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 Forschungsbericht für das Jahr 2017

Juniorprof. für Synthetic Biology of Signalling Processes

Schänzlestraße 18
79104 Freiburg
Tel: +49 761 203 67500 Fax: +49 761 203 67535
Email winfried.roemer@bioss.uni-freiburg.de
http://www.bioss.uni-freiburg.de/cms/1499.html


Wissenschaftliche Mitarbeiterinnen und Mitarbeiter

  • Jun.-Prof. Dr. Winfried Römer
  • Dr. Josef Madl
  • Dr. Julie Claudinon
  • Sahaja Aigal
  • Alessia Landi
  • Anna Savelyeva
  • Taras Sych
  • Dr. Roland Thünauer
  • Sarah Villringer
Einträge in der Rubrik "Who is Who"

Forschungsschwerpunkte

  • Cell Biology
  • Synthetic Biology of Signaling Processes
  • Synthetic Biology
  • Microbiology

Finanzierung

  • BIOSS independent junior group: ”Synthetic Biology of Signaling Processes”
  • BIOSS Research Project (together with Prof. Dr. Heiko Heerklotz): ”Lipid nano-clustering by external stimuli”
  • DFG Sachbeihilfeantrag RO 4341/2-1: ”The role of the lectin LecB in the interaction of Pseudomonas aeruginosa with epithelial cell layers“
  • DFG Sachbeihilfeantrag RO 4341/3-1: ”Energetic investigations of induced particle uptake in functionalized, synthetic membrane systems“
  • EraSynBio ”Synthetic Glycobiology - new strategies to build and functionalise proto-cells and proto-tissues (SynGlycTis)”
  • IRTG GRK 1642 ”Soft Matter Science: Concepts for the design of functional materials”

Wissenschaftliche Projekte und Forschungsvorhaben


  • Energetic investigations of induced particle uptake in functionalized, synthetic membrane systems
  • Investigation of the deformations and modifications of model and cellular lipid membranes by new fluorescence tools
  • Lipid nano-clustering by external stimuli
  • Role of the TRAPPII complex in apical membrane trafficking
  • Synchronizable Integrins
  • Synthetic Biology of Signaling Processes
  • Synthetic Glycobiology - new strategies to build and functionalise proto-cells and proto-tissues (SynGlycTis)
  • The role of the lectin LecB in the interaction of Pseudomonas aeruginosa with epithelial cell layers
    • Projektleitung: Römer W, Co-responsible: Thünauer R
    • Laufzeit: 01.07.2015 bis 30.06.2018
    • Details zum Projekt

Wissenschaftliche Publikationen

Originalarbeiten in wissenschaftlichen Fachzeitschriften:
  • Andrlova H, Mastroianni J, Madl J, Kern JS, Melchinger W, Dierbach H, Wernet F, Follo M, Technau-Hafsi K, Has C, Mittapalli VR, Idzko M, Herr R, Brummer T, Ungefroren H, Busch H, Boerries M, Narr A, Ihorst G, Vennin C, Schmitt-Graeff A, Minguet S, Timpson P, Duyster J, Meiss F, Römer W, Zeiser R: Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-beta1 expression. Oncotarget, 2017. : http://dx.doi.org/10.18632/oncotarget.17160
  • Machida T, Novoa A, Gillon E, Zheng S, Claudinon J, Eierhoff T, Imberty A, Römer W, Winssinger N: Dynamic Cooperative Glycan Assembly Blocks the Binding of Bacterial Lectins to Epithelial Cells. Angew Chem Int Edit, 2017; 56 (24): 6762-6766. : http://dx.doi.org/10.1002/anie.201700813
  • Singh PK, Roukounakis A, Frank DO, Kirschnek S, Das KK, Neumann S, Madl J, Romer W, Zorzin C, Borner C, Haimovici A, Garcia-Saez A, Weber A, Hacker G: Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis. Gene Dev, 2017; 31 (17): 1754-1769. : http://dx.doi.org/10.1101/gad.302497.117
  • Thuenauer R, Muller SK, Römer W: Pathways of protein and lipid receptor-mediated transcytosis in drug delivery. Expert Opin Drug Del, 2017; 14 (3): 341-351. : http://dx.doi.org/10.1080/17425247.2016.1220364
  • Zheng S, Eierhoff T, Aigal S, Brandel A, Thuenauer R, de Bentzmann S, Imberty A, Römer W: The Pseudomonas aeruginosa lectin LecA triggers host cell signalling by glycosphingolipid-dependent phosphorylation of the adaptor protein CrkII. Bba-mol Cell Res, 2017; 1864 (7): 1236-1245. : http://dx.doi.org/10.1016/j.bbamcr.2017.04.005

Besondere wissenschaftliche Aktivitäten

Preise / Ehrungen:
  • Dr. Roland Thünauer: Best Poster Prize, Gordon Research Conference ‘Fibronectin, Integrins & Related Molecules’; Ventura, CA, USA; 29 Jan. – 3 Feb. 2017, 29.01.2017 bis 03.02.2017.
  • Jun.-Prof. Dr. Winfried Römer: Pfizer Foundation Research Prize (Infectiology), 03.02.2011.
Stipendien:
  • Dr. Roland Thünauer: Teaching Fellowship, University College Freiburg WS 17/18, 01.10.2017 bis 01.03.2018.
Ehrung:
  • Jun.-Prof. Dr. Winfried Römer: Appointment as Principal Investigator of the Spemann Graduate School of Biology and Medicine (SGBM), seit 01.09.2011.
  • Jun.-Prof. Dr. Winfried Römer: Appointment as Principal Investigator of BIOSS-2, seit 01.10.2011.
  • Jun.-Prof. Dr. Winfried Römer: Appointment as Principal Investigator of the International Max Planck Research School of Molecular and Cellular Biology (IMPRS-MCB), seit 2012.
Fakultaet:
  • Jun.-Prof. Dr. Winfried Römer: Mitglied des Fakultätsrats, 01.09.2014 bis 31.08.2018.
Gremien:
  • Jun.-Prof. Dr. Winfried Römer: Appointment as member of the steering committee of IMPRS-MCB, seit 2014.
  • Jun.-Prof. Dr. Winfried Römer: Appointment as member of the steering committee of BIOSS, 2015 bis 2018.
  • Jun.-Prof. Dr. Winfried Römer: Appointment as Principal Investigator of the International Research Training Group “Soft Matter Science”: Concepts for the design of functional materials, 2015 bis 2019.
Andere administrative Tätigkeiten:
  • Jun.-Prof. Dr. Winfried Römer: Member of the Freiburg Centre for Interactive Materials and Bioinspired Technologies , seit 2015.

Abschlussarbeiten