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 Forschungsbericht für das Jahr 2018

Institut für Organische Chemie

Lehrstuhl für Bioorganische Chemie, Prof. H. Jessen

Albertstrasse 21
79104 Freiburg
Tel: 6073
Email henning.jessen@oc.uni-freiburg.de
http://www.jessen-lab.uni-freiburg.de


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Prof. Dr. Henning Jessen, Leitung (m/w)
  • Dr. Amit Dutta, Postdoc (m/w)
  • Dr. Richard Krieger, Leitender wissenschaftlicher Mitarbeiter (m/w)
  • Regine Schandera, Sekretariat (m/w)
  • Dominik Bezold, Doktorand (m/w)
  • Paraskevi Fouka, Doktorand (m/w)
  • Thomas Haas, Doktorand (m/w)
  • Rahel Hinkelmann, Doktorand (m/w)
  • Stephan Mundinger, Technischer Mitarbeiter (m/w)
  • Jyoti Singh, Doktorand (m/w)
  • Nicole Steck, Doktorand (m/w)
  • Christopher Wittwer, Doktorand (m/w)
  • Xuan Wang, Doktorand (m/w)
  • Tamara Bittner, Doktorand (m/w)
  • Paul Ebensperger, Doktorand (m/w)
  • Verena Eisenbeis, Doktorand (m/w)
  • Jiahui Ma, Doktorand (m/w)
  • Tobias Dürr, Doktorand (m/w)
Einträge in der Rubrik "Who is Who"

Finanzierung

  • DFG Sachbeihilfe
  • HFSP Organization
  • DFG Grossgerät
  • VW Stiftung

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Azevedo C, Singh J, Steck N, Hofer A, Ruiz F, Singh T, Jessen HJ*, Saiardi A*: Screening a protein array with synthetic biotinylated inorganic polyphosphate to define the human polyP-ome Acs Chem Biol, 2018; 13: 1958-1963. : http://dx.doi.org/10.1021/acschembio.8b00357
  • Duss M, Salvati Manni L, Moser L, Handschin S, Mezzenga R, Jessen HJ, Landau E: Lipidic mesophases as novel nanoreactor scaffolds for organocatalysts: Heterogeneously catalyzed asymmetric aldol reactions in confined water Acs Appl Mater Inter, 2018; 10: 5114-5124. : http://dx.doi.org/10.1021/acsami.7b19740
  • Fernandes-Cunha GM, McKinlay C, Vargas J, Jessen HJ, Waymouth R, Wender PA: Delivery of Inorganic Polyphosphate into Cells using Amphipathic Oligocarbonate Transporters Acs Central Sci, 2018. : http://dx.doi.org/10.1021/acscentsci.8b00470
  • Ito M, Fujii N, Wittwer C, Sasaki A, Tanaka M, Bittner T, Jessen HJ, Saiardi A, Takizawa S: Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the quantitative analysis of mammalian-derived inositol poly/pyrophosphates J Chromatogr A, 2018; 1573: 87-97. : https://doi.org/10.1016/j.chroma.2018.08.061
  • Jessen HJ: The Hitchhiker’s Guide to Organophosphate Chemistry Synlett, 2018; 29: 699-713. : http://dx.doi.org/10.1055/s-0036-1591922
  • Nair VS, Gu C, Janoshazi AK, Jessen HJ, Wang H, Shears SB: Inositol Pyrophosphate Synthesis by Diphosphoinositol Pentakisphosphate Kinase-1 is Regulated by Phosphatidylinositol(4,5)bisphosphate. Bioscience Rep, 2018; 38: BSR2017154. : http://dx.doi.org/10.1042/BSR20171549
  • Parnell A, Mordhorst S, Kemper F, Giurrandino M, Prince JR, Schwarzer NJ, Hofer A, Wohlwend D, Jessen HJ, Gerhardt S, Einsle O, Oyston PCF, Andexer JN, Roach PL: Substrate Recognition and Mechanism Revealed by Ligand-Bound Polyphosphate Kinase 2 Structures P Natl Acad Sci Usa, 2018; 115: 3350-3355. : https://doi.org/10.1073/pnas.1710741115
  • Potapenko E, Cordeiro C, Huang G, Storey M, Wittwer C, Dutta A, Jessen HJ, Starai VJ, Docampo R: 5-Diphospho-Inositol Pentakisphosphate (5-IP7) Regulates Phosphate Release from Acidocalcisomes of Trypanosoma brucei and Vacuoles of Saccharomyces cerevisiae J Biol Chem, 2018; accepted.
  • Puhl-Rubio AC, Stashko MA, Wang H, Hardy PB, Tyagi V, Li B, Wang X, Kireev D, Jessen HJ, Frye SV, Shears SB, Pearce KH: Use of Protein Kinase-Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors. SLAS Discovery, 2018. : http://dx.doi.org/10.1177/2472555218775323
  • Wang H, Gu C, Rolfes R, Jessen HJ, Shears SB: Structural and biochemical characterization of Siw14: a protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates. J Biol Chem, 2018; 293: 6905-6914. : http://www.jbc.org/cgi/doi/10.1074/jbc.RA117.001670

Besondere wissenschaftliche Aktivitäten

Preise / Ehrungen:
  • Prof. Dr. Henning Jessen: Ruzicka Preis 2015 und Medaille der ETH Zürich, 01.09.2015.

Abschlussarbeiten