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 Forschungsbericht für das Jahr 2013

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Altenmüller DM, Hebel JM, Rassner M, Freiman TM, Feuerstein TJ, Zentner J: Locally applied valproate enhances survival in rats after neocortical treatment with tetanus toxin and cobalt chloride. J Biomed Biotechnol, 2013; 2013 (online): 497485. : http://dx.doi.org/10.1155/2013/497485
  • Chakravarti A, Wang M, Robins HI, Lautenschlaeger T, Curran WJ, Brachman DG, Schultz CJ, Choucair A, Dolled-Filhart M, Christiansen J, Gustavson M, Molinaro A, Mischel P, Dicker AP, Bredel M, Mehta M: RTOG 0211: a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients. Int J Radiat Oncol, 2013; 85 (5): 1206-1211. : http://dx.doi.org/10.1016/j.ijrobp.2012.10.008
  • Fauser S, Essang C, Altenmüller DM, Staack A, Steinhoff BJ, Strobl K, Bast T, Schubert-Bast S, Doostkam S, Zentner J, Schulze-Bonhage A: Is there evidence for clinical differences related to the new classification of temporal lobe cortical dysplasia? Epilepsia, 2013; 54 (5): 909-917. : http://dx.doi.org/10.1111/epi.12147
  • Gierthmuehlen M, Freiman TM, Haastert-Talini K, Mueller A, Kaminsky J, Stieglitz T, Plachta DT: Computational Tissue Volume Reconstruction of a Peripheral Nerve Using High-Resolution Light-Microscopy and Reconstruct. Plos One, 2013; 8 (6) (online): e66191. : http://dx.doi.org/10.1371/journal.pone.0066191
  • Gläsker S, Kruger MT, Klingler JH, Wlodarski M, Klompen J, Schatlo B, Hippchen B, Neumann HP, Van Velthoven V: Hemangioblastomas and neurogenic polyglobulia. Neurosurgery, 2013; 72 (6): 930-935. : http://dx.doi.org/10.1227/NEU.0b013e31828ba793
  • Hefft S, Brandt A, Zwick S, von Elverfeldt D, Mader I, Cordeiro J, Trippel M, Blumberg J, Schulze-Bonhage A: Safety of Hybrid Electrodes for Single Neuron Recordings in Humans. Neurosurgery, 2013; 73 (1): 78-85. : http://dx.doi.org/10.1227/01.neu.0000429840.76460.8c
  • Jabbarli R, Gläsker S, Weber J, Taschner C, Olschewski M, Van Velthoven V: Predictors of Severity of Cerebral Vasospasm caused by Aneurysmal Subarachnoid Hemorrhage. J Stroke Cerebrovasc, 2013; 22 (8): 1332-1339. : http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2013.01.006
  • Jilg CA, Drendel V, Bacher J, Pisarski P, Neeff H, Drognitz O, Schwardt M, Gläsker S, Malinoc A, Erlic Z, Nunez M, Weber A, Azurmendi P, Schultze-Seemann W, Werner M, Neumann HP: Autosomal dominant polycystic kidney disease: prevalence of renal neoplasias in surgical kidney specimens. Nephron Clin Pract, 2013; 123 (1-2): 13-21. : http://dx.doi.org/10.1159/000351049
  • Klingler JH, Kluge P, Sircar R, Kogias E, Scholz C, Kruger MT, Scheiwe C, Hubbe U: First Experience Using Navigation-Guided Radiofrequency Kyphoplasty for Sacroplasty in Sacral Insufficiency Fractures. Rofo-fortschr Rontg, 2013; 185 (8): 733-740. : http://dx.doi.org/10.1055/s-0033-1335582
  • Klingler JH, Kruger MT, Lemke JR, Jilg C, Van Velthoven V, Zentner J, Neumann HP, Gläsker S: Sequence variations in the von Hippel-Lindau tumor suppressor gene in patients with intracranial aneurysms. J Stroke Cerebrovasc, 2013; 22 (4): 437-443. : http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2013.01.016
  • Klingler JH, Sircar R, Deininger MH, Scheiwe C, Kogias E, Hubbe U: Vesselplasty: a new minimally invasive approach to treat pathological vertebral fractures in selected tumor patients - preliminary results. Rofo-fortschr Rontg, 2013; 185 (4): 340-350. : http://dx.doi.org/10.1055/s-0032-1330443
  • Klingler JH, Sircar R, Hubbe U: Zervikale Vertebroplastie - perkutane Technik des anterioren Zugangs. Rofo-fortschr Rontg, 2013; 185 (12): 1202-1203.
  • Kogias E, Klingler JH, Sircar R, Deininger MH, Hubbe U: Minimally Invasive Revision of a C2 Isthmus Screw. J Neurol Surg A Cent Eur Neurosurg, 2013; 74 Suppl. 1: e211-e214. : http://dx.doi.org/10.1055/s-0033-1343982
  • Lehane C, Guelzow T, Zenker S, Erxleben A, Schwer CI, Heimrich B, Buerkle H, Humar M: Carbimazole is an inhibitor of protein synthesis and protects from neuronal hypoxic damage in vitro. J Pharmacol Exp Ther, 2013; 347: 781-793. : http://dx.doi.org/10.1124/jpet.113.205989
  • Lopez WO, Nikkhah G, Kahlert UD, Maciaczyk D, Bogiel T, Moellers S, Schultke E, Dobrossy M, Maciaczyk J: Clinical neurotransplantation protocol for Huntington's and Parkinson's disease. Restor Neurol Neuros, 2013; 31 (5): 579-595. : http://dx.doi.org/10.3233/RNN-130317
  • Miller JF, Neufang M, Solway A, Brandt A, Trippel M, Mader I, Hefft S, Merkow M, Polyn SM, Jacobs J, Kahana MJ, Schulze-Bonhage A: Neural activity in human hippocampal formation reveals the spatial context of retrieved memories. Science, 2013; 342 (6162): 1111-1114.
  • Neumann HP, Jilg C, Bacher J, Nabulsi Z, Malinoc A, Hummel B, Hoffmann MM, Ortiz-Bruechle N, Gläsker S, Pisarski P, Neeff H, Kramer-Guth A, Cybulla M, Hornberger M, Wilpert J, Funk L, Baumert J, Paatz D, Baumann D, Lahl M, Felten H, Hausberg M, Zerres K, Eng C: Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany. Nephrol Dial Transpl, 2013; 28 (6): 1472-1487. : http://dx.doi.org/10.1093/ndt/gfs551
  • Nguyen-Thanh T, Reisert M, Anastasopoulos C, Hamzei F, Reithmeier T, Vry MS, Kiselev VG, Weyerbrock A, Mader I: Global Tracking in Human Gliomas: A Comparison with Established Tracking Methods. Clin Neuroradiol, 2013; 23 (4): 263-275. : http://dx.doi.org/10.1007/s00062-013-0198-x
  • Oehlke O, Shah M, Seufert J, Grosu AL: Multimodale Therapie von Hypophysenadenomen. Onkologe, 2013; 19: 513-522. : http://DOI: 10.1007/s00761-012-2395-7
  • Plachta DT, Gierthmuehlen M, Cota O, Boeser F, Stieglitz T: BaroLoop: Using a multichannel cuff electrode and selective stimulation to reduce blood pressure. Conf Proc IEEE Eng Med Biol Soc, 2013; 2013: 755-758. : http://dx.doi.org/10.1109/EMBC.2013.6609610
  • Plachta DTT, Cota O, Stieglitz T, Gierthmühlen M: Selektive Ableitung und Stimulation für ein blutdrucksenkendes Implantat unter Verwendung von Vielkanal-Cuff-Elektroden Tm-tech Mess, 2013; 80 (5): 163-172. : http://DOI 10.1524/teme.2013.0026
  • Reithmeier T, Lopez WO, Doostkam S, Machein MR, Pinsker MO, Trippel M, Nikkhah G: Intraindividual comparison of histopathological diagnosis obtained by stereotactic serial biopsy to open surgical resection specimen in patients with intracranial tumours. Clin Neurol Neurosur, 2013; 115 (10): 1955-1960. : http://dx.doi.org/10.1186/1743-422X-10-235
  • Scholz C, Hubbe U, Deininger M, Deininger MH: Hemorrhage rates of external ventricular drain (EVD), intracranial pressure gauge (ICP) or combined EVD and ICP gauge placement within 48h of endovascular coil embolization of cerebral aneurysms. Clin Neurol Neurosur, 2013; 115 (8): 1399-1402. : http://dx.doi.org/10.1016/j.clineuro.2013.01.023
  • Setti M, Savalli N, Osti D, Richichi C, Angelini M, Brescia P, Fornasari L, Carro MS, Mazzanti M, Pelicci G: Functional Role of CLIC1 Ion Channel in Glioblastoma-Derived Stem/Progenitor Cells. Jnci-j Natl Cancer I, 2013; 105 (21): 1644-1655. : http://dx.doi.org/10.1093/jnci/djt278
  • Weidensteiner C, Reichardt W, Shami PJ, Saavedra JE, Keefer LK, Baumer B, Werres A, Jasinski R, Osterberg N, Weyerbrock A: Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI. Nitric Oxide-biol Ch, 2013; 30: 17-25. : http://dx.doi.org/10.1016/j.niox.2013.01.003
  • Wolter T, Kieselbach K, Sircar R, Gierthmuehlen M: Spinal cord stimulation inhibits cortical somatosensory evoked potentials significantly stronger than transcutaneous electrical nerve stimulation. Pain Physician, 2013; 16 (4): 405-414.
Reviews/Übersichtsartikel in wissenschaftlichen Fachzeitschriften:
  • Bausch B, Jilg C, Gläsker S, Vortmeyer A, Lutzen N, Anton A, Eng C, Neumann HP: Renal cancer in von Hippel-Lindau disease and related syndromes. Nat Rev Nephrol, 2013; 9 (9): 529-538. : http://dx.doi.org/10.1038/nrneph.2013.144
  • Vortmeyer AO, Falke EA, Gläsker S, Li J, Oldfield EH: Nervous system involvement in von Hippel-Lindau disease: pathology and mechanisms. Acta Neuropathol, 2013; 125 (3): 333-350. : http://dx.doi.org/10.1007/s00401-013-1091-z
Fallbeispiele:
  • Neubauer C, Shah MJ, Meckel S: Selläres Xanthogranulom: MRT-Bildgebung und Differenzialdiagnose. Rofo-fortschr Rontg, 2013; 185 (3): 272-274. : http://dx.doi.org/10.1055/s-0032-1325514
  • Raffauf AB, Hanna G, Woelber JP, Ermer M, Beringer A, Ratka-Krueger P: Brain abscess associated with Fusobacterium nucleatum after periodontal treatment: A case report Eur J Dent Educ, 2013. (in Druck)
  • Taschner CA, Brendecke S, van Velthoven V, Maurer CJ, Prinz M: Freiburg neuropathology case conference: a pineal region tumour in a child. Clin Neuroradiol, 2013; 23 (4): 331-338. : http://dx.doi.org/10.1007/s00062-013-0262-6
  • Taschner CA, Staszewski O, Jabbarli R, Keuler A, Prinz M: Freiburg neuropathology case conference: a partially calcified, dura-based tumour of the frontal lobe. Clin Neuroradiol, 2013; 23 (1): 63-68. : http://dx.doi.org/10.1007/s00062-013-0199-9
  • Taschner CA, Staszewski O, Scheiwe C, Mader I, Prinz M: Freiburg Neuropathology Case Conference: A Contrast-Enhancing Orbital, Intra-Conal Lesion. Clin Neuroradiol, 2013; 23 (3): 249-253. : http://dx.doi.org/10.1007/s00062-013-0240-z
Kurzbeiträge / short communications:
  • Rassner MP, van Velthoven-Wurster V, Ramantani G, Feuerstein TJ: Altered transporter-mediated neocortical GABA release in Rasmussen encephalitis. Epilepsia, 2013; 54 (3): e41-e44. : http://dx.doi.org/10.1111/epi.12093
Vorträge:
  • Gierthmuehlen M, Cota O, Stieglitz T, Zentner J, Plachta D: Detecting and influencing baroreceptor activity in the vagal nerve of the rat 2013 (64. DGNC Jahrestagung).
  • Gierthmuehlen M, Wang X, Freiman T, Haberstroh J, Rickert J, Schuettler M, Ball T: A chronic animal model for the functional evaluation of a fully implantable mECoG-based brain-machine interfacing device 2013 (64. DGNC Jahrestagung).
  • Haussler U, Bielefeld L, Wolfart J, Haas CA: Neurogenesis in the dentate gyrus. Cause of increased epileptogenicity? 2013 (Annual Conference of the German and Austrian Society for Epilepsy and the Swiss League against Epilepsy, Interlaken, Switzerland).
  • Herrlinger U, Schäfer N, Steinbach JP, Weyerbrock A, Hau P, Goldbrunner R, Friedrich F, Stockhammer F, Ringel F, Braun C, Kohnen R, Leutgeb B, Belka C, Urbach H, Stummer W, Glas M: Bevacizumab, irinotecan and radiotherapy vs. standard temozolomide and radiotherapy in newly diagnosed MGMT-nonmethylated glioblastoma patients: First results from the randomized multicenter GLARIUS trial (oral presentation). 2013 (ASCO Annual Meeting, Chicago, USA).
  • Hubbe U, Ohla V, Deininger M, Sircar R, Kogias E, Krüger MT, Scheiwe C, Klingler JH: Percutaneous minimal invasive stabilisation of pyogenic thoracal and lumbar spondylodiscitis: Long-term follow-up of 70 patients. 2013 (64. Jahrestagung der DGNC, 26.-29.5.13, Düsseldorf).
  • Jabbarli R, Shah M, Van Velthoven V: CT-Angiographie in der Notfall-Versorgung der Patienten mit nicht-traumatischer Subarachnoidalblutung: Ist der Einsatz sinnvoll? 2013 (Vaskuläre Sektionstagung der DGNC, Hamburg).
  • Krüger MT, Van Velthoven V, Klingler JH, Steiert C, Neumann HPH, Gläsker S: Polyglobulia in patients with hemangioblastomas is related to tumor size but not to EPO levels. 2013 (64. Jahrestagung der DGNC, 26.-29.5.13, Düsseldorf).
  • Nakagawa JM: Balloon cells in the epileptogenic human cortex of focal cortical dysplasia type 2b. 2013 (Poster bei der 64. Jahrestagung der DGNC in Düsseldorf).
  • Petö I, Beringer A, Scheiwe C, Weyerbrock A: Poster: Long-term outcome of medulloblastoma in adult population. Our experience with 2 patients. 2013 (EANS Annual Meeting, Tel Aviv, 11.-14.11.2013).
  • Scheiwe C: Operative Behandlung von Tumoren des Kleinhirnbrückenwinkels. 2013 (Freiburger Interdisziplinäres Onkologisches Kolloquium über Schädelbasis-Tumore, Freiburg).
  • Scheiwe C: Pathologien des Kleinhirnbrückenwinkels und der Schädelbasis: Wann ist eine operative Behandlung sinnvoll? 2013 (Fortbildungsveranstaltung für Zuweiser, Neurochirurgische Universitätsklinik Freiburg).
  • Shah MJ, Hubbe U: Verbesserung der Patientenregistrierung durch Oberflächen-Matching innerhalb der Keilbeinhöhle bei navigierten transnasalen endoskopischen Eingriffen 2013 (Sektionstagung Endoskopische Neurochirurgie, Neuronavigation und intraoperative Bildgebung der Deutschen Gesellschaft für Neurochirurgie in Zürich, 15.-16. März 2013).
  • Shah MJ, Jabbarli R, Van Velthoven V: Was tun im Falle eines raumfordernden Infarktes bei einem MoyoMoya Syndrom? 2013 (Vaskuläre Sektionstagung der Deutschen Gesellschaft für Neurochirurgie am 22. und 23.02.2013 in Hamburg).
  • Weidensteiner C, Reichardt W, Shami PJ, Saavedra JE, Keefer LK, Baumer B, Werres A, Jasinski R, Osterberg N, Weyerbrock A: Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI 2013 (folgt).
  • Weyerbrock A: Fortbildungsvortrag: Neurochirurgische Gliomtherapie – zwischen Radikalität und Funktionserhaltung. 2013 (32. Hirntumorinformationstag der Deutschen Hirntumorhilfe, Frankfurt).
  • Weyerbrock A: Fortbildungsvortrag: Hirntumore – eine interdisziplinäre Herausforderung. 2013 (Zuweiserveranstaltung, Klinik für Neurochirurgie, Universitätsklinikum Freiburg).
Konferenzbeiträge:
  • Baumgartner, Winkler C, Wagner D, von Bubnoff N, Doostkam S, Weyerbrock A, Prinz M, Lettau M, Held J, Poppert S, Trippel M, Stich O, : Poster: Zerebrale Echinokokkose als mögliche Differenzialdiagnose unklarer zerebraler Raumforderungen 2013 (DGN-Tagung, Dresden, 18-21.09.13).
  • Herrlinger U, Schäfer N, Steinbach JP, Weyerbrock A, Hau P, Goldbrunner R, Friedrich F, Stockhammer F, Ringel F, Braun C, Kohnen R, Leutgeb B, Belka C, Urbach H, Stummer W, Glas M: Bevacizumab, irinotecan and radiotherapy vs. standard temozolomide and radiotherapy in newly diagnosed MGMT-nonmethylated glioblastoma patients: First results from the randomized multicenter GLARIUS trial. J Clin Oncol, 2013; 31.
  • Klingler JH, Kluge P, Sircar R, Kogias E, Krüger MT, Scheiwe C, Hubbe U: Poster: Navigation-guided radiofrequency kyphoplasty for sacroplasty in sacral insufficiency fractures. 2013 (64. Jahrestagung der DGNC, 26.-29.5.13, Düsseldorf).
  • Stupp R, Hegi ME, Gorlia T, Erridge S, Grujici D, Steinbach JP, Wick W, Tarnawiski R, Nam DH, Weyerbrock A, Hau P, Taphoorn MJB, Nabors LB, Reardon DA, van den Bent MJ, Perry JR, Hong YK, Hicking C, Picard M, Weller M.: Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma and methylated MGMT gene promoter: Key results of the multicenter, randomized, open-label, controlled, phase III CENTRIC study J Clin Oncol, 2013; 31 (ASCO, Chicago, USA).
  • Volz F, Korinthenberg R, Van Velthoven V: Treatment strategy for occlusive hydrocephalus due to posterior fossa tumors – early tumor resection is effective Child Nerv Syst, 2013; 29 (9) (International Society for Pediatric Neurosurgery 41. Annual Meeting October 1, 2013 Mainz, Germany).
  • Weyerbrock A, Osterberg N, Aravindalochanan K, Kieninger J, Urban GA: Poster: Entwicklung und Evaluation eines mikrochipbasierten elektrochemischen Stickstoffmonoxid (NO)-Sensors zur Messung von perizellulärem NO in Gliomzellkulturen / Development and evaluation of an electrochemical nitric oxide sensing onchip cell culture system for measurement of pericellular NO in glioma cell cultures 2013 (DGNC Jahrestagung, Düsseldorf).
Sonstige Publikationen:
  • Weyerbrock A: Vom Labor zum Krankenbett. Management & Krankenhaus, Wiley-VCH Verlag GmbH & Co KGaA, GIT Verlag, Weinheim, 8/2013. Management & Krankenhaus, 2013; 8/2013: 10.