Synthetic Biology of Signaling Processes

nicht vorhanden

Projektbeginn: 01.04.2011
Projektende: 31.03.2017

Römer W

Albert-Ludwigs-Universität Freiburg
Juniorprof. für Synthetic Biology of Signalling Processes

Schänzlestraße 18
79104 Freiburg

Telefon: +49 761 203 67500
Fax: +49 761 203 67535
Email: winfried.roemer@bioss.uni-freiburg.de
http://www.bioss.uni-freiburg.de/cms/1499.html

• Excellence Initiative, Bund

• Aigal S, Claudinon J, Römer W: Plasma membrane reorganization: A glycolipid gateway for microbes. Bba-mol Cell Res, 2015; 1853 (4): 858-871. : http://dx.doi.org/10.1016/j.bbamcr.2014.11.014
• Arbeithuber B, Thuenauer R, Gravogl Y, Balogi Z, Römer W, Sonnleitner A, Tiemann-Boege I: Aquaporin 5 expression in mouse mammary gland cells is not driven by promoter methylation. Biomed Res Int, 2015; 2015: 460598-460598. : http://dx.doi.org/10.1155/2015/460598
• Burgey C, Kern WV, Römer W, Sakinc T, Rieg S: The innate defense antimicrobial peptides hBD3 and RNase7 are induced in human umbilical vein endothelial cells by classical inflammatory cytokines but not Th17 cytokines. Microbes Infect, 2015. : http://dx.doi.org/10.1016/j.micinf.2015.01.005
• Nieth A, Verseux C, Barnert S, Suss R, Römer W: A first step toward liposome-mediated intracellular bacteriophage therapy. Expert Opin Drug Del, 2015; 12 (9): 1411-1424. : http://dx.doi.org/10.1517/17425247.2015.1043125
• Schneider D, Duhren-von Minden M, Alkhatib A, Setz C, van Bergen CA, Benkisser-Petersen M, Wilhelm I, Villringer S, Krysov S, Packham G, Zirlik K, Römer W, Buske C, Stevenson FK, Veelken H, Jumaa H: Lectins from opportunistic bacteria interact with acquired variable region glycans of surface Ig in follicular lymphoma. Blood, 2015. : http://dx.doi.org/10.1182/blood-2014-11-609404
• Schubert T, Römer W: How synthetic membrane systems contribute to the understanding of lipid-driven endocytosis. Bba-mol Cell Res, 2015. : http://dx.doi.org/10.1016/j.bbamcr.2015.07.014
• Schütte OM, Patalag LJ, Weber LM, Ries A, Römer W, Werz DB, Steinem C: 2-Hydroxy Fatty Acid Enantiomers of Gb3 Impact Shiga Toxin Binding and Membrane Organization. Biophys J, 2015; 108 (12): 2775-2778. : http://dx.doi.org/10.1016/j.bpj.2015.05.009
• Arnaud J, Trondle K, Claudinon J, Audfray A, Varrot A, Römer W, Imberty A: Membrane deformation by neolectins with engineered glycolipid binding sites. Angew Chem Int Edit, 2014; 53 (35): 9267-9270. : http://dx.doi.org/10.1002/anie.201404568
• Eierhoff T, Bastian B, Thuenauer R, Madl J, Audfray A, Aigal S, Juillot S, Rydell GE, Müller S, de Bentzmann S, Imberty A, Fleck C, Römer W: A lipid zipper triggers bacterial invasion. P Natl Acad Sci Usa, 2014; 111 (35): 12895-12900. : http://dx.doi.org/10.1073/pnas.1402637111
• Kiske C, Erxleben A, Lucas X, Willmann L, Klementz D, Gunther S, Römer W, Kammerer B: Metabolic pathway monitoring of phenalinolactone biosynthesis from Streptomyces sp. Tu6071 by liquid chromatography/mass spectrometry coupling. Rapid Commun Mass Sp, 2014; 28 (13): 1459-1467. : http://dx.doi.org/10.1002/rcm.6920
• Meinel A, Trankle B, Römer W, Rohrbach A: Induced phagocytic particle uptake into a giant unilamellar vesicle. Soft Matter, 2014; 10 (20): 3667-3678. : http://dx.doi.org/10.1039/c3sm52964a
• Novoa A, Eierhoff T, Topin J, Varrot A, Barluenga S, Imberty A, Römer W, Winssinger N: A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa. Angew Chem Int Edit, 2014; 53 (34): 8885-8889. : http://dx.doi.org/10.1002/anie.201402831
• Rydell GE, Renard HF, Garcia-Castillo MD, Dingli F, Loew D, Lamaze C, Römer W, Johannes L: Rab12 localizes to Shiga toxin-induced plasma membrane invaginations and controls toxin transport. Traffic, 2014; 15 (7): 772-787. : http://dx.doi.org/10.1111/tra.12173
• Schütte, Ole M, Ries, Annika, Orth, Alexander, Patalag, Lukas J, Römer, Winfried, Steinem, Claudia, Werz, Daniel B: Influence of Gb 3 glycosphingolipids differing in their fatty acid chain on the phase behaviour of solid supported membranes: chemical syntheses and impact of Shiga toxin binding Chemical Science, 2014; 5 (8): 3104-3114.
• Sic H, Kraus H, Madl J, Flittner KA, von Munchow AL, Pieper K, Rizzi M, Kienzler AK, Ayata K, Rauer S, Kleuser B, Salzer U, Burger M, Zirlik K, Lougaris V, Plebani A, Römer W, Loeffler C, Scaramuzza S, Villa A, Noguchi E, Grimbacher B, Eibel H: Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis. J Allergy Clin Immun, 2014; 134 (2): 420-428. : http://dx.doi.org/10.1016/j.jaci.2014.01.037
• Thuenauer R, Hsu YC, Carvajal-Gonzalez JM, Deborde S, Chuang JZ, Römer W, Sonnleitner A, Rodriguez-Boulan E, Sung CH: Four-dimensional live imaging of apical biosynthetic trafficking reveals a P Natl Acad Sci Usa, 2014; 111 (11): 4127-4132. : http://dx.doi.org/10.1073/pnas.1304168111
• Thuenauer R, Rodriguez-Boulan E, Römer W: Microfluidic approaches for epithelial cell layer culture and characterisation. Analyst, 2014; 139 (13): 3206-3218. : http://dx.doi.org/10.1039/c4an00056k
• Arnaud J, Claudinon J, Trondle K, Trovaslet M, Larson G, Thomas A, Varrot A, Römer W, Imberty A, Audfray A: Reduction of lectin valency drastically changes glycolipid dynamics in membranes but not surface avidity. Acs Chem Biol, 2013; 8 (9): 1918-1924. : http://dx.doi.org/10.1021/cb400254b
• Rydell GE, Svensson L, Larson G, Johannes L, Römer W: Human GII.4 norovirus VLP induces membrane invaginations on giant unilamellar vesicles containing secretor gene dependent alpha1,2-fucosylated glycosphingolipids. Bba-biomembranes, 2013; 1828 (8): 1840-1845. : http://dx.doi.org/10.1016/j.bbamem.2013.03.016
• Audfray A, Claudinon J, Abounit S, Ruvoen-Clouet N, Larson G, Smith DF, Wimmerova M, Le Pendu J, Römer W, Varrot A, Imberty A: Fucose-binding lectin from opportunistic pathogen Burkholderia ambifaria binds to both plant and human oligosaccharidic epitopes. J Biol Chem, 2012; 287 (6): 4335-4347. : http://dx.doi.org/10.1074/jbc.M111.314831
• Orth A, Johannes L, Römer W, Steinem C: Creating and modulating microdomains in pore-spanning membranes. Chemphyschem, 2012; 13 (1): 108-114. : http://dx.doi.org/10.1002/cphc.201100644
• Sadhu KK, Eierhoff T, Römer W, Winssinger N: Photoreductive uncaging of fluorophore in response to protein oligomers by templated reaction in vitro and in cellulo. J Am Chem Soc, 2012; 134 (49): 20013-20016. : http://dx.doi.org/10.1021/ja310171s