Wissenschaftliche Publikationen

• Fack F, Espedal H, Keunen O, Golebiewska A, Obad N, Harter PN, Mittelbronn M, Bähr O, Weyerbrock A, Stuhr L, Miletic H, Sakariassen PO,, Stieber D, Rygh CB, Lund-Johansen M, Zheng L, Gottlieb E, Niclou SP, Bjerkvig R: Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas. Acta Neuropathol, 2015; 129 (1): 115-131. : http://dx.doi.org/10.1007/s00401-014-1352-5
• Fauser S, Essang C, Altenmüller DM, Staack AM, Steinhoff BJ, Strobl K, Bast T, Schubert-Bast S, Stephani U, Wiegand G, Prinz M, Brandt A, Zentner J, Schulze-Bonhage A: Long-term seizure outcome in 211 patients with focal cortical dysplasia. Epilepsia, 2015; 56 (1): 66-76. : http://dx.doi.org/10.1111/epi.12876
• Heidenreich B, Rachakonda PS, Hosen I, Volz F, Hemminki K, Weyerbrock A, Kumar R: TERT promoter mutations and telomere length in adult malignant gliomas and recurrences. Oncotarget, 2015; 6 (12): 10617-10633. : http://www.ncbi.nlm.nih.gov/pubmed/25797251
• Hohenhaus M, Shah MJ, Eckenweiler M, van Velthoven V: Decompressive hemicraniectomy in the management of acute stroke in children with Moyamoya disease: the difficult balance between the spontaneous postoperative revascularization process and the need for cranial reconstruction. Child Nerv Syst, 2015; 31 (12): 2369-2373. : http://dx.doi.org/10.1007/s00381-015-2802-7
• Hubbe U, Sircar R, Scheiwe C, Scholz C, Kogias E, Krüger MT, Volz F, Klingler JH: Surgeon, staff, and patient radiation exposure in minimally invasive transforaminal lumbar interbody fusion: impact of 3D fluoroscopy-based navigation partially replacing conventional fluoroscopy: study protocol for a randomized controlled trial. Trials, 2015; 16 (1) (online): 142. : http://dx.doi.org/10.1186/s13063-015-0690-5
• Jabbarli R, Reinhard M, Niesen WD, Roelz R, Shah M, Kaier K, Hippchen B, Taschner C, Van Velthoven V: Predictors and impact of early cerebral infarction after aneurysmal subarachnoid hemorrhage. Eur J Neurol, 2015; 22 (6): 941-947. : http://dx.doi.org/10.1111/ene.12686
• Jabbarli R, Reinhard M, Roelz R, Shah M, Niesen WD, Kaier K, Taschner C, Weyerbrock A, Van Velthoven V: Early identification of individuals at high risk for cerebral infarction after aneurysmal subarachnoid hemorrhage: the BEHAVIOR score. J Cerebr Blood F Met, 2015; 35: 1587-1592. : http://dx.doi.org/10.1038/jcbfm.2015.81
• Jabbarli R, Reinhard M, Roelz R, Shah M, Niesen WD, Kaier K, Taschner C, Weyerbrock A, Velthoven VV: Outcome prediction after non-aneurysmal non-traumatic subarachnoid hemorrhage. Curr Neurovasc Res, 2015; 12 (3): 269-276. : http://www.ncbi.nlm.nih.gov/pubmed/26036974
• Klingler JH, Scholz C, Kogias E, Sircar R, Krüger MT, Volz F, Scheiwe C, Hubbe U: Minimally Invasive Technique for PMMA Augmentation of Fenestrated Screws. Scientific World Journal, 2015 (online): 979186. : http://dx.doi.org/10.1155/2015/979186
• Klingler JH, Volz F, Krüger MT, Kogias E, Rölz R, Scholz C, Sircar R, Hubbe U: Accidental durotomy in minimally invasive transforaminal lumbar interbody fusion - frequency, risk factors and management. Scientific World Journal, 2015 (online): 532628. : http://dx.doi.org/10.1155/2015/532628
• Kreshuk A, Walecki R, Koethe U, Gierthmuehlen M, Plachta D, Genoud C, Haastert-Talini K, Hamprecht FA: Automated tracing of myelinated axons and detection of the nodes of Ranvier in serial images of peripheral nerves. J Microsc-oxford, 2015; 259 (2): 143-154. : http://dx.doi.org/10.1111/jmi.12266
• Loh CK, Weis B, van Velthoven V, Reiff C, Rössler J: Photophobia in a blind eye after removal of a progressive orbital optic glioma with denervation. J Neurol Sci, 2015; 358 (1-2): 522-524. : http://dx.doi.org/10.1016/j.jns.2015.09.375
• Oehlke O, Wucherpfennig D, Fels F, Frings L, Egger K, Weyerbrock A, Prokic V, Nieder C, Grosu AL: Whole brain irradiation with hippocampal sparing and dose escalation on multiple brain metastases : Local tumour control and survival. Strahlenther Onkol, 2015; 191 (6): 461-469. : http://www.ncbi.nlm.nih.gov/pubmed/25592907
• Ohla V, Scheiwe C: Meningiomatosis restricted to the left cerebral hemisphere with acute clinical deterioration: Case presentation and discussion of treatment options. Surg Neurol Int., 2015; 6 (online): 64. : http://dx.doi.org/10.4103/2152-7806.155447
• Pereira P, Buzek D, Franke J, Senker W, Kosmala A, Hubbe U, Manson N, Rosenberg W, Assietti R, Martens F, Barbanti Brodano G, Scheufler KM: Surgical data and early postoperative outcomes after minimally invasive lumbar interbody fusion: results of a prospective, multicenter, observational data-monitored study. Plos One, 2015; 10 (3) (online): e0122312. : http://dx.doi.org/10.1371/journal.pone.0122312
• Prasad S, Gaedicke S, Machein M, Mittler G, Braun F, Hettich M, Firat E, Klingner K, Schueler J, Wider D, Wäsch RM, Herold-Mende C, Elsässer-Beile U, Niedermann G: Effective eradication of glioblastoma stem cells by local application of an AC133/CD133-specific T cell-engaging antibody and CD8 T cells. Cancer Res, 2015; 75 (11): 2166-2176. : http://dx.doi.org/10.1158/0008-5472.CAN-14-2415
• Roelz R, Reinacher P, Jabbarli R, Kraeutle R, Hippchen B, Egger K, Weyerbrock A, Machein M: Surgical Ventricular Entry is a Key Risk Factor for Leptomeningeal Metastasis of High Grade Gliomas. Sci Rep-uk, 2015; 5 (online): 17758. : http://dx.doi.org/10.1038/srep17758
• Roelz R, Van Velthoven V, Reinacher P, Coenen VA, Mader I, Urbach H, Meckel S: Unilateral contrast-enhancing pontomedullary lesion due to an intracranial dural arteriovenous fistula with perimedullary spinal venous drainage: the exception that proves the rule. J Neurosurg, 2015; 123 (6): 1534-1539. : http://dx.doi.org/10.3171/2014.11.JNS142278
• Schneider K, Weyerbrock A, Doostkam S, Plate K, Machein M: Lack of evidence for PlGF mediating the tumor resistance after anti-angiogenic therapy in malignant gliomas. J Neuro-oncol, 2015; 121 (2): 269-278. : http://dx.doi.org/10.1007/s11060-014-1647-3
• Scholz A, Harter P, Cremer S, Yalcin B, Gurnik S, Yamaji M, Tacchio M, Sommer K, Baumgarten P, Bähr O, Steinbach J, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Braun C, Schittenhelm J, Früh J, Ullrich E, Mittelbronn M, Plate K, Reiss Y: Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma. Embo Mol Med, 2015; 8 (1): 39-57. : http://dx.doi.org/10.15252/emmm.201505505
• Scholz C, Hubbe U, Kogias E, Klingler JH: Incomplete resection of lumbar synovial cysts - Evaluating the risk of recurrence. Clin Neurol Neurosur, 2015; 136: 29-32. : http://dx.doi.org/10.1016/j.clineuro.2015.05.028
• Vongerichten AN, Santos GS, Aristovich K, Avery J, McEvoy A, Walker M, Holder DS: Characterisation and imaging of cortical impedance changes during interictal and ictal activity in the anaesthetised rat. Neuroimage, 2015; 124: 813-823. : http://dx.doi.org/10.1016/j.neuroimage.2015.09.015
• Wendling AS, Steinhoff BJ, Bodin F, Staack AM, Zentner J, Scholly J, Valenti MP, Schulze-Bonhage A, Hirsch E: Selective amygdalohippocampectomy versus standard temporal lobectomy in patients with mesiotemporal lobe epilepsy and unilateral hippocampal sclerosis: post-operative facial emotion recognition abilities. Epilepsy Res, 2015; 111 (3): 26-32. : http://dx.doi.org/10.1016/j.eplepsyres.2015.01.002

• Kogias E, Franco Jimenez P, Klingler JH, Hubbe U: Minimally invasive redo discectomy for recurrent lumbar disc herniations. J Clin Neurosci, 2015; 22 (9): 1382-1386. : http://dx.doi.org/10.1016/j.jocn.2015.02.028

• Klingler JH, Krüger MT, Kogias E, Brendecke SM, Hubbe U, Scheiwe C: Minimally invasive resection and vertebroplasty for an osteolytic C-1 metastasis of malignant meningioma: case report. J Neurosurg-spine, 2015; 23 (5): 602-606. : http://thejns.org/doi/abs/10.3171/2015.1.SPINE141041?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&
• Kogias E, Franco Jimenez P, Hubbe U: Microendoscopic lumbar discectomy: Technique and results of 188 cases. Indian J Orthop, 2015; 49 (2): 262-263. : http://dx.doi.org/10.4103/0019-5413.152551
• Roelz R, Erny D, Shah MJ, Egger K, Thiel J, Seufert J, Laubner K, Reinacher P: Case Report: Isolated Pauci-immune Vasculitis of the Pituitary Gland Revealed by Stereotactic Biopsy. Exp Clin Endocr Diab, 2015; 02 (01): e4-e7. : http://dx.doi.org/10.1055/s-0035-1548827
• Taschner CA, Erny D, Shah MJ, Eckenweiler M, Urbach H, Lutz K, Prinz M: Freiburg Neuropathology Case Conference: An Infant with a Supratentorial Mass Lesion. Clin Neuroradiol, 2015; 25 (2): 211-217. : http://dx.doi.org/10.1007/s00062-015-0400-4
• Taschner CA, Erny D, Weyerbrock A, Urbach H, Maurer C, Prinz M: Freiburg Neuropathology Case Conference. A Mass Lesion of the Fourth Ventricle. Clin Neuroradiol, 2015; 25 (4): 439-443. : http://www.ncbi.nlm.nih.gov/pubmed/26541140

• Hubbe U, Roelz R: Comparison of In-hospital Morbidity and Mortality Rates Between Anterior and Nonanterior Approach Procedures for Thoracic Disc Herniation" by Yoshihara et al. Spine, 2015; 40 (17): E999-E1000. : http://dx.doi.org/10.1097/BRS.0000000000001029

• Heiland DH, Pfeifer D, Mader I, Weyerbrock A: Integrative analysis of Magnetic-Resonance- Spectroscopy (MRS) and Genome-wide Expression. 2015 (Tagung der Sektion Neuroonkologie der Deutschen Gesellschaft für Neurochirurgie (DGNC), 30. und 31. Oktober 2015, Freiburg).
• Heiland DH, Staszewski O, Capper D, Weyerbrock A: Malignant transformation of a dysembryoplastic neuroepithelial tumor characterized by genome-wide methylation and copy-number variants. 2015 (Tagung der Sektion Neuroonkologie der Deutschen Gesellschaft für Neurochirurgie (DGNC), 30. und 31. Oktober 2015, Freiburg).
• Hubbe U, Scheufler KM, Franke J: Untergruppenanalyse: Outcomes einer minimal-invasiven lumbalen Wirbelkörperfusion (MILIF) bei Patienten mit Stenose. 2015 (Deutscher Wirbelsäulenkongress 2015, 10.-12.12.15, Frankfurt).
• Jabbarli R, Reinhard M, Niesen WD, Roelz R, Shah M, Kaier K, Taschner C, van Velthoven V: Früh-Infarkt nach Subarachnoidalblutung – klinisches Impact und Prädiktoren. 2015 (32. Auflage der Jahrestagung der Deutschen Gesellschaft für NeuroIntensiv- und Notfallmedizin und der Deutschen Schlaganfall-Gesellschaft, die vom 29. bis 31. Januar 2015 Berlin).
• Klingler JH, Krüger MT, Scholz C, Rölz R, Sircar R, Hubbe U: Minimally invasive transforaminal lumbar interbody fusion (MIS TLIF): perioperative and postoperative complications in patients aged 80 to 90 years. 2015 (66. Jahrestagung der DGNC, 07.-10.06.2015, Karlsruhe).
• Klingler JH, Volz F, Krüger MT, Kogias E, Sircar R, Hubbe U: Poster: Frequency, management and risk factors of inadvertent dural tears in minimally invasive transforaminal lumbar interbody fusion . 2015 (66. Jahrestagung der DGNC, 07.-10.06.2015, Karlsruhe).
• Krüger MT, Hubbe U, Sircar R, Scholz C, Klingler JH: Impact of morbid obesity (BMI >40 kg/m2) on complication rate and short-term outcome following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). 2015 (66. Jahrestagung der DGNC, 07.-10.06.2015, Karlsruhe).
• Laubner K, Shah MJ: Erkrankungen der Hypophyse – konservative und chirurgische Behandlung. 2015 (Kreisverein Müllheim).
• Mader I, Reinacher P, Kellner E, Heiland DH, Staszewski O, Kiselev VG, Egger K, Mast H, Urbach H, Weyerbrock A: Mesoscopic Imaging of Glioblastomas: Are Diffusion, Perfusion and Spectroscopic Measure Influenced by the Radio-Genetic Phenotype? 2015 (Tagung der Sektion Neuroonkologie der Deutschen Gesellschaft für Neurochirurgie (DGNC), 30. und 31. Oktober 2015, Freiburg).
• Masilamani AP, Bug E, Ferrarese R, Unterkircher T, Platania L, Weyerbrock A, Bredel M, Carro MS: Loss of Function of Krüppel-like Factor 6 Promotes NFkB Signaling in Glioblastoma. 2015 (Tagung der Sektion Neuroonkologie der Deutschen Gesellschaft für Neurochirurgie (DGNC), 30. und 31. Oktober 2015, Freiburg).
• Meckel S, Schumacher M, Keuler A, Boss L, Shah M, Maurer C, Förster K, Niesen WD, Cattaneo G: Endovaskuläres Kühlkathetersystem zur selektiven zerebralen Hypothermie bei der akuten Schlaganfalltherapie – eine tierexperimentelle Machbarkeitsstudie. 2015 (32. Auflage der Jahrestagung der Deutschen Gesellschaft für NeuroIntensiv- und Notfallmedizin und der Deutschen Schlaganfall-Gesellschaft, die vom 29. bis 31. Januar 2015 Berlin).
• Roelz R, Weyerbrock A, Reinacher P: Decision making between surgery and biopsy for diffuse low grade gliomas: Lessons from 126 near-randomized patients. 2015 (Tagung der Sektion Neuroonkologie der Deutschen Gesellschaft für Neurochirurgie (DGNC), 30. und 31. Oktober 2015, Freiburg).
• Roelz R, Weyerbrock A, Reinacher P: Residual Tumor Volume Rather Than Initial Management Strategy Predicts Outcome in LGG Patients / Analysis of an Eight-Year Near-Randomized Patient Distribution Between Surgery and Biopsy from 2004 - 2012. 2015 (Sektionstagung Neuroonkologie der DGNC, 30.10.2015, Freiburg).
• Scholz C, Klingler JH, Sircar R, Scheiwe C, Hubbe U: Die navigierte dorsale HW1/HW2 Spondylodese bei Patienten über 70 Jahre. 2015 (Jahrestagung der Sektion Wirbelsäule der DGNC, 02.-03.10.2015, Berlin).
• Shah MJ, Reinacher P: Kraniopharyngeom - Chirurgische Optionen. 2015 (39. Treffen KOBRA, Freiburg, 17.07.2015).

• Brabanti Brodano G, Franke J, Manson N, Buzek D, Kosmala A, Hubbe U, Rosenberg W, Pereira P, Assietti R, Martens F, Lam K, Durny P, Lidar Z, Scheufler KM, Senker W: MASTERS-D: Final Results of a Prospective Multicenter Observational Data-Monitored Study of Minimally Invasive Fusion to Treat Degenerative Lumbar Disorders. Global Spine J, 2015; 2015 (5) (online): A238 (Global Spine Congress, 20. – 23. 05. 2015, Buenos Aires, Argentina). : http://dx.doi.org/10.1055/s-0035-1554342
• Gierthmuehlen M, Gkogkidis A, Wang X, Kuehn C, Schuettler M, Henle C, Kohler F, Haberstroh J, Foerster K, Wiebe K, Wesarg T, Ball T: High-resolution µECoG-recording of auditory-evoked responses on the core and belt auditory cortex of the sheep. 2015 (Jahrestagung DGNC 2015 Karlsruhe).
• Guenzle J, Osterberg N, Weyerbrock A: Poster. The nitric oxide donor JS-K induces cell death of GBM cells by nonapoptotic mechanisms in vitro. 2015 (Tagung der Sektion Neuroonkologie der Deutschen Gesellschaft für Neurochirurgie (DGNC), 30. und 31. Oktober 2015, Freiburg).
• Guenzle J, Osterberg N, Weyerbrock A.: Poster. The nitric oxide donor JS-K induces cell death of GBM cells by nonapoptotic mechanisms in vitro. 2015 (66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie, Karlsruhe, 07.-10.06.2015.).
• Heiland DH, Ferrarese R, Claus R, Weyerbrock A, Carro MS: Poster. Identification and characterization of c-Jun- N-terminal phosphorylation as a regulator of DNA-Methyltransferase 1 and genome-wide methylation in Glioblastoma. 2015 (Tagung der Sektion Neuroonkologie der Deutschen Gesellschaft für Neurochirurgie (DGNC), 30. und 31. Oktober 2015, Freiburg).
• Heiland DH, Ferrarese R, Claus R, Weyerbrock A, Nelander S, Carro MS: Poster. Identification and characterization of C-Jun-N-terminal phosphorylation as a regulator of DNA-Methyltransferase and genome-wide methylation in glioblastoma. 2015 (Brain Tumor 2015, Berlin, 28-29.05.2015.).
• Heiland DH, Staszewski O, Masalha W, Machein M, Capper D, Prinz M, Weyerbrock A.: Poster. Malignant transformation of a dysembryoplastic neuroepithelial tumor characterized by 450k methylation array: A case report. 2015 (66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie, Karlsruhe, 07.-10.06.2015.).
• Hubbe U, Rölz R, Scholz C, Sircar R, Krüger MT, Klingler JH: Poster: Minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) using new sintered titanium cages: first results (postoperative imaging, subsidence and fusion rates). German Medical Science, 2015; 2015 (online): P069 (66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 07.-10.06.2015, Karlsruhe). : http://dx.doi.org/10.3205/15dgnc467 (download: http://www.egms.de/static/de/meetings/dgnc2015/15dgnc467.shtml)
• Oehlke O, Mix M, Mader I, Weyerbrock A, Grosu AL: Poster. Amino-acid PET versus MRI guided re-irradiation in patients with recurrent glioblastoma multiforme (GLIAA) - A randomised phase II trial. 2015 (Tagung der Sektion Neuroonkologie der Deutschen Gesellschaft für Neurochirurgie (DGNC), 30. und 31. Oktober 2015, Freiburg).
• Schmeiser B, Wagner K, Schulze-Bonhage A, Mader I, Steinhoff BJ, Prinz M, Scheiwe C, Weyerbrock A, Zentner J.: Poster. Surgical Treatment of Mesiotemporal Lobe Epilepsy: Which Approach is Favorable? 2015 (Joint Meeting of the American Academy of Neurological Surgery with the DGNC and the German Academy of Neurological Surgery, Heidelberg, 07.-10.10.2015.).