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 Forschungsbericht für das Jahr 2016

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Baumgarten P, Blank AE, Franz K, Hattingen E, Dunst M, Zeiner P, Hoffmann K, Bähr O, Mäder L, Goeppert B, Machein M, Seifert V, Steinbach JP, Plate KH, Harter PN, Mittelbronn M: Differential expression of vascular endothelial growth factor A, its receptors VEGFR-1, -2, and -3 and co-receptors neuropilin-1 and -2 does not predict bevacizumab response in human astrocytomas. Neuro-oncology, 2016; 18 (2): 173-183.
  • Bausch B, Wellner U, Peyre M, Boedeker CC, Hes FJ, Anglani M, de Campos JM, Kanno H, Maher ER, Krauss T, Sansó G, Barontini M, Letizia C, Hader C, Schiavi F, Zanoletti E, Suárez C, Offergeld C, Malinoc A, Zschiedrich S, Glasker S, Bobin S, Sterkers O, Ba Huy PT, Giraud S, Links T, Eng C, Opocher G, Richard S, Neumann HP: Characterization of endolymphatic sac tumors and von Hippel-Lindau disease in the International Endolymphatic Sac Tumor Registry. Head Neck-j Sci Spec, 2016; 38 Suppl. 1: E673-E679. : http://dx.doi.org/10.1002/hed.24067
  • Bilger A, Milanovic D, Lorenz H, Oehlke O, Urbach H, Schmucker M, Weyerbrock A, Nieder C, Grosu AL: Stereotactic fractionated radiotherapy of the resection cavity in patients with one to three brain metastases. Clin Neurol Neurosur, 2016; 142: 81-86. : http://dx.doi.org/10.1016/j.clineuro.2016.01.008
  • Cattaneo G, Schumacher M, Maurer C, Wolfertz J, Jost T, Büchert M, Keuler A, Boos L, Shah MJ, Foerster K, Niesen WD, Ihorst G, Urbach H, Meckel S: Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance. Am J Neuroradiol, 2016; 37 (5): 885-891. : http://dx.doi.org/10.3174/ajnr.A4625
  • Delev D, Wabbels B, Schramm J, Nelles M, Elger CE, von Lehe M, Clusmann H, Grote A: Vision after trans-sylvian or temporobasal selective amygdalohippocampectomy: a prospective randomised trial. Acta Neurochir, 2016; 158 (9): 1757-1765. : http://dx.doi.org/10.1007/s00701-016-2860-y
  • Egger K *, Hohenhaus M *, Van Velthoven V, Heil S, Urbach H: Spinal diffusion tensor tractography for differentiation of intramedullary tumor-suspected lesions. Eur J Radiol, 2016; 85 (12): 2275-2280. : http://dx.doi.org/10.1016/j.ejrad.2016.10.018
  • Franke J, Manson N, Buzek D, Kosmala A, Hubbe U, Rosenberg W, Pereira P, Assietti R, Martens F, Lam K, Barbanti Brodano G, Durny P, Lidar Z, Scheufler K, Senker W: MASTERS-D Study: A Prospective, Multicenter, Pragmatic, Observational, Data-Monitored Trial of Minimally Invasive Fusion to Treat Degenerative Lumbar Disorders, One-Year Follow-Up. Cureus, 2016; 8 (6) (online): e640. : http://dx.doi.org/10.7759/cureus.640
  • Gierthmuehlen M, Aguirre D, Cota O, Zentner J, Stieglitz T, Plachta DT: Influence of Clonidine on Antihypertensive Selective Afferent Vagal Nerve Stimulation in Rats. Neuromodulation, 2016; 19 (6): 597-606. : http://dx.doi.org/10.1111/ner.12463
  • Gierthmuehlen M, Stieglitz T, Zentner J, Plachta DT: Haemodynamic Responses to Selective Vagal Nerve Stimulation under Enalapril Medication in Rats. Plos One, 2016; 11 (1) (online): e0147045. : http://dx.doi.org/10.1371/journal.pone.0147045
  • Gierthmühlen M, Plachta DT: Effect of Selective Vagal Nerve Stimulation on Blood Pressure, Heart Rate and Respiratory Rate in Rats under Metoprolol Medication. Hypertens Res, 2016; 39 (2): 79-87. : http://dx.doi.org/10.1038/hr.2015.122
  • Günzle J, Osterberg N, Saavedra JE, Weyerbrock A: Nitric oxide released from JS-K induces cell death by mitotic catastrophe as part of necrosis in glioblastoma multiforme. Cell Death Dis, 2016; 7 (9) (online): e2349-e2349. : http://dx.doi.org/10.1038/cddis.2016.254
  • Hassler C, Guy J, Nietzschmann M, Plachta DT, Staiger JF, Stieglitz T: Intracortical polyimide electrodes with a bioresorbable coating. Biomed Microdevices, 2016; 18 (5) (online): 81. : http://dx.doi.org/10.1007/s10544-016-0106-7
  • Heiland DH, Masalha W, Franco P, Machein MR, Weyerbrock A: Progression-free and overall survival in patients with recurrent Glioblastoma multiforme treated with last-line bevacizumab versus bevacizumab/lomustine. J Neuro-oncol, 2016; 126 (3): 567-575. : http://dx.doi.org/10.1007/s11060-015-2002-z
  • Heiland DH, Staszewski O, Hirsch M, Masalha W, Franco P, Grauvogel J, Capper D, Schrimpf D, Urbach H, Weyerbrock A: Malignant Transformation of a Dysembryoplastic Neuroepithelial Tumor (DNET) Characterized by Genome-Wide Methylation Analysis. J Neuropath Exp Neur, 2016; 75 (4): 358-365. : http://dx.doi.org/10.1093/jnen/nlw007
  • Heiland DH *, Mader I *, Schlosser P, Pfeifer D, Carro MS, Lange T, Schwarzwald R, Vasilikos I, Urbach H, Weyerbrock A: Integrative Network-based Analysis of Magnetic Resonance Spectroscopy and Genome Wide Expression in Glioblastoma multiforme. Sci Rep-uk, 2016; 6 (online): 29052. : http://dx.doi.org/10.1038/srep29052
  • Herrlinger U, Schäfer N, Steinbach JP, Weyerbrock A, Hau P, Goldbrunner R, Friedrich F, Rohde V, Ringel F, Schlegel U, Sabel M, Ronellenfitsch MW, Uhl M, Maciaczyk J, Grau S, Schnell O, Hänel M, Krex D, Vajkoczy P, Gerlach R, Kortmann RD, Mehdorn M, Tüttenberg J, Mayer-Steinacker R, Fietkau R, Brehmer S, Mack F, Stuplich M, Kebir S, Kohnen R, Dunkl E, Leutgeb B, Proescholdt M, Pietsch T, Urbach H, Belka C, Stummer W, Glas M: Bevacizumab Plus Irinotecan Versus Temozolomide in Newly Diagnosed O6-Methylguanine-DNA Methyltransferase Nonmethylated Glioblastoma: The Randomized GLARIUS Trial. J Clin Oncol, 2016; 34 (14): 1611-1619. : http://dx.doi.org/10.1200/JCO.2015.63.4691
  • Hubbe U, Franco-Jimenez P, Klingler JH, Vasilikos I, Scholz C, Kogias E: Minimally invasive tubular microdiscectomy for recurrent lumbar disc herniation. J Neurosurg-spine, 2016; 24 (1): 48-53. : http://dx.doi.org/10.3171/2015.4.SPINE14883
  • Jabbarli R, Reinhard M, Roelz R, Shah M, Niesen WD, Kaier K, Taschner C, Weyerbrock A, Velthoven VV: The predictors and clinical impact of intraventricular hemorrhage in patients with aneurysmal subarachnoid hemorrhage. Int J Stroke, 2016; 11 (1): 68-76. : http://dx.doi.org/10.1177/1747493015607518
  • Jabbarli R, Reinhard M, Roelz R, Shah M, Niesen WD, Kaier K, Taschner C, Weyerbrock A, Van Velthoven V: Intracerebral Hematoma Due to Aneurysm Rupture: Are There Risk Factors Beyond Aneurysm Location? Neurosurgery, 2016; 78 (6): 813-820. : http://dx.doi.org/10.1227/NEU.0000000000001136
  • Jabbarli R, Reinhard M, Shah M, Roelz R, Niesen WD, Kaier K, Taschner C, Weyerbrock A, Van Velthoven V: Early Vasospasm after Aneurysmal Subarachnoid Hemorrhage Predicts the Occurrence and Severity of Symptomatic Vasospasm and Delayed Cerebral Ischemia Cerebrovasc Dis, 2016; 41 (5-6): 265-272.
  • Khalil AA, Hohenhaus M, Kunze C, Schmidt W, Brunecker P, Villringer K, Merboldt KD, Frahm J, Fiebach JB: Sensitivity of Diffusion-Weighted STEAM MRI and EPI-DWI to Infratentorial Ischemic Stroke Plos One, 2016; 11 (8) (online): e0161416. : http://dx.doi.org/10.1371/journal.pone.0161416
  • Kling T, Ferrarese R, Ó hAilín D, Johansson P, Heiland DH, Dai F, Vasilikos I, Weyerbrock A, Jörnsten R, Carro MS, Nelander S: Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma. EBioMedicine, 2016; 12: 72-85. : http://dx.doi.org/10.1016/j.ebiom.2016.08.050
  • Lykissas MG, Vasilikos I, Memtsoudis SG, Vougioukas V: Minimally invasive pedicle-based non-fusion stabilization of the lumbar spine. J Neurosurg Sci, 2016; 60 (1): 134-136. (download: http://www.minervamedica.it/en/journals/neurosurgical-sciences/article.php?cod=R38Y2016N01A0134)
  • Oehlke O, Mix M, Graf E, Schimek-Jasch T, Nestle U, Götz I, Schneider-Fuchs S, Weyerbrock A, Mader I, Baumert BG, Short SC, Meyer PT, Weber WA, Grosu AL: Amino-acid PET versus MRI guided re-irradiation in patients with recurrent glioblastoma multiforme (GLIAA) - protocol of a randomized phase II trial (NOA 10/ARO 2013-1). Bmc Cancer, 2016; 16 (1) (online): 769. : http://dx.doi.org/10.1186/s12885-016-2806-z
  • Osterberg N, Ferrara N, Vacher J, Gaedicke S, Niedermann G, Weyerbrock A, Doostkam S, Schaefer HE, Plate KH, Machein MR: Decrease of VEGF-A in myeloid cells attenuates glioma progression and prolongs survival in an experimental glioma model. Neuro-oncology, 2016; 18 (7): 939-949. : http://dx.doi.org/10.1093/neuonc/now005
  • Plachta DT, Zentner J, Aguirre D, Cota O, Stieglitz T, Gierthmuehlen M: Effect of Cardiac-Cycle-Synchronized Selective Vagal Stimulation on Heart Rate and Blood Pressure in Rats. Adv Ther, 2016; 33 (7): 1246-1261. : http://dx.doi.org/10.1007/s12325-016-0348-z
  • Ringel F, Pape H, Sabel M, Krex D, Bock HC, Misch M, Weyerbrock A, Westermaier T, Senft C, Schucht P, Meyer B, Simon M, SN1 study group: Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection. Neuro-oncology, 2016; 18 (1): 96-104. : http://dx.doi.org/10.1093/neuonc/nov145
  • Roelz R, Scholz C, Klingler JH, Scheiwe C, Sircar R, Hubbe U: Giant central thoracic disc herniations: surgical outcome in 17 consecutive patients treated by mini-thoracotomy. Eur Spine J, 2016; 25 (5): 1443-1451. : http://dx.doi.org/10.1007/s00586-016-4380-0
  • Roelz R, Strohmaier D, Jabbarli R, Kraeutle R, Egger K, Coenen VA, Weyerbrock A, Reinacher PC: Residual Tumor Volume as Best Outcome Predictor in Low Grade Glioma - A Nine-Years Near-Randomized Survey of Surgery vs. Biopsy. Sci Rep-uk, 2016; 6 (online): 32286. : http://dx.doi.org/10.1038/srep32286
  • Schmeiser B, Hammen T, Steinhoff BJ, Zentner J, Schulze-Bonhage A: Long-term outcome characteristics in mesial temporal lobe epilepsy with and without associated cortical dysplasia. Epilepsy Research, 2016; 126: 147-156. : http://dx.doi.org/10.1016/j.eplepsyres.2016.07.011
  • Scholz C, Hubbe U, Kogias E, Roelz R, Klingler JH: Microsurgical resection of juxtafacet cysts without concomitant fusion-Long-term follow-up of 74 patients. Clin Neurol Neurosur, 2016; 153: 35-40. : http://dx.doi.org/10.1016/j.clineuro.2016.12.008
  • Soteriou E, Grauvogel J, Laszig R, Grauvogel TD: Prospects and limitations of different registration modalities in electromagnetic ENT navigation. Eur Arch Oto-rhino-l, 2016; 273 (11): 3979-3986.
  • Strumia M, Reichardt W, Staszewski O, Heiland DH, Weyerbrock A, Mader I, Bock M: Glioma vessel abnormality quantification using time-of-flight MR angiography. Magn Reson Mater Phy, 2016; 29 (5): 765-775. : http://dx.doi.org/10.1007/s10334-016-0558-z
  • Watzlawick R, Rind J, Sena ES, Brommer B, Zhang T, Kopp MA, Dirnagl U, Macleod MR, Howells DW, Schwab JM: Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis. Plos Biol, 2016; 14 (5) (online): e1002468. : http://dx.doi.org/10.1371/journal.pbio.1002468
  • Wick W, Gorlia T, Bady P, Platten M, van den Bent MJ, Taphoorn MJ, Steuve J, Brandes AA, Hamou MF, Wick A, Kosch M, Weller M, Stupp R, Roth P, Golfinopoulos V, Frenel JS, Campone M, Ricard D, Marosi C, Villa S, Weyerbrock A, Hopkins K, Homicsko K, Lhermitte B, Pesce GA, Hegi ME: Phase II study of radiotherapy and temsirolimus versus radiochemotherapy with temozolomide in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation (EORTC 26082). Clin Cancer Res, 2016; 22 (19): 4797-4806. (download: http://clincancerres.aacrjournals.org/content/22/19/4797.full-text.pdf)
Buchbeiträge:
  • Gierthmühlen M: Microsurgical Approach to Spinal Canal in Rats. In: Janowski, Miroslaw (Ed.) (Hrsg.): Experimental Neurosurgery in Animal Models. Springerverlag, 2016.
Fallbeispiele:
  • Dietel T, Zentner J, Ramantani G, Schulze-Bonhage A, Hethey S, Kruse B, Reutlinger C, Mayer H, Steinhoff BJ, Bast T: Erfolgreiche Resektion einer fokalen kortikalen Dysplasie (FCD) der Zentralregion bei einem 6 Monate alten Säugling mit nur sehr milder postoperativer Parese. Z Epileptologie, 2016; 29: 161-167.
  • Taschner CA, Doostkam S, Hubbe U, Schaefer HE, Urbach H, Beck C, Prinz M: Freiburg Neuropathology Case Conference : Spinal Cord Compression Due to a Lesion Adjacent to the Dens Axis. Clin Neuroradiol, 2016; 26 (1): 121-125. : http://dx.doi.org/10.1007/s00062-016-0503-6
  • Taschner CA, Rodler C, Scheiwe C, Urbach H, Eiden S, Prinz M: Freiburg Neuropathology Case Conference : Petrosal mass lesion in a patient with von Hippel-Lindau syndrome. Clin Neuroradiol, 2016; 26 (2): 251-257. : http://dx.doi.org/10.1007/s00062-016-0518-z
Vorträge:
  • Gierthmühlen M.: Intraoperatives Neuromonitoring in der Neurochirurgie. 2016 (89. Kongress der Deutschen Gesellschaft für Neurologie (DGN), 21.-24. September 2016, Mannheim).
  • Hubbe U, Scholz C, Hohenhaus M, Klingler JH: Poster: Spine Mask: Eine neue Technik zum nicht-invasiven Tracking bei der Wirbelsäulennavigation. 2016 (Jahrestagung der Sektion Wirbelsäule der DGNC, 16.-17.09.2016, Köln).
  • Hubbe U, Scholz C, Klingler JH: Poster: HWS-Cages aus trabekulärem Titan: Die Vorteile von Titan ohne die Nachteile in der Bildgebung? 2016 (Jahrestagung der Sektion Wirbelsäule der DGNC, 16.-17.09.2016, Köln).
  • Klingler JH, Krüger MT, Scholz C, Rölz R, Hubbe U: Poster: Perioperative and postoperative complications in morbidly obese patients (BMI >40 kg/m2) undergoing minimally invasive transforaminal lumbar interbody fusion. 2016 (Eurospine 2016, 05.-07.10.2016, Berlin).
  • Klingler JH, Scholz C, Sircar R, Hubbe U: Vergleich der konventionellen Fluoroskopie und 3D Fluoroskopie-basierten Navigation bei minimal-invasiver transforaminaler lumbaler interkorporeller Fusion (MIS TLIF) hinsichtlich der Strahlenexposition – Ergebnisse einer prospektiven, randomisierten Studie. 2016 (Jahrestagung der Sektion Wirbelsäule der DGNC, 16.-17.09.2016, Köln).
  • Klingler JH, Scholz C, Sircar R, Hubbe U: Strahlenexposition bei minimal-invasiver transforaminaler lumbaler interkorporeller Fusion (MIS TLIF) mittels konventioneller Fluoroskopie und 3D Fluoroskopie-basierter Navigation - Ergebnisse einer prospektiven, randomisierten Vergleichsstudie. 2016 (11. Jahrestagung der Deutschen Wirbelsäulengesellschaft, 01.-03.12.2016, Hannover).
  • Roelz R.: Population-wide MRI-screening for early detection of glioblastoma? Considerations from a naturally occurring "Screening-Like" setting. Sitzung: DI.08 Neuroonkologie 4: Bildgebung von Gliomen (Sitzung in Deutsch) 2016 (67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 12.-15. Juni 2016, Frankfurt am Main).
  • Schindler C., Osterberg N., Weyerbrock A.: Poster: GDNF modulates the sensitivity of human Glioblastoma cells to the nitric oxide donor JS-K in vitro. 2016 (67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie in Frankfurt a.M., Juni 2016.).
  • Wolf L., Osterberg N., Weyerbrock A.: Poster: The nitric oxide donor JS-K modulates the migration activity of human glioblastoma cells in vitro. 2016 (67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie in Frankfurt a.M., Juni 2016.).
Konferenzbeiträge:
  • Boeser F, Lang BG, Stieglitz T, Plachta DT: Epoxy casting used as nonhermetic encapsulation technique for implantable electronic devices. Conf Proc IEEE Eng Med Biol Soc, 2016; 2016: 1938-1941 (38th Ann. Intern. Conference of the IEEE Engineering in Medicine and Biology Society, Orlando, Fl., USA). : http://dx.doi.org/10.1109/EMBC.2016.7591102
  • Gierthmühlen M: Funktionelle und histologische Evaluation von µECoG-Elektroden im Schaf. / Functional and histological evaluation of µECoG in sheep. 2016 (DGNC 2016 in Frankfurt).
  • Jabbarli R., Reinhard M., Roelz R., Shah M., Weyerbrock A., Van Velthoven V.: Early vasospasm after aneurysmal subarachnoid hemorrhage predicts the occurrence and severity of symptomatic vasospasm and delayed cerebral ischemia. / Früh-Vasospasm nach aneurysmaler Subarachnoidalblutung ist ein Prädiktor für Auftreten und Schwere der symptomatischen Vasospasmen und zerebralen Ischämie. Deutsche Gesellschaft für Neurochirurgie, 2016 (67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS). Frankfurt am Main, 12.-15.06.2016.), Düsseldorf: German Medical Science GMS Publishing House. (Hrsg). : http://DocMI.11.02
  • Jabbarli R., Reinhard M., Roelz R., Shah M., Weyerbrock A., Van Velthoven V.: Intraventricular hemorrhage in aneurysmal subarachnoid hemorrhage: who is at risk?. / Intraventrikuläre Blutung nach aneurysmaler Subarachnoidalblutung: Risikofaktoren bekannt? Deutsche Gesellschaft für Neurochirurgie, 2016 (67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS). Frankfurt am Main, 12.-15.06.2016.), Düsseldorf: German Medical Science GMS Publishing House. (Hrsg). : http://DocMI.11.02
  • Wagner K., Urbach H., Kaller C.P., Metternich B., Buschmann F., Schulze-Bonhage A., Foit N.: Hippocampus Sparing Resections within the Temporal Lobe in Adolescents with Epilepsy: Impact on Cognition and Remaining Hippocampal Volume. Neuropediatrics, 2016; 47: FV02-04. : http://dx.doi.org/10.1055/s-0036-1583716