, Matthies S, Colla M, Jacob C, Sobanski E, Alm B, Rösler M, Ihorst G, Gross-Lesch S, Gentschow L, Kis B, Huss M, Lieb K, Schlander M, Berger M: Evaluation of the efficacy and effectiveness of a structured disorder tailored psychotherapy in ADHD in adults: study protocol of a randomized controlled multicentre trial. ADHD Attention Deficit and Hyperactivity Disorders, 2010; 2: 203-212. : http://dx.doi.org/10.1007/s12402-010-0046-7
  • Reithmeier T, Graf E, Piroth T, Trippel M, Pinsker MO, Nikkhah G: BCNU for recurrent glioblastoma multiforme: efficacy, toxicity and prognostic factors. Bmc Cancer, 2010; 10 (online): 30. : http://dx.doi.org/10.1186/1471-2407-10-30
  • Sauerbrei W, Graf E, Schumacher M: Randomisation und Patientenaufklärung. Notwendigkeit der Randomisation aus methodischer Sicht Onkologie, 1996; 19: 184-190.
  • Schmoor C, Eisele C, Graf E, Sauerbrei W, Klingele B, Hellmer A, Rossner R, Schumacher M: Arbeitsweisen des Methodischen Zentrums am Institut für Medizinische Biometrie und Medizinische Informatik der Universität Freiburg bei der biometrischen Betreuung klinischer Studien Informatik, Biometrie und Epidemiologie in Medizin und Biologie, 1997; 28: 253-274.
  • Schmoor C, Gall C, Stampf S, Graf E: Correction of confounding bias in non-randomized studies by appropriate weighting. Biometrical J, 2011; 53: 369-387. : http://dx.doi.org/10.1002/bimj.201000154
  • Schoop R, Graf E, Schumacher M: Quantifying the predictive performance of prognostic models for censored survival data with time-dependent covariates. Biometrics, 2008; 64: 603-610.
  • Schoop R, Schumacher M, Graf E: Measures of prediction error for survival data with longitudinal covariates. Biometrical J, 2011; 53: 275-293. : http://dx.doi.org/10.1002/bimj.201000145
  • Schumacher M, Graf E, Gerds T: How to assess prognostic models for survival data: a case study in oncology. Method Inform Med, 2003; 42: 564-571.
  • Senn S, Graf E, Caputo A: Stratification for the propensity score compared with linear regression techniques to assess the effect of treatment or exposure. Correction in Stat Med 2008;27:4615. Stat Med, 2007; 26: 5529-5544.
  • Stampf S, Graf E, Schmoor C, Schumacher M: Estimators and confidence intervals for the marginal odds ratio using logistic regression and propensity score stratification. Stat Med, 2010; 29: 760-769. : http://dx.doi.org/10.1002/sim.3811
  • Vesper J, Graf E, WilleC, Tilgner, Trippel JM, Nikkhah G, Ostertag CB: Retrospective analysis of treatment outcome in 315 patients with oligodendroglial brain tumors. Bmc Neurol, 2009; 9 (online): 33. : http://dx.doi.org/10.1186/1471-2377-9-33
  • Wertzel H, Siebert H, Lange W, Swoboda L, Graf E, Hasse J: Results after surgery in stage-I bronchogenic carcinoma Thoracic and Cardiovascular Surgeon, 1998; 46: 365-369.
Book Chapters:
  • Binder H, Graf E: Brier scores. In: Kattan, M. W. (Hrsg.): Encyclopedia of Medical Decision Making. SAGE Publications, 2009.
  • Graf E: Modelling response: Traditional approaches compared to the propensity score In: Abel U Koch A (Hrsg.): Nonrandomized Comparative Clinical Studies Symposium Publishing, Düsseldorf, 1998; 187-188.
  • Graf E: Explained variation measures in survival analysis In: Armitage P Colton T (Hrsg.): Encyclopedia of Biostatistics John Wiley and Sons, Chichester, 1998; 1441-1443.
  • Graf E: Variation, explained and residual In: Kotz, S, Read, CB, Banks, DL (Hrsg.): Encyclopedia of Statistical Sciences - Update John Wiley and Sons, 1999; 776-781.
  • Graf E: Explained variation measures in survival analysis. In: Peter Armitage, Theodore Colton (Hrsg.): Encyclopedia of Biostatistics, 3. Auflage. chichester: John Wiley & Sons, Ltd, 2005; 1856-1858.
  • Graf E: Explained variation measures in survival analysis. In: Keiding N, Anderson P (Hrsg.): Survival and Event History Analysis. New York: John Wiley & Sons, 2006.
  • Graf E, Sauerbrei W, Schumacher M, Schmoor C: Berücksichtigung prognostischer Faktoren bei der Planung von Therapiestudien. In: Kunath, H., Lochmann, U., Straube, R., Jöckel, K.H., Köhler, C.O. (Hrsg.): Medizinische Informatik, Biometrie und Epidemiologie. , 1995; 475-480.
  • Schmoor C, Graf E: Hazard Ratio. In: Balakrishnan N (Hrsg.): Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs. Hoboken, New Jersey: John Wiley & Sons, Inc., 2014; 483-499.: http://dx.doi.org/10.1002/9781118596005.ch38
Short Communications:
  • Graf E, Schumacher M: Comments on 'The performance of different propensity score methods for estimating marginal odds ratios' by Peter C. Austin, Statistics in Medicine 2007; 26(16):3078-3094. Stat Med, 2008; 27: 3915-3917. : http://dx.doi.org/10.1002/sim.3271
  • Rücker G, Graf E, Schumacher M: Letter to the editor concerning Shadish WR, Clark MH, Steiner PM: Can Nonrandomized Experiments Yield Accurate Answers? A Randomized Experiment Comparing Random and Nonrandom Assignments. Journal of the American Statistical Association. December 1, 2008, 103(484): 1334-1344. doi:10.1198/016214508000000733. [Website: http://pubs.amstat.org/doi/abs/10.1198/016214508000000733]. J Am Stat Assoc, 2010 (online): 1-6. : http://pubs.amstat.org/doi/suppl/10.1198/016214508000000733/suppl_file/Letter.pdf