Dr. Giorgos Pyrowolakis

geb. am 29.09.1971 in Athen / Griechenland

1990-1996, Studies of Biology, University of Mainz and University of Heidlberg 1996, Diploma in Biology 1996-2000, PhD Thesis, Center for Molecular Biology (ZMBH), University Heidelberg and Max-Planck Institute (MPI) for Biochemistry, Martinsried 2000, PhD in Biology 2002-2006 Post-doctoral Fellow, Biozentrum, University of Basel, Switzerland Since 2006 Group leader, Developmental Biology Unit, University of Freiburg

Fakultät für Biologie

Hauptforschungsgebiete

Genetics and Developmental Biology, Cell Biology, Intercellular Signaling, Signal Transduction, Drosophila Genetics, Morphogen Signaling, Transcriptional Regulation

Wichtige Publikationen

Fuchs A., Cheung LS. Charbonnier E., Shvartsman SY. Pyrowolakis G. (2011).Transcriptional Interpretation of the EGFR Signaling Gradient. Proceedings of the National Academy of Sciences. in review. Hamaratoglu F., Morton de Lachapelle A., Pyrowolakis G., Bergmann S., Affolter M.(2011). DPP signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc. PLOS Biology, in press. Ben-Zvi D., Pyrowolakis G., Barkai N., Shilo BZ. (2011). Expansion-Repression Mechanism for Scaling the Dpp Activation Gradient in Drosophila Wing Imaginal Discs. Current Biology, 21, 1391-96. Vuilleumier R. and Pyrowolakis G. (2011). Pentagone: Patrolling BMP morphogen signalling. Fly, 5, 210-14. Vuilleumier R., Springhorn A., Patterson L., Koidl S., Hammerschmidt M., Affolter M., Pyrowolakis G. (2010). Control of Dpp morphogen distribution by a secreted feedback regulator. Nature Cell Biol.,12, 611-617. Ninov, N., Manjon, C., Menezes-Gabral, S., Weiss, A., Pyrowolakis, G., Affolter, M., and Martin-Blanco, E. (2010). Dpp Signalling directs Cell Motility and Invasiveness during Epithelial Morphogenesis. Current Biology, 20, 513-520. Weiss A., Charbonnier E., Ellertsdóttir E., Wolf C., Schuh R., Pyrowolakis G.*, Affolter M.* (2010). A conserved activation element in BMP signaling during Drosophila development. Nature Struct. Mol. Biol., 19, 69-76. *shared senior authorship Affolter M., Pyrowolakis G., Weiss A. and Basler K. (2008) Signal-Induced Repression:The Exception or the Rule in Developmental Signaling? Dev. Cell 15, 11-22. Pyrowolakis G., Hartmann B. and Affolter M. (2008). BMP and Activin Signaling in Drosophila. In: The TGF-β Family (editors: Derynck R. and Miyazono K.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. Affolter M., Pyrowolakis G. (2006). eIF4A goes beyond translation Nature Cell Biol., 15, 11-22. Pyrowolakis G., Hartmann B., Muller B., Basler K., and Affolter, M. (2004). A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev. Cell, 7, 229-240. Müller, B.*, Hartmann, B.*, Pyrowolakis, G.*, Affolter, M., and Basler K. (2003). Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell, 113, 221-33. *equal contribution Lotz C.*, Pyrowolakis G.* and Jentsch S. (2004). BRUCE, a Giant E2/E3 Ubiquitin Ligase and Inhibitor of Apoptosis Protein of the trans-Golgi Network, Is Required for Normal Placenta Development and Mouse Survival. Mol. Biol. Cell, 24, 9339-50. *equal contribution Bartke T., Pohl C., Pyrowolakis G. and Jentsch S. (2004). Dual Role of BRUCE as an Antiapoptotic IAP and a Chimeric E2/E3 Ubiquitin Ligase. Mol. Cell, 14, 801-11. Luders, J., Pyrowolakis, G. and Jentsch S. (2003). The ubiquitin-like protein HUB1 forms SDS-resistant complexes with cellular proteins in the absence of ATP. EMBO Rep., 4, 1169-74. Hoege, C., Pfander, B., Moldovan, G. L., Pyrowolakis, G. and Jentsch, S. (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Nature, 419, 135-41. Müller, S., Hoege, C., Pyrowolakis, G. and Jentsch, S. (2001) SUMO, Ubiquitin's mysterious cousin. Nat. Rev. Mol. Cell Biol., 2, 202-10. Jentsch, S. and Pyrowolakis, G. (2000) Ubiquitin and its kin: how close are the family ties? Trends Cell Biol., 10, 335-42. Hauser, H. P., Bardroff, M., Pyrowolakis, G. and Jentsch, S. (1998) A giant ubiquitin conjugating enzyme related to IAP apoptosis inhibitors. J. Cell Biol., 141, 1415-22. Pyrowolakis, G., Hoffmann, D. and Herrmann, R. (1998) The subunit b of the F0F1-type ATPase of the bacterium Mycoplasma pneumaniae is a lipoprotein. J. Biol. Chem., 273, 24792-6.

Kontaktaufnahme

Adresse / Postanschrift:
Institut für Biologie I
Entwicklungsbiologie
Hauptstr. 1
79104 Freiburg i. Br.

Telefon: ++49 761 203 2588
Email: ebio-office@biologie.uni-freiburg.de
http://www.bio1.uni-freiburg.de/ebio